- •CONTENTS
- •PREFACE
- •Ocular discharge
- •Eyelid margin inflammation
- •Inflammatory mass
- •Noninflammatory mass
- •Eyelid malpositions
- •Conjunctival lesions
- •Vascular tumors
- •References
- •2 MALIGNANT TUMORS
- •Introduction
- •Basal cell carcinoma
- •Basal cell nevus syndrome
- •Squamous cell carcinoma
- •Keratoacanthoma
- •Adenocanthoma
- •Sebaceous gland carcinoma
- •Lymphoma
- •Malignant melanoma
- •Sweat gland carcinoma
- •Merkel cell tumor
- •Rhabdomyosarcoma
- •Metastatic eyelid carcinoma
- •References
- •Pigmented lesions
- •Inflammations
- •Discoid lupus
- •Benign cystic lesions
- •Benign epithelial tumors
- •Precancerous epithelial tumors
- •Adnexal tumors
- •Xanthelasma
- •Amyloidosis
- •Neurofibromatosis (von Recklinghausen’s disease)
- •References
- •Basal cell carcinoma
- •Sebaceous carcinoma
- •Squamous cell carcinoma
- •Premalignant eyelid lesions
- •Merkel cell tumor
- •Metastatic eyelid carcinoma
- •Melanocytic tumors
- •References
- •Biopsy techniques
- •Treatment
- •References
- •Skin
- •Muscles
- •Tarsal plates
- •Orbital septum
- •Orbital fat
- •Conjunctiva
- •Vascular supply
- •Lymphatic drainage
- •Nerves of the eyelids
- •Lacrimal drainage system
- •References
- •General principles
- •Principles of radiosurgery
- •References
- •Small central lid margin defects
- •Small lateral or medial lid margin defects
- •Medium lower lid defects extending to the medial canthal angle
- •Medium defects extending beyond the medial canthal angle
- •References
- •Small upper lid margin defects
- •References
- •General considerations
- •Primary closure
- •Advancement flaps
- •Full-thickness skin grafts
- •References
- •Medial canthal defects
- •Lateral canthal defects
- •References
- •INDEX
12 Differential Diagnosis of Eyelid Tumors
EYELID MALPOSITIONS |
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VASCULAR TUMORS |
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Eyelid malignancies may present as eyelid malpositions. Patients with basal cell carcinoma may be initially diagnosed as ectropion, entropion, ptosis, or eyelid retraction (27–32).
CONJUNCTIVAL LESIONS
Benign cysts may occur on the conjunctival surface of the eyelid. They are usually filled with a clear fluid. Sometimes there is a calcium deposit or a granulomatous substance within the cyst.
Papillomatous growths tend to be pedunculated when they arise at the lid margin, but they can sometimes be sessile. The majority of papillomas are infectious or irritative in origin with no malignant potential, but, in some cases, a squamous cell carcinoma appears as a papilloma. Squamous cell carcinomas can also appear as a fleshy mass on the conjunctival surface of the eyelid (33).
The conjunctiva may be involved by vascular tumors. These may vary in size but are usually clumps of dilated vessels. Care must be taken that the visible vasculature on the eyelid is not an extension of an orbital tumor or of an orbital varix. Hemangiomas, lymphangiomas, and varices may present as vascular tumors on the conjunctival surface of the eyelid.
Vascular tumors of the eyelids are often manifestations of orbital tumors. These include capillary and cavernous hemangiomas, varices, and lymphangiomas. They may present as a bluish mass under the skin or a reddish mass in the conjunctiva (31, 32). Capillary hemangiomas of childhood often regress with time. Some should be treated if they are extensive and vision is compromised by severe ptosis. Cavernous hemangiomas may involve surrounding skin and surgical excision may be indicated.2
When evaluating an eyelid vascular tumor, care must be taken to see if there is orbital involvement. A capillary hemangioma that is localized to the skin can be excised but significant bleeding should be expected (34, 35).
RACE AND EYELID CANCER
Eyelid cancers occur in Caucasians, Asians, Hispanics, and Blacks. Since sun exposure is thought to be related to the incidence of these tumors, people with more melanin in the skin seem to be better protected. Blacks have a much lower incidence of skin cancer than Caucasians, but they do get basal cell carcinoma, squamous cell carcinoma, and melanoma. When melanoma occurs in Blacks, it is usually on the palms of the hands or soles of the feet. This, of course, suggests that the areas of less melanin in the skin
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27 Patient diagnosed with |
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lower lid ectropion actually had |
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a basal cell carcinoma causing |
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skin contraction resulting in |
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cicatricial ectropion.The |
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carcinoma with an ulcerated |
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center extends the entire |
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length of the lid just below |
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the lid margin. |
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28 This patient was treated |
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for trichiasis but careful |
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examination shows a basal |
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cell carcinoma at the inside lid |
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margin.The tumor converts the |
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lid margin to a cream colored |
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thickened area with loss of the |
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normal lid margin structures. |
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29, 30 The 85-year-old male |
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depicted in 29 was treated for |
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ptosis. At surgery (30) a basal |
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cell carcinoma was found just |
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anterior to the levator |
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aponeurosis. |
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are more prone to develop the cancer. However, sun exposure is also a factor, and these areas would receive less sun exposure. All of the factors regarding causes of skin cancer are still not known. Basal cell carcinoma accounts for about 90% of eyelid skin cancers in the Western Hemisphere, but in Asia the incidence seems to be between 30 and 50%.3 Sebaceous cell carcinoma is much more common in Asia than in the West. It accounts for 20–40% of eyelid malignancies. Squamous cell carcinoma is less common and accounts for 10–20% of eyelid cancers, whereas malignant melanoma has an incidence of between 5 and 10% in various parts of China.3 It is important to consider eyelid malignancies when evaluating eyelid tumors in non-Caucasians.
References 13
REFERENCES
1.Older JJ (1979). Encysted corneal contact lens presenting as an eyelid mass. Ann. Ophthalmol., 11(9): 1393–1394.
2.Spencer WH (1986). Ophthalmic Pathology. An Atlas and Textbook. W.B. Saunders, Philadelphia, pp. 2237–2248.
3.Liu D, Zhao G, Xu N (1996). Eyelid Tumors. In: Priciples and Practice of Ophthalmic Plastic and Reconstructive Surgery. WB Saunders, Philadelphia, pp. 721–728.
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32 |
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31, 32 The female in 31 presented with upper eyelid retraction. Inspection of the anterior eyelid skin showed a basal cell carcinoma (32).
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34 |
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33 A 55-year-old female with a conjunctival squamous cell carcinoma. |
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The tumor was removed using frozen section control and the defect |
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repaired with a Hughes procedure. Conjunctiva was allowed to heal |
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spontaneously after being left bare.The bare conjunctiva was opposed |
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to the conjunctiva of the Hughes flap and no adhesions occurred. |
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A 10-year follow-up showed no evidence of local or systemic |
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recurrence. |
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34 A 26-year-old healthy male of Mexican descent witha raised vascular |
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lesion of two months duration.There was no antecedent history of |
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injury.The lesion was removed using radiosurgery to help decrease |
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bleeding and the skin was repaired with a skin graft. |
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35 The patient in 34 one month after surgery. |
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