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Contents

Editor-in-Chief:

BENJAMIN F. BOYD, M.D., F.A.C.S.

Editors:

SUNITA AGARWAL, M.S.;D.O.;F.S.V.H.

ATHIYA AGARWAL, M.D.;D.O.;F.R.S.H.

AMAR AGARWAL, M.S.;F.R.C.S.;F.R.C.Ophth

i

 

 

 

 

 

Project Director:

Andres Caballero, Ph.D

Production Manager:

Kayra Mejia

 

 

Page Design and Typesetting:

Kayra Mejia

 

 

 

Laura Duran

 

 

Art Design:

Eduardo Chandeck

Spanish Translation:

Prof. Juan Murube, M.D.

Sales Manager:

Tomas Martinez

Marketing Manager:

Eric Pinzon

 

 

Customer Service Manager:

Miroslava Bonilla

International Communications:

Joyce Ortega

 

 

©Copyright, English Edition, 2002 by HIGHLIGHTS OF OPHTHALMOLOGY

All rights reserved and protected by Copyright. No part of this publication may be reproduced, stored in retrieval

system or transmitted in any form by any means, photocopying, mechanical, recording or otherwise, nor the illustrations

copied, modified or utilized for projection without

the prior, written permission of the copyright owner.

Due to the fact that this book will reach

ophthalmologists from different countries with different training,

cultures and backgrounds, the procedures and practices described in this book should be implemented in a manner

consistent with the professional standards set for the circumstances that apply in each specific situation. Every effort

Contents

 

has been made to confirm the accuracy of the information presented and to correctly relate generally accepted practices.

 

The authors, editors, and publisher cannot accept responsibility for errors or exclusions or for the outcome of the

 

application of the material presented herein. There is no expressed or implied warranty for this book or information

 

imparted by it.

 

Any review or mention of specific companies or products is not intended as an endorsement by the authors or

 

the publisher.

 

Boyd, Benjamin F., M.D.; Agarwal, Sunita, M.S.; Agarwal, Athiya, M.D.; Agarwal, Amar, M.D.

 

"LASIK and Beyond LASIK - Wavefront Analysis and Customized Ablation"

 

ISBN Nº 9962-613-04-3

 

Published by: Highlights of Ophthalmology Int'l

 

P.O. Box 6-3299, El Dorado

 

City of Knowledge

 

Clayton, Bldg. 207

 

Panama, Rep. of Panama

 

Tel: (507)-317-0160

 

FAX: (507)-317-0155

 

E-mail: cservice@hophthal.com

 

Worldwide Web:www.thehighlights.com

 

Printed in Bogota, Colombia.

 

You may contact HIGHLIGHTS OF OPHTHALMOLOGY INC., for additional information about other books in this

 

field or about the availability of our books.

 

ii

EDITOR-IN-CHIEF

BENJAMIN F. BOYD, M.D., D.Sc. (Hon), F.A.C.S.

Doctor Honoris Causa

Immediate Past President, Academia Ophthalmologica Internationalis

Honorary Life Member, International Council of Ophthalmology

Editor-in-Chief and Author, HIGHLIGHTS OF OPHTHALMOLOGY, 25 Hard Cover Volumes and the 15 million copies of HIGHLIGHTS OF OPHTHALMOLOGY Bi-Monthly Journal.

Recipient of the Duke-Elder International Gold Medal Award (International Council of Ophthalmology), the Barraquer Gold Medal (Barcelona), the First Benjamin F. Boyd Humanitarian Award and Gold Medal for the Americas (Pan American), the Leslie Dana Gold Medal and the National Society for Prevention of Blindness Gold Medal (United States), Moacyr Alvaro Gold Medal (Brazil), the Jorge Malbran Gold Medal (Argentina), the Favaloro Gold Medal (Italy).

Recipient of The Great Cross Vasco Nuñez de Balboa Panama's Highest National Award.

