Ординатура / Офтальмология / Английские материалы / Mechanisms of the Glaucomas_Shields, Tombran-Tink, Barnstable_2008

33.Neufeld, A. H. & Liu, B. (2003). Glaucomatous optic neuropathy: when glia misbehave.

Neuroscientist 9, 485–95.

34.Neufeld, A. H., Sawada, A. & Becker, B. (1999). Inhibition of nitric-oxide synthase 2 by aminoguanidine provides neuroprotection of retinal ganglion cells in a rat model of chronic glaucoma. Proc Natl Acad Sci USA 96, 9944–8.

35.Aloisi, F. (1999). The role of microglia and astrocytes in CNS immune surveillance and immunopathology. Adv Exp Med Biol 468, 123–33.

36.Yuan, L. & Neufeld, A. H. (2001). Activated microglia in the human glaucomatous optic nerve head. J Neurosci Res 64, 523–32.

37.Fantes, F. E. & Anderson, D. R. (1989). Clinical histologic correlation of human peripapillary anatomy. Ophthalmology 96, 20–5.

38.Jonas, J. B. & Naumann, G. O. (1989). Parapapillary retinal vessel diameter in normal and glaucoma eyes. II. Correlations. Invest Ophthalmol Vis Sci 30, 1604–11.

39.Jonas, J. B. & Grundler, A. (1996). Optic disc morphology in juvenile primary open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 234, 750–4.

40.Anderson, D. R. (1999). Introductory comments on blood flow autoregulation in the optic nerve head and vascular risk factors in glaucoma. Surv Ophthalmol 43 Suppl 1, S5–9.

41.Chiou, G. C. (2001). Review: effects of nitric oxide on eye diseases and their treatment.

J Ocul Pharmacol Ther 17, 189–98.

42.Gupta, N., Ang, L. C., Noel de Tilly, L., Bidaisee, L. & Yucel, Y. H. (2006). Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol 90, 674–8.

43.Perry, V. H., Oehler, R. & Cowey, A. (1984). Retinal ganglion cells that project to the dorsal lateral geniculate nucleus in the macaque monkey. Neuroscience 12, 1101–23.

44.Weisenhorn, D. M., Roback, J., Young, A. N. & Wainer, B. H. (1999). Cellular aspects of trophic actions in the nervous system. Int Rev Cytol 189, 177–265.

45.Korsching, S. (1993). The neurotrophic factor concept: a reexamination. J Neurosci 13, 2739–48.

46.Sloper, J. J., Headon, M. P. & Powell, T. P. (1987). Effects of enucleation at different ages on the sizes of neurons in the lateral geniculate nucleus of infant and adult monkeys. Brain Res 428, 259–65.

47.Weber, A. J., Chen, H., Hubbard, W. C. & Kaufman, P. L. (2000). Experimental glaucoma and cell size, density, and number in the primate lateral geniculate nucleus. Invest Ophthalmol Vis Sci 41, 1370–9.

48.Yucel, Y. H., Zhang, Q., Weinreb, R. N., Kaufman, P. L. & Gupta, N. (2001). Atrophy of relay neurons in magnoand parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci 42, 3216–22.

49.Yucel, Y. H., Zhang, Q., Weinreb, R. N., Kaufman, P. L. & Gupta, N. (2003). Effects of retinal ganglion cell loss on magno-, parvo-, koniocellular pathways in the lateral geniculate nucleus and visual cortex in glaucoma. Prog Retin Eye Res 22, 465–81.

50.Crawford, M. L., Harwerth, R. S., Smith, E. L., 3rd, Shen, F. & Carter-Dawson, L. (2000). Glaucoma in primates: cytochrome oxidase reactivity in parvoand magnocellular pathways. Invest Ophthalmol Vis Sci 41, 1791–802.

51.Gupta, N. & Yucel, Y. H. (2003). Brain changes in glaucoma. Eur J Ophthalmol 13 Suppl 3, S32–5.

52.Maters, L. H., Jr. (1977). Effects of neonatal deafferentation on the superficial laminae of the superior colliculus. Brain Res 126, 19–30.

53.Crawford, M. L., Harwerth, R. S., Smith, E. L., 3rd, Mills, S. & Ewing, B. (2001). Experimental glaucoma in primates: changes in cytochrome oxidase blobs in V1 cortex.

Invest Ophthalmol Vis Sci 42, 358–64.

54.Lipton, S. A. & Rosenberg, P. A. (1994). Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med 330, 613–22.

55.Osborne, N. N., Melena, J., Chidlow, G. & Wood, J. P. (2001). A hypothesis to explain ganglion cell death caused by vascular insults at the optic nerve head: possible implication for the treatment of glaucoma. Br J Ophthalmol 85, 1252–9.

56.Zeitz, O., Galambos, P., Wagenfeld, L., Wiermann, A., Wlodarsch, P., Praga, R., Matthiessen, E. T., Richard, G. & Klemm, M. (2006). Glaucoma progression is associated with decreased blood flow velocities in the short posterior ciliary artery. Br J Ophthalmol 90, 1245–8.

57.Delaney, Y., Walshe, T. E. & O’Brien, C. (2006). Vasospasm in glaucoma: clinical and laboratory aspects. Optom Vis Sci 83, 406–14.

