- •Contents
- •Foreword
- •Dedication
- •Message
- •About the Editors
- •List of Contributors
- •Acknowledgments
- •Introduction
- •Methodologic Issues
- •Review of Studies (Table 1)
- •Cohort Effects on Myopia
- •Risk Factors for Myopia
- •Near work
- •Education/Income
- •Outdoor activity
- •Race/Ethnicity
- •Nuclear cataract
- •Family aggregation/Genetics
- •Siblings
- •Parent-child
- •Other family members
- •Genetics
- •Comments
- •Acknowledgments
- •References
- •Introduction
- •Definition of Myopia in Epidemiologic Studies
- •Risk Factors for Myopia and Ocular Biometry
- •Family history of myopia
- •Near work
- •Outdoor activity
- •Stature
- •Birth parameters
- •Smoking history
- •Breastfeeding
- •Conclusion
- •References
- •Introduction
- •Aetiological Heterogeneity of Myopia
- •Clearly genetic forms of myopia
- •School or acquired myopia
- •Misunderstandings of Heritability and Twin Studies
- •But Heritability has Its Uses
- •Evidence for Genetic Associations of School Myopia
- •Evidence for the Impact of Environmental Factors on Myopia Phenotypes
- •Gene-Environment Interactions and Ethnicity
- •Gene-Environment Interactions and Parental Myopia
- •Conclusion
- •Acknowledgments
- •References
- •Introduction
- •Economic evaluations
- •Full vs partial evaluations
- •Economic evaluation of myopia
- •The Economic Cost of Myopia: A Burden-of-Disease Study
- •China
- •India
- •Europe
- •Singapore
- •Southeast Asia
- •Africa
- •South America
- •Bangladesh
- •ii. Proportion of myopes paying for correction
- •Uncorrected and undercorrected refractive error, spectacle coverage rate and reasons for spectacles nonwear
- •iii. Amount paid for myopic correction
- •Singapore
- •The burden of myopia
- •Further Directions for Economic Research
- •References
- •Introduction
- •Impact of Myopia in Adults
- •Overall Conclusion
- •Future Studies
- •References
- •Introduction
- •Definition of Pathological Myopia
- •Cataract
- •Glaucoma
- •Myopic Maculopathy
- •Myopic Retinopathy
- •Retinal Detachment
- •Optic Disc Abnormalities
- •References
- •Conclusion
- •Introduction
- •The Association Between Myopia and POAG
- •Information from epidemiological studies
- •Asian populations: Myopia and POAG
- •Myopia in other situations
- •Myopia and ocular hypertension
- •Myopia in angle closure
- •Myopia in Pigment Dispersion Syndrome (PDS)
- •Theories for a Link Between Myopia and POAG
- •Glaucoma Assessment in Myopic Eyes
- •Biometric differences
- •Axial length and CCT
- •Optic disc assessment in myopic eyes
- •Visual fields in myopic eyes
- •Imaging tests and variations with myopia
- •ONH susceptibility to damage
- •The Influence of Myopia on the Clinical Management of the Glaucoma Patient
- •Glaucoma progression and myopia
- •References
- •Posterior Staphyloma
- •Myopic Chorioretinal Atrophy
- •Lacquer Cracks
- •Myopic Choroidal Neovascularization
- •Myopic Foveoschisis
- •Myopic macular hole detachments
- •Lattice degeneration
- •Retinal tears and detachments
- •References
- •Introduction
- •Electroretinography
- •Ganzfeld electroretinography
- •Multifocal electroretinography
- •Assessment of Retinal Function
- •Outer retinal (photoreceptor) function
- •Post-receptoral (bipolar cell) and retinal transmission function
- •Inner retinal function
- •Macular function in myopic retina
- •Effect of Long-Term Atropine Usage on Retinal Function
- •Macular Function Associates with Myopia Progression
- •Factors Associated with ERG Changes in Myopia
- •Conclusion
- •References
- •Introduction
- •Genomic Convergence Using Genomic Content
- •Pathway Analysis
- •Pathway analysis in cancer genomics
- •Pathway analysis in GWAS
- •Non-parametric approaches
- •Parametric approaches
- •P-values combining approaches
- •Conclusion
- •References
- •Introduction
- •Definition of Myopia
- •The Classical Twin Model
- •What is the classical twin model?
