Ординатура / Офтальмология / Английские материалы / LASIK and Beyond LASIK Wavefront Analysis and Customized Ablation_Boyd_2001
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Chapter 45
Figure 45- 1: The two stab incisions are not radial; they are oriented parallel to the direction of lens insertion. The entry of the stab incision should be pointed directly towards the site on the iris where the enclavation will take place.
to 4 o’clock. The first two stab incisions are designed to permit the enclavation needle to enter the eye directed exactly to the spot where enclavation will take place (Figure 45-1).
Once the stab incisions are made, the anterior chamber is irrigated first with Miochol. Then it is filled with a cohesive viscoelastic such as Healon
or Amvisc Plus. A cohesive viscoelastic is very helpful in cases of phakic lens implantation, because it can be irrigated from the eye very easily at the end of the procedure (Figures 45-2,45-3).
The primary incision for phakic lens implan- |
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tation needs to be made in a very specific manner. A |
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simple shelf incision in the peripheral cornea facili- |
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tates viscoelastic leakage from the anterior chamber |
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during enclavation and makes the case more diffi- |
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cult than necessary. The best incision has a partial- |
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thickness groove and then a shallow tunnel into the |
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cornea of only 1 mm or 2 mm. This gives the eye an |
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adequate corneal incision lip and at the same time |
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limits how much the incision must be distorted in |
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order to use the enclavation instruments (Figures |
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45-4, 45-5). |
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The intraocular lens is slipped into the ante- |
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rior chamber and allowed to rest there. Immediately, |
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two or three interrupted 10-0 nylon sutures are used |
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to tightly close the incision in order to be able to con- |
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trol the anterior chamber. Contact between iris and |
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lens is essential for easy enclavation, so a lens ma- |
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nipulation hook is placed in the eye and on top of the |
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implant. It presses the lens gently down against the |
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iris to remove most of the viscoelastic separating the |
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two. Pushing the lens down also increases the dis- |
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tance of the implant from the corneal endothelium. |
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Figure 45-2: The miotic is injected into the eye. Notice that the needle is pointed directly towards the anticipated enclavation site.
Figure 45-3:After the pupil is constricted, a cohesive viscoelastic is injected into the anterior chamber. At the risk of some redundancy, notice again that the direction of the corneal incision is straight to the enclavation site and not radial.
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Figure 45-4: The incision is constructed in two planes. The first plane is a groove of about one-half the corneal thickness.
Figure 45-5: The second plane is a short tunnel of roughly 1 mm to 2 mm. The groove and the tunnel are planned so that the external groove and the internal tunnel are in a line parallel to and slightly above the iris. This minimizes the likelihood of incision distortion and viscoelastic leakage.
The lens hook then rotates the lens perpendicular to the original incision. Using again the example of a 9 o’clock incision, the lens is placed in the eye initially from 9 o’clock to 3 o’clock. It is now rotated from 6 o’clock to 12 o’clock (Figures 45-6, 45-7).
The enclavation needle is slipped into the eye through one of the stab incisions before the lens forceps are passed through the primary incision. If these steps are reversed, it is common to see viscoelastic leakage at the primary incision when the enclavation
needle is placed. Therefore, the needle is always put in first.
The lens forceps hold the optic of the lens gently downward against the iris while the first enclavation takes place. The enclavation needle pushes down and forward against the iris, gathering a knuckle of iris in front of it. The enclavation needle is then lifted into the claw, scooping iris with it in a single, easy motion. If the amount of iris secured in the claw is insufficient, the enclavation can be re-
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Figure 45-6: The intraocular lens is placed in the anterior chamber and left there until after the incision has been sutured and the anterior chamber controlled.
Figure 45-7: Alens hook is used to rotate the lens perpendicular to the direction of insertion. For example, for a temporal incision in the right eye, the lens was inserted from 9:00 towards 3:00. Now it is rotated from 12:00 to 6:00.
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Chapter 45 
Figure 45-8: The enclavation is always difficult to capsule for demonstration. The lens is held with the forceps and the enclavation needle gathers the iris. In this view the tip of the needle is pushing down and forward against the iris, gathering a fold in front, in much the way a snowplow pushes snow.
peated until a sufficient amount of iris is captured (Figures 45-8, 45-9).
Typically, at this point a little more viscoelastic is placed in the eye to deepen the chamber and again to push the lens against the iris. The last step is repeated, this time using the second stab incision to
Figure 45-10: The iridotomy is made by gathering some iris with the tip of sharp scissors, just like the enclavation needle gathered some iris for the enclavation. The scissors are twisted so that the iris lifts away from the crystalline lens. The scissors are closed, making a snip iridotomy.The tips can be opened within the iridotomy to make it larger if needed.
