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Essentials in Ophthalmology

Oculoplastics and Orbit

 

R. F. Guthoff  J. A. Katowitz 

 

Editors

Essentials in Ophthalmology

G. K. Krieglstein  R. N. Weinreb 

Series Editors

Glaucoma

Cataract and Refractive Surgery

Uveitis and Immunological Disorders

Vitreo-retinal Surgery

Medical Retina

Oculoplastics and Orbit

Pediatric Ophthalmology,

Neuro-Ophthalmology, Genetics

Cornea and External Eye Disease

Editors Rudolf F. Guthoff

James A. Katowitz

Oculoplastics

and Orbit

With 301 Figures, Mostly in Colour

and 12 Tables

123

 

 

Series Editors

Volume Editors

Günter K. Krieglstein, MD

Rudolf F. Guthoff, MD

Professor and Chairman

Professor of Ophthalmology

Department of Ophthalmology

University of Rostock

University of Cologne

Department of Ophthalmology

Kerpener Straße 62

Doberaner Straße 140

50924 Cologne

18057 Rostock

Germany

Germany

Robert N. Weinreb, MD

James A. Katowitz, MD

Professor and Director

Professor of Ophthalmology

Hamilton Glaucoma Center

Oculoplastic and Orbital Surgery Service

Department of Ophthalmology

The Children’s Hospital of Philadelphia and

University of California at San Diego

The Edwin and Fannie Gray Hall

9500 Gilman Drive

Center for Human Appearance

La Jolla, CA 92093-0946

University of Pennsylvania

USA

34th Street and Civic Center Blvd.

 

Philadelphia, PA 19104

 

USA

ISBN  978-3-540-33675-4

ISSN 1612-3212

Springer Berlin Heidelberg NewYork

 

Library of Congress Control Number: 2007931905

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from SpringerVerlag. Violations are liable for prosecution under the German Copyright Law.

Springer is a part of Springer Science + Business Media springer.com

© Springer-Verlag Berlin Heidelberg 2007

The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use.

Product liability: The publishers cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature.

Editor: Marion Philipp, Heidelberg, Germany

Desk Editor: Martina Himberger, Heidelberg, Germany Production: LE-TeX Jelonek, Schmidt & Vöckler GbR, Leipzig, Germany

Cover Design: WMXDesign GmbH, Heidelberg, Germany

Printed on acid-free paper 24/3180Wa    5 4 3 2 1 0

Foreword

The series Essentials in Ophthalmology was initiated two years ago to expedite the timely transfer of new information in vision science and evidence-based medicine into clinical practice. We thought that this prospicient idea would be moved and guided by a resolute commitment to excellence. It is reasonable to now update our readers with what has been achieved.

The immediate goal was to transfer information through a high quality quarterly publication in which ophthalmology would be represented by eight subspecialties. In this regard, each issue has had a subspecialty theme and has been overseen by two internationally recognized volume editors, who in turn have invited a bevy of experts

to discuss clinically relevant and appropriate topics. Summaries of clinically relevant information have been provided throughout each chapter.

Each subspecialty area now has been covered once, and the response to the first eight volumes in the series has been enthusiastically positive. With the start of the second cycle of subspecialty coverage, the dissemination of practical information will be continued as we learn more about the emerging advances in various ophthalmic subspecialties that can be applied to obtain the best possible care of our patients. Moreover, we will continue to highlight clinically relevant information and maintain our commitment to excellence.

G. K. Krieglstein

R. N. Weinreb

Series Editors

Preface

Ophthalmic plastic and reconstructive surgery continues to evolve as an important subspecialty dealing with a large variety of complex challenges. Despite close relationships and overlap with other surgical and nonsurgical disciplines, it has developed into a distinct identity, while also achieving a high level of patient satisfaction.

The second volume of Oculoplastics and Orbit in the Essentials of Ophthalmology series addresses a wide spectrum of disorders including oncology, ophthalmic manifestations of systemic diseases, as well as functional and aesthetic concerns involving orbital, periorbital, and facial structures.

In order to achieve optimal results, a full understanding of the surgical anatomy, as described in Chapter 5, should be combined with recent surgical advances, including microsurgical approaches. Newer techniques using various alloplastic and autologous materials have also been developed to provide or replace orbital volume.

Various clinical applications that are dependent upon the stage of each disorder and the experience of the surgeon have significantly improved patient outcomes.

