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Ординатура / Офтальмология / Английские материалы / Evaluation and Management of Blepharoptosis_Cohen, Weinberg_2010.pdf
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12  Neurogenic Blepharoptosis

 

127

 

 

 

Table 12.4Surgical options for neurogenic ptosis

 

 

Procedure

 

 

 

 

 

 

 

Frontalis sling

Levator advancement/resection

Müllerectomy

 

 

 

 

Third nerve palsy

Horner syndrome

Horner syndrome

Apraxia of eyelid opening

Negative response to phenylephrine

Positive response to phenylephrine

 

Ptosis >2 mm

Ptosis <2 mm

 

Dermatochalasis

 

 

 

Previous levator surgery

 

 

vanillylmandelic acid (VMA) and homovanillic acid (HVA) (24-h collection) are obtained to look for elevated catecholamine levels [20]. A serologic laboratory panel is rarely diagnostic but can be used to guide further testing (liver function tests, CBC, LDH, ferritin levels). Chest and abdominal imaging with CT scans is the mainstay for evaluating the thoracic and retroperitoneal cavities. MRI is recommended for evaluating the head, neck, and paraspinal regions. Finally, a methyliodobenzyguanadine (MIBG) scan is a specific method for documenting skull and skeletal metastases in neuroblastoma since this agent accumulates in catecholaminergic cells.

be adequately explained on an anatomic basis. The clinical response of Müller’s muscle to phenylephrine suggests that the muscle fibers can be pharmacologically activated by its adrenergic receptors. However, the surgical success of Müllerectomy in Horner syndrome patients is somewhat surprising since the denervated muscle is atonic. Glatt and Putterman postulated that the mechanism of action of Müllerectomy in these cases is independent of its effect on Müller’s muscle, and likely related to a shortening or augmentation of the levator aponeurosis [21]. In any case, the surgical approach for correcting eyelid ptosis in a Horner syndrome patient is based on the response to topical phenylephrine and other preoperative surgical factors (see Table 12.4).

Treatment

As with other causes of neurogenic ptosis, the strategy for treating Horner syndrome is aimed at correcting the underlying etiology. However, even with successful treatment of the primary disease, it is not uncommon for the blepharoptosis to persist, particularly for patients with longstanding Horner syndrome. Since levator excursion is normal in Horner syndrome, the blepharoptosis can be treated with either an anterior approach (i.e., levator surgery) or posterior approach (i.e., Müllerectomy) ptosis repair. Determining a patient’s candidacy for posterior approach ptosis repair is based on the patient’s response to topical phenylephrine; if eyelid elevation is adequate following the instillation of 2.5% phenylephrine, Müllerectomy can be recommended. The prognostic effect of topical phenylephrine in Horner syndrome patients cannot

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