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Ординатура / Офтальмология / Английские материалы / Glaucoma Identification and Co-management_Edgar, Rudnicka_2007

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194 INDEX

 

pattern deviation plots 66–7, 69,

demographic factors 110

light sensitivity see retina, light

 

71, 72, 73

short-term fluctuations 108–10

sensitivity

 

pattern standard deviation 67,

in glaucoma diagnosis 107–18

lipophilicity 143

68, 70, 71, 72, 73

phasing 109

Lumigan 151, 158

 

reliability parameters 64, 65, 66

practical advice 109, 110, 112,

 

 

short-term fluctuation 67, 68,

116

magnocellular (M) pathway 78–80

70, 71

in glaucoma management 140, 153,

frequency-doubling stimulus 82

 

STATPAC 64, 66, 68

155

motion perception 83

 

STATPAC 2 94, 100, 101

and glaucomatous damage 79

Mamre eye study 4, 5, 7

 

total deviation plots 66, 71, 72,

management, medical 158

managed care 185

73

loss of effect 159

see also co-management

 

fixation loss errors 64

pressure-lowering drugs 141,

management see laser treatment; medical

 

‘normal’ reference field 66

143

management; surgical

 

programmes 61

measurement 108

management

 

suprathreshold screening strategies

normal 108

matrix metalloproteinases (MMPs) 24

 

age reference 60–2, 71

in ocular hypertension 3

mechanical theory of glaucomatous

 

quantify defect strategy 62

parasympathomimetics, action of

optic neuropathy 32–3

 

three zone screening strategy 62

144–5, 146

medical management 153–5

 

threshold-related 62

and POAG 2–3, 5, 33, 95, 107,

aims 140

 

technical specifications 62

110–11

combination therapy 161

 

threshold strategies

as risk factor 6–7

current therapy 157, 159

 

fast threshold 63

as screening test 11

mechanics of 159–60

 

FASTPAC 63

provocative water drinking test

economics of glaucoma therapy

 

full threshold 62–3, 65, 68,

110

157, 158

 

70–1

referral guidelines 117

first- vs second-line 159

 

from prior data 63

target pressure 161–2

history 153–5

 

in superior hemifield loss 97

and visual field loss 155

loss of effect 159

 

staircase algorithm 62, 63

intrinsic sympathomimetic activity (ISA)

monotherapy 159

 

SITA (Swedish Interactive

142

neuroprotection 158, 162

 

Threshold Algorithm) 56,

ion transport/transporters 20–1

non-responders 159

 

63–4, 72–3

IOP see intraocular pressure

pharmacological principles 137–53

 

hypertension

Iopidine 158

side effects

 

and IOP 111

iridectomy, surgical 178

local 156

 

as POAG risk factor 9

iridocorneal angle see drainage angle

systemic 156–7

 

see also blood pressure; ocular

iris root 47

see also specific drugs/classes of

 

hypertension

iris vessels 48

drug

 

hyphaema 173

ischaemia and cell death 34

target IOP 162

 

 

isofluorophate 154

see also drugs

 

imaging

isolated paracentral scotomata 57

melanosomes 19

 

optic disc 122

 

Melbourne Visual Impairment study 4,

 

optic nerve 127–8

juxtacanalicular tissue 22–3

5, 6, 7

 

Imbert–Fick law 112

‘plaque-like’ deposits 25

metipranolol 142, 143

 

incidence 2

 

Metipranolol Minims 142

 

see also under specific diseases

Keeler Pulsair EasyEye 114, 115

midget cells 78

 

indentation (compression) gonioscopy

Koeppe gonioscopy 40

mitomycin C 175

 

49–50

Kowa KT-5000 114

mitotics see parasympathomimetics

 

infantile glaucoma 153

 

Molteno tube 176

 

inferior hemifield loss 103

lamina cribrosa 28, 31–2

monotherapy 141, 159–60

 

inflammatory PAS 48

laser treatment 155, 171

Moorfields Regression Analysis 129,

 

‘Integrating Primary and Secondary

argon laser trabeculoplasty 172

130

 

