- •Contents
- •Foreword
- •Dedication
- •Message
- •About the Editors
- •List of Contributors
- •Acknowledgments
- •Introduction
- •Methodologic Issues
- •Review of Studies (Table 1)
- •Cohort Effects on Myopia
- •Risk Factors for Myopia
- •Near work
- •Education/Income
- •Outdoor activity
- •Race/Ethnicity
- •Nuclear cataract
- •Family aggregation/Genetics
- •Siblings
- •Parent-child
- •Other family members
- •Genetics
- •Comments
- •Acknowledgments
- •References
- •Introduction
- •Definition of Myopia in Epidemiologic Studies
- •Risk Factors for Myopia and Ocular Biometry
- •Family history of myopia
- •Near work
- •Outdoor activity
- •Stature
- •Birth parameters
- •Smoking history
- •Breastfeeding
- •Conclusion
- •References
- •Introduction
- •Aetiological Heterogeneity of Myopia
- •Clearly genetic forms of myopia
- •School or acquired myopia
- •Misunderstandings of Heritability and Twin Studies
- •But Heritability has Its Uses
- •Evidence for Genetic Associations of School Myopia
- •Evidence for the Impact of Environmental Factors on Myopia Phenotypes
- •Gene-Environment Interactions and Ethnicity
- •Gene-Environment Interactions and Parental Myopia
- •Conclusion
- •Acknowledgments
- •References
- •Introduction
- •Economic evaluations
- •Full vs partial evaluations
- •Economic evaluation of myopia
- •The Economic Cost of Myopia: A Burden-of-Disease Study
- •China
- •India
- •Europe
- •Singapore
- •Southeast Asia
- •Africa
- •South America
- •Bangladesh
- •ii. Proportion of myopes paying for correction
- •Uncorrected and undercorrected refractive error, spectacle coverage rate and reasons for spectacles nonwear
- •iii. Amount paid for myopic correction
- •Singapore
- •The burden of myopia
- •Further Directions for Economic Research
- •References
- •Introduction
- •Impact of Myopia in Adults
- •Overall Conclusion
- •Future Studies
- •References
- •Introduction
- •Definition of Pathological Myopia
- •Cataract
- •Glaucoma
- •Myopic Maculopathy
- •Myopic Retinopathy
- •Retinal Detachment
- •Optic Disc Abnormalities
- •References
- •Conclusion
- •Introduction
- •The Association Between Myopia and POAG
- •Information from epidemiological studies
- •Asian populations: Myopia and POAG
- •Myopia in other situations
- •Myopia and ocular hypertension
- •Myopia in angle closure
- •Myopia in Pigment Dispersion Syndrome (PDS)
- •Theories for a Link Between Myopia and POAG
- •Glaucoma Assessment in Myopic Eyes
- •Biometric differences
- •Axial length and CCT
- •Optic disc assessment in myopic eyes
- •Visual fields in myopic eyes
- •Imaging tests and variations with myopia
- •ONH susceptibility to damage
- •The Influence of Myopia on the Clinical Management of the Glaucoma Patient
- •Glaucoma progression and myopia
- •References
- •Posterior Staphyloma
- •Myopic Chorioretinal Atrophy
- •Lacquer Cracks
- •Myopic Choroidal Neovascularization
- •Myopic Foveoschisis
- •Myopic macular hole detachments
- •Lattice degeneration
- •Retinal tears and detachments
- •References
- •Introduction
- •Electroretinography
- •Ganzfeld electroretinography
- •Multifocal electroretinography
- •Assessment of Retinal Function
- •Outer retinal (photoreceptor) function
- •Post-receptoral (bipolar cell) and retinal transmission function
- •Inner retinal function
- •Macular function in myopic retina
- •Effect of Long-Term Atropine Usage on Retinal Function
- •Macular Function Associates with Myopia Progression
- •Factors Associated with ERG Changes in Myopia
- •Conclusion
- •References
- •Introduction
- •Genomic Convergence Using Genomic Content
- •Pathway Analysis
- •Pathway analysis in cancer genomics
- •Pathway analysis in GWAS
- •Non-parametric approaches
- •Parametric approaches
- •P-values combining approaches
- •Conclusion
- •References
- •Introduction
- •Definition of Myopia
- •The Classical Twin Model
- •What is the classical twin model?
