- •Contents
- •Foreword
- •Dedication
- •Message
- •About the Editors
- •List of Contributors
- •Acknowledgments
- •Introduction
- •Methodologic Issues
- •Review of Studies (Table 1)
- •Cohort Effects on Myopia
- •Risk Factors for Myopia
- •Near work
- •Education/Income
- •Outdoor activity
- •Race/Ethnicity
- •Nuclear cataract
- •Family aggregation/Genetics
- •Siblings
- •Parent-child
- •Other family members
- •Genetics
- •Comments
- •Acknowledgments
- •References
- •Introduction
- •Definition of Myopia in Epidemiologic Studies
- •Risk Factors for Myopia and Ocular Biometry
- •Family history of myopia
- •Near work
- •Outdoor activity
- •Stature
- •Birth parameters
- •Smoking history
- •Breastfeeding
- •Conclusion
- •References
- •Introduction
- •Aetiological Heterogeneity of Myopia
- •Clearly genetic forms of myopia
- •School or acquired myopia
- •Misunderstandings of Heritability and Twin Studies
- •But Heritability has Its Uses
- •Evidence for Genetic Associations of School Myopia
- •Evidence for the Impact of Environmental Factors on Myopia Phenotypes
- •Gene-Environment Interactions and Ethnicity
- •Gene-Environment Interactions and Parental Myopia
- •Conclusion
- •Acknowledgments
- •References
- •Introduction
- •Economic evaluations
- •Full vs partial evaluations
- •Economic evaluation of myopia
- •The Economic Cost of Myopia: A Burden-of-Disease Study
- •China
- •India
- •Europe
- •Singapore
- •Southeast Asia
- •Africa
- •South America
- •Bangladesh
- •ii. Proportion of myopes paying for correction
- •Uncorrected and undercorrected refractive error, spectacle coverage rate and reasons for spectacles nonwear
- •iii. Amount paid for myopic correction
- •Singapore
- •The burden of myopia
- •Further Directions for Economic Research
- •References
- •Introduction
- •Impact of Myopia in Adults
- •Overall Conclusion
- •Future Studies
- •References
- •Introduction
- •Definition of Pathological Myopia
- •Cataract
- •Glaucoma
- •Myopic Maculopathy
- •Myopic Retinopathy
- •Retinal Detachment
- •Optic Disc Abnormalities
- •References
- •Conclusion
- •Introduction
- •The Association Between Myopia and POAG
- •Information from epidemiological studies
- •Asian populations: Myopia and POAG
- •Myopia in other situations
- •Myopia and ocular hypertension
- •Myopia in angle closure
- •Myopia in Pigment Dispersion Syndrome (PDS)
- •Theories for a Link Between Myopia and POAG
- •Glaucoma Assessment in Myopic Eyes
- •Biometric differences
- •Axial length and CCT
- •Optic disc assessment in myopic eyes
- •Visual fields in myopic eyes
- •Imaging tests and variations with myopia
- •ONH susceptibility to damage
- •The Influence of Myopia on the Clinical Management of the Glaucoma Patient
- •Glaucoma progression and myopia
- •References
- •Posterior Staphyloma
- •Myopic Chorioretinal Atrophy
- •Lacquer Cracks
- •Myopic Choroidal Neovascularization
- •Myopic Foveoschisis
- •Myopic macular hole detachments
- •Lattice degeneration
- •Retinal tears and detachments
- •References
- •Introduction
- •Electroretinography
- •Ganzfeld electroretinography
- •Multifocal electroretinography
- •Assessment of Retinal Function
- •Outer retinal (photoreceptor) function
- •Post-receptoral (bipolar cell) and retinal transmission function
- •Inner retinal function
- •Macular function in myopic retina
- •Effect of Long-Term Atropine Usage on Retinal Function
- •Macular Function Associates with Myopia Progression
- •Factors Associated with ERG Changes in Myopia
- •Conclusion
- •References
- •Introduction
- •Genomic Convergence Using Genomic Content
- •Pathway Analysis
- •Pathway analysis in cancer genomics
- •Pathway analysis in GWAS
- •Non-parametric approaches
- •Parametric approaches
- •P-values combining approaches
- •Conclusion
- •References
- •Introduction
- •Definition of Myopia
- •The Classical Twin Model
- •What is the classical twin model?