EDITORS

DR. SUNITA AGARWAL, M.S.;D.O.;F.S.V.H. (Germany)

Contents

Pioneer in the world in the field of Laser Cataract Surgery. She heads Dr.Agarwal’s Eye Hospital at Bangalore, India and Dr.Agarwal’s Eye Clinic at Dubai (UAE). She is an expert in the field of Lasik Laser as she is in the field of cataract surgery under No Anesthesia. She has brought out for the first time in the world the use of the Air Pump as a new method to prevent surge and also found out that the internal tube of the phaco machine can lead to endophthalmitis . She practices at Dr.Agarwal’s Eye Hospital, 15 Eagle Street, Langford town, Bangalore-560 025, India and at Dr.Agarwal’s Eye Clinic,Villa No.2, Roundhouse 3, Al Wasl Road, Dubai Post box 9168, UAE.

DR. ATHIYA AGARWAL, D.O.;F.R.S.H. (London)

Excellent surgeon who trains ophthalmologists from all over the world in Lasik and Phaco.

She performs No anesthesia cataract surgery, Phakonit and Lasik Laser quite easily. Dr.Athiya is a very good speaker and teaches routinely in various conferences nationally and internationally. She practices at Dr.Agarwal’s Eye Hospital, 19 Cathedral Road, Chennai (Madras) – 600 086, India.

DR. AMAR AGARWAL, M.S.;F.R.C.S.;F.R.C.Ophth (London)

Started for the first time in the world "No anesthesia cataract surgery", "Phakonit (cataract removal through a 0.9 mm incision)" and "Favit" a new technique to remove dropped nuclei. He is a very dynamic speaker. He has a double FRCS to his credit. His parents Dr. J. Agarwal and Dr. Mrs.T.Agarwal, Sister Dr.Sunita Agarwal, wife Dr.Athiya Agarwal and Brother-in-law Mr.Pankaj Sondhi help him in his aim to perfection. He practices at Dr.Agarwal’s Eye Hospital, 19 Cathedral Road, Chennai (Madras) – 600 086, India.

Dr.Agarwal’s Eye hospital at Chennai is the only eye hospital in the world built in the shape of an eye and has been included in the Ripley’s Believe it or not series. Dr.Agarwal’s Eye Hospital is at Chennai (India), Bangalore (India) and Dubai. The web site of the hospital is: http://www.dragarwal.com

iii

Contributing Authors

Agarwal, Amar, M.S.,FRCS;FRCOphth

Medical Director,

Dr. Agarwal's Group of Eye Hospital

Chennai, India

Agarwal, J., FORCE;DO;FICS

Chairman,

Dr. Agarwal's Group of Eye Hospital,

Chennai, India;

Bangalore, India;

Dubai (UAE)

Agarwal, Sunita, MS;DO;FSVH

Medical Director;

Dr. Agarwal's Group of Eye Hospital

Bangalore, India

Agarwal, T.; FORCE;DO;FICS

Managing Director,

Dr. Agarwal's Group of Eye Hospital,

Chennai, India;

Bangalore, India;

Dubai (UAE)

Alio, Jorge L., M.D.

Director,

Instituto Oftalmologico de Alicante Alicante, Spain

Attia, Walid, M.D.

Instituto Oftalmologico de Alicante Alicante, Spain

Avalos U., Guillermo, M.D.

Carvalho, Luis A., PhD.

Chief, Department of Ophthalmology

Institute of Physics

Hospital Sagrado Corazon;

University of Sao Paulo, Brazil

Medical Director,

 

Clinica Laser Oftalmico

Castro, Jarbas C., PhD.

Guadalajara, Mexico

Professor,

 

Institute of Physics

Belda, Jose I., M.D.

University of Sao Paulo, Brazil

Instituto Oftalmologico de Alicante

Contents

Alicante, Spain

Cigales, Melania, M.D.

 

Instituto Oftalmologico de Sabadell

Benelli, Umberto, M.D.

Sabadell, Spain

Department of Neurosciences

 

Section of Ophthalmology

Coelho, Etelvino, M.D.

