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14 Cortical Visual Disorders—Functional Localization and Pathophysiology

351

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INDEX

Page numbers followed by ‘f’ indicate material found within a figure. Page numbers followed by ‘t’ indicate tabular material.

A

Abducens nerve, 12f, 16, 321 Abnormal liver function tests, 126

Acetylcholine receptor antibody, 317–318 Achondroplasia, 303

Achromatic contrast sensitivity, measures spatial luminance, 138

Achromatopsia, central, from occipitotemporal lesions, 29

Acquired arterial pulsation, 60–63

Acquired immunodeficiency syndrome (AIDS), 160

Acquired ocular motility disorders abnormal spontaneous eye movements,

327–328 nystagmus, 327

saccadic intrusions, 327–328 clinical approach and diagnostic tools,

313–315 introduction, 312–313 ophthalmoparesis, 323–324

brainstem disorders, 322–323 cranial nerve palsies, 321–322 extraocular muscles, 315–316 neuromuscular junction, 316–318 supranuclear ocular motility control,

323–324

Acquired pendular nystagmus (APN), 325 in setting visual loss, 325

treatment of, 325 Acromegaly

and Cushing’s disease, 240–241 from somatotroph cells, 239

ACTH. See Adrenocorticotropin-stimulating hormone

ACTH-secreting tumors, 243–244 ACTH-staining types, 245

Active duction, globe retraction during, 67 Active inflammatory eye disease, 270 Acuity loss, 161

Acute arteritic anterior ischemic optic neuropathy, with giant cell arteritis, 125f, 126f

Acute bacterial sinusitis, 165

Acute bilateral visual loss, in giant cell arteritis, 125f

Acute bleeding, with anemia, 120 Acute/chronic inflammation, with systemic

diseases, 80 Acute dacryoadenitis

with nonsteroidal anti-inflammatory drugs, 81 with tenderness, 66–67

Acute demyelinating optic neuritis, 171–172 Acute idiopathic blind spot enlargement

syndrome (AIBSE), 50–51 Acute inflammatory symptoms, 66–67 Acute leukemia

form of, 231

of infiltrative optic neuropathy, 231

Acute macular neuroretinopathy (AMN), 50–51 Acute myeloid leukemia, 90

Acute NAION, treatment of, 121 Acute nausea, 63–64

Acute optic neuritis

neuro-ophthalmologic complications, 159 perivenous sheathing in, 140f

Acute optic neuropathy, 45 causes of, 117

ION, common, 112

Acute orbital decompression, 87–88 Acute sinusitis, 75

Acute surgical intervention, 87–88

Acute visual loss, with acute nausea, 63–64 Acute zonal occult outer retinopathy (AZOOR),

50–51

Adenoid cystic carcinoma common lacrimal malignancy, 90 of right lacrimal gland, 90f

Adenomas, 242, 243

ADH. See Antidiuretic hormone Adrenoceptors, cause dilation or mydriasis, 264 Adrenocorticotropin-stimulating hormone

(ACTH), 239

Age

of presentation, 249

and pupil diameter, relation between, 266f Age-related macular degeneration, 49–50 Aggressive disease, management of, 59 Agnosia

disorder of visual perception, 343 visual object, 340–341

AIBSE syndrome. See Acute idiopathic blind spot enlargement syndrome

AION. See Anterior ischemic optic neuropathy Airborne spores, inhalation of, 160 Akinetopsia, 338–339

Alexia, testing for, 24 Allotypic expression, 203 Alzheimer’s disease, 346 Amaurosis fugax, 47

American Academy of Neurology, Quality Standards subcommittee of, 148–149

Amsler grid testing, 27

to assess macula function, 27f

357

358 Index

AMN. See Acute macular neuroretinopathy ANA. See Antinuclear antibody Anastomotic circle of Zinn-Haller, 3–4

ANCA. See Anti-neutrophil cytoplasmic antigen Ancillary testing, 44

Aneurysm

with bitemporal visual failure, 256f presence of, 13–14

Angioimmunoblastic lymphadenopathy, 229 Angle closure glaucoma, 47

Anisocoria, 31–32 form of, 31–32 pathologic, 32

Annulus of Zinn, 11–12, 15, 16–17 Anoxic brain damage, diffuse, 40

Anterior function syndromes, rarities of, 240 Anterior ischemic optic neuropathy (AION),