- •Historical perspective
- •Statistical approaches
- •Twins, Myopia and Heritability Studies
- •Heritability studies for myopia using twins
- •Limitations of using twins in heritability studies
- •Twins and Myopia — Other Studies
- •The Importance of Twin Registries
- •Concluding Comments
- •Acknowledgments
- •References
- •Introduction
- •Candidate Gene Selection Strategies for Myopia
- •Genes Associated With Myopia-Related Phenotypes
- •The HGF/cMET ligand-receptor axis
- •The collagen family of genes
- •Concluding Remarks
- •Acknowledgments
- •References
- •Introduction
- •Phenotypes for Myopia Genetic Studies
- •Study Design
- •Genotyping and Quality Controls
- •Population Structure
- •Association Tests
- •Correlated Phenotypes
- •Imputation and Meta-Analysis
- •Visualization Tools
- •Drawing Conclusions
- •Acknowledgments
- •References
- •Introduction
- •The Search for Error Signals
- •The blur hypothesis
- •Bidirectional lens-compensation
- •Recovery from ametropia vs. compensation for lenses
- •The complication of the emmetropization end-point
- •Optical aberrations as error signals
- •Other possible visual error signals
- •How Important is Having a Fovea?
- •Mechanisms of Emmetropization
- •Scleral similarities and differences between humans and chickens
- •Retinal signals
- •Glucagon-insulin
- •Retinoic acid
- •Dopamine
- •Acetylcholine
- •Choroidal signals
- •The Role of the Choroid in the Control of Ocular Growth
- •Diurnal rhythms and control of ocular growth
- •Conclusions
- •References
- •Introduction
- •Gross Scleral Anatomy
- •Structural organization of the sclera
- •Cellular content of the sclera
- •Mechanical properties of the sclera
- •Structural Changes to the Sclera in Myopia
- •Development of structural and ultrastructural scleral changes in myopia
- •Scleral pathology and staphyloma
- •Biochemical Changes in the Sclera of Myopic Eyes
- •Structural biochemistry of the sclera in myopia
- •Degradative processes in the sclera of myopic eyes
- •Cellular changes in the sclera in myopia
- •Biomechanical Changes in the Sclera of Myopic Eyes
- •Regulators of scleral myofibroblast differentiation
- •Myofibroblast-extracellular matrix interactions
- •Cellular and matrix contributions to altered scleral biomechanics and myopia
- •Scleral Changes in Myopia are Reversible
- •Eye growth regulation during recovery from induced myopia
- •Summary and Conclusions
- •Acknowledgments
- •References
- •Introduction
- •Spatial Visual Performance and Optical Features of the Eye
- •Axial eye growth and development of refractive state
- •Lens thickness and vitreous chamber depth
- •Corneal radius of curvature
- •Schematic eye data
- •Techniques Currently Available for Myopia Studies in the Mouse, Both for Its Induction and Measurement
- •Devices to induce refractive errors
- •Techniques to measure the induced refractive errors and changes in eye growth
- •Refractive state
- •Corneal radius of curvature
- •Axial length measurements and ocular biometry
- •Measurements of the optical aberrations of the mouse eye
- •Behavioral measurement of grating acuity and contrast sensitivity in the mouse
- •Recent Studies on Myopia in the Mouse Model: Some Examples
- •Magnitudes of experimentally induced refractive errors in wild-type mice
- •Refractive development in mutant mice
- •Pharmacological studies to inhibit axial eye growth in mice
- •Image processing and regulation of retinal genes and proteins
- •Summary
- •Acknowledgments
- •References
- •Introduction
- •A Brief Introduction to Comparative Genomics
- •Comparative Expression
- •Genes in Retina and Sclera in Animal Models of Myopia
- •ZENK (EGR-1)
- •Scleral Gene Expression in a Mouse Model of Myopia
- •RNA, Target cDNA and Microarray Chip Preparation
- •Microarray Data Analysis
- •Scleral Gene Expression in the Myopic Mouse
- •Summary
- •References
- •Introduction
- •Possible Mechanisms of Pharmacological Treatment
- •Efficacy Studies
- •Other Issues Related to Drugs
- •Potential Side Effects
- •The Future of Drug Treatment in Myopia
- •Conclusions
- •References
