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Eyelid Tumors

Clinical Diagnosis and

Surgical Treatment

Second Edition

Jay Justin Older MD, FACS

Affiliate Professor of Ophthalmology

University of South Florida

College of Medicine

Tampa, Florida, USA

With a contribution from

Richard J Grostern MD

Assistant Professor of Ophthalmology and Pathology

Rush Medical College of Rush University

Chicago, Illinois, USA

MANSON

PUBLISHING

Dedication

To my wife, Lois, and my children, Jessica and Benjamin, for their continued love and support.

Acknowledgements

This textbook is the product of my experience and knowledge, which, in great measure, is derived from those who taught and encouraged me. My parents, Dr. Lester Older and Gertrude Older encouraged me to study medicine. My mother deserves special recognition for reviewing the manuscript for the first edition. My brother, Dr. Robert Older, assisted me with many computer related topics.

Four men were instrumental in shaping my medical career. In Stanford Medical School, I benefited from the guidance of Dr. Lowell Rantz and Dr. Kenneth Vosti. During my fellowship year at the University of California in San Francisco, Dr. Crowell Beard and Dr. Marvin Quickert instilled in me the values and skills that would carry me through a career in oculoplastic surgery.

Photography for the second edition was done by my office assistants, Ms. Lori Gilmore, Ms. Lisa McLeod, Ms. Sue Ramsey and Ms. Wendy Shuford. Ms. Susan Commee deserves credit for assistance with the manuscript review and references.

I would like to thank Mr. Michael Manson, the publisher, for giving me the opportunity to write a second edition of this text. Ms. Jill Northcott was very helpful in the early phases of preparation. Mr. Paul Bennett, Ms. Clair Chaventré and Ms. Ruth Maxwell assisted me with all phases of the manuscript. Ms. Susan Tyler of Cactus Design and Illustration did an excellent job of creating accurate and representative drawings of the surgical procedures.

Copyright © 2003 Manson Publishing Ltd

ISBN: 1–84076–029–X

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means without the written permission of the copyright holder or in accordance with the provisions of the Copyright Act 1956 (as amended), or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 33–34 Alfred Place, London WC1E 7DP, UK.

Any person who does any unauthorized act in relation to this publication may be liable to criminal prosecution and civil claims for damages.

A CIP catalogue record for this book is available from the British Library.

For full details of all Manson Publishing Ltd titles please write to:

Manson Publishing Ltd, 73 Corringham Road, London NW11 7DL, UK.

Tel: +44(0)20 8905 5150

Fax: +44(0)20 8201 9233

Email: manson@man-pub.demon.co.uk

Website: www.manson-publishing.co.uk

Commissioning editor: Jill Northcott

Project manager: Paul Bennett

Printed in Spain

Contents

PREFACE

6 3 BENIGN TUMORS AND RELATED

 

 

 

CONDITIONS

38

SECTION 1: DIAGNOSIS

 

Pigmented lesions

38

AND MANAGEMENT

7

Freckle (ephelis)

38

 

 

Lentigo

38

1 DIFFERENTIAL DIAGNOSIS OF

 

Lentigo maligna (melanotic freckle of

 

EYELID TUMORS

7

Hutchinson)

38

Ocular discharge

7

Nevus

38

Eyelid margin inflammation

7

Junctional nevus

38

Inflammatory mass

8

Intradermal nevus

38

Noninflammatory mass

9

Compound nevus

38

Eyelid malpositions

12

Blue nevus

40

Conjunctival lesions

12

Congenital oculodermal melanocytosis

 

Vascular tumors

12

(nevus of Ota)

40

Race and eyelid tumors

12

Treatment

40

References

13

Inflammations

40

2 MALIGNANT TUMORS

14

Blepharitis

40

Seborrheic blepharitis

40

Introduction

14

Staphylococcal blepharitis

40

Basal cell carcinoma

14

Treatment

40

Treatment

18

Comment

40

Comment

18

Hordeolum

41

Basal cell nevus syndrome

20

External hordeolum

41

Squamous cell carcinoma

20

Internal hordeolum

41

Keratoacanthoma

25

Treatment

41

Adenocanthoma

25

Chalazion

42

Treatment

25

Treatment

42

Comment

25

Comment

42

Sebaceous gland carcinoma

26

Viral inflammations

42

Treatment

28

Molluscum contagiosum

42

Lymphoma

28

Verruca (wart)

