- •Contents
- •Foreword
- •Dedication
- •Message
- •About the Editors
- •List of Contributors
- •Acknowledgments
- •Introduction
- •Methodologic Issues
- •Review of Studies (Table 1)
- •Cohort Effects on Myopia
- •Risk Factors for Myopia
- •Near work
- •Education/Income
- •Outdoor activity
- •Race/Ethnicity
- •Nuclear cataract
- •Family aggregation/Genetics
- •Siblings
- •Parent-child
- •Other family members
- •Genetics
- •Comments
- •Acknowledgments
- •References
- •Introduction
- •Definition of Myopia in Epidemiologic Studies
- •Risk Factors for Myopia and Ocular Biometry
- •Family history of myopia
- •Near work
- •Outdoor activity
- •Stature
- •Birth parameters
- •Smoking history
- •Breastfeeding
- •Conclusion
- •References
- •Introduction
- •Aetiological Heterogeneity of Myopia
- •Clearly genetic forms of myopia
- •School or acquired myopia
- •Misunderstandings of Heritability and Twin Studies
- •But Heritability has Its Uses
- •Evidence for Genetic Associations of School Myopia
- •Evidence for the Impact of Environmental Factors on Myopia Phenotypes
- •Gene-Environment Interactions and Ethnicity
- •Gene-Environment Interactions and Parental Myopia
- •Conclusion
- •Acknowledgments
- •References
- •Introduction
- •Economic evaluations
- •Full vs partial evaluations
- •Economic evaluation of myopia
- •The Economic Cost of Myopia: A Burden-of-Disease Study
- •China
- •India
- •Europe
- •Singapore
- •Southeast Asia
- •Africa
- •South America
- •Bangladesh
- •ii. Proportion of myopes paying for correction
- •Uncorrected and undercorrected refractive error, spectacle coverage rate and reasons for spectacles nonwear
- •iii. Amount paid for myopic correction
- •Singapore
- •The burden of myopia
- •Further Directions for Economic Research
- •References
- •Introduction
- •Impact of Myopia in Adults
- •Overall Conclusion
- •Future Studies
- •References
- •Introduction
- •Definition of Pathological Myopia
- •Cataract
- •Glaucoma
- •Myopic Maculopathy
- •Myopic Retinopathy
- •Retinal Detachment
- •Optic Disc Abnormalities
- •References
- •Conclusion
- •Introduction
- •The Association Between Myopia and POAG
- •Information from epidemiological studies
- •Asian populations: Myopia and POAG
- •Myopia in other situations
- •Myopia and ocular hypertension
- •Myopia in angle closure
- •Myopia in Pigment Dispersion Syndrome (PDS)
- •Theories for a Link Between Myopia and POAG
- •Glaucoma Assessment in Myopic Eyes
- •Biometric differences
- •Axial length and CCT
- •Optic disc assessment in myopic eyes
- •Visual fields in myopic eyes
- •Imaging tests and variations with myopia
- •ONH susceptibility to damage
- •The Influence of Myopia on the Clinical Management of the Glaucoma Patient
- •Glaucoma progression and myopia
- •References
- •Posterior Staphyloma
- •Myopic Chorioretinal Atrophy
- •Lacquer Cracks
- •Myopic Choroidal Neovascularization
- •Myopic Foveoschisis
- •Myopic macular hole detachments
- •Lattice degeneration
- •Retinal tears and detachments
- •References
- •Introduction
- •Electroretinography
- •Ganzfeld electroretinography
- •Multifocal electroretinography
- •Assessment of Retinal Function
- •Outer retinal (photoreceptor) function
- •Post-receptoral (bipolar cell) and retinal transmission function
- •Inner retinal function
- •Macular function in myopic retina
- •Effect of Long-Term Atropine Usage on Retinal Function
- •Macular Function Associates with Myopia Progression
- •Factors Associated with ERG Changes in Myopia
- •Conclusion
- •References
- •Introduction
- •Genomic Convergence Using Genomic Content
- •Pathway Analysis
- •Pathway analysis in cancer genomics
- •Pathway analysis in GWAS
- •Non-parametric approaches
- •Parametric approaches
- •P-values combining approaches
- •Conclusion
- •References
- •Introduction
- •Definition of Myopia
- •The Classical Twin Model
- •What is the classical twin model?