58.Flammer, J., Orgul, S., Costa, V. P., Orzalesi, N., Krieglstein, G. K., Serra, L. M., Renard, J. P. & Stefansson, E. (2002). The impact of ocular blood flow in glaucoma.

Prog Retin Eye Res 21, 359–93.

59.Osborne, N. N., Chidlow, G., Wood, J. P., Schmidt, K. G., Casson, R. & Melena, J. (2001). Expectations in the treatment of retinal diseases: neuroprotection. Curr Eye Res 22, 321–32.

60.Rich, K. M. (1992). Neuronal death after trophic factor deprivation. J Neurotrauma 9 Suppl 1, S61–9.

61.Harvey, A. R. & Robertson, D. (1992). Time-course and extent of retinal ganglion cell death following ablation of the superior colliculus in neonatal rats. J Comp Neurol 325, 83–94.

62.von Bartheld, C. S., Williams, R., Lefcort, F., Clary, D. O., Reichardt, L. F. & Bothwell, M. (1996). Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J Neurosci 16, 2995–3008.

63.Ikeda, K., Tanihara, H., Honda, Y., Tatsuno, T., Noguchi, H. & Nakayama, C. (1999). BDNF attenuates retinal cell death caused by chemically induced hypoxia in rats. Invest Ophthalmol Vis Sci 40, 2130–40.

64.Mey, J. & Thanos, S. (1993). Intravitreal injections of neurotrophic factors support the survival of axotomized retinal ganglion cells in adult rats in vivo. Brain Res 602, 304–17.

65.Mansour-Robaey, S., Clarke, D. B., Wang, Y. C., Bray, G. M. & Aguayo, A. J. (1994). Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells. Proc Natl Acad Sci USA 91, 1632–6.

66.Ko, M. L., Hu, D. N., Ritch, R., Sharma, S. C. & Chen, C. F. (2001). Patterns of retinal ganglion cell survival after brain-derived neurotrophic factor administration in hypertensive eyes of rats. Neurosci Lett 305, 139–42.

67.Sievers, J., Hausmann, B., Unsicker, K. & Berry, M. (1987). Fibroblast growth factors promote the survival of adult rat retinal ganglion cells after transection of the optic nerve.

Neurosci Lett 76, 157–62.

68.Leaver, S. G., Cui, Q., Plant, G. W., Arulpragasam, A., Hisheh, S., Verhaagen, J. & Harvey, A. R. (2006). AAV-mediated expression of CNTF promotes long-term survival and regeneration of adult rat retinal ganglion cells. Gene Ther 13, 1328–41.

69.van Adel, B. A., Arnold, J. M., Phipps, J., Doering, L. C. & Ball, A. K. (2005). Ciliary neurotrophic factor protects retinal ganglion cells from axotomy-induced apoptosis via modulation of retinal glia in vivo. J Neurobiol 63, 215–34.

70.Klocker, N., Braunling, F., Isenmann, S. & Bahr, M. (1997). In vivo neurotrophic effects of GDNF on axotomized retinal ganglion cells. Neuroreport 8, 3439–42.

71.Carmignoto, G., Maffei, L., Candeo, P., Canella, R. & Comelli, C. (1989). Effect of NGF on the survival of rat retinal ganglion cells following optic nerve section. J Neurosci 9, 1263–72.

72.Kermer, P., Klocker, N., Labes, M. & Bahr, M. (2000). Insulin-like growth factor-I protects axotomized rat retinal ganglion cells from secondary death via PI3-K-dependent Akt phosphorylation and inhibition of caspase-3 In vivo. J Neurosci 20, 2–8.

73.Woldemussie, E., Wijono, M. & Ruiz, G. (2004). Muller cell response to laser-induced increase in intraocular pressure in rats. Glia 47, 109–19.

74.Shohami, E., Ginis, I. & Hallenbeck, J. M. (1999). Dual role of tumor necrosis factor alpha in brain injury. Cytokine Growth Factor Rev 10, 119–30.

75.Galasso, J. M., Wang, P., Martin, D. & Silverstein, F. S. (2000). Inhibition of TNF-alpha can attenuate or exacerbate excitotoxic injury in neonatal rat brain. Neuroreport 11, 231–5.

76.Yang, J., Tezel, G., Patil, R. V., Romano, C. & Wax, M. B. (2001). Serum autoantibody against glutathione S-transferase in patients with glaucoma. Invest Ophthalmol Vis Sci 42, 1273–6.

77.Hsu, H., Xiong, J. & Goeddel, D. V. (1995). The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation. Cell 81, 495–504.

78.Thorburn, A. (2004). Death receptor-induced cell killing. Cell Signal 16, 139–44.

79.Aktas, O., Prozorovski, T. & Zipp, F. (2006). Death ligands and autoimmune demyelination. Neuroscientist 12, 305–16.

80.Tezel, G. & Wax, M. B. (2000). Increased production of tumor necrosis factor-alpha by glial cells exposed to simulated ischemia or elevated hydrostatic pressure induces apoptosis in cocultured retinal ganglion cells. J Neurosci 20, 8693–700.

81.Tezel, G., Li, L. Y., Patil, R. V. & Wax, M. B. (2001). TNF-alpha and TNF-alpha receptor-1 in the retina of normal and glaucomatous eyes. Invest Ophthalmol Vis Sci 42, 1787–94.