42

Treatment

28

Other inflammations

42

Comment

28

Discoid lupus

43

Malignant melanoma

30

Benign cystic lesions

44

Treatment

30

Sudoriferous cysts

44

Comment

30

Sebaceous cysts

44

Malignant melanoma of the conjunctiva

32

Epidermal inclusion cysts

44

Sweat gland carcinoma

32

Epidermoid cysts

46

Merkel cell tumor

32

Dermoid cysts

46

Rhabdomyosarcoma

34

Treatment

46

Metastatic eyelid carcinoma

34

Comedo (blackhead)

46

References

35

 

 

3 BENIGN TUMORS AND RELATED CONDITIONS (continued)

Benign epithelial tumors Papilloma

Seborrheic keratosis (basal cell papilloma, seborrheic wart, senile verruca)

Inverted follicular keratosis (basosquamous cell epidermal tumor, basosquamous cell acanthoma, irritated seborrheic keratosis)

Precancerous epithelial tumors Actinic keratosis (solar keratosis) Dysplasia

Adnexal tumors Sebaceous gland tumors

Congenital sebaceous gland hyperplasia (nevus sebaceous Jadassohn, congenital sebaceous gland hamartoma)

Sebaceous adenoma Tumors of hair follicles

Trichoepithelioma

Calcifying epithelioma of Malherbe (pilomatrixoma)

Trichofolliculoma and trichilemmoma Sweat gland tumors

Syringoma

Eccrine spiradenoma (nodular hidradenoma, clear cell hidradenoma, clear cell myoepithelioma)

Syringocystadenoma papilliferum Xanthelasma

Treatment Amyloidosis

Necrobiotic xanthogranuloma Neurofibromatosis (von Recklinghausen’s

disease) Treatment

References

 

5 TREATMENT OF EYELID TUMORS

61

 

Biopsy techniques

61

47

Treatment

62

47

Surgery

62

 

Mohs technique

62

48

Frozen section control

62

 

Radiation therapy

63

 

Cryotherapy

63

48

Comment

63

49

References

64

49

 

 

49

SECTION 2: RECONSTRUCTION

 

50

 

50

OF THE EYELIDS

65

50

6 SURGICAL ANATOMY

65

Skin

65

50

Muscles

66

50

Orbicularis oculi

66

50

Levator palpebrae superioris

66

 

50

Capsulopalpebral fascia

66

Müller’s muscles

67

50

Tarsal plates

68

50

Comment

68

50

Orbital septum

68

 

 

Orbital fat

68

50

Conjunctiva

69

Comment

69

50

Vascular supply

69

52

Arteries

69

52

Veins

70

52

Lymphatic drainage

70

52

Comment

70

 

52

Nerves of the eyelids

70

Comment

70

52

Lacrimal drainage system

71

54

References

71

 

4 HISTOPATHOLOGY OF EYELID TUMORS

55

Richard J Grostern

 

Basal cell carcinoma

55

Sebaceous carcinoma

56

Squamous cell carcinoma

56

Premalignant eyelid lesions

58

Actinic keratosis

58

Bowen’s disease

58

Radiation dermatosis

58

Merkel cell tumor

58

Metastatic eyelid carcinoma

58

Melanocytic tumors

58

Melanocytic nevus

58

Malignant melanoma

60

References

60

7 GENERAL PRINCIPLES OF EYELID

 

RECONSTRUCTION AND RADIOSURGERY

72

General principles

72

Principles of radiosurgery

72

Technique

73

Skin incisions

74

Soft tissue dissection

74

Flaps

74

Grafts

74

Anesthesia

77

References

77

8 LOWER EYELID RECONSTRUCTION

Small central lid margin defects

Small lateral or medial lid margin defects Defects which extend medial to the punctum Medium lower lid defects extending to the

medial canthal angle

Medium to large lower lid defects Medium defects extending beyond the

medial canthal angle

Medium-sized defects in the lateral aspect of the lower lid

Medium to large lower lid defects Modifications

Alternative method for lateral lower lid defect

Alternative method for medial or central lower lid medium defect

Second stage Hughes procedure References

9 UPPER EYELID RECONSTRUCTION

78 11 RECONSTRUCTION OF THE MEDIAL

 

