Ординатура / Офтальмология / Английские материалы / Hyperopia and Presbyopia_Tsubota, Boxer Wachler, Azar_2003
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A B
C
Figure 1 (A) The human lens when not accommodating. (B) Accommodation according to Helmholtz’s theory. (C) Accommodation according to Schachar’s theory.
of the cornea. This technique, however, was primarily applicable to young presbyopes, as the average increase in the amplitude of accommodation was only about 1.50 D (16). Additionally, as the incisions healed, the effect regressed.
The first scleral expansion procedures using an encircling band were performed in 1992 (16). In these procedures, a plastic polymethylmethacrylate (PMMA) band (Fig. 2) was sutured to the sclera and covered with conjunctiva. The results were dramatic; however, the procedure was plagued with variable results, conjunctival erosion, and increased intraocular pressure. Various modifications were attempted to circumvent these problems. One such method involved passing portions of the bands through the sclera, forming scleral belt loops (17). This method did not include the use of scleral sutures in an effort to
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Figure 2 A complete encircling band.
simplify the surgical technique, reduce the complications, and decrease the variability of the results.
In 1997 we reported six consecutive nonmyopic patients who underwent scleral expansion using a complete encircling band (17). The band was passed through four separate scleral belt loops located at the 12, 3, 6, and 9 o’clock cardinal positions (Fig. 3) (17). The bands were then ultrasonically fused together at the 1:30, 4:30, 7:30, and 10:30 o’clock positions (Fig. 4). All six patients demonstrated a marked improvement in near vision (Table 1). Surprisingly, in our study, there was a lesser but definite increase in the amplitude and near point of accommodation in the unoperated eyes of all patients. The mechanism of this finding is not clear but was postulated to be related to an increased central neurostimulation of the ciliary muscle of the unoperated eye as a result of the increased function of the ciliary muscle of the operated eye.
Figure 3 Passage of a scleral expansion band into a scleral belt loop.
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Table 1 Summary of Primary Outcome Variables at Each Follow-up Period (Mean SD)
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Operated eye |
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Nonoperated eye |
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Variable |
Preop (n 6) |
1 month (n 6) |
3 months (n 6) |
6 months (n 3) |
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Preop (n 6) |
1 month (n 6) |
3 months (n 6) |
6 months (n 3) |
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NPA (cm) |
69 1.67 |
20.83 5.19 |
20.83 6.31a |
24.67 5.69a |
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69 1.26 |
40.17 28.58 |
27.5 6.12a |
32 2.65a |
SEb (diopters) |
1.2 1.33 |
0.81 1.13 |
1.13 1.2 |
0.75 0.5 |
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1.08 1.15 |
1.17 1.18 |
1.06 1.10 |
0.5 0.22 |
Cylinder |
0.42 0.52 |
0.63 0.44 |
0.58 0.5 |
0 0 |
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0.5 0.52 |
0.58 0.56 |
0.63 0.52 |
0.5 0.25 |
Distance VAc |
0.33 0.5 |
0.11 0.16 0.14 0.19 |
0.06 0.1 |
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0.33 0.5 |
0.11 0.22 0.12 0.24 |
0.03 0.06 |
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20/43 |
20/26 |
20/28 |
20/23 |
20/43 |
20/26 |
20/26 |
20/21 |
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Near VA |
0.85 0.16 |
0.03 0.07a |
0.06 0.07a |
0.03 0.06a |
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0.85 0.16 |
0.47 0.45 0.12 0.21a |
0.06 0.10a |
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20/142 |
20/21 |
20/23 |
20/21 |
20/142 |
20/59 |
20/26 |
20/23 |
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Blur point |
0.63 0.14 |
1.95 1.05 |
2.67 2.63 |
0.67 1.66 |
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0.54 0.25 |
1.65 0.49a |
1.54 0.37a |
0.33 1.61 |
IOP |
17.2 2.7 |
16.2 0.84 |
13.6 1.14 |
14 1.73 |
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17.3 2.0 |
16.4 1.5 |
17.1 1.8 |
15.8 0.76 |
a Significant difference between the preop and the follow-up measurements using paired t-test (p 0.05). b SE spherical equivalent.
c Both distance and near vision are computed based on log10 scale. The numbers below these numbers indicate the equivalent snellen refraction.
Yee and Phillips
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Figure 4 Ultrasonic fusion of portions of a scleral expansion band.
Unfortunately, five of the six patients required removal of their scleral expansion bands 3 to 6 months later due to conjunctival erosion from the roughened areas where the PMMA bands were ultrasonically welded together. After removal of the scleral expansion bands, the accommodative amplitude of these five patients returned to preoperative values.