82.Lipton, S. A., Choi, Y. B., Pan, Z. H., Lei, S. Z., Chen, H. S., Sucher, N. J., Loscalzo, J., Singel, D. J. & Stamler, J. S. (1993). A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds. Nature 364, 626–32.

83.Moncada, S. (1992). Nitric oxide gas: mediator, modulator, and pathophysiologic entity.

J Lab Clin Med 120, 187–91.

84.Bo, L., Dawson, T. M., Wesselingh, S., Mork, S., Choi, S., Kong, P. A., Hanley, D. & Trapp, B. D. (1994). Induction of nitric oxide synthase in demyelinating regions of multiple sclerosis brains. Ann Neurol 36, 778–86.

85.Hunot, S., Boissiere, F., Faucheux, B., Brugg, B., Mouatt-Prigent, A., Agid, Y. & Hirsch, E. C. (1996). Nitric oxide synthase and neuronal vulnerability in Parkinson’s disease. Neuroscience 72, 355–63.

86.Malinski, T., Bailey, F., Zhang, Z. G. & Chopp, M. (1993). Nitric oxide measured by a porphyrinic microsensor in rat brain after transient middle cerebral artery occlusion. J Cereb Blood Flow Metab 13, 355–8.

87.Morgan, J., Caprioli, J. & Koseki, Y. (1999). Nitric oxide mediates excitotoxic and anoxic damage in rat retinal ganglion cells cocultured with astroglia. Arch Ophthalmol 117, 1524–9.

88.Neufeld, A. H., Hernandez, M. R. & Gonzalez, M. (1997). Nitric oxide synthase in the human glaucomatous optic nerve head. Arch Ophthalmol 115, 497–503.

89.Liu, B. & Neufeld, A. H. (2000). Expression of nitric oxide synthase-2 (NOS-2) in reactive astrocytes of the human glaucomatous optic nerve head. Glia 30, 178–86.

90.Liu, B. & Neufeld, A. H. (2001). Nitric oxide synthase-2 in human optic nerve head astrocytes induced by elevated pressure in vitro. Arch Ophthalmol 119, 240–5.

91.Liu, B. & Neufeld, A. H. (2003). Activation of epidermal growth factor receptor signals induction of nitric oxide synthase-2 in human optic nerve head astrocytes in glaucomatous optic neuropathy. Neurobiol Dis 13, 109–23.

92.Yoshimura, A., Mori, H., Ohishi, M., Aki, D. & Hanada, T. (2003). Negative regulation of cytokine signaling influences inflammation. Curr Opin Immunol 15, 704–8.

93.Neufeld, A. H., Das, S., Vora, S., Gachie, E., Kawai, S., Manning, P. T. & Connor, J. R. (2002). A prodrug of a selective inhibitor of inducible nitric oxide synthase is neuroprotective in the rat model of glaucoma. J Glaucoma 11, 221–5.

94.Wax, M. B. (2000). Is there a role for the immune system in glaucomatous optic neuropathy? Curr Opin Ophthalmol 11, 145–50.

95.Tezel, G. & Wax, M. B. (2004). The immune system and glaucoma. Curr Opin Ophthalmol 15, 80–4.

96.Wax, M. B., Yang, J. & Tezel, G. (2001). Serum autoantibodies in patients with glaucoma.

J Glaucoma 10, S22–4.

97.Tezel, G., Hernandez, R. & Wax, M. B. (2000). Immunostaining of heat shock proteins in the retina and optic nerve head of normal and glaucomatous eyes. Arch Ophthalmol 118, 511–8.

98.Park, K. H., Cozier, F., Ong, O. C. & Caprioli, J. (2001). Induction of heat shock protein 72 protects retinal ganglion cells in a rat glaucoma model. Invest Ophthalmol Vis Sci 42, 1522–30.

99.Higashi, T., Takechi, H., Uemura, Y., Kikuchi, H. & Nagata, K. (1994). Differential induction of mRNA species encoding several classes of stress proteins following focal cerebral ischemia in rats. Brain Res 650, 239–48.

100.Costigan, M., Mannion, R. J., Kendall, G., Lewis, S. E., Campagna, J. A., Coggeshall, R. E., Meridith-Middleton, J., Tate, S. & Woolf, C. J. (1998). Heat shock protein 27: developmental regulation and expression after peripheral nerve injury. J Neurosci 18, 5891–900.

101.Tezel, G. & Wax, M. B. (2000). The mechanisms of hsp27 antibody-mediated apoptosis in retinal neuronal cells. J Neurosci 20, 3552–62.

102.Whitlock, N. A., Lindsey, K., Agarwal, N., Crosson, C. E. & Ma, J. X. (2005). Heat shock protein 27 delays Ca2+-induced cell death in a caspase-dependent and -independent manner in rat retinal ganglion cells. Invest Ophthalmol Vis Sci 46, 1085–91.

103.Kretz, A., Schmeer, C., Tausch, S. & Isenmann, S. (2006). Simvastatin promotes heat shock protein 27 expression and Akt activation in the rat retina and protects axotomized retinal ganglion cells in vivo. Neurobiol Dis 21, 421–30.

104.Mehlen, P., Schulze-Osthoff, K. & Arrigo, A. P. (1996). Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporineinduced cell death. J Biol Chem 271, 16510–4.

105.Mehlen, P., Hickey, E., Weber, L. A. & Arrigo, A. P. (1997). Large unphosphorylated aggregates as the active form of hsp27 which controls intracellular reactive oxygen species and glutathione levels and generates a protection against TNFalpha in NIH-3T3-ras cells.