- •Introduction
- •Accommodation
- •Close work
- •Physical characteristics of the retinal image
- •Visual deprivation
- •Compensatory changes in refraction
- •Intensity and periodicity of light exposure
- •Spatial frequency
- •Light periodicity
- •Image clarity
- •Outdoor activity and retinal image blur
- •Light vergence and photon catch
- •Chromaticity
- •Therapeutic implications
- •References
- •Index
91 Quality of Life and Myopia
limited available evidence, more work is needed to gain a better understanding of the impact of myopia on vision-specific functioning and HRQoL in children and younger adults not only in Asia but also other countries. In adults, unilateral visual impairment associated with refractive error (including myopia) appears to have a limited impact general health. However, bilateral correctable visual impairment and severe stage myopia negatively impact general and vision-specific HRQoL. Correction of myopia does not impact on vision-specific functioning24 although more information is needed to establish its impact on emotional well-being and social inclusion.25
Future Studies
Future work to improve the understanding of the impact of myopia should focus on myopia-specific QoL scales, which include a number of life domains such as well-being, economic concerns, cognition, independence, and social interaction. Our understanding of the impact of myopia in these areas is limited. There is also a need for future investigators to use modern psychometric methods to analyze questionnaire data. With the exception of one study, most studies have used Classical Test Theory methods such as a mean or summary score.24 Summary scoring, termed Likert scoring, allocates an ordinal assignment of a numerical value to a participant’s response and assumes a score based on an interval scale. The validity of such summary scores has been questioned by the Item Response Theory (IRT) methods, namely Rasch analysis.2,33–36 Rasch analysis states that the probability of an individual choosing a response on a particular item depends on both the person’s ability and item difficulty. Thus, Rasch analysis is taken as a criterion for the structure of the responses, which should be satisfied rather than a simple statistical description of the responses commonly evidenced in studies that have investigated the impact of myopia. Once the data fits the Rasch model, estimates of measures on an interval scaling are provided, which can improve the accuracy of scoring and remove measurement noise.35,37–39 The transformed score can then be used in analysis of variance and regression more readily than the raw score, which has floor and ceiling effects. The utilization of some form of IRT in future studies will ensure an improved measurement of the impact of myopia on HRQoL.
92 E.L. Lamoureux and H.-B. Wong
Finally, reports have suggested that there is an “epidemic” of myopia in Asia. Population-based studies in urban Asian cities indicate a high prevalence of myopia compared to European-derived populations.40–42 Paradoxically, there has been very little work undertaken in these countries to better understand the impact of myopia, particularly in adults. Valid vision-specific QoL questionnaires are needed to determine the impact of myopia and refractive error on all aspects of daily living in Asian countries. Several scales have been developed in Western countries, such as the Refractive Status and Vision Profile,17 the National Eye Institute Refractive Quality of Life,43 and the Quality of Life Impact of Refractive Correction.39 These scales either should be validated in Asian cultures or new scales specific to Asian countries need to be developed and validated, preferably using IRT methods.
References
1.Massof RW, Rubin GS. (2001) Visual function assessment questionnaires.
Survey of Ophthalmol 45: 531–548.
2.Lamoureux EL, Pallant JF, Pesudovs K, et al. (2006) The Impact of Vision Impairment Questionnaire: an evaluation of its measurement properties using Rasch analysis. Investigative Ophthalmol Vis Sci 47: 4732–4741.
