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Вуз:

Ростовский Государственный Медицинский Университет

Предмет:

Медицина общая

Файл:

Illustrated Tutorials in Ophthalmology Kanski, Bolton 2001

.pdf

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28.03.2026

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Behçet5 Disease

1.Idiopathic multisystem disease

2.Presentation - third to fourth decade

3.Most prevalent in Mediterranean region and Japan

4.Associated with HLA-B5 in Turkey and Japan

5.Major diagnostic criteria

•Oral aphthous ulceration (100%)

•Genital ulceration (90%)

•Skin lesions (80%)

•Uveitis (70%)

Mucocutaneous ulceration in Behçet disease


Oral aphthous ulceration - painful, recurrent	Genital ulceration

Skin lesions in Behçet disease

Erythema nodosum

Acneiform

Pustule after scratching skin	Lines after stroking skin
(pathergy test)	(dermatographism)

Vascular lesions in Behçet disease


Migratory thrombophlebitis	Obliterative thrombophlebitis
of extremities	of major internal veins

Uveitis in Behçet disease

Acute iritis

Retinitis

Occlusive periphlebitis

Diffuse leakage

Signs of Vogt-Koyanagi syndrome

Granulomatous	Alopecia
iridocyclitis

Poliosis

Vitiligo

Harada syndrome

Progression of Harada disease


Multifocal choroiditis	Multifocal sensory retinal	Exudative retinal
	detachments	detachment

Inflammatory bowel disease

Ulcerative colitis

Crohn disease

	• Large bowel ulceration	• Stricture and ‘rose thorn’
		ulceration
	Acute iritis - uncommon
		• Acute iritis - uncommon

Tubulointerstitial nephritis and uveitis (TINU)

Renal histology

Urine

•	Most frequently affects women and children	• Proteinuria and renal
•	Hypersensitivity reaction to drugs	failure
•	Bilateral, recurrent anterior uveitis	• Good response to systemic
		steroids

UVEAL INFECTIONS AND INFESTATIONS

1.Viruses

•Herpes zoster ophthalmicus

•Acute retinal necrosis

•Cytomegalovirus (CMV)

2.Spirochaetes

•Syphilis

•Lyme disease

3.Mycobacteria

•Tuberculosis

•Leprosy

4.Protozoa and worms

•Toxoplasmosis

•Ocular toxocariasis

5.Fungi

•Presumed ocular histoplasmosis syndrome

•Candidiasis

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