Biochem Biophys Res Commun 241, 187–92.

106.Young, D. B. (1992). Heat-shock proteins: immunity and autoimmunity. Curr Opin Immunol 4, 396–400.

107.Ellis, H. M. & Horvitz, H. R. (1986). Genetic control of programmed cell death in the nematode C. elegans. Cell 44, 817–29.

108.Chowdhury, I., Tharakan, B. & Bhat, G. K. (2006). Current concepts in apoptosis: The physiological suicide program revisited. Cell Mol Biol Lett 11(4), 506–25.

109.Cohen, G. M. (1997). Caspases: the executioners of apoptosis. Biochem J 326 (Pt 1), 1–16.

110.Chaum, E. (2003). Retinal neuroprotection by growth factors: a mechanistic perspective.

J Cell Biochem 88, 57–75.

111.Tezel, G. & Wax, M. B. (1999). Inhibition of caspase activity in retinal cell apoptosis induced by various stimuli in vitro. Invest Ophthalmol Vis Sci 40, 2660–7.

112.Fernandes-Alnemri, T., Litwack, G. & Alnemri, E. S. (1994). CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme. J Biol Chem 269, 30761–4.

113.Liu, X., Kim, C. N., Yang, J., Jemmerson, R. & Wang, X. (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell 86, 147–57.

114.Zou, H., Henzel, W. J., Liu, X., Lutschg, A. & Wang, X. (1997). Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 90, 405–13.

115.Abu-Amero, K. K., Morales, J. & Bosley, T. M. (2006). Mitochondrial abnormalities in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 47, 2533–41.

116.De Marco, N., Buono, M., Troise, F. & Diez-Roux, G. (2006). Optineurin increases cell survival and translocates to the nucleus in a Rab8-dependent manner upon an apoptotic stimulus. J Biol Chem 281, 16147–56.

117.Korsmeyer, S. J., Gross, A., Harada, H., Zha, J., Wang, K., Yin, X. M., Wei, M. & Zinkel, S. (1999). Death and survival signals determine active/inactive conformations of pro-apoptotic BAX, BAD, and BID molecules. Cold Spring Harb Symp Quant Biol 64, 343–50.

118.Kluck, R. M., Bossy-Wetzel, E., Green, D. R. & Newmeyer, D. D. (1997). The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275, 1132–6.

119.Napankangas, U., Lindqvist, N., Lindholm, D. & Hallbook, F. (2003). Rat retinal ganglion cells upregulate the pro-apoptotic BH3-only protein Bim after optic nerve transection.

Brain Res Mol Brain Res 120, 30–7.

120.Nickells, R. W. (1999). Apoptosis of retinal ganglion cells in glaucoma: an update of the molecular pathways involved in cell death. Surv Ophthalmol 43 Suppl 1, S151–61.

121.Chierzi, S., Strettoi, E., Cenni, M. C. & Maffei, L. (1999). Optic nerve crush: axonal responses in wild-type and bcl-2 transgenic mice. J Neurosci 19, 8367–76.

122.Isenmann, S., Engel, S., Gillardon, F. & Bahr, M. (1999). Bax antisense oligonucleotides reduce axotomy-induced retinal ganglion cell death in vivo by reduction of Bax protein expression. Cell Death Differ 6, 673–82.

123.Qin, Q., Patil, K. & Sharma, S. C. (2004). The role of Bax-inhibiting peptide in retinal ganglion cell apoptosis after optic nerve transection. Neurosci Lett 372, 17–21.

124.Libby, R. T., Li, Y., Savinova, O. V., Barter, J., Smith, R. S., Nickells, R. W. & John, S. W. (2005). Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage.

PLoS Genet 1, 17–26.

125.Di Polo, A., Aigner, L. J., Dunn, R. J., Bray, G. M. & Aguayo, A. J. (1998). Prolonged delivery of brain-derived neurotrophic factor by adenovirus-infected Muller cells temporarily rescues injured retinal ganglion cells. Proc Natl Acad Sci USA 95, 3978–83.

126.Thanos, C. & Emerich, D. (2005). Delivery of neurotrophic factors and therapeutic proteins for retinal diseases. Expert Opin Biol Ther 5, 1443–52.

127.Straten, G., Schmeer, C., Kretz, A., Gerhardt, E., Kugler, S., Schulz, J. B., Gravel, C., Bahr, M. & Isenmann, S. (2002). Potential synergistic protection of retinal ganglion cells from axotomy-induced apoptosis by adenoviral administration of glial cell line-derived neurotrophic factor and X-chromosome-linked inhibitor of apoptosis. Neurobiol Dis 11, 123–33.

128.Ali, R. R., Reichel, M. B., De Alwis, M., Kanuga, N., Kinnon, C., Levinsky, R. J., Hunt, D. M., Bhattacharya, S. S. & Thrasher, A. J. (1998). Adeno-associated virus gene transfer to mouse retina. Hum Gene Ther 9, 81–6.

129.Miyoshi, H., Takahashi, M., Gage, F. H. & Verma, I. M. (1997). Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci USA 94, 10319–23.

130.Derksen, T. A., Sauter, S. L. & Davidson, B. L. (2002). Feline immunodeficiency virus vectors. Gene transfer to mouse retina following intravitreal injection. J Gene Med 4, 463–9.