119t, 135–137 acute, 120

disorders and drugs suggested with occurrence of, 119t

embolic, 120 nonarteritic, 118t

Anterior uveitis, 166, 176 Anticholinergic toxin, 318 Antidiuretic hormone (ADH), 240

overproduction of, 240 Anti-GQ1b antibody, 322

Anti-neutrophil cytoplasmic antigen (ANCA), 70–71, 172–173

Antinuclear antibody (ANA), 170–171 and anti-DNA antibody, 177–178 in ONTT, 141

Antiphospholipid antibody syndrome, 172–173, 179

Antiplatelet agents and calcium-channel blocker, 108

Antiretroviral therapy, mitochondrial function, 198

Anton’s syndrome, 11, 336 Aortic arch atherosclerosis, 100 Aphasia, 11

APN. See Acquired pendular nystagmus Aquaporin-4 water channel, 173 Arachnoid hyperplasia, 208

Arcuate bundles inferior, 2–3 superior, 2–3 Area V5, 338–339

Argyll Robertson pupil, 277–278 Arnold-Chiari malformation, 326 Arteriosclerotic vascular risk factors, treatment

of, 108

Arteritic AION, 112–113, 118t, 121 clinical presentation of, 121–124 nature of, 126–127

Arteritic ION, 112–113

Artery biopsy, with Churg-Strauss syndrome, 181f

Artery occlusions branch retinal, 52 central retinal, 52f

Aspergilloma, within nasal sinusitis, 160 Aspergillus, 160, 165

Asymmetric pupil size, 31–32

Asymptomatic abnormalities, of visual function, 140–141

Ataxia and meningoencephalitis, 154–155 ATECO. See Autotriggered elliptic centric-

ordered

Atherosclerosis-related vascular diseases, 121 Atonia, of efferent urinary tract, 201 Atropine, to dilate pupils, 268–269 Autoantibodies

prevalence of, 171–172 thyroid associated, 172 Autoimmune disease, 253

Autoimmune optic neuropathy, 171–172 Automated perimetry, 30 Autosomal-dominant optic atrophy, 191,

199–200

Autosomal recessive disorder, 201–202 Autotriggered elliptic centric-ordered (ATECO)

MRV, 291 Axonal swelling, 281

Azathioprine, immunosuppression with, 167 AZOOR. See Acute zonal occult outer

retinopathy

B

Bacille Calmette-Guerin (BCG), 172 Balint’s syndrome, 343

Bartonella henselae, causes cat scratch disease, 160

Basal dura, stretching of, 241 Basilar invagination, 326

B-cell non-Hodgkin’s lymphomas, 91–92 BCG. See Bacille Calmette-Guerin

Behc¸et’s syndrome, 138, 166–167, 176, 176f Benign orbital diseases, 88

B. henselae, treatment for, 162–163 Bilateral chronic dacryoadenitis, 83f Bilateral Horner’s syndrome, 272f

Bilateral lacrimal drainage obstruction, infant with, 77f

Bilateral optic neuritis, development of, 178 Binocular diplopia, 313, 313f

Biopsy, 254–255 Bitemporal field loss, 241 Blindsight, 336–337 Blood sugar, elevated, 95

Blood supply, for optic chiasm, 8 Blood tests, 149

Blowout fracture, 65f Bone scalloping

on CT scans, 251

with intact cortex, 73–74

 

Index

359

Botulism, 318

Central retinal vein occlusion (CRVO), 53, 211

 

Brachytherapy, implantation, 90–91

descriptions of, 53

 

Brain

Central serous retinopathy (CSR), 48–49

 

CT of, 195

Centrocecal scotomas, in ONTT, 138

 

MRI of, 173

Cephaloceles, with neurofibromatosis, 75–76

 

Brainstem injury, complete, 39–40

Cerebral achromatopsia, 337–338

 

