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Ординатура / Офтальмология / Английские материалы / LASIK and Beyond LASIK Wavefront Analysis and Customized Ablation_Boyd_2001

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Chapter 40

Wavefront technology will help us better understand these subtle benefits of asphericity in the future as well. Krueger's experience with the FDA approved Alcon-Summit Autonomous LADARVision Laser is that up to 6 diopters of hyperopia can be treated with up to 6 diopters of hyperopic astigmatism as well as mixed astigmatism. In the past a small plus refraction with a higher minus cylinder mixed astigmatism could not be treated with the laser. Now the entire continuum from farsightedness to farsighted astigmatism to mixed astigmatism to myopic astigmatism to myopia can be treated using the laser.

Krueger advocates LASIK, but not in combination with thermokeratoplasty. He is somewhat skeptical of the possibility that significant regression may occur over time. If patients are not expecting a temporary procedure with a change in their refraction with time, they might tend to be dissatisfied and have unrealistic expectations.

Again, in presbyopia complicated by moderate hyperopia, Steven E. Wilson, M.D. advises patients with up to 4 diopters of hyperopia that LASIK can do a beautiful job of correcting their problem. Patients who are 1 to 4 diopters farsighted, which amplifies the presbyopic problem, can have their near vision dramatically improved just by the correction of their hyperopia, depending on the age of the patient. Wilson has even observed that in patients in their 60s or 70s with 2 to 4 diopters of hyperopia, the hyperopia excimer laser correction can result in 20/20 or 20/25 vision at distance and provide the ability to read. This cannot be promised to the patient, but is likely to occur due to the multifocality of the ablation for hyperopia when using the Visx 52 Star laser.

Wilson never promises his patients these results because the results are not uniform. The specific way the hyperopic correction is produced with LASIK probably causes some patients to get enough multifocal effect on the cornea to see both distance and near. Wilson once performed this procedure on both members of a couple. The husband was so thrilled after his surgery that he recommended it to his wife, who was also farsighted. She underwent it 1 month later. Wilson was very careful to warn her she might not have the same surgical result. In fact, she still needs glasses to read. But her glasses no longer need to be so thick.

Marguerite McDonald, M.D., always suggests monovision to her refractive patients who have presbyopia, with one eye for distance (dominant eye) and one eye for near. Otherwise, she feels they will have traded one pair of glasses for another.

In hyperopia and presbyopia, in a patient who is +2.00 diopters in both eyes, Dr. McDonald performs a LASIK procedure and corrects the dominant eye for distance using a full +2.00 diopters correction. Patients aged 40 to 43 will be treated in the non-dominant eye to end up with a +1.00 addition to the +2.00 hyperopic correction. That is, they will have +3.00 diopters correction to induce myopia in the reading eye (non-dominant eye). In slightly older patients, those between 44 and 46, she induces a correction of +3.50 (+2.00 of hyperopia and +1.50 addition). In patients above 46 years, she induces a +3.75 correction (+2.00 of hyperopia and +1.75 diopters addition to induce myopia for reading). The strongest addition Dr. McDonald gives patients is +1.75. Otherwise, distance vision becomes so uncomfortable in the reading eye that patients have much difficulty fusing the images.

Emmetropia with Presbyopia (Monovision Method)

Krueger has treated several emmetropic patients who complain about their inability to read. He makes them slightly myopic in the non-dominant eye, using LASIK. Only the non-dominant eye is treated. This monovision treatment give patients the ability to read, and yet not lose the distance vision in their other eye.

In their patients also, Krueger uses the FDA approved Alcon Summit Autonomous LADARVision Laser.

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

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Description of Operations on the Sclera to Improve Presbyopia

In order to understand the current trends in surgical improvement of presbyopia through operations on the sclera, it is important that we keep in mind the two theories of accommodation that have

428 SECTION VI

been under intense discussion during the past 4 years. They are:

Helmholtz's Theory: this has been and continues to be the generally accepted theory of accommodation since it was postulated in 1855. Helmholtz formally stated that accommodation occurs through a change in the shape of the lens. He postulated that the ciliary muscle is relaxed when the eye is focused for distance. The relaxed ciliary muscle maintains the zonule under tension to flatten the crystalline lens for distance viewing. When the eye focuses on a near object, the ciliary muscle contracts and releases tension on the zonule. The release of zonular tension results in increased curvature of both the anterior and posterior surfaces of the crystalline lens. This in turn allows the crystalline lens to become more curved due to elastic forces in the lens.