Figure 45-9: In this view a split second later, the needle is lifted |
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into the claw of the lens, still pushing the iris in front of it. The |
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tips of the claw give way as the needle and iris pass between |
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them. When the needle is completely through the claw, the tips |
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close against the iris, capturing it and causing fixation. |
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make the second enclavation. The position of the |
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lens during enclavation is critical because the lens |
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must be perfectly centered over the pupil when iris |
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fixates it. If it is not centered, the iris should be pushed |
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out of the claw, the lens recentered, and the |
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enclavation repeated. |
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Figure 45-11: Aclose-up of an enclavation showing an adequate amount of iris captured in the claws.
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Figure 45-12: The completed case, with the lens centered, adequate enclavations, and an iridotomy.
A small peripheral iridectomy or iridotomy must be performed. The easiest method is to slip very small, very sharp scissors into the anterior chamber and use one tip of the scissor to capture and lift a piece of iris. When the scissors close, they snip a piece of the iris, forming an iridotomy. If necessary, the tips of the scissors can be placed in the small iridotomy and opened to enlarge the opening (Figure 45-10).
Figure 45-13: The lashes of the lateral upper eyelid are draped because they could interfere with the movement of the microkeratome.
The final step is to remove the viscoelastic |
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from the eye by irrigating the anterior chamber and |
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simultaneously pressing on the corneal lip. The co- |
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hesive viscoelastic can be burped from the eye eas- |
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ily, ensuring a near-total removal. An additional |
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10-0 nylon suture is placed if necessary. At the con- |
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clusion of the operation, the lens is centered over the |
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iris with two adequate enclavations (Figures |
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45-11,45-12). |
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Surgical Technique: LASIK |
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The LASIK technique varies depending upon |
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the laser and the fixation method used. When I con- |
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ducted this study, I used a Summit Apex Plus Laser |
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and a Moria LSK One microkeratome. The LASIK |
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flap was made with a nasal hinge. Immediately after |
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the microkeratome is removed, the vacuum of the |
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Moria unit is turned to the low setting, allowing the |
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surgeon to continue holding on to the eye with the |
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ring while near-normal intraocular pressure is restored |
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to the eye. In this way the eye can be manually fix- |
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ated and steadily held under the laser while the abla- |
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tion is performed (Figures 45-13 -- 45-15). |
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I use a lint-free cellulose sponge in two ways: |
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as a sponge to attract moisture and as an instrument |
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to manipulate the flap. Once the flap is cut, I use the |
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sponge to dry most of the moisture on the surface of |
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Figure 45-14: The Moria suction ring is placed on the eye, centered, and activated with high vacuum in preparation for making the flap.
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Figure 45-15: The flap is made with the forward pass of the microkeratome while the ring is on high vacuum. When the head reaches its stop, the motor is inactivated and the vacuum is reduced to its low setting before the head is retracted. Retraction under low vacuum reduces epithelial friction and abrasions.
the ring except where the flap will rest when flipped. I used to dry everywhere but once I lost suction and the ring moved. The flap was stuck to the dried ring and ripped off the eye, leaving a free cap (Figure 45-16).
The tip of a second sponge is used to lift the flap and flip it over. That same sponge is immedi-
Figure 45-16:The superior, inferior, and temporal areas of the |
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ring’s surface are dried to reduce the moisture to the stromal |
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bed. The nasal area is left moist to prevent flap adhesion to the |
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ring. |
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ately used to wipe the moisture from the stromal bed. |
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If moisture appears on the stroma during the abla- |
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tion, it is wiped away with a sponge, but if the cornea |
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remains adequately dry during the ablation, the laser |
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is fired until the treatment is finished (Figures |
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45-17 -- 45-21). |
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Figure 45-17: Stage one of lifting the flap with the cellulose sponge. A new, dry sponge is used as a pusher, engaging the flap at its temporal edge.
Figure 45-18: Stage two of lifting the flap with the cellulose sponge. The tip of the sponge pushes the flap and begins to flip it over.
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Figure 45-19: Stage three of lifting the flap with the cellulose sponge. The flap is completely lifted and flipped. The sponge smoothes out the flap to prevent wrinkles.
After the ablation the corneal bed and the underside of the flap are irrigated vigorously with balanced salt solution and wiped thoroughly with the cellulose sponge. After I am confident that both surfaces are completely clean and free of debris, the same
Figure 45-20: The same sponge is immediately used to dry any moisture that may have settled on the stromal bed.
sponge is used to reposition the flap. The surface of the flap is massaged several times with the lint-free sponge to remove underlying fluid, the gutters are dried, and the flap is allowed to seal in place (Figures 45-22 -- 45-25).