Another area of development has been the use of minimally invasive approaches for the surgical repair of lid, lacrimal, and orbital problems, including the use of filler materials and injectable self-inflating pellets for augmenting orbital volume.

Chapters dealing with complications such as orbital implant exposure or problems with salivary gland transposition surgery are openly discussed and will hopefully stimulate efforts to find better techniques for further reducing surgical side effects and complications.

The editors have selected specific topics for this volume in an effort to provide an up-to-date review of various eyelid, lacrimal, and orbital problems including aesthetic concerns regarding the aging face. This volume is intended not only for subspecialists, but also for comprehensive ophthalmologists and other healthcare professionals with an interest in oculoplastic disorders. It is our hope that the information presented may be useful in improving the understanding and management of these complex problems.

R. F. Guthoff

J. A. Katowitz

Editors

Contents

Chapter 1

Repair of Involutional Ectropion

and Entropion: Transconjunctival

Surgery of the Lower Lid Retractors

Markus J. Pfeiffer

1.1Introduction  . . . . . . . .   1

1.2Surgical Anatomy

 

of the Lower Lid  . . . .

.

.   1

1.2.1

Lower Lid Position

 

 

 

and the Intercanthal Line 

.

.   2

1.2.2

Posterior Lamella

 

 

 

of the Lower Lid  . . . .

.

.   2

1.2.3

Anterior Lamella

 

 

 

of the Lower Lid  . . . .

.

.   2

1.2.4Relationship Between the Anterior and Posterior

Lamellae  . . . . . . . . . .   2

1.2.5Lower Lid Crease  . . . . . .   4

1.2.6Orbital Septum

and the Orbitomalar Septum    4

1.2.7Lid Margin Shape

and the Lid Margin Angle

at the Lacrimal Punctum  . . . . .   4

1.3Preoperative Evaluation

and Surgical Planning  . . . .   4

1.3.1Evaluation

of the Intercanthal Line  . . .   5

1.3.2Evaluation of the anterior

and posterior Surface  . . . .   5

1.3.3Evaluation of the Three Vectors Influencing Lid

Function  . . . . . . . . . .   5

1.3.4Evaluation of the Lid Margin

and the Punctum  . . . . . .   5

1.4Surgical Technique

for Ectropion Repair  . . . . .   6

1.4.1Principle of Retractor

Fixation  . . . . . . . . . .   6

1.4.2Access to the Medial

Retractors  . . . . . . . . .   6

1.4.3Access to the Central

Retractors  . . . . . . . . .   7

1.4.4Exposure of the Inferior

 

Tarsal Border  . .

. . .

.

.

.   7

1.4.5

Suture Technique 

. . .

.

.

.   7

1.4.6Correction of Horizontal

Laxity  . . . . . . . . . . .   9

1.5Surgical Technique

for Entropion Repair  . . . .   10

1.5.1Principle of Retractor

Fixation  . . . . . . . . . .  10

1.5.2Access to the Lower Lid Retractors  . . . . . . . . .  10

1.5.3

Suture Technique  . . . . .   10

1.6Repair of Complicated Cases and Complications

of Retractor Surgery  . . . .   10

1.6.1Complicated Involutional Ectropion  . . . . . . . . .  10

1.6.2Complicated Involutional Entropion  . . . . . . . . .  10

1.6.3Complications of Retractor Surgery  . . . . . . . . . .  12

Chapter 2

Update on Mohs Micrographic Surgery Techniques for Excision and Reconstruction of Periocular

Tumors: A Multidisciplinary Approach

Christopher J. Miller, William R. Katowitz

2.1Introduction  . . . . . . . .  14

2.1.1Role of Mohs Micrographic Surgery in Treating

the Patient with Periocular Malignancy  . . . . . . . .   14

2.1.2History of Mohs Micrographic Surgery in the Treatment of Periocular

Malignancies  . . . . . . .   14

2.1.3Clarification of the Meaning

of Clinical, Surgical,

and Pathologic Margins  . .   14

2.2Steps of Mohs Micrographic Surgery  . . . . . . . . . .  15

Contents

2.2.1

Step 1: Determination

 

2.6.2.2

History of Prior Irradiation 

.   24

 

of Clinical Margins  . . . .

.  15

2.6.2.3

Immunosuppressed Patient 

24

2.2.2

Step 2: Debulking

 

2.6.2.4

Additional Historical Risk

 

 

of the Tumor  . . . . . .