3.Stelmack J. (2001) Quality of life of low-vision patients and outcomes of low-vision rehabilitation. Optom Vis Sci 78: 335–342.
4.World Health Organization. (2001) The international classification of functioning, disability and health (ICF). World Health Organization, Geneva, Switzerland.
5.Ware JE Jr, Sherbourne CD. (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30: 473–483.
6.Wong HB, Machin D, Tan SB, et al. (2009) Visual impairment and its impact on health-related quality of life in adolescents. Am J Ophthalmol 147: 505–511 e1.
7.WHO. (1948) Constitution of the World Health Organization basic document, p. 1. World Health Organization, Geneva, Switzerland.
8.Varni JW, Seid M, Kurtin PS. (2001) PedsQL 4.0: Reliability and validity of the Pediatric Quality of Life Inventory version 4.0 generic core scales in healthy and patient populations. Med Care, 39: 800–812.
9.Brown GC, Brown MM, Sharma S, et al. (2001) The reproducibility of ophthalmic utility values. Trans Am Ophthalmol Soc 99: 199–203; discussion 203–204.
93Quality of Life and Myopia
10.Brown MM, Brown GC, Sharma S, Garrett S. (1999) Evidence-based medicine, utilities, and quality of life. Curr Opinion Ophthalmol 10: 221–226.
11.Torrance GW. (1986) Measurement of health state utilities for economic appraisal. J Health Econ 5: 1–30.
12.Gafni A. (1994) The standard gamble method: what is being measured and how it is interpreted. Health Serv Res 29: 207–224.
13.Saw SM, Gazzard G, Au Eong, KG, Koh D. (2003) Utility values and myopia in teenage school students. Br J Ophthalmol 87: 341–345.
14.Lim WY, Saw SM, Singh MK, Au Eong KG (2005) Utility values and myopia in medical students in Singapore. Clin Exp Ophthalmol 33: 598–603.
15.Congdon N, Wang Y, Song Y, et al. (2008) Visual disability, visual function, and myopia among rural chinese secondary school children: the Xichang Pediatric Refractive Error Study (X-PRES) — report 1. Inv Ophthalmol & Vis Sci 49: 2888–2894.
16.Esteso P, Castanon A, Toledo S, et al. (2007) Correction of moderate myopia is associated with improvement in self-reported visual functioning among Mexican school-aged children. Inv Ophthalmol & Vis Sci 48: 4949–4954.
17.Vitale S, Schein OD, Meinert CL and Steinberg EP. (2000) The refractive status and vision profile: a questionnaire to measure vision-related quality of life in persons with refractive error. Ophthalmol 107: 1529–1539.
18.Takashima T, Yokoyama T, Futagami S, et al. (2001) The quality of life in patients with pathologic myopia. Jap J Ophthalmol 45: 84–92.
19.Chia EM, Mitchell P, Rochtchina E, et al. (2003) Unilateral visual impairment and health related quality of life: the Blue Mountains Eye Study. Br J Ophthalmol 87: 392–395.
20.Ahmadian L, Massof R. (2008) Impact of general health status on validity of visual impairment measurement. Ophth Epidemiol 15: 345–355.
21.Chia EM, Wang JJ, Rochtchina E, et al. (2004) Impact of bilateral visual impairment on health-related quality of life: the Blue Mountains Eye Study.
Inv Ophthalmol Vis Sci 45: 71–76.
22.Kuang TM, Tsai SY, Hsu WM, et al. (2007) Correctable visual impairment in an elderly Chinese population in Taiwan: the Shihpai Eye Study. Inv Ophthalmol Vis Sci 48: 1032–1037.
23.Hollands H, Brox AC, Chang A, et al. (2009) Correctable visual impairment and its impact on quality of life in a marginalized Canadian neighbourhood.
Can J Ophthalmol 44: 42–48.
