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CHAPTER 2. NUTRITION AND MACULAR DEGENERATION
Overview
In this chapter, we will show you how to find studies dedicated specifically to nutrition and macular degeneration.
Finding Nutrition Studies on Macular Degeneration
The National Institutes of Health’s Office of Dietary Supplements (ODS) offers a searchable bibliographic database called the IBIDS (International Bibliographic Information on Dietary Supplements; National Institutes of Health, Building 31, Room 1B29, 31 Center Drive, MSC 2086, Bethesda, Maryland 20892-2086, Tel: 301-435-2920, Fax: 301-480-1845, E-mail: ods@nih.gov). The IBIDS contains over 460,000 scientific citations and summaries about dietary supplements and nutrition as well as references to published international, scientific literature on dietary supplements such as vitamins, minerals, and botanicals.7 The IBIDS includes references and citations to both human and animal research studies.
As a service of the ODS, access to the IBIDS database is available free of charge at the following Web address: http://ods.od.nih.gov/databases/ibids.html. After entering the search area, you have three choices: (1) IBIDS Consumer Database, (2) Full IBIDS Database, or (3) Peer Reviewed Citations Only.
Now that you have selected a database, click on the “Advanced” tab. An advanced search allows you to retrieve up to 100 fully explained references in a comprehensive format. Type “macular degeneration” (or synonyms) into the search box, and click “Go.” To narrow the search, you can also select the “Title” field.
7 Adapted from http://ods.od.nih.gov. IBIDS is produced by the Office of Dietary Supplements (ODS) at the National Institutes of Health to assist the public, healthcare providers, educators, and researchers in locating credible, scientific information on dietary supplements. IBIDS was developed and will be maintained through an interagency partnership with the Food and Nutrition Information Center of the National Agricultural Library, U.S. Department of Agriculture.
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The following is a typical result when searching for recently indexed consumer information on macular degeneration:
•Dietary carotenoids and certain cancers, heart disease, and age-related macular degeneration: a review of recent research.
Author(s): Department of Regulatory and Clinical Development, Procter & Gamble Company, Cincinnati, OH 45224-1703, USA.
Source: Cooper, D A Eldridge, A L Peters, J C Nutr-Revolume 1999 July; 57(7): 201-14 0029-6643
•Nutrition and macular degeneration.
Source: Dysart, J.M. Nutr-M-D. Van Nuys, Calif. : PM, Inc. May 1992. volume 18 (5) page 1-2. 0732-0167
•Zinc and macular degeneration.
Source: Nutr-Rev. New York, N.Y. : Springer-Verlag New York Inc. July 1990. volume 48
(7) page 285-287. 0029-6643
The following information is typical of that found when using the “Full IBIDS Database” to search for “macular degeneration” (or a synonym):
•A novel relation of fatty acid with age-related macular degeneration.
Author(s): Department of Ophthalmology, Kyoto Prefectural University of Medicine, 465 Kawaramachi, Hirokoji agaru, Kajiicho, Kamigyo-ku Kyoto City, Kyoto 602-8566, Japan. mouchi@ophth.kpu.m.ac.jp
Source: Ouchi, M Ikeda, T Nakamura, K Harino, S Kinoshita, S Ophthalmologica. 2002 Sep-October; 216(5): 363-7 0030-3755
•A2E and blue light in the retina: the paradigm of age-related macular degeneration.
Author(s): Institute of Biochemistry, Swiss Federal Institute of Technology (ETH), Zurich.
Source: Shaban, H Richter, C Biol-Chem. 2002 Mar-April; 383(3-4): 537-45 1431-6730
•Age-related macular degeneration.
Author(s): Vitreo-Retinal Foundation, Memphis, TN, USA.
Source: Elfervig, L S Nurse-Pract-Forum. 1998 March; 9(1): 4-6 1045-5485
•Antioxidant vitamin and mineral supplementation for preventing age-related macular degeneration.
Author(s): 'Glaxo' Department of Ophthalmology Epidemiology, Institute of Ophthalmology (UCL) and Moorfields Eye Hospital, City Road, London, UK, EC1V 2PD. jennifer.evans@ucl.ac.uk
Source: Evans, J R Henshaw, K Cochrane-Database-Syst-Revolume 2000; (2): CD000253 1469-493X
•Are antioxidants or other supplements protective for age-related macular degeneration?
Author(s): Retinal Vascular Center, Wilmer Ophthalmological Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Source: Fekrat, S Bressler, S B Curr-Opin-Ophthalmol. 1996 June; 7(3): 65-72 1040-8738
•Biochemical defects in retina-specific human ATP binding cassette transporter nucleotide binding domain 1 mutants associated with macular degeneration.
