- •Contents
- •Preface
- •Abstract
- •Morphological Lesions
- •Visual Impairment in Diabetic Retinopathy
- •Conclusions
- •References
- •Abstract
- •Physiology of the Retinal Vascular Network
- •Physiology of the Blood-Retinal Barrier
- •Macular Edema
- •Assays for Studying the Permeability of the Blood-Retinal Barrier
- •Conclusions
- •References
- •In vivo Models of Diabetic Retinopathy
- •Abstract
- •Animal Models of Diabetic Retinopathy
- •Neovascularization
- •Conclusions
- •References
- •Pericyte Loss in the Diabetic Retina
- •Abstract
- •Pericyte
- •Retinal Pericyte Function
- •Pericyte Loss in Diabetic Retinopathy
- •Mechanisms of Pericyte Loss
- •Conclusions
- •References
- •Neuroglia in the Diabetic Retina
- •Abstract
- •Microglial Cells
- •Astrocytes
- •Müller Cells
- •Conclusions
- •Acknowledgements
- •References
- •Regulatory and Pathogenic Roles of Müller Glial Cells in Retinal Neovascular Processes and Their Potential for Retinal Regeneration
- •Abstract
- •Control of Extracellular Matrix Deposition by Müller Cells
- •Neuroprotective Role of Müller Glia
- •Müller Glial Cells as a Source of Retinal Neurons in the Adult Eye
- •Potential Barriers for Stem Cell Transplantation to Regenerate Retinal Neurons in the Diabetic Retina
- •Potential of Müller Stem Cells for the Development of Human Therapies to Restore Retinal Function Damaged by Disease
- •References
- •Growth Factors in the Diabetic Eye
- •Abstract
- •Vascular Endothelial Growth Factor
- •Insulin-Like Growth Factor 1
- •Platelet-Derived Growth Factor
- •Fibroblast Growth Factor
- •Hepatocyte Growth Factor
- •Angiopoietins
- •Connective Tissue Factor
- •Stromal Cell-Derived Factor 1
- •References
- •Balance between Pigment Epithelium-Derived Factor and Vascular Endothelial Growth Factor in Diabetic Retinopathy
- •Abstract
- •VEGF and PEDF in the Eye
- •PEDF/VEGF in the Diabetic Retinopathy
- •Anti-VEGF Therapy for Diabetic Retinopathy
- •References
- •The Renin-Angiotensin System in the Eye
- •Abstract
- •History of the Renin-Angiotensin System
- •The Circulating Renin-Angiotensin System
- •Tissue Renin-Angiotensin Systems
- •The Renin-Angiotensin System in the Eye
- •Conclusions
- •References
- •Interactions of Leukocytes with the Endothelium
- •Abstract
- •Multistep Process of Leukocyte Recruitment
- •Leukocyte Transendothelial Migration
- •References
- •Stem and Progenitor Cells in the Retina
- •Abstract
- •Niches
- •Characteristics of a Stem Cell
- •Types of Stem and Precursor Cells
- •Methods for Studying Stem/Progenitor Cell Behavior
- •CD34+ and CD14+ Cells in Diabetes
- •Conclusion
- •References
- •Role of Pericytes in Vascular Biology
- •Abstract
- •Pericytes Are Cells with a Unique Position in the Microvascular Wall
- •Identification of Pericytes
- •Functions of Pericytes
- •Acknowledgements
- •References
- •Current Approaches to Retinopathy as a Predictor of Cardiovascular Risk
- •Abstract
- •Diabetic Retinopathy and Mortality
- •Diabetic Retinopathy and Heart Disease
- •Retinal Venules and Cardiovascular Disease
- •Pathogenic Links between Retinopathy and Cardiovascular Disease
- •Genetic Links between Retinopathy and Cardiovascular Disease
- •Implications
- •Conclusion
- •References
- •From Bedside to Bench and Back: Open Problems in Clinical and Basic Research
- •Abstract
- •References
- •Author Index
- •Subject Index
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Prof. Massimo Porta, MD, PhD
Department of Medicine, University of Turin Corso Dogliotti 14
IT–10126 Turin (Italy)
Tel. +39 011 6632354, Fax +39 011 6634751, E-Mail massimo.porta@unito.it
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