HSV Cytopathic Effect: Early Changes

Fig. 1.1  HSV cytopathic effect in cell culture infected with a laboratory strain of HSV type 1 (HSV-1). The figure shows foci (arrows) containing swollen/rounded infected cells (arrowheads)

Fig. 1.2  In the living human corneal epithelium, incipient HSV cytopathic effect appears as foci (white arrow) containing swollen/rounded cells (arrowhead). Black arrows indicate a corneal nerve

Fig. 1.3  a–b HSV cytopathic effect in the living human corneal epithelium. (a) Several partly confluent foci (arrows) containing swollen/rounded cells (arrowheads). (b) Individual swollen/rounded cells (arrowheads) close to each other

Fig. 1.4  a–b HSV cytopathic effect in the living human corneal epithelium. (a) Two adjacent foci (arrows) containing swollen/ rounded cells (arrowheads). In the left focus, and in the periphery of the right one, the cells appear dull (black arrowheads). In the center of the right focus are visible bright rounded cells (white arrowhead); here, the surface layer seems missing. (b) As in (a), the dull-appearing cells (black arrowheads) seem situated below a preserved surface layer, and the bright ones (white arrowhead) appear denuded. A few cells stained red with rose bengal

Comment

The condition of the surface can be visualized with fluorescein sodium (cf. Fig.1.10).