131.Nunez, G. & del Peso, L. (1998). Linking extracellular survival signals and the apoptotic machinery. Curr Opin Neurobiol 8, 613–8.

132.Datta, S. R., Brunet, A. & Greenberg, M. E. (1999). Cellular survival: a play in three Akts. Genes Dev 13, 2905–27.

133.Grewal, S. S., York, R. D. & Stork, P. J. (1999). Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9, 544–53.

134.Clarke, D. B., Bray, G. M. & Aguayo, A. J. (1998). Prolonged administration of NT- 4/5 fails to rescue most axotomized retinal ganglion cells in adult rats. Vision Res 38, 1517–24.

135.Cui, Q., So, K. F. & Yip, H. K. (1998). Major biological effects of neurotrophic factors on retinal ganglion cells in mammals. Biol Signals Recept 7, 220–6.

136.Frank, L., Wiegand, S. J., Siuciak, J. A., Lindsay, R. M. & Rudge, J. S. (1997). Effects of BDNF infusion on the regulation of TrkB protein and message in adult rat brain. Exp Neurol 145, 62–70.

137.Chen, H. & Weber, A. J. (2004). Brain-derived neurotrophic factor reduces TrkB protein and mRNA in the normal retina and following optic nerve crush in adult rats. Brain Res 1011, 99–106.

138.Meyer-Franke, A., Kaplan, M. R., Pfrieger, F. W. & Barres, B. A. (1995). Characterization of the signaling interactions that promote the survival and growth of developing retinal ganglion cells in culture. Neuron 15, 805–19.

139.Meyer-Franke, A., Wilkinson, G. A., Kruttgen, A., Hu, M., Munro, E., Hanson, M. G., Jr., Reichardt, L. F. & Barres, B. A. (1998). Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons. Neuron 21, 681–93.

140.Shen, H., Chung, J. M. & Chung, K. (1999). Expression of neurotrophin mRNAs in the dorsal root ganglion after spinal nerve injury. Brain Res Mol Brain Res 64, 186–92.

141.Klocker, N., Cellerino, A. & Bahr, M. (1998). Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of brain-derived neurotrophic factor on axotomized retinal ganglion cells in vivo. J Neurosci 18, 1038–46.

142.Cellerino, A., Arango-Gonzalez, B. A. & Kohler, K. (1999). Effects of brain-derived neurotrophic factor on the development of NADPH-diaphorase/nitric oxide synthasepositive amacrine cells in the rodent retina. Eur J Neurosci 11, 2824–34.

143.Ko, M. L., Hu, D. N., Ritch, R. & Sharma, S. C. (2000). The combined effect of brainderived neurotrophic factor and a free radical scavenger in experimental glaucoma. Invest Ophthalmol Vis Sci 41, 2967–71.

144.Thanos, S., Mey, J. & Wild, M. (1993). Treatment of the adult retina with microgliasuppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro. J Neurosci 13, 455–66.

145.Moalem, G., Yoles, E., Leibowitz-Amit, R., Muller-Gilor, S., Mor, F., Cohen, I. R. & Schwartz, M. (2000). Autoimmune T cells retard the loss of function in injured rat optic nerves. J Neuroimmunol 106, 189–97.

146.Moalem, G., Leibowitz-Amit, R., Yoles, E., Mor, F., Cohen, I. R. & Schwartz, M. (1999). Autoimmune T cells protect neurons from secondary degeneration after central nervous system axotomy. Nat Med 5, 49–55.

147.Bakalash, S., Kipnis, J., Yoles, E. & Schwartz, M. (2002). Resistance of retinal ganglion cells to an increase in intraocular pressure is immune-dependent. Invest Ophthalmol Vis Sci 43, 2648–53.

148.Casson, R. J. (2006). Possible role of excitotoxicity in the pathogenesis of glaucoma. Clin Exp Ophthalmol 34, 54–63.

149.Yoles, E., Wheeler, L. A. & Schwartz, M. (1999). Alpha2-adrenoreceptor agonists are neuroprotective in a rat model of optic nerve degeneration. Invest Ophthalmol Vis Sci 40, 65–73.

150.WoldeMussie, E., Ruiz, G., Wijono, M. & Wheeler, L. A. (2001). Neuroprotection of retinal ganglion cells by brimonidine in rats with laser-induced chronic ocular hypertension. Invest Ophthalmol Vis Sci 42, 2849–55.

151.Wheeler, L., WoldeMussie, E. & Lai, R. (2003). Role of alpha-2 agonists in neuroprotection. Surv Ophthalmol 48 Suppl 1, S47–51.

152.Melena, J., Stanton, D. & Osborne, N. N. (2001). Comparative effects of antiglaucoma drugs on voltage-dependent calcium channels. Graefes Arch Clin Exp Ophthalmol 239, 522–30.

153.Evans, D. W., Hosking, S. L., Gherghel, D. & Bartlett, J. D. (2003). Contrast sensitivity improves after brimonidine therapy in primary open angle glaucoma: a case for neuroprotection. Br J Ophthalmol 87, 1463–5.

154.Hare, W. A., WoldeMussie, E., Lai, R. K., Ton, H., Ruiz, G., Chun, T. & Wheeler, L. (2004). Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, I: Functional measures. Invest Ophthalmol Vis Sci 45, 2625–39.