Schachar's Theory: Ronald Schachar, M.D., from Texas has challenged the Helmholtz's theory and presented his own theory in 1995,

Figure 40-1: Concept of Scleral Incisions (Slits) Technique for Correction of Presbyopia (ACS Procedure)

This procedure involves the use of a 3 to 4 small radial sclerotomy incisions (slits S) over the area of the ciliary body (C) to induce a shift of the ciliary body out (red arrows). Each incision is 600 microns in depth. The mode of action of this operation theoretically is to change the distance between the ciliary body (C) and lens (L), possibly increasing the ability of zonular fibers to exert traction (white arrows) on the lens capsule and consequently change the shape of the lens. These incisions cause expansion of the sclera in the region of the ciliary muscle thereby changing the biomechanical forces and restore accommodation to some degree (pseudoaccommodation. Notice the change in shape (blue arrow) of the sclera in the area of the slits

(S). (After Boyd´s "Atlas of Refractive Surgery").

PRESBYOPIA

which has created a great deal of controversy. Dr. Schachar's theorizes that presbyopia occurs because normal lens growth, as a result of age, increases its equatorial diameter and, as a result, the lens equator moves closer to the ciliary muscle, rendering the contracting muscles less capable of steepening the crystalline lens curvature.

OPERATIONS FOR SCLERAL

EXPANSION

Two different operations performed on the sclera are currently used to surgically treat presbyopia without resorting to the monovision method. These operations are generally known as scleral expansion procedures. They are very different from one another. These operations are: 1) the anterior ciliary sclerotomy (ACS) (Figs. 40-1 and 40-2) and Schachar's procedure, or scleral expansion buckles

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

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Chapter 40

Figure 40-2: External Configuration of Scleral Slits Technique for Correction of Presbyopia (ACS Procedure)

This external view of the eye shows the location, size and number of radial sclerotomy incisions or slits (S) placed in the area between the extraocular muscles (M), for the treatment of presbyopia. The limitation of this procedure is that the scleral incisions close with time leading to regression. H. Fukasaku, M.D., in Japan has attempted to "integrate" this operation with the surgical principles of the Schachar 's procedure (Figs. 40-3 to 40-8) by inserting silicone expansion plugs or rods within the radial sclerotomy incisions to delay their closure, increase the effect of ACS and overcome regression to a limited extent. (After Boyd´s "Atlas of Refractive Surgery").

Contents

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Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

(Figs. 40-3 - 40-5). Krueger finds both of these methods problematic because the principles on which they are based go against the mainstream theories of Helmholtz. These methods are based on an opposing theory for loss of accommodation, and they intend to stretch the sclera overlying the ciliary musculature to make more space in the posterior chamber, allowing the lens more room to expand equatorially during accommodation. A number of vision scientists in the U.S., however, have made rather conclusive observations that confirm the accuracy of the Helmholtz theory which allows the lens to relax equatorially during accommodation.

This leads us to wonder what scleral incisions (Figs. 40-1 and 40-2) and bands (Figs. 40-3 - 40-5) actually do. Krueger points out that in some

cases these procedures seem to work; in others, they are unsuccessful. Murube believes that although Schachar's theory of accommodation may be incorrect, the surgical procedures based on his theory do

work, although they result in small amounts of cor-

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rection. One proposed explanation when they work is that these patients develop pseudo accommodation. Scleral implants and scleral incisions (slits) probably work according to the same mechanism. Krueger feels that something in the re-adjustment of the sclera is allowing the lens or the cornea to behave a little differently so that the patients perceive an improvement. It is very curious that when only one eye is treated with the scleral bands (Figs. 40-3 - 40-5) , patients often report that both the treated and untreated eyes can now see up close when nothing

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Figure 40-4: Scleral Implant Surgical Technique for Correction of Presbyopia

The conjunctiva has been reflected in the four quadrants. Two small parallel vertical slits have been made with a short diamond knife at 2 mm posterior to the limbus, pre-marked with dye. A long diamond knife (F) is used to create a scleral tunnel (arrow) between the two vertical slits. (After Boyd´s

"Atlas of Refractive Surgery").