University of Pisa

Director, Centro de Microcirugia

Pisa, Italy

Refrativa & Excimer Laser de

 

Minas Gerais

Border, Andrea D., O.D.

Belo Horizonte, MG Brazil

Discover Vision Centers

 

Kansas City, Missouri

Coret, Andreu, M.D.

 

Medical Director,

 

Instituto Oftalmologico de Barcelona

Boyd, Benjamin F., M.D., F.A.C.S.

Barcelona, Spain

Editor-in-Chief,

 

Highlights of Ophthalmology Int.,

Cummings, Arthur, MB, ChB Mmed

Panama, Rep. of Panama

(Ophth) FCS(SA), FRCS (Edin)

 

Wellington Ophthalmic Laser Clinic

Butler, Jason, M.D.

Dublin, Ireland

Long Beach Laser Center

 

Long Beach, California

Charles, Steve, M.D.

 

Clinical Professor

Carriazo E., Cesar, M.D.

Department of Ophthalmology

Medical and Scientific Director

University of Tennessee

Carriazo Ophthalmological Center,

Center of Health Science

Colombia

Memphis, Tennessee

iv

 

 

CONTRIBUTING AUTHORS

Chamon, Wallace, PhD.

Hardten, David R., M.D.

Lindstrom, Richard, M.D.

Refractive Surgery Division

Director of Refractive Surgery

Medical

Director,

Escola Paulista de Medicina

Minnesota Eye Consultants;

Phillips Eye Center for Teaching

University of Sao Paulo, Brazil

Clinical Associate Professor of

and Research;

 

Ophthalmology

Clinical Professor,

Choudhry, Saurabh, D.O., FERC.

University of Minnesota

University of Minnesota,

Fellow, Dr. Agarwal's Eye Hospital,

Minneapolis, Minnesota

Minnesota, Minneapolis

Chennai, India

 

 

 

 

Haw, Weldon, M.D.

Mahmoud M. Ismail, M.D., Ph.D.

Choudhry, Reena, M., DO.;FERC.

Cornea & Refractive Surgery,

University of Al-Azhar,

Fellow, Dr. Agarwal's Eye Hospital,

Department of Ophthalmology,

Cairo, Egypt

Chennai, India

Stanford University School of Medicine

 

 

 

Stanford, California

Manche, Edward E., M.D.

Davis, Elizabeth, A., M.D.

 

Assistant Professor of Ophthalmology

Associate,

Hoyos, Jairo E., M.D.

Stanford University

Minnesota Eye Consultants, PA;

Medical Director

School of Medicine

Assistant Clinical Professor

Instituto Oftalmologico de Sabadell

Stanford, California

University of Minnesota

Sabadell, Spain

 

 

Minneapolis, Minnesota

 

Martiz, Jaime R., M.D.

 

Hoyos-Chacon, Jairo, M.D.

Refractive Surgery Consultant;

Denning, James A., B.A., B.S.

Instituto Oftalmologico de Sabadell

The Laser Center, Houston, Texas;

Discover Vision Centers

Sabadell, Spain

Course Director & President

Kansas City, Missouri

 

International Lasik Course

 

Katsanevaki, VJ, M.D.

Houston, Texas

Doane, John F., M.D.

Department of Ophthalmology

 

 

Discover Vision Centers

University of Crete-Medical School

McDonald, Marguerite, M.D.

Kansas City, Missouri

Crete, Greece

Director,

Contents

 

 

Southern Vision Institute

EuDaly, Lon S., O.D.

Knorz, Michael C., M.D.

New Orleans, Louisiana

Discover Vision Centers

Klinikum Mannheim

 

 

Kansas City, Missouri

Mannheim, Germany

Morris, Scot, O.D.

 

 

Discover Vision Centers

Feinerman, Gregg, M.D.

Koch, Paul S., M.D.

Kansas City, Missouri

Medical Director,

Koch Eye Associates

 

 

Feinerman Vision Institute,

Warwick, Rhode Island

Murube, Juan, M.D.