155.Hare, W. A., WoldeMussie, E., Weinreb, R. N., Ton, H., Ruiz, G., Wijono, M., Feldmann, B., Zangwill, L. & Wheeler, L. (2004). Efficacy and safety of memantine treatment for reduction of changes associated with experimental glaucoma in monkey, II: Structural measures. Invest Ophthalmol Vis Sci 45, 2640–51.

156.Collignon-Brach, J. (1994). Longterm effect of topical beta-blockers on intraocular pressure and visual field sensitivity in ocular hypertension and chronic open-angle glaucoma. Surv Ophthalmol 38 Suppl, S149–55.

157.Drance, S. M. (1998). A comparison of the effects of betaxolol, timolol, and pilocarpine on visual function in patients with open-angle glaucoma. J Glaucoma 7, 247–52.

158.Levkovitch-Verbin, H., Martin, K. R., Quigley, H. A., Baumrind, L. A., Pease, M. E. & Valenta, D. (2002). Measurement of amino acid levels in the vitreous humor of rats after chronic intraocular pressure elevation or optic nerve transection. J Glaucoma 11, 396–405.

159.Honkanen, R. A., Baruah, S., Zimmerman, M. B., Khanna, C. L., Weaver, Y. K., Narkiewicz, J., Waziri, R., Gehrs, K. M., Weingeist, T. A., Boldt, H. C., Folk, J. C., Russell, S. R. & Kwon, Y. H. (2003). Vitreous amino acid concentrations in patients with glaucoma undergoing vitrectomy. Arch Ophthalmol 121, 183–8.

160.Wamsley, S., Gabelt, B. T., Dahl, D. B., Case, G. L., Sherwood, R. W., May, C. A., Hernandez, M. R. & Kaufman, P. L. (2005). Vitreous glutamate concentration and axon loss in monkeys with experimental glaucoma. Arch Ophthalmol 123, 64–70.

161.Otori, Y., Kusaka, S., Kawasaki, A., Morimura, H., Miki, A. & Tano, Y. (2003). Protective effect of nilvadipine against glutamate neurotoxicity in purified retinal ganglion cells. Brain Res 961, 213–9.

162.Kermer, P., Klocker, N., Labes, M. & Bahr, M. (1998). Inhibition of CPP32-like proteases rescues axotomized retinal ganglion cells from secondary cell death in vivo. J Neurosci 18, 4656–62.

163.Chaudhary, P., Ahmed, F., Quebada, P. & Sharma, S. C. (1999). Caspase inhibitors block the retinal ganglion cell death following optic nerve transection. Brain Res Mol Brain Res 67, 36–45.

164.McKinnon, S. J., Lehman, D. M., Tahzib, N. G., Ransom, N. L., Reitsamer, H. A., Liston, P., LaCasse, E., Li, Q., Korneluk, R. G. & Hauswirth, W. W. (2002). Baculoviral IAP repeat-containing-4 protects optic nerve axons in a rat glaucoma model. Mol Ther 5, 780–7.

165.Tezel, G. & Yang, X. (2004). Caspase-independent component of retinal ganglion cell death, in vitro. Invest Ophthalmol Vis Sci 45, 4049–59.

166.Kermer, P., Klocker, N. & Bahr, M. (1999). Long-term effect of inhibition of ced 3-like caspases on the survival of axotomized retinal ganglion cells in vivo. Exp Neurol 158, 202–5.

167.Yrjanheikki, J., Keinanen, R., Pellikka, M., Hokfelt, T. & Koistinaho, J. (1998). Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95, 15769–74.

168.Du, Y., Ma, Z., Lin, S., Dodel, R. C., Gao, F., Bales, K. R., Triarhou, L. C., Chernet, E., Perry, K. W., Nelson, D. L., Luecke, S., Phebus, L. A., Bymaster, F. P. & Paul, S. M. (2001). Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson’s disease. Proc Natl Acad Sci USA 98, 14669–74.

169.Arvin, K. L., Han, B. H., Du, Y., Lin, S. Z., Paul, S. M. & Holtzman, D. M. (2002). Minocycline markedly protects the neonatal brain against hypoxic-ischemic injury. Ann Neurol 52, 54–61.

170.Aronson, A. L. (1980). Pharmacotherapeutics of the newer tetracyclines. J Am Vet Med Assoc 176, 1061–8.

171.Chen, M., Ona, V. O., Li, M., Ferrante, R. J., Fink, K. B., Zhu, S., Bian, J., Guo, L., Farrell, L. A., Hersch, S. M., Hobbs, W., Vonsattel, J. P., Cha, J. H. & Friedlander, R. M. (2000). Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med 6, 797–801.

172.Zhu, S., Stavrovskaya, I. G., Drozda, M., Kim, B. Y., Ona, V., Li, M., Sarang, S., Liu, A. S., Hartley, D. M., Wu, D. C., Gullans, S., Ferrante, R. J., Przedborski, S., Kristal, B. S. & Friedlander, R. M. (2002). Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417, 74–8.

173.Lin, S., Wei, X., Xu, Y., Yan, C., Dodel, R., Zhang, Y., Liu, J., Klaunig, J. E., Farlow, M. & Du, Y. (2003). Minocycline blocks 6-hydroxydopamine-induced neurotoxicity and free radical production in rat cerebellar granule neurons. Life Sci 72, 1635–41.

