Vermis

FN

?

IO

Fig. 3. Schematic drawing of the climbing fiber pathway from the medulla (lower part) to the cerebellar cortex (vermis). It originates in the inferior olive (IO) and is interrupted by lateral medullary infarction (shaded area). The lesions causes disinhibition of Purkinje cell simple spike resting activity in the vermis, and as a consequence increased inhibition in the FN. The resulting SPEM and saccade deficits are shown in table 1; from Helmchen et al. [88].

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Prof. Dr. U. Büttner Department of Neurology

Klinikum Grosshadern, Marchioninistrasse 15 DE–81377 Munich (Germany)

Tel. 49 89 7095 2560, Fax 49 89 7095 5561, E-Mail ulrich.buettner@med.uni-muenchen.de