- •Historical perspective
- •Statistical approaches
- •Twins, Myopia and Heritability Studies
- •Heritability studies for myopia using twins
- •Limitations of using twins in heritability studies
- •Twins and Myopia — Other Studies
- •The Importance of Twin Registries
- •Concluding Comments
- •Acknowledgments
- •References
- •Introduction
- •Candidate Gene Selection Strategies for Myopia
- •Genes Associated With Myopia-Related Phenotypes
- •The HGF/cMET ligand-receptor axis
- •The collagen family of genes
- •Concluding Remarks
- •Acknowledgments
- •References
- •Introduction
- •Phenotypes for Myopia Genetic Studies
- •Study Design
- •Genotyping and Quality Controls
- •Population Structure
- •Association Tests
- •Correlated Phenotypes
- •Imputation and Meta-Analysis
- •Visualization Tools
- •Drawing Conclusions
- •Acknowledgments
- •References
- •Introduction
- •The Search for Error Signals
- •The blur hypothesis
- •Bidirectional lens-compensation
- •Recovery from ametropia vs. compensation for lenses
- •The complication of the emmetropization end-point
- •Optical aberrations as error signals
- •Other possible visual error signals
- •How Important is Having a Fovea?
- •Mechanisms of Emmetropization
- •Scleral similarities and differences between humans and chickens
- •Retinal signals
- •Glucagon-insulin
- •Retinoic acid
- •Dopamine
- •Acetylcholine
- •Choroidal signals
- •The Role of the Choroid in the Control of Ocular Growth
- •Diurnal rhythms and control of ocular growth
- •Conclusions
- •References
- •Introduction
- •Gross Scleral Anatomy
- •Structural organization of the sclera
- •Cellular content of the sclera
- •Mechanical properties of the sclera
- •Structural Changes to the Sclera in Myopia
- •Development of structural and ultrastructural scleral changes in myopia
- •Scleral pathology and staphyloma
- •Biochemical Changes in the Sclera of Myopic Eyes
- •Structural biochemistry of the sclera in myopia
- •Degradative processes in the sclera of myopic eyes
- •Cellular changes in the sclera in myopia
- •Biomechanical Changes in the Sclera of Myopic Eyes
- •Regulators of scleral myofibroblast differentiation
- •Myofibroblast-extracellular matrix interactions
- •Cellular and matrix contributions to altered scleral biomechanics and myopia
- •Scleral Changes in Myopia are Reversible
- •Eye growth regulation during recovery from induced myopia
- •Summary and Conclusions
- •Acknowledgments
- •References
- •Introduction
- •Spatial Visual Performance and Optical Features of the Eye
- •Axial eye growth and development of refractive state
- •Lens thickness and vitreous chamber depth
- •Corneal radius of curvature
- •Schematic eye data
- •Techniques Currently Available for Myopia Studies in the Mouse, Both for Its Induction and Measurement
- •Devices to induce refractive errors
- •Techniques to measure the induced refractive errors and changes in eye growth
- •Refractive state
- •Corneal radius of curvature
- •Axial length measurements and ocular biometry
- •Measurements of the optical aberrations of the mouse eye
- •Behavioral measurement of grating acuity and contrast sensitivity in the mouse
- •Recent Studies on Myopia in the Mouse Model: Some Examples
- •Magnitudes of experimentally induced refractive errors in wild-type mice
- •Refractive development in mutant mice
- •Pharmacological studies to inhibit axial eye growth in mice
- •Image processing and regulation of retinal genes and proteins
- •Summary
- •Acknowledgments
- •References
- •Introduction
- •A Brief Introduction to Comparative Genomics
- •Comparative Expression
- •Genes in Retina and Sclera in Animal Models of Myopia
- •ZENK (EGR-1)
- •Scleral Gene Expression in a Mouse Model of Myopia
- •RNA, Target cDNA and Microarray Chip Preparation
- •Microarray Data Analysis
- •Scleral Gene Expression in the Myopic Mouse
- •Summary
- •References
- •Introduction
- •Possible Mechanisms of Pharmacological Treatment
- •Efficacy Studies
- •Other Issues Related to Drugs
- •Potential Side Effects
- •The Future of Drug Treatment in Myopia
- •Conclusions
- •References
- •Introduction
- •Accommodation
- •Close work
- •Physical characteristics of the retinal image
- •Visual deprivation
- •Compensatory changes in refraction
- •Intensity and periodicity of light exposure
- •Spatial frequency
- •Light periodicity
- •Image clarity
- •Outdoor activity and retinal image blur
- •Light vergence and photon catch
- •Chromaticity
- •Therapeutic implications
- •References
- •Index
1.4
The Economics of Myopia
Marcus C.C. Lim* and Kevin D. Frick†
The economics of myopia is not well elucidated. Economic evaluation can take several forms. This chapter gives an overview of myopia economics and provides a walkthrough for the calculation of the burden of disease related to worldwide myopia. Directions for further research are suggested.