78

AND LATERAL CANTHI

113

79

Medial canthal defects

113

80

General considerations

113

 

Spontaneous granulation

113

80

Full-thickness skin grafts

116

80

Advancement and rotation flaps

117

 

Advancement flap

117

84

Myocutaneous island flap

118

 

‘V’ to ‘Y’ rotation flap

118

86

Midline forehead flap

120

90

Cheek rotation flap

120

95

Lateral canthal defects

122

 

General considerations

122

95

Periosteal flaps

122

 

References

125

96

INDEX

126

96

96

 

 

97

 

 

Small upper lid margin defects

97

Medium-sized upper lid margin defects

98

Lateral advancement flap

98

Modified tarsoconjunctival flap

99

Large defects in the upper eyelid

102

References

106

10 REPAIR OF DEFECTS NOT INVOLVING

 

EYELID MARGINS

107

General considerations

107

Primary closure

107

Advancement flaps

108

Full-thickness skin grafts

112

References

112

6

Preface

Eyelid Tumors was written to help the physician diagnose eyelid tumors in the clinical setting and to assist the surgeon who might wish to remove the tumors and repair the eyelid defects. One of the reasons to write the book was that I had seen many patients in my oculoplastic practice with a history of late diagnoses of malignant eyelid tumors. Early diagnosis of eyelid malignancies would lead to better patient care, in the majority of cases. The other reason for writing the text was to share my surgical experiences with other surgeons. Many of the texts in print at the time I wrote the first edition listed a variety of repairs for a specific condition. I, however, chose to discuss only those techniques that gave me the best results. The first section contained many pictures of different lesions with descriptions and anecdotal information. It was my belief that the clinician would look at the book as help in diagnosing the eyelid lesion. By comparing the patient’s lesion with the photos in the book, the physician would be in a better position to make a differential diagnosis and continue with the patient’s care. The care might require further testing, a referral, or definitive treatment.

The first edition was sold out and was not reprinted. Newer techniques of surgical repair were developed since that edition was published. My experience with eyelid tumors increased during the next 15 years and I continue to see patients who present with late diagnoses of eyelid malignancies. My research indicated that eyelid tumors are relatively common in most parts of the world. It is my hope that an expanded second edition will be accepted by an

international audience and result in better medical care for those patients who present with eyelid tumors.

The second edition is divided into two parts. The first deals with the diagnosis of eyelid tumors. Chapter 1 emphasizes the difficulty in the differential diagnosis of malignant tumors because different conditions look similar and the same type of tumor may have a variety of presentations. The next two chapters deal with the presentation and performance of benign and malignant eyelid tumors. By including more than 150 photographs, I intend to show the reader the wide variety of eyelid tumor presentations. Chapter 4 includes the microscopic pathology of malignant eyelid tumors, a subject not included in the first edition. It is written by Dr. Richard Grostern, an ophthalmic pathologist.

The second part of the text discusses the surgical treatment of eyelid tumors and eyelid repair. A new addition to the second edition is the discussion of radiosurgery. This is important in understanding the surgical repair techniques since radiosurgery is my main method of soft tissue dissection. This second part includes newer techniques of eyelid repair. Although there are many methods for repair of eyelid defects, I included only those procedures which I have used and found to be most effective. It is my belief that clinical photos of surgery combined with explicit drawings of these techniques will aid the reader in performing eyelid tumor surgery.

Jay Justin Older

Jay Justin Older, MD, FACS

Dr. Older graduated from Rutgers University, New Jersey. He then completed his medical and ophthalmology training at Stanford University, California. After finishing his residency in ophthalmology, Dr. Older completed a fellowship in oculoplastic surgery at the University of California in San Francisco.

Dr. Older is board certified in ophthalmology and is a fellow of the American Academy of Ophthalmology from which he has received both the Honor Award and the Senior Honor Award for distinguished service in the field of education. He is past President of the American Society of Ophthalmic Plastic and Reconstructive Surgery, and he has also lectured extensively on the subject of eyelid surgery in America, Europe, and Asia.