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Ординатура / Офтальмология / Английские материалы / Jaypee Gold Standard mini Atlas Series Lasik_Aragawal, Jacob_2009

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BASICS AND PREOPERATIVE ASSESSMENT / 27

The residual bed thickness (RBT) of the cornea is the crucial factor contributing to the biomechanical stability of the cornea after LASIK. The flap as such does not contribute much after its repositioning to the stromal bed. This is easily seen by the fact that the flap can be easily lifted up even up to 1 year after treatment. The decreased RBT as well as the lamellar cut in the cornea both contribute to the decreased biomechanical stability of the cornea. A reduction in the RBT results in a long-term increase in the surface parallel stress on the cornea. The intraocular pressure (IOP) can cause further forward bowing and thinning of a structurally compromised cornea. Inadvertent excessive eye rubbing, prone position sleeping, and the normal wear and tear of the cornea may also play a role. The RBT should not be less than 250 μm to avoid subsequent iatrogenic keratectasias. Reoperations should be undertaken very carefully in corneae with RBT less than 300 μm. Increasing myopia after every operation is known as “dandelion keratectasia”.

The ablation diameter also plays a very important role in LASIK. Postoperative optical distortions are more common with diameters less than 5.5 mm. Use of larger ablation diameters implies a lesser RBT postoperatively. Considering the formula: Ablation depth [μm] = 1/3.

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(diameter [mm])2 × (intended correction diopters [D])), it becomes clear that to preserve a sufficient bed thickness, the range of myopic correction is limited and the upper limit of possible myopic correction may be around 12 D.

Detection of a mild keratectasia requires knowledge about the posterior curvature of the cornea. Posterior corneal surface topographic changes after LASIK are known. Increased negative keratometric diopters and oblate asphericity of the PCC, which correlate significantly with the intended correction are common after LASIK leading to mild keratectasia. This change in posterior power and the risk of keratectasia was more significant with a RBT of 250 µm or less. The difference in the refractive indices results in a 0.2 D difference at the back surface of the cornea becoming equivalent to a 2.0 D change in the front surface of the cornea. Increase in posterior power and asphericity also correlates with the difference between the intended and achieved correction 3 months after LASIK. This is because factors like drying of the stromal bed may result in an ablation depth more than that intended. Reinstein et al predict that the standard deviation of uncertainty in predicting the RBT preoperatively is around 30 µm. [Invest Ophthalmol Vis Sci 40 (Suppl):S403, 1999]. Age, attempted correction, the

BASICS AND PREOPERATIVE ASSESSMENT / 29

optical zone diameter and the flap thickness are other parameters that have to be considered to avoid post-LASIK ectasia.

The flap thickness may not be uniform throughout its length. In studies by Seitz et al, it has been shown that the Moris Model One microkeratome and the Supratome cut deeper towards the hinge, whereas the Automated Corneal Shaper and the Hansatome create flaps that are thinner towards the hinge. Thus, accordingly, the area of corneal ectasia may not be in the center but paracentral, especially if it is also associated with decentered ablation. Flap thickness has also been found to vary considerably, even up to 40 µm, under similar conditions and this may also result in a lesser RBT than intended. It is known that corneal ectasias and keratoconus have posterior corneal elevation as the earliest manifestation. The precise course of progression of posterior corneal elevation to frank keratoconus is not known. Hence, it is necessary to study the posterior corneal surface preoperatively in all LASIK candidates.

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Figure 1.11A

Figure 1.11B

BASICS AND PREOPERATIVE ASSESSMENT / 31

Figure 1.11C

Figure 1.11D

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Figure 1.11E

Figure 1.11F

BASICS AND PREOPERATIVE ASSESSMENT / 33

Figure 1.11G

Figure 1.11H

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Figure 1.11I

Figures 1.11A to I: Overview display from a patient with a history of conductive keratoplasty and cataract using the Pentacam (Courtesy-Tracy Swartz)

The Pentacam ocular scanner (Figure 1.11A) is a specialized camera which utilizes Scheimpflug imaging to accomplish with a variety of ophthalmic applications.

BASICS AND PREOPERATIVE ASSESSMENT / 35

Scheimpflug imaging was patented by Theodor Scheimpflug in 1904 after he diskovered that when the planes within a camera intersect rather than be placed in parallel, the depth of focus is extended. In a typical camera, three imaginary surfaces exist: the film plane, lens plane and sharp image plane. These are parallel to each other such that the image of the object placed in the plane of sharp focus will pass through the lens plane perpendicular to the lens axis, and fall on to the film plane. The depth of focus is limited in such a camera. Figure 1.11B shows a Scheimpflug image of a flap tear. Thinning is seen secondary to loss of tissue where the flap was rotated away from the bed.

In a Scheimpflug camera, the three planes are not parallel but intersect in a line, called the “Scheimpflug line”. When the lens is tilted such that it intersects the film plane, the plane of sharp focus also passes through the Scheimpflug line, extending the depth of focus. Note that this results in mild image distortion, which is then corrected by the Pentacam system. A two-dimensional cross-sectional image results. When performing a scan, two cameras are used to capture the image. One centrally located camera detects pupil size and orientation, and controls fixation. The second rotates 180 degrees to

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capture 25 or 50 images of the anterior segment to the level of the iris, and through the pupil to evaluate the lens. 500 true elevation data points are generated per image to yield up to 25,000 points for each surface. Data points are captured for the center of the cornea, an area that placido disk topographers and slit-scanning devices are unable to evaluate.

Elevation data measured using this technique has several advantages. Because it is independent of axis, orientation and position, it yields a more accurate representation of true corneal shape. Thus, the Pentacam’s curvature map, because it is not sensitive to position, is theoretically more accurate. The elevation maps are created using one of three reference bodies: A best fit sphere, an ellipse of revolution, and toric. The best fit sphere calculation approximates the sphere as accurately as possible to the true nature of the cornea. This facilitates comparison between other topographers but is not the best fit for the aspheric cornea. The ellipsoid of revolution is calculated from the keratometry eccentricity and the mean central radius. This reference shape correlates well with the true shape of the normal cornea. The toric is based on the central radii and keratometry eccentricity as well. The flat and steep radii are automatically used. The toric is a good estimation for astigmatic corneas. The toric ellipsoid float display best facilitates pattern recognition of

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