174.Levkovitch-Verbin, H., Kalev-Landoy, M., Habot-Wilner, Z. & Melamed, S. (2006). Minocycline delays death of retinal ganglion cells in experimental glaucoma and after optic nerve transection. Arch Ophthalmol 124, 520–6.

175.Senatorov, V. V., Ren, M., Kanai, H., Wei, H. & Chuang, D. M. (2004). Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington’s disease. Mol Psychiatry 9, 371–85.

176.Huang, X., Wu, D. Y., Chen, G., Manji, H. & Chen, D. F. (2003). Support of retinal ganglion cell survival and axon regeneration by lithium through a Bcl-2-dependent mechanism. Invest Ophthalmol Vis Sci 44, 347–54.

177.Cho, K. S., Chan, P. M., So, K. F., Yip, H. K. & Chung, S. K. (1999). Ciliary neurotrophic factor promotes the regrowth capacity but not the survival of intraorbitally axotomized retinal ganglion cells in adult hamsters. Neuroscience 94, 623–8.

178.Jiao, J., Huang, X., Feit-Leithman, R. A., Neve, R. L., Snider, W., Dartt, D. A. & Chen, D. F. (2005). Bcl-2 enhances Ca(2+) signaling to support the intrinsic regenerative capacity of CNS axons. EMBO J 24, 1068–78.

179.Pernet, V. & Di Polo, A. (2006). Synergistic action of brain-derived neurotrophic factor and lens injury promotes retinal ganglion cell survival, but leads to optic nerve dystrophy in vivo. Brain 129, 1014–26.

180.Chierzi, S. & Fawcett, J. W. (2001). Regeneration in the mammalian optic nerve. Restor Neurol Neurosci 19, 109–18.

181.Sofroniew, M. V. (2005). Reactive astrocytes in neural repair and protection. Neuroscientist 11, 400–7.

182.Hermanns, S., Klapka, N., Gasis, M. & Muller, H. W. (2006). The collagenous wound healing scar in the injured central nervous system inhibits axonal regeneration. Adv Exp Med Biol 557, 177–90.

183.Yiu, G. & He, Z. (2006). Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7, 617–27.

184.Teng, F. Y. & Tang, B. L. (2006). Axonal regeneration in adult CNS neurons–signaling molecules and pathways. J Neurochem 96, 1501–8.

185.Chuckowree, J. A., Dickson, T. C. & Vickers, J. C. (2004). Intrinsic regenerative ability of mature CNS neurons. Neuroscientist 10, 280–5.

186.Chen, D. F., Jhaveri, S. & Schneider, G. E. (1995). Intrinsic changes in developing retinal neurons result in regenerative failure of their axons. Proc Natl Acad Sci USA 92, 7287–91.

187.Goldberg, J. L., Klassen, M. P., Hua, Y. & Barres, B. A. (2002). Amacrine-signaled loss of intrinsic axon growth ability by retinal ganglion cells. Science 296, 1860–4.

188.Chen, D. F., Schneider, G. E., Martinou, J. C. & Tonegawa, S. (1997). Bcl-2 promotes regeneration of severed axons in mammalian CNS. Nature 385, 434–9.

189.Kretz, A., Kugler, S., Happold, C., Bahr, M. & Isenmann, S. (2004). Excess Bcl-XL increases the intrinsic growth potential of adult CNS neurons in vitro. Mol Cell Neurosci 26, 63–74.

190.Fischer, D., Pavlidis, M. & Thanos, S. (2000). Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture.

Invest Ophthalmol Vis Sci 41, 3943–54.

191.Leon, S., Yin, Y., Nguyen, J., Irwin, N. & Benowitz, L. I. (2000). Lens injury stimulates axon regeneration in the mature rat optic nerve. J Neurosci 20, 4615–26.

192.Yin, Y., Cui, Q., Li, Y., Irwin, N., Fischer, D., Harvey, A. R. & Benowitz, L. I. (2003). Macrophage-derived factors stimulate optic nerve regeneration. J Neurosci 23, 2284–93.

193.Yin, Y., Henzl, M. T., Lorber, B., Nakazawa, T., Thomas, T. T., Jiang, F., Langer, R. & Benowitz, L. I. (2006). Oncomodulin is a macrophage-derived signal for axon regeneration in retinal ganglion cells. Nat Neurosci 9, 843–52.

194.Heiduschka, P., Fischer, D. & Thanos, S. (2005). Recovery of visual evoked potentials after regeneration of cut retinal ganglion cell axons within the ascending visual pathway in adult rats. Restor Neurol Neurosci 23, 303–12.

195.Lorber, B., Berry, M. & Logan, A. (2005). Lens injury stimulates adult mouse retinal ganglion cell axon regeneration via both macrophageand lens-derived factors. Eur J Neurosci 21, 2029–34.

196.Jo, S. A., Wang, E. & Benowitz, L. I. (1999). Ciliary neurotrophic factor is and axogenesis factor for retinal ganglion cells. Neuroscience 89, 579–91.

197.Cui, Q., Lu, Q., So, K. F. & Yip, H. K. (1999). CNTF, not other trophic factors, promotes axonal regeneration of axotomized retinal ganglion cells in adult hamsters.

Invest Ophthalmol Vis Sci 40, 760–6.