- •Historical perspective
- •Statistical approaches
- •Twins, Myopia and Heritability Studies
- •Heritability studies for myopia using twins
- •Limitations of using twins in heritability studies
- •Twins and Myopia — Other Studies
- •The Importance of Twin Registries
- •Concluding Comments
- •Acknowledgments
- •References
- •Introduction
- •Candidate Gene Selection Strategies for Myopia
- •Genes Associated With Myopia-Related Phenotypes
- •The HGF/cMET ligand-receptor axis
- •The collagen family of genes
- •Concluding Remarks
- •Acknowledgments
- •References
- •Introduction
- •Phenotypes for Myopia Genetic Studies
- •Study Design
- •Genotyping and Quality Controls
- •Population Structure
- •Association Tests
- •Correlated Phenotypes
- •Imputation and Meta-Analysis
- •Visualization Tools
- •Drawing Conclusions
- •Acknowledgments
- •References
- •Introduction
- •The Search for Error Signals
- •The blur hypothesis
- •Bidirectional lens-compensation
- •Recovery from ametropia vs. compensation for lenses
- •The complication of the emmetropization end-point
- •Optical aberrations as error signals
- •Other possible visual error signals
- •How Important is Having a Fovea?
- •Mechanisms of Emmetropization
- •Scleral similarities and differences between humans and chickens
- •Retinal signals
- •Glucagon-insulin
- •Retinoic acid
- •Dopamine
- •Acetylcholine
- •Choroidal signals
- •The Role of the Choroid in the Control of Ocular Growth
- •Diurnal rhythms and control of ocular growth
- •Conclusions
- •References
- •Introduction
- •Gross Scleral Anatomy
- •Structural organization of the sclera
- •Cellular content of the sclera
- •Mechanical properties of the sclera
- •Structural Changes to the Sclera in Myopia
- •Development of structural and ultrastructural scleral changes in myopia
- •Scleral pathology and staphyloma
- •Biochemical Changes in the Sclera of Myopic Eyes
- •Structural biochemistry of the sclera in myopia
- •Degradative processes in the sclera of myopic eyes
- •Cellular changes in the sclera in myopia
- •Biomechanical Changes in the Sclera of Myopic Eyes
- •Regulators of scleral myofibroblast differentiation
- •Myofibroblast-extracellular matrix interactions
- •Cellular and matrix contributions to altered scleral biomechanics and myopia
- •Scleral Changes in Myopia are Reversible
- •Eye growth regulation during recovery from induced myopia
- •Summary and Conclusions
- •Acknowledgments
- •References
- •Introduction
- •Spatial Visual Performance and Optical Features of the Eye
- •Axial eye growth and development of refractive state
- •Lens thickness and vitreous chamber depth
- •Corneal radius of curvature
- •Schematic eye data
- •Techniques Currently Available for Myopia Studies in the Mouse, Both for Its Induction and Measurement
- •Devices to induce refractive errors
- •Techniques to measure the induced refractive errors and changes in eye growth
- •Refractive state
- •Corneal radius of curvature
- •Axial length measurements and ocular biometry
- •Measurements of the optical aberrations of the mouse eye
- •Behavioral measurement of grating acuity and contrast sensitivity in the mouse
- •Recent Studies on Myopia in the Mouse Model: Some Examples
- •Magnitudes of experimentally induced refractive errors in wild-type mice
- •Refractive development in mutant mice
- •Pharmacological studies to inhibit axial eye growth in mice
- •Image processing and regulation of retinal genes and proteins
- •Summary
- •Acknowledgments
- •References
- •Introduction
- •A Brief Introduction to Comparative Genomics
- •Comparative Expression
- •Genes in Retina and Sclera in Animal Models of Myopia
- •ZENK (EGR-1)
- •Scleral Gene Expression in a Mouse Model of Myopia
- •RNA, Target cDNA and Microarray Chip Preparation
- •Microarray Data Analysis
- •Scleral Gene Expression in the Myopic Mouse
- •Summary
- •References
- •Introduction
- •Possible Mechanisms of Pharmacological Treatment
- •Efficacy Studies
- •Other Issues Related to Drugs
- •Potential Side Effects
- •The Future of Drug Treatment in Myopia
- •Conclusions
- •References
- •Introduction
- •Accommodation
- •Close work
- •Physical characteristics of the retinal image
- •Visual deprivation
- •Compensatory changes in refraction
- •Intensity and periodicity of light exposure
- •Spatial frequency
- •Light periodicity
