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Ординатура / Офтальмология / Английские материалы / Imaging of Orbital and Visual Pathway Pathology_Muller-Forell_2005

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366

W. Müller-Forell

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Fig. 7.25a–d. A 69-year-old man with slowly progressing bilateral visual deficit with emphasis to the left. Diagnosis: meningioma of the sphenoid plane. Axial, contrast-enhanced CT: a Homogeneous enhancement of a spherical tumor with emphasis to the left is seen at the posterior part of the frontal base. Note a slight perifocal edema in the left frontal white matter. MRI: b Corresponding T2-weighted view with displacing growth of the extraparenchymal tumor, indicative of the so-called tumor “belly” (arrow). Note hyperintensity of the left frontal white matter, due to perifocal edema (compare with a) c Coronal T1weighted, contrast-enhanced view with clearly visible homogeneous tumor enhancement and a knotty tumor surface. Only slight narrowing of the left ICA (arrow), located in the medial region of the meningioma. d Midsagittal, T1-weighted, contrastenhanced image where the origin of the meningioma is distinguished by thickening of the secondary curved sphenoid plane. Note intrasellar tumor expansion with compression of the pituitary stalk at the dorsum sellae (arrows). (From Müller-Forell and Lieb 1995)

Intracranial Pathology of the Visual Pathway

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Fig. 7.26a–f. A 61-year-old man with acute loss of vision in the left eye. Diagnosis: meningioma of the tuberculum sellae. T1weighted MRI: a Coronal native view at the level of the optic canal, showing an isointense formation with compression and elevation of the left rectus gyrus. b Corresponding contrast-enhanced view showing that the left optic nerve is flattened by tumor infiltration of the optic canal. c Coronal native view at the level of the chiasm, which appears to be slightly depressed from inferior. Note the normal configuration of the pituitary gland in a normal-sized sella and differentiation of the pituitary stalk in between. d Corresponding contrast-enhanced image. e Midsagittal, T1-weighted, contrast-enhanced image demonstrating the tumor growth at the tuberculum sellae and sphenoid plane and also the flattened chiasm at the posterior circumference of the meningioma. f Corresponding diagram: 12.2 = chiasm, 13.11 = pituitary gland, 13.23 = chiasmatic recess (of the third ventricle), 13.24 = recess of the pituitary stalk (of the third ventricle)

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Fig. 7.27a–f. A 45-year-old man with slowly progressing visual deficit of the right eye. Diagnosis: intraand extracranial sphenoid meningioma. CT: a Axial native view of the suprasellar region showing homogeneous calcification of the right posterior sphenoid plane, extending to the area of the dorsum sella. b 3D-reconstruction, view from above (right is left and vice versa) where the calcification occludes the distal right optic canal (arrow), while the left is seen to be almost free from calcification. c Coronal view in bone window, demonstrating occlusion of the right optic canal by the predominantly calcified tumor, showing expansion primarily in the sphenoid sinus and only some expansion at the sphenoid plane. The arrow indicates the left intact optic canal. T1-weighted, contrast-enhanced MRI: d Corresponding coronal view. While the left optic nerve is seen in the optic canal (arrow), the right optic nerve is not distinguishable in the tumor mass. e Midsagittal view, showing extension of the meningioma to the normal local chiasm as well as its growth along the sphenoid plane (so-called meningeal “tail”) with hyperostosis of the origin (arrow). f Right paramedian, sagittal view where the right optic nerve is seen distal from the optic canal (arrow). (MR images with permission of Radiologische Abteilung Krankenhaus, Winnenden)

Intracranial Pathology of the Visual Pathway

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Fig. 7.28a,b. A 53-year-old woman with slowly progressing visual deficit. Diagnosis: meningioma of the tuberculum sella. T1weighted, contrast-enhanced MRI: a Coronal view at the level of the optic canal showing a homogeneous, sharply defined tumor of the left tuberculum sellae, encasing the ipsilateral ICA, although without diminution of the ICA diameter. No differentiation of the left optic nerve is possible because the tumor crosses the midline and reaches the right optic canal (arrow). b Midsagittal view with the typical meningeal „tail“ along the sphenoid plane (arrowheads). Empty sella as an incidental finding. (From