- •Historical perspective
- •Statistical approaches
- •Twins, Myopia and Heritability Studies
- •Heritability studies for myopia using twins
- •Limitations of using twins in heritability studies
- •Twins and Myopia — Other Studies
- •The Importance of Twin Registries
- •Concluding Comments
- •Acknowledgments
- •References
- •Introduction
- •Candidate Gene Selection Strategies for Myopia
- •Genes Associated With Myopia-Related Phenotypes
- •The HGF/cMET ligand-receptor axis
- •The collagen family of genes
- •Concluding Remarks
- •Acknowledgments
- •References
- •Introduction
- •Phenotypes for Myopia Genetic Studies
- •Study Design
- •Genotyping and Quality Controls
- •Population Structure
- •Association Tests
- •Correlated Phenotypes
- •Imputation and Meta-Analysis
- •Visualization Tools
- •Drawing Conclusions
- •Acknowledgments
- •References
- •Introduction
- •The Search for Error Signals
- •The blur hypothesis
- •Bidirectional lens-compensation
- •Recovery from ametropia vs. compensation for lenses
- •The complication of the emmetropization end-point
- •Optical aberrations as error signals
- •Other possible visual error signals
- •How Important is Having a Fovea?
- •Mechanisms of Emmetropization
- •Scleral similarities and differences between humans and chickens
- •Retinal signals
- •Glucagon-insulin
- •Retinoic acid
- •Dopamine
- •Acetylcholine
- •Choroidal signals
- •The Role of the Choroid in the Control of Ocular Growth
- •Diurnal rhythms and control of ocular growth
- •Conclusions
- •References
- •Introduction
- •Gross Scleral Anatomy
- •Structural organization of the sclera
- •Cellular content of the sclera
- •Mechanical properties of the sclera
- •Structural Changes to the Sclera in Myopia
- •Development of structural and ultrastructural scleral changes in myopia
- •Scleral pathology and staphyloma
- •Biochemical Changes in the Sclera of Myopic Eyes
- •Structural biochemistry of the sclera in myopia
- •Degradative processes in the sclera of myopic eyes
- •Cellular changes in the sclera in myopia
- •Biomechanical Changes in the Sclera of Myopic Eyes
- •Regulators of scleral myofibroblast differentiation
- •Myofibroblast-extracellular matrix interactions
- •Cellular and matrix contributions to altered scleral biomechanics and myopia
- •Scleral Changes in Myopia are Reversible
- •Eye growth regulation during recovery from induced myopia
- •Summary and Conclusions
- •Acknowledgments
- •References
- •Introduction
- •Spatial Visual Performance and Optical Features of the Eye
- •Axial eye growth and development of refractive state
- •Lens thickness and vitreous chamber depth
- •Corneal radius of curvature
- •Schematic eye data
- •Techniques Currently Available for Myopia Studies in the Mouse, Both for Its Induction and Measurement
- •Devices to induce refractive errors
- •Techniques to measure the induced refractive errors and changes in eye growth
- •Refractive state
- •Corneal radius of curvature
- •Axial length measurements and ocular biometry
- •Measurements of the optical aberrations of the mouse eye
- •Behavioral measurement of grating acuity and contrast sensitivity in the mouse
- •Recent Studies on Myopia in the Mouse Model: Some Examples
- •Magnitudes of experimentally induced refractive errors in wild-type mice
- •Refractive development in mutant mice
- •Pharmacological studies to inhibit axial eye growth in mice
- •Image processing and regulation of retinal genes and proteins
- •Summary
- •Acknowledgments
- •References
- •Introduction
- •A Brief Introduction to Comparative Genomics
- •Comparative Expression
- •Genes in Retina and Sclera in Animal Models of Myopia
- •ZENK (EGR-1)
- •Scleral Gene Expression in a Mouse Model of Myopia
- •RNA, Target cDNA and Microarray Chip Preparation
- •Microarray Data Analysis
- •Scleral Gene Expression in the Myopic Mouse
- •Summary
- •References
- •Introduction
- •Possible Mechanisms of Pharmacological Treatment
- •Efficacy Studies
- •Other Issues Related to Drugs
- •Potential Side Effects
- •The Future of Drug Treatment in Myopia
- •Conclusions
- •References
- •Introduction
- •Accommodation
- •Close work
- •Physical characteristics of the retinal image
- •Visual deprivation
- •Compensatory changes in refraction
- •Intensity and periodicity of light exposure
- •Spatial frequency
- •Light periodicity
- •Image clarity
- •Outdoor activity and retinal image blur
- •Light vergence and photon catch
- •Chromaticity
- •Therapeutic implications
- •References
- •Index
75 The Economics of Myopia
The Singapore study49 on myopic schooling teenagers found a conservative median annual cost of US$83. This is slightly higher but in the same magnitude as the USA estimate. This is probably because the Lim et al. study was on a prospective cohort of myopes measuring actual expenditures. In contrast, Vitale et al. used cost data based on Centers for Medicare & Medicaid Services fee schedules for 2000, and expenditure data from the Medical Expenditure Panel Survey. Also, the amount that a private individual is willing to pay is larger than the amount the government is willing to subsidize. The difference could be equated to the extra amount private individuals are willing to pay for other factors such as design and esthetics — it is possible to get a cheap pair of spectacles in Singapore for US$35.