Brainstem pathways

effect of, 337–338

 

for horizontal gaze, 17f

etiology of, 337

 

for vertical saccades, 18

Cerebral akinetopsia, 338–339

 

Brain tumors, 302

Cerebral artery infarction, 105f

 

and space-occupying tumors, 289

Cerebral infarction, 333

 

Breathing pattern, evaluation of, 39

Cerebral lesions, cause visual disorders, 335

 

Bright light, to assess pupils, 31

Cerebral polyopia, 345

 

Brucella infection, of nervous system, 159

Cerebrospinal fluid (CSF), 154–155

 

Bull’s-eye maculopathy, with cone

abnormal, 143

 

dystrophy, 55f

pressure, 60–63

 

Buried drusen, 287f

Cerebrovenous thrombosis, 302

 

Burst neurons, in brainstem, 323

Cervical cord, sagittal MRI of, 174f

 

Busacca nodules, 166

Charcot-Marie-Tooth disease (CMT), 201–202

 

 

Charles Bonnet syndrome, 346–347

 

C

Chester-Erdheim disease, 255

 

Calcarine cortex

Chiasmal disease, common defect of, 8

 

occipital lobes and, 9–10

Chiasmal lesions, 276–277

 

upper and lower bank of, 9

Chiasmal/retrochiasmal disease, visual field

 

Campylobacter jejuni infections, 322

defects from, 4

 

Candle wax drippings, 166–167

Chiasmal syndrome, etiology of, 8

 

CAR. See Carcinoma-associated retinopathy

Chiasmal visual loss, 8

 

Carbonic anhydrase inhibitors, complications

Childhood, familial storage diseases and cerebral

 

of, 296

degenerations of, manifest optic atrophy,

 

Carcinoma-associated retinopathy (CAR), 56

202t

 

Cardiac disease, as manifestations of systemic

Chin depression, 34

 

disorders, 2

Chocolate cysts, 77–78

 

Carotico-cavernous fistula

Choked disc, 280

 

with acute proptosis, 79–80

Cholesterol, multiple and platelet-fibrin emboli,

 

atheromatous, 81f

100f

 

Carotid angiogram, 103f, 256f

Chondrosarcomas, 250–251

 

Cataracts, cause blurring, darkening, 46

Chordomas, 251

 

Cat scratch disease, 162

Chorioretinitis, retinal periphlebitis on,

 

Cavernous hemangioma

166–167

 

adulthood benign orbital mass, 78–79

Choroidal circulation, 52

 

during surgical removal, 80f

Choroidal folds

 

Cavernous meningioma, 247f

on funduscopy, 63–64

 

Cavernous sinus syndrome, 15, 18, 246, 321

and macular edema, 296

 

Cushing’s tumor invading, 245f

Choroidal hypoperfusion, on retinal fluorescein

 

diagram of, 13f

angiogram, 102f

 

with ophthalmoplegia, 241

Choroidal ischemia, TMVL from isolated, 102

 

orbital apex and, 18

Choroidoretinitis, 160

 

and pituitary fossa, 251

Choroid plexus papilloma, 302–303

 

Celiac disease, 176–177

Chronic anterior uveitis, 160

 

with anti-gliadin antibodies, 176–177

Chronic degenerative changes, 49–50

 

with neurologic complications, 176–177

Chronic headache, causes of, 298

 

Cellular anaplasia, degree of, 214

Chronic hypoperfusion, 101–102

 

Cellular components, 214

Chronic inflammation, 270

 

Central acuity loss, cause for, 27

Chronic insidious panuveitis, 167

 

Central nervous system (CNS), 225

Chronic ocular hypoperfusion, 101–102

 

Central retinal artery (CRA), 52

Chronic progressive external ophthalmoplegia

 

occlusion of, 52

(CPEO), 316

 

cases of, 52

Chronic relapsing inflammatory optic

 

funduscopic appearance of, 52

neuropathy (CRION), 170f, 171f

 

360

 

Index

 

 

Chronic uveitis, 166

Corneal sensation, 68

 

Churg-Strauss syndrome, 154, 181

Corneal surface, luster of, 47

 

Ciliary arteries, posterior, 3–4

Coronary artery bypass graft surgery, bilateral

 