24.Lamoureux EL, Saw SM, Thumboo J, et al. (2009) The impact of corrected and uncorrected refractive error on visual functioning: the Singapore Malay Eye Study. Inv Ophthalmol Vis Sci 50: 2614–2620.
25.Chen CY, Keeffe JE, Garoufalis P, et al. (2007) Vision-related quality of life comparison for emmetropes, myopes after refractive surgery, and myopes wearing spectacles or contact lenses. J Refract Surg 23: 752–759.
94E.L. Lamoureux and H.-B. Wong
26.Rose K, Harper R, Tromans C, et al. (2000) Quality of life in myopia. Br J Ophthalmol 84: 1031–1034.
27.Owsley C, McGwin G Jr, Scilley K, et al. (2007) Effect of refractive error correction on health-related quality of life and depression in older nursing home residents. Arch Ophthalmol 125: 1471–1477.
28.Broman AT, Munoz B, Rodriguez J, et al. (2002) The impact of visual impairment and eye disease on vision-related quality of life in a Mexican-American population: proyecto VER. Inv Ophthalmol Vis Sci 43: 3393–3398.
29.Chia EM, Mitchell P, Ojaimi E, et al. (2006) Assessment of vision-related quality of life in an older population subsample: the Blue Mountains Eye Study. Ophth Epidemiol 13: 371–377.
30.Lin LL, Shih YF, Hsiao CK, Chen CJ. (2004) Prevalence of myopia in Taiwanese schoolchildren: 1983 to 2000. Ann Acad Med Singapore 33: 27–33.
31.Wu HM, Seet B, Yap EP, et al. (2001) Does education explain ethnic differences in myopia prevalence? A population-based study of young adult males in Singapore. Optom Vis Sci 78: 234–239.
32.Wong TY, Foster PJ, Hee J, et al. (2000) Prevalence and risk factors for refractive errors in adult Chinese in Singapore. Inv Ophthalmol Vis Sci, 41: 2486–2494.
33.Fisher WP Jr, Eubanks RL, Marier RL. (1997) Equating the MOS SF36 and the LSU HSI Physical Functioning Scales. J Outcome Measure 1: 329–362.
34.Massof RW. (2002) The measurement of vision disability. Optom Vis Sci 79: 516–552.
35.Pesudovs K. (2006) Patient-centered measurement in ophthalmology — a paradigm shift. BMC Ophthalmol 6: 25.
36.Wright BD, Linacre JM. (1989) Observations are always ordinal; measurements, however, must be interval. Arch Phys Med Rehab 70: 857–860.
37.Garamendi E, Pesudovs K, Stevens MJ, Elliott DB. (2006) The Refractive Status and Vision Profile: Evaluation of psychometric properties and comparison of Rasch and summated Likert-scaling. Vis Res 46: 1375–1383.
38.Norquist JM, Fitzpatrick R, Dawson J, Jenkinson C. (2004) Comparing alternative Rasch-based methods vs. raw scores in measuring change in health. Med Care 42: I25–I36.
39.Pesudovs K, Garamendi E, Elliott DB. (2004) The Quality of Life Impact of Refractive Correction (QIRC) Questionnaire: development and validation.
Optom Vis Sci 81: 769–777.
40.Seet B, Wong TY, Tan DT, et al. (2001) Myopia in Singapore: taking a public health approach. Br J Ophthalmol 85: 521–526.
41.Saw SM, Katz J, Schein OD, et al. (1996) Epidemiology of myopia. Epidemiol
Rev 18: 175–187.
95Quality of Life and Myopia
42.Saw SM, Chan YH, Wong WL, et al. (2008) Prevalence and risk factors for refractive errors in the Singapore Malay Eye Survey. Ophthalmology 115: 1713–1719.
43.Berry S, Mangione CM, Lindblad AS, McDonnell PJ. (2003) Development of the National Eye Institute refractive error correction quality of life questionnaire: Focus groups. Ophthalmology 110: 2285–2291.
This page intentionally left blank
