Healing of HSV Epithelial Keratitis with Acyclovir Ointment

Fig. 2.6  a–b The same lesions as in Fig. 2.5 a few minutes later and after application of rose bengal dye. (a) There is extensive fluorescein diffusion into the surroundings (cf. inset). The peripheral parts of the lesions show a bright green hue (white arrow); bright green dots (black arrows) are suggestive of cystic spaces. A few diseased cells stain with rose bengal (arrowhead). (b) Patchy rose bengal staining present in the lower lesion; the majority of the swollen/rounded cells (arrowhead) did not stain. (Adapted from [7])

Fig. 2.7  a–b After 24 h of treatment with acyclovir ointment five times a day,the same lesions appear smaller.(a) Fluorescein diffusion is limited to the lesions. There is patchy staining with rose bengal. (b) Patchy rose bengal staining visualizes surface debris. Structures indicated by arrowheads represent either swollen/rounded cells or small cysts. (Adapted from [7])

Fig. 2.8  a–b Seen after 48 h of treatment are small cystic spaces (black arrows), patchy rose bengal staining (white arrows), and swollen/rounded cells or small cysts (arrowheads). (Adapted from [7])

Fig. 2.9  a–b Two weeks after onset. Small cystic spaces (black arrows), patchy rose bengal staining (white arrows), and accumulated lightreflecting abnormal cells (arrowheads). For close view, see Fig. 2.11, overleaf (the markers are placed in corresponding locations)