Author(s): Department of Laboratory Sciences, Program in Biotechnology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Source: Suarez, Tatiana Biswas, Subhasis B Biswas, Esther E J-Biol-Chem. 2002 June 14; 277(24): 21759-67 0021-9258
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•By the way doctor. I'm 72 and was recently told that I am losing a bit of my sight because of macular degeneration. My doctor assured me that it was progressing very slowly, but also said there wasn't really anything to do about it. But I read that zinc or vitamins might help. Should I be taking them?
Source: Lee, Thomas H Harv-Health-Lett. 2002 February; 27(4): 8 1052-1577
•Can high-dose supplementation with vitamins C and E, beta carotene, and zinc slow the progression of macular degeneration?
Author(s): Clarkson Family Practice Residency Program, Omaha, NE, USA.
Source: Gordon, Josette E Schooff, Michael J-Fam-Pract. 2002 February; 51(2): 105 00943509
•Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration.
Author(s): Wilmer Eye Institute, Baltimore, MD 21287-9115, USA. glutty@jhmi.edu Source: Lutty, G Grunwald, J Majji, A B Uyama, M Yoneya, S Mol-Vis. 1999 November 3; 535 1090-0535
•Cigarette smoking and retinal carotenoids: implications for age-related macular degeneration.
Author(s): Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston MA 02114, USA. Rhammond@vision.eri.harvard.edu
Source: Hammond, B R Wooten, B R Snodderly, D M Vision-Res. 1996 September; 36(18): 3003-9 0042-6989
•Could statins prevent age-related macular degeneration?
Author(s): MRC Environmental Epidemiology Unit, University of Southampton & Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. nigel.hall@orange.net
Source: Hall, N F Martyn, C N Expert-Opin-Pharmacother. 2002 July; 3(7): 803-7 14656566
•Current use of dietary supplementation in patients with age-related macular degeneration.
Author(s): Department of Ophthalmology, University of Alberta, Edmonton, Alta. Source: Chang, C W Chu, G Hinz, B J Greve, M D Can-J-Ophthalmol. 2003 February; 38(1): 27-32 0008-4182
•Dietary prevention of age-related macular degeneration.
Source: Pratt, S J-Am-Optom-Assoc. 1999 January; 70(1): 39-47 0003-0244
•Does coenzyme Q10 play a role in opposing oxidative stress in patients with agerelated macular degeneration?
Author(s): Department of Ophthalmology, University of L'Aquila, L'Aquila, Italy. Source: Blasi, M A Bovina, C Carella, G Genova, M L Jansen, A M Lenaz, G Brancato, R Ophthalmologica. 2001 Jan-February; 215(1): 51-4 0030-3755
•Free radicals and antioxidant supplementation: a review of their roles in age-related macular degeneration.
Author(s): Pacific University, College of Optometry, Forest Grove, OR 97116.
Source: van der Hagen, A M Yolton, D P Kaminski, M S Yolton, R L J-Am-Optom-Assoc. 1993 December; 64(12): 871-8 0003-0244
•Ginkgo biloba extract for age-related macular degeneration.
Author(s): 'Glaxo' Department of Ophthalmology Epidemiology, Institute of Ophthalmology (UCL) and Moorfields Eye Hospital, City Road, London, UK, EC1V 2PD. jennifer.evans@ucl.ac.uk
110Macular Degeneration
Source: Evans, J R Cochrane-Database-Syst-Revolume 2000; (2): CD001775 1469-493X
•Implant radiotherapy for exudative macular degeneration associated with subretinal neovascularization.
Author(s): New York Eye Cancer Center, New York, N.Y., USA. pfinger@maculardegeneration.org
Source: Finger, P T Front-Radiat-Ther-Oncol. 2001; 35: 86-93 0071-9679
•Interaction of A2E with model membranes. Implications to the pathogenesis of agerelated macular degeneration.
Author(s): Howard Hughes Medical Institute, Laboratory of Molecular Biology and Biochemistry, The Rockefeller University, New York, NY 10021, USA.
Source: De, S SakMarch, T P J-Gen-Physiol. 2002 August; 120(2): 147-57 0022-1295
•Is there a prevention and treatment strategy for macular degeneration?
Author(s): VA Medical Center, N. Chicago, IL 60064.
Source: Richer, S P J-Am-Optom-Assoc. 1993 December; 64(12): 838-50 0003-0244
•Lutein, zeaxanthin, and age-related macular degeneration.
Source: Bruno, R.S. Medeiros, D.M. J-nutraceuticals-funct-med-foods. Binghamton, NY : Pharmaceutical Products Press, an imprint of the Haworth Press, Inc., c1997-. 2000. volume 3 (1) page 79-85. 1089-4179
•Macular degeneration in older adults.
Author(s): Department of Nursing at Xavier University in Cincinnati, Ohio, USA. Source: Moore, L W Geriatr-Nurs. 2001 Mar-April; 22(2): 96-9 0197-4572
•Multicenter ophthalmic and nutritional age-related macular degeneration study--part 1: design, subjects and procedures.