PRESBYOPIA

Figure 40-3: Schachar's Procedure - External Configuration of Scleral Implants for Correction of Presbyopia

This external view of the eye shows the location and size of the four scleral PMMA implants buried in the area between the extraocular muscles (M). One implant (I) is shown just before implantation into the scleral tunnel (T). Although the implant shown here looks like a straight rod, its real shape is curved, the center has a concave shape so that, when buried, as shown in this figure, it will exert pressure on the sclera inward over the ciliary body to lift it away from the lens, thereby altering the relative positions of the ciliary muscle and the lens. (After Boyd´s "Atlas of Refractive Surgery").

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

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Chapter 40

Figure 40-5: Scleral Implant Surgical Technique for Correction of Presbyopia

The tubular implant (I) has been inserted into the scleral tunnel with forceps. This magnified view of one quadrant shows the final position of the scleral implant (I) within the scleral tunnel (T). At the two end points (entry and exit) the sclera has been pushed away over the ciliary body to lift the ciliary body away from the lens. As a consequence, the zonules become tense which in turn facilitates accommodation. In real life, the ends of the implant

(I) do not protrude nearly as much as shown here for didactic purposes. (After Boyd´s "Atlas of Refractive Surgery").

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

was done to the other eye. Why should that happen? It is very important that we learn exactly what is the mechanism of action so we can understand what we are doing and ensure that we are not surgically harming the eye. A large database of scleral incision patients (ACS) is being collected by Spencer Thornton, M.D., and others in the U.S. They have not published their results, probably because they are waiting for long term follow-up.

Steven Wilson, M.D., Professor and Chairman, Department of Ophthalmology, University of Washington Medical Center in Seattle, Washington

believes that of the primary theories currently ad-

 

vanced to explain presbyopia, the Helmholtz theory

 

is closer to the truth based on fairly conclusive data

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presented recently. There are occasional anecdotal

 

reports form physicians who believe that success-

 

ful treatment of individual patients can be based

 

on scleral expansion theories (Figs. 40-1 - 40-5).

 

Wilson points out that Robert Maloney. M.D. from

 

Los Angeles, California, is a careful investigator

 

who reports that some patients get increased accom-

 

modation using the Schachar's procedure. Accord-

 

ing to Wilson, even if the Shachar's hypothesis is

 

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incorrect, something involved in scleral expansion treatment corrects at least part of the problem. Wilson does not perform scleral expansion surgery because he does not believe it has enough efficacy to be warranted.

Changing the Anatomy of the

Anterior Segment

These surgical procedures are based on the theory that loss of accommodation is a problem of geometry rather than of muscle atrophy or hardening of the lens with age. The two operations that have been proposed and that we here describe change the anatomy of the anterior segment, altering the relative positions of the ciliary muscle and the lens. An operation on the sclera may possibly change the biomechanical dynamics in the anterior segment to restore accommodation (Figs. 40-1 to 40-5).

ANTERIOR CILIARY

SCLEROTOMY (ACS)

This approach involves creating radial sclerotomy incisions in the sclera over the ciliary muscle (Figs. 40-1 and 40-2). These incisions cause expansion of the sclera in the region of the ciliary muscle, which changes the biomechanical forces and restores accommodation to some degree or more likely, a pseudo-accommodation. Dr. Spencer Thornton, who was a pioneer of this approach has found that it helps restore reading vision in some patients.

The problem with this procedure is that the scleral incisions close with time and regression takes place in about 10 months. Hideharu Fukasaku, M.D., of Yokohama, Japan, has modified the original ACS procedure in order to avoid or significantly delay regressions. He performs eight 3-mm incisions divided equally in the four quadrants (Fig. 40-2). Each incision is 600 micron deep using a diamond keratotomy blade. He is inserting silicone - expansion plugs in each incision to delay closure of the incisions, increase the effect of ACS and overcome regression. His results seem to be encouraging although they don't last long enough. There is a significant reduction of presbyopia but again, does not last.