An additional three consecutive patients subsequently underwent the same procedure. In an effort to provide a better cosmetic result with more accommodation, the scleral belt loops were made much deeper. These three patients subsequently developed anterior
Table 2 Scleral Expansion Patient Selection
Ideal surgical candidate |
Relative contraindications |
Contraindications |
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40 to 70 years old |
Severe keratoconjunctivitis |
Previous cataract extraction |
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sicca |
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No refractive error at distance |
Insulin-dependent diabetes or |
Scleromalacia |
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poorly controlled diabetes |
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Binocular vision |
Monocular patienta |
Previous trabeculectomy |
Less than 1.00 of hyperopia |
Patients beyond 70 years of |
Coagulopathies |
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ageb |
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Patients with hyperopia |
Collagen vascular diseases |
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greater than 1.00c |
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aImportant because of the investigational status of scleral expansion.
bThese patients should be informed of the possibility of ciliary muscle atrophy and thus the possibility of a smaller range of accommodation.
cThese patients should have surgical correction prior to scleral expansion, as they will use a significant amount of their accommodative amplitude for distance vision, leaving less for near vision. Additionally, without prior surgical correction of hyperopia, these patients are more likely to require bilateral procedures.
Source: Ref. 20.
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Figure 5 The scleral expansion procedure. The conjunctiva is opened at the limbus from 2:30 to 10:30 o’clock and from 4:30 to 7:30 o’clock with vertical relaxing incisions at 12:00 and 6:00 o’clock. Scleral belt loops, 3.5 mm posterior to the posterior limbus, 4 mm long, 1.5 mm wide, and 300 to 400 m deep are made in each of the four oblique quadrants.
ischemic syndrome (AIS) and had their bands removed 24 to 96 h after surgery. Given previous reports of treatment of AIS with hyperbaric oxygen (18,19), we opted to treat these patients with hyperbaric oxygen. All patients responded well to hyperbaric oxygen therapy and none lost vision as a result of the procedure. This was the first known occurrence of AIS as a result of scleral expansion. Despite the posterior insertions of the rectus muscles, these deeper tunnels likely resulted in a significant reduction of blood flow through the anterior ciliary arteries that perforate the sclera at the insertions of the rectus muscles. In order to avoid compression of the anterior ciliary arteries and AIS, surgeons began placing the scleral belt loops along the 45-degree meridians at 1:30, 4:30, 7:30, and 10:30 o’clock.
Further modifications to the scleral expansion band followed. Unfortunately, conjunctival erosion continued to be a problem. In 1998, however, a new prototype was developed consisting of four individual PMMA segments that were not connected to each other, resulting in decreased rates of conjunctival erosion, a simplified procedure, and a significant decrease in instrumentation cost (120). To decrease the risk of AIS, these segments were also placed in scleral belt loops along the 45-degree meridians, away from the ciliary artery insertions (Fig. 5).
Not everyone, however, is a candidate for scleral expansion. See Table 2 for patient selection.
C. CURRENT METHOD OF SCLERAL EXPANSION
1. Preop Medications
If the patient has no contraindications, it has been recommended that oral nonsteroidal anti-inflammatory drugs (NSAIDs) be started 1 to 2 days preop. Nonsteroidals decrease surgical pain and swelling and produce a smoother postoperative course. Additionally, there is some thought that NSAIDs may help to preserve anterior segment circulation (70).
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Figure 6 Marking the limbus with the quadrant marker.
Mark the 12 o’clock position at the slit lamp. This is an important reference mark to be used later for proper segment placement away from the area of ciliary arteries. If this reference mark is not made, cyclotorsion of the eye can occur when the patient lies down for the procedure. This will increase the risk of anterior ischemic syndrome from malpositioned segments. After the patient is taken to the operating room, the 12 o’clock meridian is used to align the quadrant marker in order to mark the location of the scleral expansion segments (Fig. 6.).
D. ANESTHESIA
A small amount of subconjunctival anesthesia is injected at the 12:00 and 6:00 o’clock meridians to elevate the conjunctiva and produce a surgical plane for dissection. Retrobulbar and peribulbar anesthesia is generally avoided because the pupil dilates and the eye may become soft, making it more difficult to construct the scleral belt loops. Additionally, a dilated pupil precludes evaluation of iris sphincter function, which is necessary to assess anterior segment circulation.