Healthcare’ 182

iridotomy 177–8

motion perimetry 83–5

 

intraocular muscles in IOP 109

latanoprost 151, 154

muscarinic receptors 139, 140

 

intraocular pressure (IOP) 6, 109

adverse effects 156

ocular 141

 

borderline 109

combination therapy 155, 161

muscles, intraocular/extraocular 109

 

canal of Schlemm and 23

monotherapy 160

MYOC gene 8, 9

 

distribution, theoretical 108

levobunolol 142, 143

myopia

 

factors influencing 108

costs 158

and IOP fluctuations 110

 

clinical factors 110–11

and ocular blood flow 163

as POAG risk factor 7

INDEX 195

narrow angle glaucoma see angle closure glaucoma

nasal step

on Henson Pro 5000 61 in POAG 57

nasalisation 126

neodymium:ytrium aluminium garnet (Nd : YAG) lasers 177, 178

nervous system 137

neural rim see neuroretinal rim neurohumoral transmitters 138–9 neuroprotection 158, 162 neuroretinal rim 121

in cup/disc ratio measurement 123, 124

measurement 135 normal appearance 125

notching/erosion 123, 125 focal notch 124

pallor 125

rim : disc ratio 129, 130 neurotransmission/neurotransmitters

binding at receptor site 139 schematic 139 sympathetic/parasympathetic

systems 139

see also specific neurotransmitters

NHS design and co-management 184 nicotinic receptors 139, 140

Nidex NT-2000/4000 114 nifedipine 162

non-contact tonometry 114–15 vs contact tonometry 115 non-pigmented epithelium (NPE)

19–20 noradrenaline 138, 147

normal tension glaucoma (NTG) 107

intraocular pressure in 33 management, medical 162 POAG studies 111

Normal Tension Glaucoma Study 102–3

Nyogel 143, 158

OCT 3 131

ocular adverse effects 156

see also specific drugs/classes of drug ocular blood flow (OBF) 33, 158,

162–3

ocular blood flow tonometer 116 ocular disease and IOP 110

ocular hypertension (OHT) 3, 107 definition 3

drug action 18 target IOP 161–2

Ocular Hypertension Treatment Study (OHTS) 107, 111, 161–2

ocular hypotensive lipids 162 oligodendrocytes 29

ONH see optic nerve head open angle glaucoma 2

gonioscopy indications 38, 39 optic nerve head changes in 31–2 pattern of visual field loss 57 treatment options 171

see also primary open angle glaucoma ophthalmologists in glaucoma care

181, 183–4

ophthalmoscopy, confocal scanning laser 128

optic disc (optic papilla) 27 anatomy 120–1

change detection 127 complete

examination/documentation

127

cup/disc ratio see under optic disc cupping

examination 121–2 standardisation for co-

management 186 features 122–5

imaging 122 normal 120 pallor 124–5

racial variations 121 saucerisation 124 size 121

vascular changes 125–7 local 126–7

optic disc cupping 122 concentric pathological 124 cup/disc ratio 122–4 evaluation 123, 124, 135 focal 124

and intraocular pressure 33 optic disc haemorrhage 125–6

clearance 126 identification 125

optic nerve anatomy 120

in glaucoma 119 imaging 127–8

optic nerve head (ONH) blood flow 30–1 blood supply 29–30

examination/evaluation 121–2 for glaucoma diagnosis 119–36

gross appearance 28 histopathology in POAG 31–2 imaging 128

local vascular changes 126–7 measurement 135 microscopic appearance 27–9

laminar zone 28–9

post-laminar zone 29 pre-laminar zone 28, 29

pathogenesis 32–3 mechanical theory 32–3 vasogenic theory 33

stereoscopic colour photographs 128

optic papilla see optic disc

optical coherence tomography 131, 134

ONH Analysis Report 134 OPTN gene 8, 9 optometrists

Association of Optometrists (AOP) website 189

in glaucoma care 184, 185, 189

pachymetry 110 paracentral scotomata 57 parallel care 185

parasol cells 78 parasympathetic nervous system

neurotransmission 139 receptors 140

parasympathomimetics (cholinergic agonists) (miotics) 144–6

action 144 pharmacological 144–5

adverse effects ocular 145 systemic 145–6

dosage/time of action 145 glaucoma management

acute angle closure 145 POAG 145

IOP reduction 141

in ophthalmology 144 pars plana 19

pars plicata 19

partial agonist activity 142 parvocellular pathway 78–80

PAS see peripheral anterior synechiae Pascal DCT 117

pattern discrimination perimetry 86 pattern electroretinogram (PERG) 87 Pelli–Robson test 80

perimetry 68 advantages/disadvantages of

automation 68 in glaucoma 81–6 learning/fatigue 56 light intensity 55–6

recording parameters 55

visual field patterns in glaucoma 56–8

within-patient fluctuations 56 see also Henson perimeters;

