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EVIDENCE-BASED

OPHTHALMOLOGY

Edited by Richard Wormald, Liam Smeeth and Katherine Henshaw

Evidence-based Ophthalmology

Evidence-based Ophthalmology

Edited by

Richard Wormald

Consultant Ophthalmologist, Moorfields Eye Hospital,

Honorary Senior Lecturer, London School of Hygiene and Tropical Medicine and Coordinating Editor, Cochrane Eyes and Vision Group, London, UK

Liam Smeeth

Senior Lecturer in Clinical Epidemiology, London School of Hygiene and Tropical Medicine, General Practitioner, London and Editor, Cochrane Eyes and Vision Group, London, UK

Katherine Henshaw

Review Group Coordinator, Cochrane Eyes and Vision Group, London, UK

With research by Anupa Shah

Trial Search Coordinator, Cochrane Eyes and Vision Group, London, UK

© BMJ Publishing Group 2004

BMJ Books is an imprint of the BMJ Publishing Group

All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording and/or otherwise, without the prior written permission of the publishers.

First published in 2004

by BMJ Books, BMA House, Tavistock Square, London WC1H 9JR

www.bmjbooks.com

British Library Cataloguing in Publication Data

A catalogue record for this book is available from the British Library

ISBN 0 7279 1443 X

Typeset by SIVA Math Setters, Chennai, India

Printed and bound by MPG Books, Bodmin, Cornwall

Contents

Contributors

ix

Preface

xiii

Evidence-based Ophthalmology CD Rom

xiv

Glossary

xv

Section I: The basics

1

 

 

 

1

Finding the evidence

3

 

Kay Dickersin

 

2

Synthesising the evidence

7

 

Jennifer Evans

 

3

Evidence in practice

11

 

Richard Wormald

 

Section II: Primary care

15

Aziz Sheikh, Editor

 

 

 

 

4

Allergic conjunctivitis

17

 

Christopher G Owen, Katherine Henshaw, Liam Smeeth, Aziz Sheikh

 

5

Acute bacterial conjunctivitis

33

 

Aziz Sheikh

 

6

Viral conjunctivitis

37

 

Hazel Everitt

 

7

Screening older people for impaired vision

41

 

Liam Smeeth

 

Section III: Paediatrics and ocular motility

45

Jugnoo S Rahi, Clare Gilbert, Editors

 

 

 

 

8

Congenital and infantile cataract

47

 

Jugnoo S Rahi

 

9

Congenital glaucoma

53

 

Maria Papadopoulos, PT Khaw

 

10

Retinopathy of prematurity

57

 

Clare Gilbert

 

11

Ophthalmia neonatorum

71

 

Jane Moseley

 

v

Evidence-based Ophthalmology

12

Unilateral amblyopia

81

 

Cathy Williams

 

13

Infantile esotropia

87

 

Lorraine Cassidy, Jugnoo S Rahi

 

14

Accommodative esotropia

91

 

Michael Clarke

 

15

Childhood exotropia

95

 

Sarah Richardson, Lawrence Gnanaraj

 

16

Prevention of myopia progression

101

 

Ian Flitcroft

 

Section IV: Adnexal

109

Michael J Wearne, Editor

 

 

 

 

17

Entropion and ectropion

111

 

Kostas G Boboridis, Michael J Wearne

 

18

Thyroid eye disease

115

 

Michael J Wearne, Silvia Wengrowicz

 

19

Lacrimal obstruction

119

 

Vinidh Paleri, Andrew K Robson, Michael Bearn

 

Section V: Cornea and external disease

123

Linda Ficker, Editor

 

 

 

 

20

Trachoma

125

 

Denise Mabey

 

21

Corneal abrasion and recurrent erosion

129

 

David F Anderson

 

22

Herpes simplex keratitis

137

 

Alonso Rodriguez

 

23

Suppurative keratitis

145

 

Stephanie L Watson

 

Section VI: Uveitis

155

Carlos Pavesio, Editor

 

 

 

 

24

Ocular toxoplasmosis

157

 

Carlos Pavesio

 

25

Onchocerciasis

161

 

Henry Ejere

 

26

Idiopathic (autoimmune) sight-threatening uveitis

167

 

Philip I Murray

 

vi

 

 

Contents

 

 

 

27

Cytomegalovirus retinitis in patients with AIDS

175

 

Adnan Tufail

 

28

Anterior uveitis

191

 

Nicholas P Jones

 

Section VII: Glaucoma

195

Richard Wormald, Editor

 

 

 

 

29

Primary open angle glaucoma and ocular hypertension

197

 

Richard Wormald, Rajiv Shah

 

30

Acute and chronic angle closure glaucoma

205

 

Richard Wormald, Rajiv Shah

 

31

Modification of wound healing in glaucoma drainage surgery

211

 

JF Kirwan, Richard Wormald

 

Section VIII: Cataract

219

Emma Hollick, Editor

 

 

 

 

32

Cataract surgical techniques

221

 

Jodhbir S Mehta

 

33

Intraocular lens implant biocompatibility

243

 

Emma Hollick

 

34

Multifocal and monofocal intraocular lenses

259

 

Martin Leyland

 

35

Perioperative management of cataract surgery

269

 

Vincenzo Maurino

 

Section IX: Retinal diseases

287

Bill Aylward, Editor

 

 

 

 

36

Age-related macular degeneration

289

 

Jennifer Evans

 

37

Treatment of lattice degeneration and asymptomatic retinal breaks to

 

 

prevent rhegmatogenous retinal detachment

301

 

Charles P Wilkinson

 

38

Surgery for proliferative vitreoretinopathy

303

 

David G Charteris

 

39

Rhegmatogenous retinal detachment

307

 

Graham Duguid, Sarit Lesnik-Oberstein

 

40

Surgical management of full-thickness macular hole

317

 

Eric Ezra

 

41

Retinal vein occlusion

323

 

Heather Baldwin

 

vii

Evidence-based Ophthalmology

Section X: Diabetic retinopathy

329

Bernd Richter, Editor

 

 

 

 

42

Medical interventions for diabetic retinopathy

331

 

Bernd Richter, Eva Kohner

 

43

Photocoagulation for sight threatening diabetic retinopathy

341

 

Jonathan GF Dowler

 

44

Vitrectomy for diabetic retinopathy

347

 

Paul Sullivan, Alistair Laidlaw

 

Section XI: Neuro-ophthalmology

351

James Acheson, Editor

 

 

 

 

45

Optic neuritis

353

 

Simon J Hickman

 

46

Arteritic and non-arteritic anterior ischaemic optic neuropathy

357

 

Ahmed Toosy

 

47

Idiopathic intracranial hypertension

363

 

Christian J Lueck, Gawn G McIlwaine

 

48

Toxic and nutritional optic neuropathies

367

 

Fion Bremner

 

49

Traumatic optic neuropathy

371

 

Andrew S Jacks

 

Section XII: Ophthalmic oncology

373

Arun D Singh, Editor

 

 

 

 

50

Ocular adnexal and orbital tumours

375

 

Santosh G Honavar, Arun D Singh

 

51

Uveal melanoma

383

 

Arun D Singh, Paul A Rundle, Ian G Rennie

 

52

Retinoblastoma

387

 

Arun D Singh

 

Section XIII: Rehabilitation

393

Gary Rubin, Editor

 

 

 

53 Vision rehabilitation

395

Gary Rubin

 

Index

401

viii