- •Image clarity
- •Outdoor activity and retinal image blur
- •Light vergence and photon catch
- •Chromaticity
- •Therapeutic implications
- •References
- •Index
72 M.C.C. Lim and K.D. Frick
need).” This is 66% in Tehran using a 20/40 visual acuity cutoff,39 and 25.2% or 40.5% in Bangladesh, using 20/40 and 20/60 visual acuity cutoffs respectively.3
Even if subjects have glasses, there is evidence from other countries that not all want to wear them. In Mexico, 493 school children received free spectacles through a local program and underwent unannounced examination within 18 months.2 Only 13.4% of them were found to be wearing spectacles. The reasons they gave included appearance of the glasses or fear of being teased. A study of Tanzanian school children showed that at 3 months, only 47% were wearing the free spectacles they had been given.40 Of 580 Chinese children owning spectacles, 17.9% did not wear them at school and a common reason for nonwear was the belief that spectacles weaken the eyes.41 In African school children, barriers to spectacles use included peer pressure, parental concern about the safety of spectacles use and their costs.42 In Southern India, a population-based study found that the prevalence of current spectacles use in those with spherical equivalent +/−3.00 Diopters or worse was 34.2%, and among those who had used spectacles previously, 43.8% discontinued because they felt either the prescription was incorrect or the spectacles were uncomfortable.37 However, there might be differences in cultural attitudes between countries as a study of Australian children found unnecessary or overuse of spectacles.43,44 The proportion of myopes with correction for each region shown in Table 7.
iii. Amount paid for myopic correction
USA
In the USA, burden-of-disease studies have been carried out on myopia. It has been estimated that US$2 billion per year in 198345 and US$4.6 billion per year in 199446 were spent in the USA on correcting myopic refractive errors. The figure in 1990 for vision products (eyeglass frames, lenses and contact lenses) for all refractive errors is higher, at $US8.1 billion.47 After adjustment for inflation (U.S. Department of Labor), this equates to $13.4 billion.
A cross-sectional study in the USA showed that 110 million Americans could and do achieve normal vision with refractive correction and the estimated cost of this was US$3.8 billion48 or approximately US$4.9 billion
73 The Economics of Myopia
today. From these studies we can estimate that the cost of optical correction of myopia lies in the range of US$2–5 billion. Since data are available, we can use them to calculate the cost per myope in order to help us calculate the cost of myopia in other countries with less data. Table 4 shows the calculation for how the number of myopes in the USA is estimated to be approximately 80 million. If we use a conservative estimate of the cost of myopia correction to be $4 billion, then the annual amount spent per myope is US$4 billion divided by 80 million which is US$50. Note that this is the average amount spent annually for all myopes, whether they wear glasses or change them regularly or not. The “true” cost is higher than this as we estimate that 95% of myopes in this population buy optical correction aids.30 The estimate may also be low because some myopes may not change glasses annually.
Singapore
The cost data for a study of Singaporean school children aged 12–17 were collected using questionnaires; the resulting estimate was that they spent an average of S$222 (US$148) per year or a median of S$125 (US$83) on glasses or contact lenses from opticians.49 Unfortunately no data are available indicating how much is spent by other demographic groups on glasses, laser refractive surgery and other complications resulting from myopia as well as days lost from work. Thus we have to use the data from the single age group to derive a bottom-up estimate for the direct costs of myopia. This bottom-up approach entails estimating the costs of single elements and then extrapolating upwards to the entire population, whereas a topdown approach might look at the global cost of myopia and then working downwards to an estimate for Singapore. Often both approaches are used to determine if the estimates are in the correct magnitude.