198.Ming, G. L., Song, H. J., Berninger, B., Holt, C. E., Tessier-Lavigne, M. & Poo, M. M. (1997). cAMP-dependent growth cone guidance by netrin-1. Neuron 19, 1225–35.

199.Hanson, M. G., Jr., Shen, S., Wiemelt, A. P., McMorris, F. A. & Barres, B. A. (1998). Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro. J Neurosci 18, 7361–71.

200.Song, H. J. & Poo, M. M. (1999). Signal transduction underlying growth cone guidance by diffusible factors. Curr Opin Neurobiol 9, 355–63.

201.Nishiyama, M., Hoshino, A., Tsai, L., Henley, J. R., Goshima, Y., Tessier-Lavigne, M., Poo, M. M. & Hong, K. (2003). Cyclic AMP/GMP-dependent modulation of Ca2+ channels sets the polarity of nerve growth-cone turning. Nature 423, 990–5.

202.Cai, D., Qiu, J., Cao, Z., McAtee, M., Bregman, B. S. & Filbin, M. T. (2001). Neuronal cyclic AMP controls the developmental loss in ability of axons to regenerate. J Neurosci 21, 4731–9.

203.Cai, D., Shen, Y., De Bellard, M., Tang, S. & Filbin, M. T. (1999). Prior exposure to neurotrophins blocks inhibition of axonal regeneration by MAG and myelin via a cAMP-dependent mechanism. Neuron 22, 89–101.

204.Monsul, N. T., Geisendorfer, A. R., Han, P. J., Banik, R., Pease, M. E., Skolasky, R. L., Jr. & Hoffman, P. N. (2004). Intraocular injection of dibutyryl cyclic AMP promotes axon regeneration in rat optic nerve. Exp Neurol 186, 124–33.

205.Cui, Q., Yip, H. K., Zhao, R. C., So, K. F. & Harvey, A. R. (2003). Intraocular elevation of cyclic AMP potentiates ciliary neurotrophic factor-induced regeneration of adult rat retinal ganglion cell axons. Mol Cell Neurosci 22, 49–61.

206.Watanabe, M., Tokita, Y., Kato, M. & Fukuda, Y. (2003). Intravitreal injections of neurotrophic factors and forskolin enhance survival and axonal regeneration of axotomized beta ganglion cells in cat retina. Neuroscience 116, 733–42.

207.Park, K., Luo, J. M., Hisheh, S., Harvey, A. R. & Cui, Q. (2004). Cellular mechanisms associated with spontaneous and ciliary neurotrophic factor-cAMP-induced survival and axonal regeneration of adult retinal ganglion cells. J Neurosci 24, 10806–15.

208.Lehmann, M., Fournier, A., Selles-Navarro, I., Dergham, P., Sebok, A., Leclerc, N., Tigyi, G. & McKerracher, L. (1999). Inactivation of Rho signaling pathway promotes CNS axon regeneration. J Neurosci 19, 7537–47.

209.Bertrand, J., Winton, M. J., Rodriguez-Hernandez, N., Campenot, R. B. & McKerracher, L. (2005). Application of Rho antagonist to neuronal cell bodies promotes neurite growth in compartmented cultures and regeneration of retinal ganglion cell axons in the optic nerve of adult rats. J Neurosci 25, 1113–21.

210.Gilbert, R. J., McKeon, R. J., Darr, A., Calabro, A., Hascall, V. C. & Bellamkonda, R. V. (2005). CS-4,6 is differentially upregulated in glial scar and is a potent inhibitor of neurite extension. Mol Cell Neurosci 29, 545–58.

211.Properzi, F., Carulli, D., Asher, R. A., Muir, E., Camargo, L. M., van Kuppevelt, T. H., ten Dam, G. B., Furukawa, Y., Mikami, T., Sugahara, K., Toida, T., Geller, H. M. & Fawcett, J. W. (2005). Chondroitin 6-sulphate synthesis is up-regulated in injured CNS, induced by injury-related cytokines and enhanced in axon-growth inhibitory glia. Eur J Neurosci 21, 378–90.

212.Fawcett, J. W. (2006). The glial response to injury and its role in the inhibition of CNS repair. Adv Exp Med Biol 557, 11–24.

213.Yick, L. W., Cheung, P. T., So, K. F. & Wu, W. (2003). Axonal regeneration of Clarke’s neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Exp Neurol 182, 160–8.

214.Davies, J. E., Tang, X., Denning, J. W., Archibald, S. J. & Davies, S. J. (2004). Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Eur J Neurosci 19, 1226–42.

215.Chen, M. S., Huber, A. B., van der Haar, M. E., Frank, M., Schnell, L., Spillmann, A. A., Christ, F. & Schwab, M. E. (2000). Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 403, 434–9.

216.GrandPre, T., Nakamura, F., Vartanian, T. & Strittmatter, S. M. (2000). Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein. Nature 403, 439–44.

217.Fournier, A. E., GrandPre, T. & Strittmatter, S. M. (2001). Identification of a receptor mediating Nogo-66 inhibition of axonal regeneration. Nature 409, 341–6.

218.Wong, S. T., Henley, J. R., Kanning, K. C., Huang, K. H., Bothwell, M. & Poo, M. M. (2002). A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelinassociated glycoprotein. Nat Neurosci 5, 1302–8.

219.Wang, K. C., Kim, J. A., Sivasankaran, R., Segal, R. & He, Z. (2002). P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature 420, 74–8.