PRESBYOPIA

THE SCHACHAR PROCEDURE

Another approach in the scleral expansion procedures has been spearheaded by Ronald Shachar, M.D., Ph.D from Texas. It is an ingenious procedure that involves placing four small implants partially buried in the sclera like small scleral buckles over the ciliary body to lift the ciliary body away from the lens (Figs. 40-3 to 40-5). These small buckles consist of small segments of polymethylmethacrylate (PMMA) in each quadrant. Although this surgery has been reported to restore accommodation and reading vision in some patients, data are still incomplete, and no published peer reviewed scientific studies have taken place. There is positive experience by prestigious surgeons that the operation seems to work, providing a small presbyopic correction perhaps through pseudo accommodation that enables some patients to read without glasses.

MODIFYING THE CRYSTALLINE LENS

The next frontier in presbyopia correction will probably involve modifying the crystalline lens, to restore its elastic properties or perhaps to change its shape in some way. Then we could actually restore accommodation, rather than creating pseudo accommodation or a multifocal corneal ablation.

Krueger estimates that we are still years away from restoring real accommodation to the presbyopic lens. He is now working on using very short pulse lasers inside the lens to see if the properties of the lens can be changed. But no concrete data are yet available to show if this will work on the in vivo human lens. Application of laser shots to the crystalline lens is at the stage of experimentation with animal models, and with explanted human cadaver lenses. Krueger has not seen long-term cataracts develop, although critics of these experiments predict this procedure will never work because of probable development of cataracts. The future of this technology is still uncertain but it is likely that wavefront technology will help us in the process of understanding this further.

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

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PRESBYOPIA

Chapter 41

PRESBYOPIA

Guillermo Avalos-Urzua, M.D., Ariadna Silva-Lepe, M.D.

Introduction

Definition

Presbyopia is the age-related normal process where accommodation is lost and the eye is no longer capable to comfortably sustain the accommodation necessary for clear near vision. It is a fact that the range of accommodative amplitude decreases with increasing age, such that the nearest point that can be focused gradually recedes, leading (in humans, at least) to the need for optical prostheses for close work such as reading and, eventually, even for focus in the middle distance. It is the most frequent eye problem in the world, since 40% of the population is presbyopic. In Latin America there are 115 millions of presbyopic, and every year this number increases up to 3 millions; it is said that in 2010 there are going to be almost 145 millions. Even thought it is not a legal blindness cause, the cost from this problem in productivity loss is high in USA.

Figure 41-1. Clear visual zones in an emmetropic eye (a), neutralizing (b) and with add correction (c).

In presbyopia the nearest point that can be

focused gradually recedes, leading to the need for

Contents

 

optical prostheses for close work such as reading and,

Section 1

eventually, even for focus in the middle distance. For

 

emmetropic persons, presbyopia seems to appear

Section 2

practically overnight when they reach their mid 40s.

Section 3

However, the loss of near focus is actually progressive

 

over a person’s lifetime, whether he or she is

Section 4

emmetropic, myopic, or hyperopic, and the age at

Section 5

which a person requires assistance for near focus will

 

depend in large part on his or her refractive error

Section 6

(Fig. 41-1).

 

 

Section 7

 