The result is an annual figure of S$373m, or US$250m. Table 6 summarizes the estimated total annual direct cost of myopia in Singapore. Sensitivity analyses can also be carried out to calculate the upper and lower bounds of our estimate. If we use the median annual cost of S$125 instead, the annual cost is S$180m.
It can be argued that myopia correction in older adults (the average age of the LASIK patient in a Singapore tertiary hospital is 33 years of age — unpublished data) may be more costly especially with the advent of laser refractive surgery. However, this does not necessarily result in a substantial
74 |
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M.C.C. Lim and K.D. Frick |
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Table 6. Cost of Myopia Correction in Singapore |
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Total |
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Annual Cost |
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Source of |
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Annual |
in Singapore |
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Percentage |
Data for |
|
Cost Per |
Dollars (S$) |
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|
Number |
of Myopes |
Preceding |
Number |
Myope |
US$1≈S$1.50 |
|
|
Age |
of People |
(%) |
Column |
of Myopes |
($) |
($) |
|
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|
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|
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|
0–4 |
196,500 |
5 |
Estimated |
9825 |
100 |
982,500 |
|
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|
5–9 |
240,100 |
29 |
Tan et al.14 |
69,629 |
222 |
15,388,009 |
|
|
10–14 |
261,500 |
60 |
Estimated |
156,900 |
222 |
34,674,900 |
||
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15–19 |
249,900 |
74 |
Quek et al.15 |
184,926 |
222 |
40,868,646 |
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20–24 |
222,400 |
79 |
Wu et al.16 |
175,696 |
222 |
38,828,816 |
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25–29 |
257,300 |
70 |
Estimated |
180,110 |
222 |
39,804,310 |
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30–34 |
302,700 |
60 |
Estimated |
181,620 |
222 |
40,138,020 |
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35–39 |
308,200 |
60 |
Estimated |
184,920 |
222 |
40,867,320 |
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40–44 |
331,900 |
45 |
Tanjong Pagar17 |
149,355 |
222 |
33,007,455 |
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|
45–49 |
319,300 |
45 |
Tanjong Pagar17 |
143,685 |
222 |
31,754,385 |
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|
50–54 |
272,200 |
25 |
Tanjong Pagar17 |
68,050 |
222 |
15,039,050 |
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|
55–59 |
219,100 |
25 |
Tanjong Pagar17 |
54,775 |
222 |
12,105,275 |
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60–64 |
120,900 |
30 |
Tanjong Pagar17 |
36,270 |
222 |
8,015,670 |
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65–69 |
111,500 |
30 |
Tanjong Pagar17 |
33,450 |
222 |
7,392,450 |
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70–74 |
80,600 |
32 |
Tanjong Pagar17 |
25,792 |
222 |
5,700,032 |
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75–79 |
57,600 |
32 |
Tanjong Pagar17 |
18,432 |
222 |
4,073,472 |
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80+ |
56,700 |
32 |
Estimated |
18,144 |
222 |
4,009,824 |
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Total |
3,608,500 |
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372,650,134 |
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change in the economic cost of myopia as the cost of laser surgery may be offset by future savings in spectacles and contact lenses. Contact lenses have been shown to be more costly than LASIK, which is itself more costly than eyeglasses.50 If we take an average cost of LASIK to be US$2000 for both eyes, then this is approximately the cost of 15 years of spectacles and contact lenses, based on a mean annual cost of US$148. Javitt et al. found that PRK was equivalent to wearing daily-wear soft contact lenses for 10 years.46 The average age of the LASIK patient in Singapore is 33-years, as mentioned earlier. This patient, whom we still classify as “myopic,” has spent US$3000 on LASIK, but does not have to pay for refractive correction for the next 10–15 years, until she becomes presbyopic 10 years later, when she will start spending approximately as much as a myope annually. This is because myopes who have been rendered emmetropic by LASIK will have to purchase reading glasses when they become presbyopic in their mid 40s.