Ciliary ganglion, damage to, 274–275

anterior ischemic optic neuropathy after,

 

Cilio-retinal shunt vessels, 70

129f

 

Circle of Zinn-Haller, 113–114, 113f

Cortical blindness, 11, 336

 

Circulation stenosis, anterior, 100

Cortical visual disorders

 

Claude’s syndrome, 15

prognosis for, 349

 

Clioquinol, toxins, 172–173

types of, 350

 

Clival chordoma, compressing brainstem, 251f

Corticosteroids, 154–155

 

CMT. See Charcot-Marie-Tooth disease

with acute papilledema, 296

 

CNS. See Central nervous system

with arteritic ION, 127

 

Cogan’s lid twitch sign, 34, 316

and cyclophosphamide, 182

 

Cold caloric test, 39–40

Cover-uncover test, 37–38

 

Color agnosia, 338

CPEO. See Chronic progressive external

 

Color anomia, 338

ophthalmoplegia

 

Color blindness, tests for congenital, 25–26

CRA. See Central retinal artery

 

Color bottle top, to detect color difference, 25f

Cranial nerve deficits, multiple, 63–64

 

Color-coded Doppler B-mode imaging, for

Cranial nerve nuclei, 322–323

 

 

vascular anomalies, 71–72

Cranial nerve paresis, causes of third, fourth,

 

Color-naming defect, 338

and sixth, 322t

 

Color plate test, utility of, 25–26

Cranial nerves, anatomic considerations of third,

 

Color selective area, 332

fourth, and sixth, 16–18

 

Color vision, 25–26, 193, 337

Cranial neuropathy, investigation of, causing

 

 

abnormal, 145

diplopia, 321

 

 

assessed using Ishihara, 25–26

Craniopharyngiomas, 243, 249

 

 

tests of, 137

Craniotomy

 

Coma

for giant tumors, 245

 

 

abnormal ocular fundi in, 41

route of, 247–248

 

 

causes of, 38

CRAO. See Cental retinal artery (CRA),

 

 

eye movement abnormalities in, 40–41

occlusion of

 

 

neuroanatomic correlates of, 38

C-reactive protein

 

 

pupillary abnormalities in, 40

ESR and, 127

 

 

unexplained, 38

and fibrinogen, 106, 126

 

Comatose patients

CRION. See Chronic relapsing inflammatory

 

 

approach to, 39

optic neuropathy

 

 

examination in, 39–40

Crossed innervation, 15

 

Complex cells, 334

CRVO. See Central retinal vein occlusion

 

Computed tomography angiography (CTA), 106

Cryptococcus, 161

 

Computed tomography, modality for orbital

CSF. See Cerebrospinal Fluid

 

 

conditions, 60

CSF absorption, interference with, 300

 

Computerized perimetry, with glaucoma or

CSF lymphocyte pleocytosis, 162

 

 

papilledema, 30

CSR. See Central serous retinopathy

 

Cone dystrophy

CTA. See Computer tomography angiography

 

 

bilateral loss of central vision, 54

Cup-to-disc ratio, illustration of, 116f

 

 

as bilateral optic neuropathy, 55f

Cushing’s disease, from corticotroph cells, 239

 

Congenital fourth nerve palsy, diagnosis of,

Cushing’s tumors, pretreatment of, 244–245

 

 

36–37

Cyberknife, LINAC units, 220

 

Conjugate gaze, in vertical and horizontal

Cytoplasmic-pattern ANCA (c-ANCA), 181–182

 

 

planes, 19

 

 

Conjunctival chemosis, gross, 81f

 

 

Contrast sensitivity

D

 

 

and low-contrast letter acuity, 26

Dalen-Fuchs nodules, 177

 

 

measure of visual function, 26

Death, risk of, 104

 

 

types of, 26

Defective visual localization, 344

 

Corneal haze, 47

Degenerations, retinal, 54–56

 

Corneal light reflection test, 314f

Degenerative brainstem diseases, 323–324

 

Corneal reflexes, testing of, 40

Demyelinating disease, primary, 135

 

Corneal scarring, 276

Dermoid cysts, 66–67, 73–74