Ординатура / Офтальмология / Английские материалы / Illustrated Tutorials in Ophthalmology Kanski, Bolton 2001
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Leber hereditary optic neuropathy
Maternal mitochondrial DNA mutations
Presents
•Typically in males - third decade
•Occasionally in females - any age
•Initially unilateral visual loss
•Fellow eye involved within 2 months
•Bilateral optic atrophy
Signs
•Disc hyperaemia and dilated capillaries (telangiectatic microangiopathy)
•Vascular tortuosity
•Swelling of peripapillary nerve fibre layer
•Subsequent bilateral optic atrophy
PAPILLOEDEMA
1.Introduction
•Circulation of cerebrospinal fluid
•Causes of raised intracranial pressure
•Hydrocephalus
2.Classification of papilloedema
•Early
•Established (acute)
•Longstanding (chronic)
•Atrophic (secondary optic atrophy)
Circulation of cerebrospinal fluid
a |
(a) Subarachnoid space |
b |
(b) Lateral ventricle |
c
d (c) Third ventricle
e
(d) Aqueduct
(e) Fourth ventricle
Hydrocephalus
Dilated cerebral ventricles
Communicating - obstruction to CSF flow in basilar cisterns or cerebral subarachnoid space
Non-communicating - obstruction to CSF flow in ventricular
system or at exit of foramina of fourth ventricle
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