Humphrey Field Analyzer

196 INDEX

peripapillary atrophy 127

peripheral anterior synechiae (PAS) 48 peripheral nervous system 138 phospholine iodide 144 physostigmine 144, 154 pigmentation 48

pigmented epithelium (PE) 19, 20 pilocarpine 144

adverse effects 157

in aqueous drainage 24

in argon laser trabeculoplasty 172 combination therapy 161

costs 158

dosage/time of action 145 history 154

IOP reduction 141

and ocular blood flow 162–3 Pilocarpine Minims 144

Pilogel 144 pneumatonometry 116

POAG see primary open angle glaucoma polarimetry, scanning laser 131

Posner lenses 41, 42, 43 posterior ciliary arteries 30 posterior embryotoxon 47 posture and IOP 109 prevalence 2

see also under specific diseases primary angle closure glaucoma

(PACG) 3

primary glaucomas 2, 38–9

primary open angle glaucoma (POAG) argon laser trabeculoplasty in 172 asymmetrical progression 94 classification 3

co-management, factors for 183, 184

description 2–3 epidemiology

geographical/ethnic distribution 4

incidence 4, 6 prevalence 3–4, 5–6

ganglion cell death 33–4 intraocular pressure 2–3, 5, 33, 107,

110–11

as risk factor 6–7

as screening test 11, 95 normal tension 111 ocular blood flow 162

optic nerve head changes in 31–2 risk factors 95

demographic/genetic 7–9 ocular 6–7

systemic disease 9–10 screening 10–12, 95 surgical treatment 156 tonometry 111–12

predictive power 112–13 sensitivity/specificity 112

visual field loss 56–7 progression of disease 129, 130 Propine 154, 174

propranolol 154 prostaglandin analogues

action 150 pharmacological 150–1

adverse effects 151

in aqueous drainage 24 glaucoma management 150 history 154

IOP reduction 141 prostaglandin F150

protocols for co-management 186 ptosis after trabeculectomy 174 pulsatile ocular blood flow (POBF)

162–3

race see ethnic factors receptors

autonomic nervous system 139–41 classification 139

reduced redundancy theory 98 referral

guidelines for intraocular pressure 117

re-referral in co-management 187, 188

Reichert non-contact tonometers 114, 115

Reichert Ocular Response Analyser 116 retina

light sensitivity 55–6 within-patient fluctuations 56 see also perimetry

organisation of 78 retinal ganglion cells 28

cell death 32, 33–4 classification 78 colour vision 78 spatial field size 79

spatio-temporal properties 79 retinal nerve fibre layer (RNFL) 120

atrophy 126 evaluation 131–3 haemorrhage 125 imaging 128 retardation 131

risk factors 1–2

see also under specific diseases

Roscommon eye study 5, 7

Royal Colleges’ Tripartite guidelines 185

Sampaolesi’s line 47 saucerisation 124

scanning laser ophthalmoscopy, confocal 128

scanning laser polarimetry 131 glaucoma, moderate 133 normal eye 132

Schwalbe’s line 46–7 scleral flap 172 scleral lenses 41

coupling solutions 41, 42 gonioscopy technique 44–6

scleral spur 47 sclerectomy, deep 176 sclerostomy 173 scotomata

blue-on-yellow perimetry 84 in POAG 57

and visual field loss 77 screening 78

criteria 10 measures 11

tests for POAG 11–12

see also under specific diseases secondary glaucomas 2, 24–5

gonioscopy indications 39 management 156

sensitivity of screening 11 sex see gender

Shaffer angle classification system 51, 52

shared care 185

debate on services 182 definition 182

see also co-management; parallel care short posterior ciliary arteries (SPCAs)

30

SITA (Swedish Interactive Threshold Algorithm) 56, 63–4, 72–3

slit lamp for optic disc examination 121–2

small bi-stratified cells 78 smoking 8 socioeconomic status 8

Spaeth angle classification system 51–2

spatial contrast sensitivity 80 spatial field size 79 specificity of screening 11 St Lucia eye study 4, 5, 7 static perimetry 79

statins 9

STATPAC see under Humphrey Field Analyzer

stereoscopic photographs of ONH 128

Stratus OCT 135 superior hemifield loss

classification of field defects 102 full threshold HFA plot 84

INDEX 197

surgical management 155

topical agents, reducing systemic effects

visual field defects

 