The burden of myopia
Table 7 shows the number of myopes, approximately 900 million, around in the world who pay for vision correction. In the US, the annual cost is approximately $US50. Since the Singapore cost estimate is higher, we used the US cost data as a conservative estimate for the cost of myopia. However, the cost in US dollars in poorer countries like India would be lower than that in the USA, so we can use purchasing power parity to estimate the cost of myopia in these countries. A pair of spectacles in USA is the same as the cost of a pair of spectacles in Russia. In real life, it is not as simple as that, but it will suffice for an approximation for the global cost of myopia. Thus the global burden of myopia would be approximately $US50 x 900 million, or $US45 billion.
Further Directions for Economic Research
A major limitation in our analysis is the paucity of cost data from large regions of the world. This necessitated the extrapolation of cost data from the USA, rather than from Singapore, as the USA cost data were more conservative. Instead of just a burden of disease study, we could perform partial and full evaluations examining the benefits of treating myopia as well as the costs, and define possible alternatives of action. The benefits of reducing myopia would include reduction of diseases which myopes are at greater risk, e.g., cataract, glaucoma and retinal detachment, and their attendant direct and indirect costs. Alternative courses of action might include government programs for free sight tests and glasses.
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Table 7. |
Estimation of Number of Myopes with Optical Correction Globally |
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Continents |
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Asia |
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North America |
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South |
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Parameters |
China |
India |
Indonesia |
Pakistan |
Bangladesh |
Others |
Africa |
USA |
Mexico |
Canada |
Others |
America |
Europe |
Australia |
TOTAL |
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Population, |
1.32 |
1.15 |
0.23 |
0.17 |
0.15 |
1.01 |
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0.92 |
0.30 |
0.11 |
0.03 |
0.09 |
0.38 |
0.73 |
0.03 |
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billion |
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Total |
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3.88 |
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0.92 |
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0.53 |
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0.38 |
0.73 |
0.03 |
6.47 |
population, |
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billion |
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Myopia |
0.29 |
0.21 |
0.26 |
0.18 |
0.20 |
0.20 |
|
0.10 |
0.27 |
0.18 |
0.27 |
0.27 |
0.21 |
0.27 |
0.07 |
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prevalence |
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No. of myopes |
0.38 |
0.16 |
0.06 |
0.03 |
0.03 |
0.2 |
|
0.09 |
0.08 |
0.02 |
0.01 |
0.02 |
0.08 |
0.2 |
0.002 |
1.44 |
||
Percentage |
80% |
33% |
50% |
33% |
33% |
50% |
|
20% |
95% |
80% |
90% |
80% |
80% |
90% |
85% |
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of myopes |
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with |
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correction |
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No. of myopes |
0.30 |
0.05 |
0.03 |
0.01 |
0.01 |
0.10 |
|
0.02 |
0.08 |
0.02 |
0.01 |
0.02 |
0.06 |
0.18 |
0.00 |
0.89 |
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having |
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correction |
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Frick .D.K and Lim .C.C.M 76
77 The Economics of Myopia
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78M.C.C. Lim and K.D. Frick
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79The Economics of Myopia
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80M.C.C. Lim and K.D. Frick
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Section 2
Clinical Studies and
Pathologic Myopia
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