Long Beach Laser Center,

 

Professor of Ophthalmology,

Long Beach, California;

Krueger, Ronald, M.D.

University of Alcala;

Assistant Clinical Professor,

Medical Director,

Chairman, Dept. of Ophthalmology,

University of California,

Department of Refractive Surgery,

Hospital Ramon y Cajal

Irvine, California

The Cleveland Clinic Foundation

Madrid, Spain

 

Cole Eye Institute

 

 

Gatell, Jordi, M.D.

Cleveland, Ohio

Narang, Sameer, M.S.

Instituto Oftalmologico de Barcelona

 

Director, Narang Eye Clinic

Barcelona, Spain

Lara, Elvira, O.D.

Ahmedabad, Gujarat, India

 

Instituto Oftalmologico de Barcelona

 

 

Ginis, HS., BSc

Barcelona, Spain

Narang, Priya, M.S.

Department of Ophthalmology

 

Director, Narang Eye Clinic

University of Crete-Medical School

Lavery, Frank, MCh FRCSI FRCS

Ahmedabad, Gujarat, India

Crete, Greece

(Edin) DOMS

 

 

 

Wellington Ophthalmic Laser Clinic

Narasimhan, Smita, M.B.B.S.,FERC

Gomez, Javier J., M.D.

Dublin, Ireland

Consultant, Dr. Agarwal's Eye Hospital,

Instituto Oftalmologico de Alicante

 

Chennai, India

Alicante, Spain

 

 

 

v

CONTRIBUTING AUTHORS

 

 

 

Nardi, Marco, M.D.

Preetha R., M.B.B.S; FERC

Simon-Castellvi, Jose Ma., M.D.

 

Associate Professor

Fellow, Dr. Agarwal's Eye Hospital,

Clinica Oftalmologica Simon,

 

Department of Neurosciences

Chennai, India

Barcelona, Spain

 

Section of Ophthalmology

 

 

 

University of Pisa

Probst, Louis E., M.D.

Simon-Castellvi, Sarabel, M.D.

 

Pisa, Italy

Medical Director,

Clinica Oftalmologica Simon,

 

 

TLC The Windsor Laser Eye Center,

Barcelona, Spain

 

Nguyen, Kim, M.D.

Windsor, Ontario, Canada

 

 

Long Beach Laser Center

 

Slade, Stephen G., M.D.

 

Long Beach, California

Sasikanth, RR., MD

The Laser Center,

 

 

Dr. Agarwal's Eye Hospital

Houston, Texas

 

Oliveira, Canrobert, M.D.

Chennai, India

 

 

Director, Hospital de Olhos de Brasilia

 

Viera de Carvalho, Luis A., PhD.

 

Brasilia, DF Brazil

Schor, Paulo, PhD, M.D.

Professor,

 

 

Bioengineering Division

University of Sao Paulo

 

Pallikaris, Ioannis G., M.D.

Escola Paulista de Medicina

Brazil

 

Department of Ophthalmology

University of Sao Paulo

 

 

University of Crete-Medical School

Sao Paulo, Brazil

Waring, George, M.D.

 

Crete, Greece

 

Professor of Ophthalmology

 

 

 

Emory University;

 

Parul, Goel, M.S., F.E.R.C.

Shalaby, Ahmad, M., M.D.

Co-Founder

 

Consultant, Dr. Agarwal's Eye Hospital,

Instituto Oftalmologico de Alicante

Emory Vision Correction Center

 

Chennai, India

Alicante, Spain

Atlanta, Georgia

 

Perez-Santoja, Juan J., M.D.

Simon-Castellvi, Cristina, M.D.

Werner, Leonardo P., M.D.