Subjects Index

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Chapter 41

Theories of Accommodation

Helmholtz’s book on Physiological Optics is a careful combination of experimental observations and closely reasoned progressions of logic to demonstrate that accommodation occurs through a change in the shape of the lens, attributing the origin of this hypothesis to Descartes and mentioning an earlier version of this hypothesis, from Leeuwenhoek, which assumed that the lens material was itself contractile like muscle. He observed that the accommodative process is associated with, in addition to pupillary contraction and an anterior movement of the iris, an increased curvature of both the anterior and posterior surfaces of the crystalline lens. The anterior surface of the lens changes curvature with greater amplitude than the posterior surface, and these changes in lens shape result in (1) a thicker lens along the symmetry axis, (2) a thinner lens along the equatorial axis, (3) a shallowing of the anterior chamber as the anterior lens surface is moved forward, and (4) essentially no change in the distance from the cornea to the posterior lens surface along the symmetry axis. Thus, when the human eye is focused on infinity, the lens is under maximum stress and at its thinnest and least sharply curved. As accommodation to a closer focal point proceeds (Fig. 41-2), the contraction of the ciliary muscle is coupled with a controlled elastic recovery or relaxation that allows the lens to “round up” and make a greater refractive contribution to overall globe power through its more sharply curved shape and decreased anterior distance from the cornea.

The zonular geometry described by Farnsworth and Burke is more complex, since some of the zonules from the anterior of the lens pass through the ciliary processes to attach quite posteriorly to the lens, near the ora serrata, while others can attach more anteriorly.

The zonules from the posterior of the lens also attach in a posterior location, and the equatorial zonules attach perpendicular to the lens equator. During the contraction of the ciliary muscle, both the anterior and posterior zonular attachments to the ciliary body would be moved forward and inward, and the resultant change in shape of the lens would be a function of the relative degrees of relaxation of the variously oriented fibers.

Figure 41-2: Schematic representation of retinal image for a near object.

The classical Helmholtz theory of

 

accommodation has, over the years, not gone

Contents

unchallenged and most recently has been opposed by

 

Schachar et al. who suggest that increased zonular

Section 1

tension increases rather than decreases the power of

Section 2

the lens. This view is supported by a numerical

 

analysis of the lens based on a linear form of the

Section 3

governing equations.

Section 4

Burd et al proposed an alternative numerical

model in which the geometric non-linear behavior of

Section 5

the lens is explicitly included. Their results differ

 

from those of Schachar and are consistent with the

Section 6

classical Helmholtz mechanism.

Section 7

 

Age-Related Changes of

Accommodation

Accommodative amplitude (the difference between the nearest and farthest point of comfortable focus) decreases with increasing age. The far point is essentially unaffected, while the near point gradually recedes (Fig. 41-3), resulting in an accommodative amplitude of only about 2 diopters by age 50 years, much of which comes from the pinhole effect of a constricted iris and the intrinsic depth of field of the crystalline lens itself.

As the lens grows and thickens in the polar and equatorial directions, the location of internal regions relative to the cornea changes. Cortical growth, which along the optical axis is the same for the anterior and posterior regions, shifts the location of the lens nucleus in the anterior direction. The central

Subjects Index

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436 SECTION VI

Figure 41-3: Ranges of accommodation for an emmetropic (a), myopic (b) and hypermetropic (c) eye.

sulcus, too, is shifted toward the anterior. Thus as the mass of the lens increases, its center of mass is shifted toward the cornea, as are three of the four major refractive surfaces of the lens (the lens-aqueous boundary and the anterior and posterior cortex nucleus boundaries). These age-dependent changes, all other factors being unchanged, should result in a greater overall refractive contribution by the lens and concomitant degradation of far vision.

Signs and Symptoms

As we already defined, presbyopia is the agerelated loss of the ability to comfortably sustain the accommodation necessary for clear vision. This loss of accommodation is not to be considered as abnormal, and it proceeds gradually throughout the whole life without any sudden alterations. At first no inconvenience is experienced, but eventually a time comes when the near point has receded beyond the distance to which the individual is accustomed to read or to

PRESBYOPIA

work or beyond the distances to which his arm allows him o her to hold the printage page, and then, being unable to see clearly.

At early age the amplitude of accommodation (AA) is about 14D, and the near point is situated at 7 cm distance. At age of 36 it has reached 14 cm, and the AA is now 7 D; by the age of 45 it has reached 25 cm, and the AA is only 4D, at the age of 60 being only about 1D.

This has been studied by Blystone who reported that in 23 years of practice recorded from his patients the age and the add power needed to correct presbyopia. He found in nearly 3,600 refractions a nearly parabolic relationship between age and addition from approximately the age of 40 to 75 years.

