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..............................

Macular and Retinal Diseases

..............................

Developments

in Ophthalmology

Vol. 29

Series Editor

W. Behrens-Baumann, Magdeburg

Basel ´ Freiburg ´ Paris ´ London ´ New York ´ New Delhi ´ Bangkok ´ Singapore ´ Tokyo ´ Sydney

..............................

Macular and Retinal Diseases

Recent Advances

in Diagnosis and Therapy

Volume Editors P. Wiedemann, Leipzig

L. Kohen, Leipzig

30 figures, 4 in color and 7 tables, 1997

Basel ´ Freiburg ´ Paris ´ London ´ New York ´ New Delhi ´ Bangkok ´ Singapore ´ Tokyo ´ Sydney

..............................

Peter Wiedemann, Leon Kohen

UniversitaÈtsklinikum, Klinik und Poliklinik fuÈr Augenheilkunde Liebigstrasse 14, D 04103 Leipzig

Continuation of `Bibliotheca Ophthalmologica', `Advances in Ophthalmology', and `Modern Problems in Ophthalmology'

Founded 1926 as `Abhandlungen aus der Augenheilkunde und ihren Grenzgebieten' by C. Behr, Hamburg and J. Meller, Wien

Former Editors: A. Bruckner, Basel (1938±1959); H. J. M. Wewe, Utrecht (1938±1962); H. M. Dekking, Groningen (1954±1966); E. B. Streiff, Lausanne (1954±1979);

J. FrancËois, Gand (1959±1979); J. van Doesschate, Utrecht (1967±1971);

M. J. Roper-Hall, Birmingham (1966±1980); H. Sautter, Hamburg (1966±1980); W. Straub, Marburg a. d. Lahn (1981±1993)

Library of Congress Cataloging-in-Publication Data

Macular and retinal diseases: recent advances in diagnosis and therapy / volume editors, P. Wiedemann, L. Kohen.

(Developments in ophthalmology; vol. 29)

Based on a symposium titled New approaches in the diagnosis and therapy of macular and retinal diseases, held Nov. 1996 in Leipzig, Germany.

Includes bibliographical references and indexes.

1. Macula lutea±Diseases±Atlases. 2. Retina±Diseases±Atlases. I. Wiedemann, Peter. II. Kohen, L. (Leon) III. Series.

[DNLM: 1. Retinal Diseases-congresses. 2. Macula Lutea-congresses. W1 DE998NG v.29 1998WW 270 M17515 1997]

RE661.M3M332 1997 617.7'35-dc21

ISBN 3-8055-6553-4 (hardcover: alk. paper)

Bibliographic Indices. This publication is listed in bibliographic services, including Current Contents and Index Medicus.

Drug Dosage. The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any change in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.

All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.

Copyright 1997 by S. Karger AG, P. O. Box, CH-4009 Basel (Switzerland) Printed in Switzerland on acid free paper by Reinhardt Druck, Basel

ISBN 3-8055-6553-4

..............................

Contents

VII Preface

1Recent Developments in Scanning Laser Ophthalmoscopy

Wolf, S. (Aachen)

8Multifocal ERG Recording by the VERIS Technique and its Clinical Applications

Kretschmann, U.; Gendo, K.; Seeliger, M.; Zrenner, E. (Tubingen)

15 Advances in the Management of Vitreomacular Traction Syndrome and Macular Hole

Koerner, F.; Garweg, J. (Berne)

30Use of Autologous Platelet Concentrate in Macular Hole Surgery: Report of 77 Cases

Gaudric, A.; Paques, M.; Massin, P.; Santiago, P. Y.; Dosquet, C. (Paris)

36Autologous Platelet Concentrate in the Surgical Management of Macular Holes

Minihan, M.; Cleary, P. E. (Cork)

44Hemorrhagic Macular Cysts in Terson's Syndrome and Its Implications for Macular Surgery

Morris, R. (Birmingham, Ala.); Kuhn, F. (Birmingham, Ala./PeÂcs); Witherspoon, C. D. (Birmingham, Ala.); Mester, V. (PeÂcs); Dooner, J. (Birmingham, Ala.)

55Complications in the Removal of the Posterior Vitreous Cortex

Ripandelli, G.; CoppeÂ, A. M.; Falsini, B.; Fedeli, R.; Stirpe, M. (Rome)

61 Epiretinal Macular Membranes: Pathogenesis and Treatment

Miller, B. (Haifa)

V

64Local Therapy of CMV Retinitis: A New Therapeutical Approach

Fuchs, A.V.; Scheider, A.; Klauss, V.; Kampik, A. (Munich)

69A Retained Catheter for Retrobulbar Administration of Interferon for Age-Related Macular Degeneration

Lincoff, H. (New York, N. Y.); Kreissig, I.; Gelisken, F. (Tubingen); Stanga, P. (New York, N. Y.)

78Experimental Therapies for Age-Related Macular Degeneration

Soubrane, G.; Coscas, G. (CreÂteil)

85Evaluation of Macular Therapy

Blach, R. K. (London)

95Author Index

96Subject Index

Contents

VI

..............................

Preface

On the occasion of the construction of the New University Eye Hospital in Leipzig, Germany, a symposium was held in November 1996, under the title `New approaches in the diagnosis and therapy of macular and retinal diseases'. The aim of the symposium was for internationally recognized experts to inform the participants regarding the status, goals and perspectives of macular and retinal research.

The symposium was a success due to the great efforts of the speakers and we are grateful for their excellent presentations. In order to share some of the ideas and knowledge presented in Leipzig, we collected most of the papers.

New diagnostic techniques are presented by Wolf and Kretschmann. Different experiences in the surgery of macular holes are described by KoÈ rner, Cleary and Gaudric. Surgery of Terson's syndrome is presented by Kuhn and Morris, and epiretinal membrane surgery by Miller. Stirpe refers to complications in the removal of the posterior vitreous cortex. The use of an intraocular implant for drug delivery is explained by Kampik group. Kreissig and Lincoff introduce the therapeutic balloon for the treatment of AMD, while Soubrane gives a review of current experimental therapies for AMD. Blach points out the problems of macular therapy and evaluates the treatment strategies.

Transplantation into the subretinal space, gene therapy of retinal diseases, molecular-based diagnosis, retina implant, and cellular and biochemical aspects of retinal diseases will be published in Ophthalmic Research.

We are very grateful to the editors of Developments in Ophthalmology and to the publisher for the opportunity to present these subjects in their book series.

Peter Wiedemann, Leipzig Leon Kohen, Leipzig

VII