Introduction
Economic science is the study of allocation of scarce resources. Fundamentally, all forms of economic evaluation are undertaken for one reason: Resources are limited and decision makers need guidance (which is all that economic evaluation can provide) for making resource allocation decisions between alternatives. In health economics, resources include time (for the patient and any caregivers), money, medical manpower and other resources to produce health and health services. Economists are interested in the modification of resource allocation or prices that will change the way those resources are allocated and bring about a change in health. With regard to myopia, questions that can be answered at a local or global level by an economic evaluation include:
•What is the cost of vision correction for myopia?
•What is the total cost related to myopia, combining vision correction, the costs of treating associated eye disease as well as loss of productivity?
*Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore 168751.
†Johns Hopkins Bloomberg School of Public Health, 624 N. Broadway, Rm. 606, Baltimore MD 21205, USA. E-mail: kfrick@Jhsph.edu
63
64M.C.C. Lim and K.D. Frick
•What benefits are there from vision correction of myopia? What is the magnitude of future costs that will be offset?
•Does government subsidization of spectacles for myopes make economic sense?
•How much could we save if there was a cure for myopia?
Economic evaluations
One purpose of economic evaluation is to describe and compare the costs and benefits of health care services. This type of analysis can help us to answer any of the questions above. One methodological step necessary to perform economic analysis is to decide what set of costs and benefits should be measured. The set of costs and benefits considered is defined by the perspective taken, using economic jargon. The perspective could be the hospital, the Ministry of Health, the government as a whole or society. Generally, economists favor analyses at the broadest category, society. From a societal perspective, an economic evaluation of myopia would describe and compare the inputs (costs) and outputs (benefits) of treating myopia for all those who are affected. The costs include the cost of optical correction of myopia, in the form of spectacles, contacts lenses and refractive surgery, regardless of who pays. The benefits include increased productivity and increased quality of life.
Since the outcome of every economic evaluation depends on both the action contemplated and the alternative, it is important to specify the alternative. The alternative could be the status quo. If it is, the status quo must be precisely defined. In our example, a course of action might be for government to fund spectacles for myopes. This would be compared with the status quo alternative, which could be to continue with private funding.
Full vs partial evaluations
Economic evaluations can be classified into full or partial evaluations by the answers to the following two questions1:
1)Does the evaluation look at both costs and benefits?
2)Does it involve two or more alternatives?
Translating these answers into a form of economic evaluation is demonstrated in the table below.1
65 The Economics of Myopia
|
YES |
CEA, CUA |
Partial |
|
Does the |
or CBA |
|||
|
|
|||
|
|
|
||
evaluation |
|
|
|
|
look at |
|
|
|
|
both costs |
|
|
|
|
and |
|
|
A description |
|
benefits? |
NO |
Partial |
||
of costs or |
||||
|
|
|
benefits |
|
|
|
|
|
|
|
|
YES |
NO |
Does it involve two or more alternatives?
The differences between cost-effectiveness analysis (CEA), cost-utility analysis (CUA) or cost-benefit analysis (CBA) are the means of valuing the health benefit. For CEA, the benefit measure is usually stated as $/change in disease-specific measure of health-related benefits. For CUA, the result is stated as $/Quality-Adjusted Life Year (QALY); for CBA, it is stated as “Net benefit” ($(benefit)–$(cost)). In international settings, the result can be expressed in local currency units.
Economic evaluation of myopia
Why perform an economic evaluation of myopia? Cynics might suggest that this is an academic exercise and nothing more, as the correction of myopia is not funded by the state in most countries. Free markets do not require economic evaluations as it is assumed that individuals will only make decisions that benefit their own interests. Countries that make provincial or national provision and coverage decisions are more likely to use economic evaluations, e.g. the United Kingdom, Canada and Australia and not the United States. For example, in the United States, multiple private insurers fund a significant portion of healthcare (for which the market measures value rather than simulating a market through an economic evaluation) while in the United Kingdom, it is the governmentcontrolled National Health Service, the world’s third largest employer, who funds healthcare. Nevertheless, screening programs for refractive error are becoming increasingly common throughout the world.2 In addition, research has shown that off-the-shelf spectacles are suitable for a large