Müller-Forell and Lieb 1995)

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Fig. 7.29a–d. A 20-year-old man with acute right N VI paresis persisting for 14 days. Diagnosis: suspected meningioma of the right lateral clivus (including Dorell canal). T1-weighted MRI: a Coronal contrast-enhanced view of the cavernous sinus where the location of the right abducent nerve is distinguished in the cavernous sinus (white arrow). Note a small, round structure at the upper end of the right cavernous sinus (black arrow) corresponding to the upper end of the tumor. b Axial contrast-enhanced image demonstrating a slight asymmetry of the cavernous sinus configuration of the right side.c Right paramedian,sagittal native view,lateral to the pituitary gland with a slightly hyperintense mass and thickening of the dura.d Corresponding contrast-enhanced image,showing enhancement of both the mass and the dura of the clivus. The patient was transferred for stereotactic radiation but lost to follow-up

370

W. Müller-Forell

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Fig. 7.30a–f. A 52-year-old woman with rapidly progressing

 

 

 

 

 

 

visual field deficits of the left eye and ipsilateral proptosis. Diag-

 

 

 

 

 

 

nosis: meningioma of the inferior part of the left sphenoid

 

 

 

 

 

 

wing. MRI: a Axial T2-weighted image at the level of the optic

 

 

 

 

 

 

canal where only slight thickening of the left clinoid process

 

 

 

 

 

 

is seen. b Axial T1-weighted native HR image (3D data set) at

 

 

 

 

 

 

the level of the superior orbital fissure, showing thickening of

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the left sphenoid bone with depression of the lateral orbit and

 

 

 

 

inferior optic nerve, identified by the high signal of the oph-

 

 

 

 

 

 

 

 

 

 

 

 

thalmic artery (small white arrows). c Corresponding contrast-

 

 

 

 

 

 

enhanced image with identification of the intraorbital and tem-

 

 

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poral parts of the tumor. d Coronal, T1-weighted, contrast-

 

 

 

 

 

 

enhanced view at the level of the optic canal where inferior

 

 

 

 

 

 

expansion of the tumor becomes apparent, although a direct

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relationship to the optic nerve cannot be determined. e Coro-

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nal reconstruction of the contrast-enhanced 3D data with con-

 

 

 

 

 

 

 

 

 

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firmation of the relationship to the left optic nerve, showing

 

 

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inferior compression of the ophthalmic artery, originating from

 

 

 

 

the tumor growth through the superior orbital fissure. f Cor-

 

 

 

 

 

 

responding diagram: 3.6 = superior orbital fissure, 3.9 = round foramen, 3.12 = sphenoid sinus, 10.11 = optic nerve, 10.14 = ophthalmic artery

Intracranial Pathology of the Visual Pathway

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Fig. 7.31. A 51-year-old woman with progressive visual deficit of the left eye. Diagnosis: left sphenoid (small) wing meningioma. T1-weighted, contrast-enhanced HR-MRI: the tumor progresses from the distal area of the clinoid process (arrow) to the optic canal. Note the anterior dislocation of the prechiasmal part of the flattened, attenuated optic nerve (small arrows) to the lateral posterior wall of the sphenoid sinus, and the flattened, impressed, dorsal dislocation of the (hyperintense) ICA bifurcation area with proximal MCA (white star: chiasm). (From Müller-Forell and Lieb 1995)

or chiasmal compression (Figs. 7.28, 7.31, 7.33), and therefore do not normally exceed 2 cm in diameter (Sartor 1992).