E. CONJUNCTIVAL DISSECTION
A 4 to 5-mm vertical incision is placed perpendicular to the limbus at the 12 and 6 o’clock meridians. These incisions are extended circumferentially at the limbus approximately 1 mm past the oblique quadrant marks. The conjunctiva from 7:30 to 10:30 o’clock and from 2:30 to 4:30 o’clock is left intact to avoid postoperative redness in the palpebral opening. The flap is dissected approximately 5 mm posterior to the limbus, leaving no Tenon’s capsule in the area where the scleral expansion segments will be placed. As little cautery as possible should be used so as to preserve the structural integrity of the sclera.
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Figure 7 Limbus marker.
It is particularly important to avoid cauterizing the sclera between the area of the implant bed and the limbus.
F. MARK THE SCLERAL BELT LOOPS
The limbus and the previous oblique quadrant marks are identified. Using a specially designed marker (Fig. 7), the parallel entrance and exit ends of the scleral belt loop incisions are marked so that the anterior aspect of the exit and entrance incisions of the scleral belt loop will be 3.5 mm from the limbus (Fig. 8).
Figure 8 Marks (see arrows) are 3.5 mm posterior to the limbus.
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A B
Figure 9 (A and B) The 300- m guarded diamond blade has a width of 1500 m and makes an incision 300 m deep.
G. DISSECT THE SCLERAL BELT LOOPS
A specially designed scleral fixator is used to grasp the sclera. The scleral fixator should be firmly inserted approximately 1.5 to 2 mm distal to the exit side of the future scleral tunnel. Avoid setting the scleral fixator either too far forward or back to avoid significant torque and tension when making the loop and inserting the segment.
A 300- m guarded square diamond blade (Fig. 9A and B) is used to make parallel incisions at the previously marked locations (Fig. 10A and B). The incisions should be
Figure 10 (A and B) A calibrated marker is used to check the measurements and the diamond blade is used to make the parallel incisions while stabilizing the eye with the scleral fixator.
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Figure 11 The 5-mm lamella diamond blade.
parallel to each other, not radial to the limbus. If the incisions are not parallel, the segment may rotate within the incision losing most of its lift. Care should be taken to remove all of Tenon’s capsule near the incision so as to avoid a shallow incision.
Without losing scleral fixation, a 5-mm-long 1.5-mm-wide lamella diamond blade (Fig. 11) is placed in the incision located furthest from the scleral fixator. The diamond blade is slowly advanced through the sclera toward the other incision near the scleral fixator (Fig. 12). By observing the relative visibility of the lamella diamond blade through the sclera, one controls the depth of the blade. The very tip of the diamond lamella blade should not be visible as the blade is passed through the sclera. Only a slight elevation or bulge of the sclera at the lateral edges of the blade should be seen. If the blade is easily
Figure 12 The lamella diamond blade being used to make a scleral belt loop.
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Figure 13 The thickness of the scleral belt loops and the exit wound are checked with the 1.4- mm-wide spatula.
seen through the sclera, then the loop is too shallow and the effect of the surgery will be greatly reduced. In making the scleral belt loop, care should be taken not to retract and advance the blade unnecessarily to avoid making blind pockets that will increase the difficulty of passing the scleral expansion segment.
On nearing the exit incision with the diamond blade, the sclera is depressed with the scleral fixator to help open the exit incision. It is usually necessary to aim the lamella blade upward just before exiting to prevent a blind pocket under the exit incision. The entire lamella diamond blade is 5 mm long. The front curve of the blade is 1 mm long. Therefore, by seeing the complete front curve of the blade, the surgeon is assured that the scleral belt loop is no longer than 4 mm.
In removing the lamella diamond blade, the surgeon must maintain fixation with the scleral fixator and remove the lamella blade slowly and in a controlled manner. In doing so, the surgeon avoids cutting the edges of the entrance incision, avoids perforating the belt loop, and ensures that the blade is not passed into the suprachoroidal space. If there is any doubt that the lamella blade is completely passed through the exit incision, test the incision using a 1.4-mm-wide spatula (Fig. 13). It should be possible to readily pass the spatula through the incision in the same direction that the scleral expansion segment will be passed.
H. PLACE THE SCLERAL EXPANSION SEGMENTS
The four scleral expansion segments (Fig. 14A and B) come packaged in much the same way as an intraocular lens (IOL). Prior to grasping the segments, place one or two drops of sterile saline into the well holding the segments. This prevents loss of the segments due to static electricity. Either a specifically designed scleral expansion segment holder or the injector can be used to pass the segment through the scleral belt loop (Fig. 15). Load the segment into the injector or segment holder curved side up. Without moving the scleral fixator, the segment is passed into the scleral belt loop. In difficult cases it is