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Figure 45-21: Stage three of lifting the flap with the cellulose sponge. The flap is completely lifted and flipped. The sponge smoothes out the flap to prevent wrinkles.
Figure 45-22: Once the ablation is completed, the assistant irrigates the bed and the underside of the flap vigorously with BSS, while the surgeon scrubs each with the cellulose sponge.
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Figure 45-23: Once all the debris has been cleaned from the bed, the same sponge is used to wipe the flap back into position and to massage it several times to remove much of the underlying fluid.
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Figure 45-24: A new, dry sponge is used to dry the
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gutter.
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Figure 45-25: The edge of the gutter is dried a second time with a gentle flow of compressed air. Only the gutter is dried, not the flap itself. Too much drying will desiccate the flap and displace it.
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The Study: Ophtec Artisan Myopia Implant vs. LASIK
In order to determine whether one technique is demonstrably superior to the other, we conducted a prospective study in which we enrolled patients who required refractive correction of –8.00 to –12.00 diopters. In this evaluation, we included 97 eyes, 79 of which were treated with LASIK, and 18 of which had the Artisan™ myopia implant. We were able to follow both of these groups for a period of time ranging from 6 to 24 months.
The two groups were not thoroughly randomized. Some patients had astigmatism greater than the 2 diopters allowed for enrollment in the Artisan lens clinical study. All patients in this subgroup were treated with LASIK. Other patients had corneal curvatures too flat or thicknesses too thin for LASIK and therefore had lens implantation. Other patients
preferred one procedure over another and could therefore not be randomized.
The preoperative BCVA was different for the two groups. Patients having LASIK saw better before surgery than the patients who received the Artisan implant. This was not part of the study design, nor does it reflect a bias; it was simply a coincidence of patient distribution. The pre-operative BCVA are summarized in Table 1 and Graph 1 which demonstrate clearly that far more patients in the LASIK group had a potential visual acuity of 20/20 than those eyes in the Artisan implant group.
When patients with preexisting astigmatism were assigned to have LASIK, the laser was used to correct the astigmatism as well. Only patients with 2 diopters of astigmatism or less were enrolled in the Artisan implant group. The only attempt to correct the astigmatism in this group was through incision placement and suture tension.
Table 1
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Chapter 45 
Results
Following surgery, the postoperative uncorrected visual acuities were very similar. 43% of the LASIK patients and 50% of the Artisan patients saw 20/20 or better without correction. A total of 68% of the LASIK patients and 66% of the Artisan patients saw 20/25 or better, and 88% of the LASIK patients and 94% of the Artisan patients saw 20/40 or better. The trend toward improved vision in the Artisan patients had mild statistical significance (p=0.04), but the difference between the two is still very slight (Table 2, Graph 2).
There is, however, a tremendous difference in the postoperative BCVA between the two treatment groups. Sixty-three percent of the LASIK group and 94% of the Artisan implant group were able to see 20/20 or better with correction following surgery. All of the Artisan patients saw at least 20/25 or better. However, only 84% of the LASIK patients saw 20/25, and only 97% of them saw 20/40. This represents a dramatic shift from the BCVA prior to surgery, where the LASIK patients clearly had the advantage. Postoperatively, the advantage shifted to the Artisan lens patients. This is statistically significant to the level of p=0.0001 (Table 3, Graph 3).
Table 2
Table 3
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The average visual acuity in the LASIK group fell slightly, from 20/21 to 20/24, while in the Artisan lens group it improved slightly from 20/24 to 20/18 (Table 4).
In the Artisan lens group, there was a dramatic improvement in the number of eyes that gained BCVA. Thirteen percent of the LASIK eyes improved by one or more lines of visual acuity, and only 2% improved by two lines of vision or more. On the other hand, 83% of the Artisan patients improved by one or more lines, and 22% of the eyes improved by two or more lines (Table 5).
Just the reverse was found when we examined loss of BCVA. None of the Artisan implant eyes lost any visual acuity; however, 25% of the LASIK eyes lost one or more lines, and 6% lost two or more lines of BCVA. In many cases, the recorded loss of one line occurred because some patients before surgery were examined while wearing a hard contact lens, whereas they were examined behind the phoropter postoperatively. This variable applied to Artisan lens patients as well. There was no question that the Artisan lens eyes gained more vision and lost no vision, while the LASIK eyes gained only a little vision and lost some as well (Table 6).
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Section 7 |
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Table 5 |
Table 6 |
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