Imaging Characteristics. Due to their high cell density and psammomatous calcification, meningiomas of the sellar region present on CT as isodense to hyperdense midline lesions. Diffuse hyperostosis is particularly apparent on CT images of en plaque meningioma (Figs. 6.195, 6.174). A perifocal edema is detected only in the rare cases where the cerebral cortex is destroyed by this tumor (Fig. 7.25). Apart from the differentiation of pituitary adenomas, where a transsphenoidal approach is the preferred operative procedure, the most important question for neurosurgeons is the possible invasion of the cavernous sinus and/or narrowing of the ICA, which is best addressed by MRI. The high-resolu- tion, multidirectional imaging provided by this method enables an accurate, detailed description of anatomic and pathologic morphology. In view of the fact that meningiomas often show an isointense signal for gray matter, contrast administra-

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Fig. 7.32a–c. A 73-year-old man with slowly progressing visual deficit of the right eye. Diagnosis: sphenoid wing meningioma. T1-weighted, contrast-enhanced MRI: a Axial view with thickening of the large wing of the right sphenoid. The tumor occupies the temporal pole and the superior orbital fissure, extending to and invading the anterior part of the cavernous sinus without encasement or dislocation of the ipsilateral ICA. b Coronal view at the apex-orbital level visualizing tumor invasion extending to the base of the large sphenoid wing and to the superior orbital fissure. c Corresponding diagram: 3.6 = superior orbital fissure, 10.11 = optic nerve

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Intracranial Pathology of the Visual Pathway

tion is absolutely indicated to detect even tumors or tumor parts in areas only millimeters in size (Figs. 7.30, 7.33). Homogeneous, intensive enhancement is detected in almost all cases after i.v.-iodin- ated contrast medium, due to the presence of high tumor vascularization. Knowledge of MRI anatomy including the location and shape of the basal cisterns and vessels is required to establish the accurate diagnosis, especially with en plaque meningiomas of the sphenoid wing. With regard to diagnostic evidence, sagittal and coronal views are superior to axial images even in thin slices, a factor of relevance for all lesions of the sellar region. Despite the low sensitivity for compact bone, MR demonstration of hyperostosis indicating the origin of the meningioma is in some cases superior to that provided by CT (Figs. 7.14, 7.25, 7.27, 7.31, 7.33) (Sartor 1992; Osborn 1994a).

The differential diagnosis for globular meningioma and partially thrombosed giant aneurysms (see chapter 7.2.1.6) of the ICA is facilitated by the high sensitivity of MRI for flow and thrombi. Other important lesions to be excluded include supraand extrasellar pituitary adenoma, trigeminal schwannoma, metastasis, and inflammatory granu-loma. Differentiation between a suprasellar pituitary adenoma and a meningioma originating from the sellar diaphragm can be achieved based on the definition of a normal pituitary gland inferior to the lesion and the demonstration of the sellar diaphragm, especially on the coronal view (Fig. 7.34).

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7.2.1.4 Craniopharyngioma

Craniopharyngiomas correspond to the WHO grade I tumor classification and are defined as benign, partly cystic, epithelial tumors of the sellar region, typically occurring in children and adolescents. They are assumed to arise from Rathke’s pouch epithelium and account for 1.2%–4.6% of all intracranial tumors and thus represent the second most frequent tumors of the sellar region after pituitary adenomas. Craniopharyngiomas show no sex bias but a bimodal age distribution, with one peak involving children and adolescents and another one involving adults (Adamson et al. 1990; Crotty et al. 1995). A clinicopathologic distinction is made between adamantinous and papillary craniopharyngioma. Most adamantinomas are hormone-inactive lesions and present as solid tumors with a variable, at times predominantly cystic component, containing cholesterol-rich, thick, brown- ish-yellow fluid with the appearance of machine oil. Although craniopharyngiomas have a smooth surface, reactive fibrous tissue components are in some instances responsible for their firm attachment to adjacent brain structures (Figs. 7.35, 7.36), impeding complete neurosurgical removal. As described above, craniopharyngiomas can be divided into an adamantinous and a papillary type, with the cystic component being predominant in the majority of cases. The adamantinous type is seen more frequently in children and is often marked by calcification, with a crumbly consistency in the solid parts and a shell-like appear-