Contents

Refractive Surgery and Cornea Unit

Clinica Oftalmologica Simon,

Department of Ophthalmology,

Alicante Institute of Ophthalmology

Barcelona, Spain

São Geraldo Eye Hospital,

 

Miguel Hernandez University

 

Federal University of Minas Gerais

 

School of Medicine

Simon-Castellvi, Guillermo L., M.D.

and the "Instituto Vizibelli"

 

Alicante, Spain

University of Barcelona,

Belo Horizonte, Minas Gerais, Brazil

 

 

Faculty of Medicine,

 

 

Peters, Tim, M.D.

Dept. of Ophthalmology;

Wilson, Steven E., M.D.

 

Nationwide Vision Laser & Eye Center,

Chief Anterior Segment Surgeon,

Chair, Department of Ophthalmology,

 

Clinical Lecturer,

Clinica Oftalmologica Simon,

and Professor of Vision Research

 

University of Arizona

Barcelona, Spain

University of Washington

 

Phoenix, Arizona

 

Seattle, Washington

 

vi

Contents

SECTION I - LASIK

FUNDAMENTAL PRINCIPLES OF DIAGNOSIS, CORNEAL MAPPING,

MECHANISM OF ACTION OF EXCIMER LASERS

CHAPTER 1

CHAPTER 3

UNDERSTANDING REFRACTIVE LASERS

EVALUATION OF THE LASIK FLAP BY

 

CONFOCAL MICROSCOPY

Therapeutic Principles of Excimer Lasers

1

Advances in Excimer Laser Technology

2

Scanning Lasers

2

Eye Tracking Systems

6

How the Corneal Tissues are Affected in

 

LASIK vs Incisional Keratotomy

6

CHAPTER 2

 

FUNDAMENTALS ON

 

CORNEAL TOPOGRAPHY

 

Introduction: Human Optics and the

 

Normal Cornea

9

Instruments to Measure the Corneal Surface

10

Causes of Artefacts of the Corneal

 

Topography Map

14

Understanding and Reading Corneal Topography 15

Topographic Scales

16

Computer Displays: Presentation of

 

Topographic Information

16

Special Software Applications and Displays

23

ATLAS OF CORNEAL TOPOGRAPHY

31-42

TOPOGRAPHERS NOW AVAILABLE

43

Frequent Problems With the Flap

61

What is Confocal Microscopy?

61

Confocal Microscopy Procedure

62

Results

62

The Importance of Confocal Microscopy to the

 

Sands of Sahara’s Syndrome

63

How to Prevent Sands of Sahara Syndrome

63

CHAPTER 4

PREDICTIVE FORMULAS FOR LASIK

The Predictive Formulas Main Components

65

Developing Individualized Predictive Formulas

65

The Healing Pattern of the Cornea

65

Excimer Laser Ablation Nomograms for:

 

Photorefractive Keratectomy

66

LASIK

66

Predictive Formulas for LASIK with:

67

VISX S2 SmoothScan

68

Chiron Technolas 116

69

Technolas 217 Excimer Laser

70

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

Help ?

vii

CONTENTS

SECTION II - LASIK

HIGHLIGHTS OF SURGICAL INSTRUMENTATION (MICROKERATOMES)

AND SURGICAL TECHNIQUES

CHAPTER 5

CHAPTER 9

MICROKERATOMES

LIMITATIONS AND

 

CONTRAINDICATIONS OF LASIK

Different Mechanical Components

78-80

Applanation Lenses

80

Tonometer

80

Guidelines for Microkeratome Use

80

Astigmatism Inductions by Hinge Ablation

86

Free Cap

87

The Main Microkeratomes:

87-99

Outline

 

Description

 

How to Use Them

 

CHAPTER 6

AUTOMATIC CORNEAL SHAPER

Note from the Editor-in-Chief

101

Different Components & Instrumentation

101-3

Surgical Technique Step by Step

104-5

Troubleshooting

105

Care, Handling & Sterilization

107

CHAPTER 7

 

DOWN UP LASIK

 

Setting up of the Hansatome

109

Care, Maintenance & Sterilization

112

Troubleshooting

114

Surgical Technique Step by Step

114

Advantages & Disadvantages

114

CHAPTER 8

 

