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NEUROOPHTHALMOLOGY

Edited by

DESMOND P. KIDD, MD, FRCP

Consultant Neurologist

Department of Clinical Neurosciences

Royal Free Hospital and University College Medical School London, United Kingdom

NANCY J. NEWMAN, MD

LeoDelle Jolley Professor of Ophthalmology

Professor of Ophthalmology and Neurology

Instructor in Neurological Surgery

Emory University School of Medicine

Atlanta, Georgia

´

VALERIE BIOUSSE, MD

Cyrus H. Stoner Professor of Ophthalmology Professor of Ophthalmology and Neurology Emory University School of Medicine Atlanta, Georgia

1600 John F. Kennedy Blvd.

Ste 1800

Philadelphia, PA 19103-2899

NEURO-OPHTHALMOLOGY

ISBN: 978-0-7506-7548-2

Copyright # 2008 by Butterworth-Heinemann, an imprint of Elsevier Inc.

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Permissions may be sought directly from Elsevier’s Rights Department: phone: (þ1) 215 239 3804 (US) or (þ44) 1865 843830 (UK); fax: (þ44) 1865 853333; e-mail: healthpermissions@elsevier.com. You may also complete your request on-line via the Elsevier website at http://www.elsevier.com/permissions.

Notice

Knowledge and best practice in this field are constantly changing. As new research and experience broaden our knowledge, changes in practice, treatment and drug therapy may become necessary or appropriate. Readers are advised to check the most current information provided (i) on procedures featured or (ii) by the manufacturer of each product to be administered, to verify the recommended dose or formula, the method and duration of administration, and contraindications. It is the responsibility of the practitioner, relying on their own experience and knowledge of the patient, to make diagnoses, to determine dosages and the best treatment for each individual patient, and to take all appropriate safety precautions. To the fullest extent of the law, neither the Publisher nor the Editors assume any liability for any injury and/or damage to persons or property arising out of or related to any use of the material contained in this book.

The Publisher

Library of Congress Cataloging-in-Publication Data

Neuro-ophthalmology / [edited by] Desmond P. Kidd, Nancy J. Newman, Vale´rie Biousse. – 1st ed. p. ; cm. – (Blue books of neurology series; v.32)

Includes bibliographical references and index. ISBN 978-0-7506-7548-2

1. Neuroophthalmology. I. Kidd, Desmond P. II. Newman, Nancy J. III. Biousse, Vale´rie. IV. Series: Blue books of neurology; 32. [DNLM: 1. Eye Diseases. 2. Nervous System Diseases. W1 BU9749 v.32 2008 / WW 460 N4915 2008]

RE725.N45682 2008

 

617.7032–dc22

2007040909

Acquisitions Editor: Adrianne Brigido

Developmental Editor: Joan Ryan

Project Manager: Mary Stermel

Design Direction: Steven Stave

Marketing Manager: Todd Liebel

Printed in China

Last digit is the print number: 9 8 7 6 5 4 3 2 1

CONTRIBUTING AUTHORS

LAURA J. BALCER, MD, MSCE

Associate Professor of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

´

VALERIE BIOUSSE, MD

Cyrus H. Stoner Professor of Ophthalmology, Professor of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia

FION D. BREMNER, PhD, FRCOphth

Consultant Neuro-Ophthalmic Surgeon, The National Hospital for Neurology and Neurosurgery, London, United Kingdom

CHOTIPAT DANCHAIVIJITR, MD, MRCP (UK)

Instructor in Neurology, Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

KATHLEEN DIGRE, MD

Professor of Neurology and Ophthalmology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah

STEVEN L. GALETTA, MD

Van Meter Professor of Neurology and Ophthalmology; Director, Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Scheie Eye Institute, and The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

CHRISTOPHER KENNARD, PhD, FRCP, FMedSci

Professor of Clinical Neurology, Department of Clinical Neuroscience, Imperial College London, Charing Cross Campus, London, United Kingdom

DESMOND P. KIDD, MD, FRCP

Consultant Neurologist, Department of Clinical Neurosciences, Royal Free Hospital and University College Medical School, London, United Kingdom

GRANT T. LIU, MD

Professor of Neurology and Ophthalmology, Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, and The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

ix

xContributing Authors

NEIL R. MILLER, MD, FACS

Professor of Ophthalmology, Neurology and Neurosurgery and Frank B. Walsh Professor of Neuro-Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, Maryland

NANCY J. NEWMAN, MD

LeoDelle Jolley Professor of Ophthalmology, Professor of Ophthalmology and Neurology, Instructor in Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia

GORDON T. PLANT, MA, MD (Cantab), FRCP (UK), FRCOphth

Consultant Neurologist, The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and St. Thomas’ Hospital, London, United Kingdom

MICHAEL POWELL, FRCS, FRCP

Senior Consultant Neurosurgeon, The National Hospital for Neurology and Neurosurgery, London, United Kingdom

GEOFFREY E. ROSE, BSc, MBBS, MS, DSc, MRCP, FRCOphth

Consultant Orbital, Lacrimal, and Oculoplastic Surgeon, Moorfields Eye Hospital, London, United Kingdom

JANET C. RUCKER, MD

Assistant Professor of Neurology and Ophthalmology, Rush University Medical Center, Chicago, Illinois

DAVID H. VERITY, MA, BM BCh, FRCOphth

Consultant Orbital, Lacrimal, and Oculoplastic Surgeon, Moorfields Eye Hospital, London, United Kingdom

CONTRIBUTING AUTHORS

LAURA J. BALCER, MD, MSCE

Associate Professor of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania

´

VALERIE BIOUSSE, MD

Cyrus H. Stoner Professor of Ophthalmology, Professor of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia

FION D. BREMNER, PhD, FRCOphth

Consultant Neuro-Ophthalmic Surgeon, The National Hospital for Neurology and Neurosurgery, London, United Kingdom

CHOTIPAT DANCHAIVIJITR, MD, MRCP (UK)

Instructor in Neurology, Division of Neurology, Department of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand

KATHLEEN DIGRE, MD

Professor of Neurology and Ophthalmology, John A. Moran Eye Center, University of Utah, Salt Lake City, Utah

STEVEN L. GALETTA, MD

Van Meter Professor of Neurology and Ophthalmology; Director, Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Scheie Eye Institute, and The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

CHRISTOPHER KENNARD, PhD, FRCP, FMedSci

Professor of Clinical Neurology, Department of Clinical Neuroscience, Imperial College London, Charing Cross Campus, London, United Kingdom

DESMOND P. KIDD, MD, FRCP

Consultant Neurologist, Department of Clinical Neurosciences, Royal Free Hospital and University College Medical School, London, United Kingdom

GRANT T. LIU, MD

Professor of Neurology and Ophthalmology, Division of Neuro-Ophthalmology, Departments of Neurology and Ophthalmology, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, and The Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania

ix

xContributing Authors

NEIL R. MILLER, MD, FACS

Professor of Ophthalmology, Neurology and Neurosurgery and Frank B. Walsh Professor of Neuro-Ophthalmology, Johns Hopkins Medical Institutions, Baltimore, Maryland

NANCY J. NEWMAN, MD

LeoDelle Jolley Professor of Ophthalmology, Professor of Ophthalmology and Neurology, Instructor in Neurological Surgery, Emory University School of Medicine, Atlanta, Georgia

GORDON T. PLANT, MA, MD (Cantab), FRCP (UK), FRCOphth

Consultant Neurologist, The National Hospital for Neurology and Neurosurgery, Moorfields Eye Hospital and St. Thomas’ Hospital, London, United Kingdom

MICHAEL POWELL, FRCS, FRCP

Senior Consultant Neurosurgeon, The National Hospital for Neurology and Neurosurgery, London, United Kingdom

GEOFFREY E. ROSE, BSc, MBBS, MS, DSc, MRCP, FRCOphth

Consultant Orbital, Lacrimal, and Oculoplastic Surgeon, Moorfields Eye Hospital, London, United Kingdom

JANET C. RUCKER, MD

Assistant Professor of Neurology and Ophthalmology, Rush University Medical Center, Chicago, Illinois

DAVID H. VERITY, MA, BM BCh, FRCOphth

Consultant Orbital, Lacrimal, and Oculoplastic Surgeon, Moorfields Eye Hospital, London, United Kingdom

SERIES PREFACE

The Blue Books of Neurology have a long and distinguished lineage. Life began as the Modern Trends in Neurology series and continued with the monographs forming BIMR Neurology. The present series was first edited by David Marsden and Arthur Asbury, and saw the publication of 25 volumes over a period of 18 years.

The guiding principle of each volume, the topic of which is selected by the Series Editors, was that each should cover an area where there had been significant advances in research and that such progress had been translated to new or improved patient management.

This has been the guiding spirit behind each volume, and we expect it to continue. In effect, we emphasize basic, translational, and clinical research but principally to the extent that it changes our collective attitudes and practices in caring for those who are neurologically afflicted.

Tony Schapira took over as joint editor in 1999 following David’s death, and together with Art oversaw the publication and preparation of a further 8 volumes. In 2005, Art Asbury ended his exceptional co-editorship after 25 years of distinguished contribution and Martin Samuels was asked to continue the co-editorship with Tony.

The current volumes represent the beginning of the next stage in the development of the Blue Books. The editors intend to build upon the excellent reputation established by the Series with a new and attractive visual style incorporating the same level of high-quality review. The ethos of the Series remains the same: up-to-date reviews of topic areas in which there have been important and exciting advances of relevance to the diagnosis and treatment of patients with neurological diseases. The intended audience remains those neurologists in training and those practicing clinicians in search of a contemporary, valuable, and interesting source of information.

ANTHONY H.V. SCHAPIRA

MARTIN A. SAMUELS

SERIES EDITORS

xi

PREFACE

The practice of neurology is both interesting and challenging owing to the wide diversity of clinical problems and syndromes, and, oftentimes, the difficulty of establishing the pathology of the disease process without gaining access to tissue. Neuro-ophthalmology lies at the extreme of this; visual symptoms may arise as a result of disease anywhere within the eye and brain, and neuro-ophthalmologists, unlike many other subspecialists, have the added challenge of including all disease processes in their differential diagnosis of visual symptoms, including those of inflammatory, vascular, degenerative, neoplastic, toxic, traumatic, and metabolic origin. Although neurologists may find neuro-ophthalmologic problems somewhat daunting because of the need to gain an understanding of the ways of ophthalmologists and their equipment, neuro-ophthalmology is in essence the application of an understanding of neurological diseases and their pathophysiology to visual symptoms.

This volume of the Blue Book series is the first to deal with neuroophthalmology and its practice; it is not intended as an exhaustive textbook on neuro-ophthalmology but is comprised of a series of chapters that deal in turn with each of the main and common conditions seen in neuro-ophthalmology, with an emphasis on modern methods of assessment and treatment. It is designed to interest neurologists, neurosurgeons, and ophthalmologists of any level of experience, with the hope that they will come to find neuro-ophthalmic cases as fascinating as we do.

We would like to thank all our co-authors for their experience, expertise, clear writing, and attention to deadlines. We would also like to thank the staff at Elsevier for their help and professionalism in managing the volume, particularly Susan Pioli, whose calmness was especially helpful.

DESMOND P. KIDD

NANCY J. NEWMAN

VALE´ RIE BIOUSSE

xiii

Dedication

To our families

xv