 

closed angle glaucoma 177

of 157

associated with POAG 93–4

 

cycloablative procedures 178–9

trabecular meshwork (TM)

classification 102–3

 

cyclocryotherapy 178–9

in aqueous drainage 21, 22, 23

multistage criteria 103–4

 

diode cyclophotoablation

contraction/relaxation 24

detection of changes 95–6, 99–102

 

(cyclodiode) 178

cribriform layer see juxtacanalicular

box and whisker plots 99–100

 

iridectomy 178

tissue

linear regression 100–2

 

non-penetrating surgery 176–7

gonioscopic anatomy 47

visual inspection 99

 

deep sclerotomy 176

histology 22

evolution 94

 

results 177

trabeculectomy (drainage surgery)

transient

95

 

viscocanalostomy 176–7

(filtration surgery)

variability

95, 96–9

 

open angle glaucoma 171

172–6

frequency-of-seeing (FOS) curves

 

reasons for choosing 171

blebs 175

 

96, 98, 104

 

trabeculoplasty, argon laser 172

complications

reduced redundancy theory 98

 

trabeculotomy 172–6

early 173

visual field loss

 

trans-scleral cyclophotoablation 178

later 174

defining 94

 

see also laser treatment

drainage tubes/implants/setons

detection

 

 

Sussman lenses 41, 42, 43

175–6

practical considerations 103–4

 

sympathetic nervous system

long-term IOP control after 174

scoring systems 94–5

 

neurotransmission 138, 139

risk factors for failure 174

grading 102–3

 

receptors 140

scarring 175

horizontal midline, differences across

 

sympathomimetic agonists see

technique 173

57–8

 

 

adrenoceptor agonists

wound healing 174–5

and intraocular pressure 155

 

systemic adverse effects 156–7

5-fluorouracil 175

patterns in glaucoma 56–8

 

reducing 157

mitomycin C 175

rate measurement 96

 

see also specific drugs/classes of drug

trabeculoplasty, argon laser 172

repeat test strategy 103–4

 

systemic disease

trans-scleral cyclophotoablation 178

visual field testing 56

 

and IOP fluctuations 110–11

Travatan 151, 158

standardisation for co-management

 

and POAG 9–10

travoprost 151, 155, 161

186

 

 

 

Trusopt 149, 158

see also perimetry

 

target IOP 161–2

TSNIT graph 131, 132

visual function 77–91

 

temporal contrast sensitivity 81

glaucoma, moderate 133

in glaucoma 79–87

 

Tenoptic 142

 

colour vision 78, 81

 

Thorpe type lenses 42

‘Universal’ lens 41

in foveal/para-foveal regions

 

time of day see diurnal variation

uveal meshwork 22

 

80

 

timolol 142, 143, 154

uveitis after trabeculectomy 173

perimetry 81–6

 

combination therapy 155, 161

 

spatial contrast sensitivity 80–1

 

costs 158

van Herick’s slit lamp angle grading

temporal contrast sensitivity 81

 

monotherapy 160

system 37, 38

M (magno) pathway 78–80

 

and ocular blood flow 163

vascular signs 125–7

objective tests 85–6

 

Timoptol 142, 158

local changes 126–7

P (parvo) pathway 78–80

 

Timpilo 161

vasoconstricting/vasodilating factors

Volk lenses 122

 

tonometry

31

 

 

 

developments 116–17

vasogenic theory of glaucomatous optic

white-on-white perimetry 81–2

 

IOP measurement 112–16

neuropathy 33

field analysis plots 83

 

predictive power 111–12

vasospasm 9–10

 

 

 

sensitivity/specificity 111

viscocanalostomy 176–7

Xalacom 142, 143, 151, 155, 161

 

standardisation for co-management

visual acuity

costs 158

 

186

low contrast test 80

Xalatan 151, 158

 

see also applanation tonometry

from spatial contrast sensitivity 80

 

 

 

Topcon CT80/80A 114, 115

visual field changes 93–105

Zeiss lenses 41, 42