Fig. 2.1  a–d Healing of two small HSV lesions located in the lower part of the cornea (cf. drawing, opposite page)

Left column: At presentation, the lesions showed (a) swollen/rounded“bright” cells in the center (white arrowheads) and“dull” cells in the surroundings (black arrowheads); (b) with fluorescein sodium, surface elevation (white arrow) or depression (black arrow) and (c) no diffusion (white arrow) or diffusion (black arrow); and (d) with rose bengal, no staining or a few red dots (arrowhead)

Right column: After 24 h of treatment, (a) some swollen cells (arrowhead) are still visible (cf. also d), (b) some swollen cells are protruding (arrowhead) in the green-stained tear fluid, (c) there is no diffusion into the tissues, and (d) both lesions show weak staining with rose bengal (arrowhead)

a 48 hrs b 7 days

Fig. 2.2   a–d The same two lesions as in Fig. 2.1. Starting after 48 h of treatment, (a) the lesions show abnormal cells (a, b, c, d, arrowheads) and additional features such as (b) patchy red staining with rose bengal after 7 days of treatment.(c) Surface elevations (arrows) 22 days after onset. (d) A subepithelial opacity containing light-reflecting abnormal cells (arrowheads) 5.5 weeks after onset

Case Report

A 47-year-old woman with recurrent HSV epithelial keratitis

in the left eye presented within 24 h of symptoms. The cor- area of observation nea showed a larger lesion and about 10 small ones, arranged

in a bowed line running subcentrally from about 9 o’clock toward 4 o’clock (cf. drawing). The patient was treated with acyclovir ointment for 12 days. Nine months after onset, when last seen, the cornea showed fine subepithelial opacities in the locations of the original lesions.