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Fig. 7.33a–f. A 33-year-old man with known amaurosis of the left eye persisting for 2 years; presenting to the attending physician complaining of double vision for the previous 2 weeks. Diagnosis: sphenoid wing meningioma with secondary optic nerve sheath infiltration. T1-weighted MRI: a Axial native view at the level of the normal-sized optic canal. In addition to slight thickening of the optic nerve complex, a small solid mass is visualized in the area of the thickened left clinoid process with lateralisation of the slightly nidened ophthalmic artery (black arrow). Note posterior dislocation of the C1 segment of the ipsilateral ICA (white arrow). b Corresponding contrast-enhanced (FS) image. Although the identified mass is small, the pathologic process is delineated around the left clinoid process with the tumor mass extending from the middle cranial fossa to the right optic canal, to the ipsilateral intraorbital space, and to the region of the posterior fossa. c Paramedian, sagittal, contrast-enhanced (FS) view, showing the trapped intracranial optic nerve dividing the tumor of the enlarged clinoid process. Note the various compartments affected by tumor expansion, including the orbital space along the optic nerve sheath, the anterior cranial fossa at the clinoid process, the suprasellar region, and the posterior cranial fossa with tumor growth along the clivus. d Corresponding diagram: 1.2 = maxillary sinus, 3.1 = (thickened) anterior clinoid process, 3.5 = clivus, 3.12 = sphenoid sinus, 10.1 = inferior rectus muscle, 10.3 = superior rectus muscle, 10.11 = optic nerve. e Coronal, T1-weighted, contrast-enhanced view (at the level of the dotted line in d) demonstrating supraclinoid expansion of the bulbous tumor formation with elevation of the left chiasm. The enlargement of the cavernous sinus indicates tumor invasion, obviously responsible for eye movement disorders. f Corresponding diagram: 3.10 = oval foramen, 12.2 = chiasm, 12.8 = oculomotor nerve (N III), 12.12 = ophthalmic nerve (NV1), 14.2 = ICA

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Fig. 7.34a–f. A 59-year-old man with progressing visual deficit of the left eye. Diagnosis: meningioma of the tuberculum sellae and a clinically compensated occlusive hydrocephalus. T1-weighted MRI: a Coronal native view, demonstrating a suprasellar mass with lower signal intensity than the pituitary gland, depressing the sellar diaphragm and compressing the left chiasm from inferior. b In the corresponding contrast-enhanced view, differentiation between the tumor and the gland is poorer after i.v. gadolinium. Note the lateral tumor expansion between the cavernous (inferior) and C1 part (superior) of the left ICA. c Corresponding diagram: 3.12 = sphenoid sinus, 12.2 = chiasm, 13.11 = pituitary gland, 14.2 = ICA, 14.8 = ACA, 14.9 = MCA. d Midsagittal T1-weighted native image demonstrating anterior compression of the chiasm. Note the different signal for the meningioma and the pituitary gland. e Corresponding diagram: 12.2 = chiasm, 13.11 = pituitary gland, 13.21 = third ventricle, 13.25 = fourth ventricle, 13.26 = aqueduct. f Corresponding contrast-enhanced view with superior visualization of the “tail” of the meningioma along the sphenoid floor. Note the enlarged supratentorial ventricles that are apparently due to compensated occlusion of the aqueduct (independent finding). (With permission of Radiologen am Brand, Mainz)

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Fig. 7.35a–d. MRI of a 20-year-old woman suffering from headache and visual deficit of both eyes, with dominance of the right side. Diagnosis: recurrent craniopharyngioma. MRI: a axial proton density view with inhomogeneous signal patterns of a bilateral, primarily median, frontal tumor. Note that the hyperintense cyst on the right side exhibits a more intense signal than the CSF of the right frontobasal parenchymal defect (star) after initial operation. b Corresponding T1-weighted native view demonstrating an intermediate signal of the cystic area, which is accounted for by the protein content of the cyst. c Enlarged corresponding T1-weighted, contrast-enhanced view where the cystic wall as well as the solid regions of the tumor exhibit strong signal enhancement. d Midsagittal, T1-weighted, contrast-enhanced T1-weightedview with widening of the sella and depression of the floor of the third ventricle and of the inferior frontal lobe by the tumor cyst. Neither chiasmal nor pituitary stalk structures can be differentiated

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