ALL LASER LASIK With the

 

Pulsion FS Laser

 

Preoperative Evaluation

119

Surgical Logistics

120

Surgical Technique Step by Step

120-4

Postoperative Care

125

Preoperative Evaluation

127

Special Cases

134

LASIK after IOL Implantation

134

Bilateral Simultaneous vs. Sequential Surgery

134

LASIK after RK

134

Alternatives to LASIK

135

PRK

135

Refractive Lensectomy

135

Phakic Intraocular Lens

136

Thermokeratoplasty (LTK)

136

CHAPTER 10

LASIK SURGICAL TECHNIQUE

Patient Selection

139

PREOPERATIVE PREPARATION

140

The Patient

140

The Instruments

140

The Laser

140

The Keratome

141

The Surgeon

142

PREPARATION IN OPERATING ROOM

142

Draping

142

Speculum

142

Positioning the Patient

143

THE LASIK PROCEDURE

143

Marking

143

Placement of the Suction Ring

143

The Microkeratome Cut

144

Laser Ablation

145

Replacing the Flap

146

Intraoperative Bleeding in LASIK

148

Postoperative Care

150

Home Care Instructions

150

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

Help ?

viii

CHAPTER 11

PEARLS IN LASIK TECHNIQUE

Patient Counseling

151

Achieving Adequate Exposure

151

Achieve and Confirm Adequate Suction

152

Create a Complete Flap

153

 

CONTENTS

Maintain Consistent Hydration

153

Perform the Appropriate Ablation

154

Prevent and Remove Debris from

 

Beneath the Flap

155

Properly Align the Flap

156

Achieve Good Flap Adhesion

157

Avoid and Treat Loose Epithelium

157

Conclusion

158

SECTION III

LASIK IN COMPLEX CASES

CHAPTER 12

LASIK FOR HYPEROPIA

Technique, Safety and Efficacy

161

Hyperopic Correction using the Excimer Laser

162

Patient Selection and Preoperative Considerations163

Technique

164

Clinical Results

164

Secondary Hyperopia

165

Hyperopia with Astigmatism

165

CHAPTER 13

LASIK FOR IRREGULAR ASTIGMATISM

Etiology of Irregular Astigmatism

169

Diagnosis

170

Clinical Classification

170

Corneal Topography Patterns

170

1.Irregular astigmatism with defined pattern 170

2.Irregular astigmatism with undefined

pattern

171

Preoperative Evaluation

171

Treatment of Irregular Astigmatism

175

Surgical Techniques with Excimer Laser

175

Automated Anterior Lamellar Keratoplasty

184

Intracorneal Ring Segments (INTACS)

184

Other Non-Surgical Procedures

184

Contact Lens Management

184

CHAPTER 14

LASIK IN MIXED ASTIGMATISM

Classification

187

Simple Myopic Astigmatism

187

Compound Myopic Astigmatism

188

Simple Hyperopic Astigmatism

188

Compound Hyperopic Astigmatism

188

Mixed Astigmatism

189

Negative Cylinder Ablation to Treat

 

Mixed Astigmatism

189

Positive Cylinder Ablation to Treat

 

Mixed Astigmatism

190

Bitoric Ablation to Treat Mixed Astigmatism 190

Results of Lasik in Mixed Astigmatism

192

Conclusion

192

CHAPTER 15

 

RELASIK

 

Procedure

195

Results

196

Discussion

198

CHAPTER 16

 

LASIK AFTER RK AND PRK

 

Results of LASIK After RK and PRK

201

RK Group

202

PRK Group

203

Discussion

204

CHAPTER 17

LASIK AFTER PENETRATING

KERATOPLASTY

Eligible Patients

208

Timing of Surgery

208

Surgical Technique

209

Postoperative Treatment

209

Risks and Possible Complications

210

Results

210

Conclusions

212

Contents

Section 1

Section 2

Section 3

Section 4

Section 5

Section 6

Section 7

Subjects Index

Help ?

ix