Author(s): Eye Clinic 112e, DVA Medical Center, North Chicago, IL 60064, USA. Source: Richer, S J-Am-Optom-Assoc. 1996 January; 67(1): 12-29 0003-0244
•Neovascular age-related macular degeneration and its relationship to antioxidant intake.
Author(s): Department of Epidemiology and Biostatistics, University Medical Centre, Nijmegen, Netherlands.
Source: Snellen, E L Verbeek, A L Van Den Hoogen, G W Cruysberg, J R Hoyng, C B Acta-Ophthalmol-Scand. 2002 August; 80(4): 368-71 1395-3907
•No efficacious treatment for age-related macular degeneration.
Author(s): Department of Ophthalmology, Algemeen Ziekenhuis Sint-Jozef, Turnhout, Belgium.
Source: Roodhooft, J Bull-Soc-Belge-Ophtalmol. 2000; 27683-92 0081-0746
•Nutritional supplement use and age-related macular degeneration.
Author(s): National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.
Source: Chew, E Y Curr-Opin-Ophthalmol. 1995 June; 6(3): 19-24 1040-8738
•Oxidative damage and age-related macular degeneration.
Author(s): Eye Research Institute, Oakland University, Rochester, MI 48309, USA. winkler@oakland.edu
Source: Winkler, B S Boulton, M E Gottsch, J D Sternberg, P Mol-Vis. 1999 November 3; 532 1090-0535
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•Relationship between anticoagulant medication and massive intraocular hemorrhage in age-related macular degeneration.
Author(s): Institute of Ophthalmology, University Hospital Nijmegen, The Netherlands. m.tilanus@ohk.azn.nl
Source: Tilanus, M A Vaandrager, W Cuypers, M H Verbeek, A M Hoyng, C B Graefes- Arch-Clin-Exp-Ophthalmol. 2000 June; 238(6): 482-5 0721-832X
•Resonance Raman measurement of macular carotenoids in normal subjects and in age-related macular degeneration patients.
Author(s): Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. paul.bernsteinhsc@hsc.utah.edu
Source: Bernstein, P S Zhao, D Y Wintch, S W Ermakov, I V McClane, R W Gellermann, W Ophthalmology. 2002 October; 109(10): 1780-7 0161-6420
•Risk factors for age-related macular degeneration.
Author(s): Department of Epidemiology and International Eye Health, Institute of Ophthalmology, Bath street, EC1V 9EL, London, UK. jennifer.evans@ucl.ac.uk
Source: Evans, J R Prog-Retin-Eye-Res. 2001 March; 20(2): 227-53 1350-9462
•Study of antiangiogenic agents with possible therapeutic applications in neoplastic disorders and macular degeneration.
Author(s): Department of Internal Medicine, State University of NY at Buffalo Medical School-Kaleida Health Systems, 14203, USA.
Source: Ambrus, J L Toumbis, C A Karakousis, C P Kulaylat, M Akhter, S Plavsic, L J- Med. 2000; 31(5-6): 278-82 0025-7850
•Supplements may slow age-related macular degeneration.
Source: Anonymous Mayo-Clin-Health-Lett. 2002 March; 20(3): 4 0741-6245
•Tetrathiomolybdate as an antiangiogenesis therapy for subfoveal choroidal neovascularization secondary to age-related macular degeneration.
Author(s): Department of Ophthalmology and Visual Sciences, University of Michigan Medical Center, Ann Arbor, USA.
Source: Vine, A K Brewer, G J Trans-Am-Ophthalmol-Soc. 2002; 100: 73-6; discussion 76- 7 0065-9533
•The macular pigment: a possible role in protection from age-related macular degeneration.
Author(s): Department of Chemistry, Florida International University, Miami 33199, USA.
Source: Landrum, J T Bone, R A Kilburn, M D Adv-Pharmacol. 1997; 38537-56 1054-3589
•Treatment of macular degeneration, according to Bangerter.
Author(s): King Khaled Eye Specialist Hospital P.O. Box Riyadh 7191, Riyadh 11 462 Kingdom of Saudi Arabia ++966 1/482 1234 ++966 1/482 1908.
Source: Teichmann, K D Eur-J-Med-Res. 1997 October 30; 2(10): 445-54 0949-2321
•Verteporfin therapy of subfoveal choroidal neovascularization in patients with agerelated macular degeneration: additional information regarding baseline lesion composition's impact on vision outcomes-TAP report No. 3.
Author(s): Wilmer Photograph Reading Center, The Johns Hopkins University School of Medicine, Baltimore, MD 21205-2002, USA. nmboffice@jhmi.edu
Source: Bressler, N M Arnold, J Benchaboune, M Blumenkranz, M S Fish, G E Gragoudas, E S Lewis, H Schmidt Erfurth, U Slakter, J S Bressler, S B Manos, K Hao, Y