The failure of accommodation becomes evident gradually, and as a rule becomes apparent first in reading. Small prints becomes indistinct, and in order to get within the limits of the receding near point, the patients tends to hold his head back and the book well forward until a distance is reached when clear vision in any circumstances is difficult. Trouble is experienced at first in the evening, when the light is dim and the pupils are dilated, permitting large diffusion circles; at this time, too, after the work of the day, fatigue comes on easily. For this reason, in more advanced years when the pupils become smaller, and old person with no accommodation may see near objects with a fair degree of detail.

Complaint is usually made of visual failure rather than visual fatigue. Sooner or later, however, symptoms of eyestrain appear. The ciliary apparatus working near its limit becomes fatigued, and the accommodative effort, strained in excess of the convergence, gives rise to distress. Headaches may occur, and the eyes feel tired and ache, sometimes tend to assume a chronically suffused appearance.

Treatment

Contents

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Section 6

Section 7

Subjects Index

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The treatment of presbyopia is to provide the patient the best near vision doing so by the reinforcement of the accommodation, bringing the near point within a useful working distance or both. The correction of presbyopia requires knowledge of refraction, accommodative status and working point of the patient.

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For some patients, standard optical correction for presbyopia is not satisfactory. That is why surgeons
SURGICAL METHODS
Multifocals (Simultaneous Vision)
The monovision approach to contact lens use utilizes one eye for distance and the other for near
vision. Although the dominant eye is usually selected Simultaneous vision lens designs are based for distance correction, this is not mandatory. This on the concurrent presentation of distance and near method of correction provides functional distance images on the retina, and their success is dependent and near visual acuity but may compromise stereopsis, on the patient’s ability to ignore the undesired image. contrast sensitivity, and other aspects of binocular Several designs are available: annular-concentric, visual function. Patients with uncompromising vision aspheric, and diffractive.
requirements who need higher add powers (more than 2.00 D) are usually not good candidates for monovision correction unless the reading add is prescribed in steps over a period of time.
CONTACT LENSES: MONOVISION, BIFOCALS, MULTIFOCALS
Monovision
Segment bifocal contact lenses resemble their spectacle counterparts in having superiorly located distance and inferiorly located reading powers. The translation of the lens that occurs with a change in gaze is accompanied by the shift of the visual axis into the appropriate zone as the eye rotates under the lens. Proper orientation of segment bifocal designs is achieved by prism ballasting, lens truncation, and periballasting. Lens wearing comfort may be compromised by the tendency of these lenses to position low. Patients having hyperopic refractive errors tend to be more successful with these lens designs.
Concentric translating bifocal contact lenses incorporate the reading power circumferentially and therefore do not require a specific rotational orientation. The transition from the center distance power to the peripheral reading add is abrupt. Since translating bifocal designs are gaze-dependent, near acuity is achieved only in the traditional reading posture. Patients requiring near acuity in primary gaze are poor candidates for this design. Since predictable translation is required, translating soft lenses are less effective than translating rigid lenses.
Beginning with the refraction for distance, an estimated add is chosen by subtracting half the amplitude of accommodation from the number of diopters needed for the desired working distance. With the estimated add in place, the resulting range of accommodation is measured and add adjusted so that the patient’s near tasks are brought within the zone of clarity and comfort. Usually the patient is best served by placing most of the range of clarity farther away than the chosen working distance, choosing a lesser add (it is better to undercorrect than overcorrect). This avoids blurring of the middle distance and gives a larger range of accommodation. For adds less than +1.25 D, separate reading glasses may be preferable to bifocals, as the patient is likely to want the add only for prolonged reading.
Eyes with unequal visual acuities, but equal AA, should be given equal adds. On the other hand, when the amplitudes of accommodation are unequal, adds are prescribed so that each eye is using half of its respective amplitude of accommodation for clarity at the desired reading distance. The presumption here is that this amount of accommodation will be produced by equal accommodative innervation of the two eyes.
Optical Devices
Bifocals
Translating designs use temporally spaced images through two distinct contact lens zones: one for distance and one for near. The retina is expected to receive only one focused image at a time. Translating lenses have either a segment or an annular-concentric design.
Chapter 41

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

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