.   15

 

Factors  . . . . . . . . . .   24

2.2.3

Step 3: Excising the Initial

 

2.6.2.5

Size and Location  . . . .

.   24

 

Mohs Specimen  . . . . .

.  17

2.6.2.6

Histologic Subtypes  . . .

.   24

2.2.4

Step 4: Gross Sectioning

 

2.6.2.7

Perineural Involvement  . .

.  25

 

and Inking the Fresh Tissue

 

2.6.3

Mohs Micrographic Surgery

 

 

Mohs Specimen  . . . . .

.  18

 

for Sebaceous Carcinoma  

.   25

2.2.5

Step 5: Mapping the Mohs

 

2.6.4

Mohs Micrographic Surgery

 

 

Specimen  . . . . . . . .

.  18

 

for Melanoma  . . . . . .

.  26

2.2.6

Step 6: Embedding,

 

2.7

Reconstruction of Periocular

 

 

Sectioning, and Staining

 

 

Defects after Mohs

 

 

the Pieces of the Mohs

 

 

Micrographic Surgery  . .

.   27

 

Specimen  . . . . . . . .

.  18

2.7.1

Preoperative Considerations    27

2.2.7

Step 7: Interpretation

 

2.7.2

Periocular Reconstruction 

.   27

 

of the Pathologic Margins

 

2.7.3

Eyelid Reconstruction  . .

.   29

 

by the Mohs Surgeon  . .

.   18

2.7.3.1

General Principles of Eyelid

 

2.3

Advantages of Mohs

 

 

Reconstruction  . . . . .

.   29

 

Micrographic Surgery  . .

.   19

2.7.3.2

Upper Eyelid Reconstruction    29

2.3.1

High Cure Rates   . . . . .

.  19

2.7.3.3

Reconstruction of Lower

 

2.3.2

Tissue Conservation  . . .

.   20

 

Lid Defects After Mohs

 

2.3.3

Optimal Division of Labor  

.   20

 

Micrographic Surgery  . .

.   34

2.4

Differences Between Mohs

 

2.7.3.4

Reconstruction of Medial

 

 

Micrographic Surgery  

 

 

Canthal Defects After Mohs

 

 

and Common Standard

 

 

Micrographic Surgery  . .

.   34

 

Excision Techniques   . . .

.  20

2.8

Conclusion  . . . . . . .

.   40

2.4.1Determining Appropriate

 

Surgical Margins: How Does

 

Chapter 3

 

 

One Decide Where to Cut? 

.   20

Upper Eyelid Retraction:

 

2.4.2

Comparing and Contrasting

 

Current Concepts in Management

 

 

Methods of Microscopic

.  21

James Kirszrot, Peter A.D. Rubin

 

 

Margin Evaluation  . . . .

3.1

Introduction  . . . . . . . .  45

2.4.3

Dual Vs. Separate Roles

 

 

of Surgeon and Pathologist 

21

3.2.

Differential Diagnosis

 

2.5

Potential Pitfalls of Mohs

 

 

of Upper Lid Retraction   .

.   45

 

Micrographic Surgery  . .

.   22

3.3

Etiology of Thyroid-related

 

2.6

Periocular Tumors:

 

 

Upper Lid Retraction   . . . . . . .  46

 

Indications for Mohs

 

3.4

Physical Examination  . . .

.  46

 

Micrographic Surgery  . .

.   23

3.5

Sequelae of Upper Lid

 

2.6.1

Choosing a Management

 

 

Retraction  . . . . . . . . .  47

 

Plan Based on Risk

 

3.6

Medical Management

 

 

Assessment of the Periocular

 

of Thyroid-related Upper Lid

 

 

Malignancy  . . . . . . . .   23

 

Retraction  . . . . . . . . .  47

2.6.2

Mohs Micrographic Surgery

 

3.7

Important Considerations

 

 

for Basal Cell and Squamous

 

 

Before Addressing Surgery

 

 

Cell Cancers  . . . . . . .

.  23

 

for Upper Lid Retraction  .

.   48

2.6.2.1

Recurrent Versus Primary

 

3.8

Basic Principles for Surgical

 

 

Tumors  . . . . . . . . .

.  24

 

Correction of Retraction  .

.   48

Contents XI

3.9

Preoperative Medication  . .  50

3.10Surgical Recession:

Posterior Approach  . . . .   51

3.11Surgical Recession:

Anterior Approach  . . . . .  54

3.11.1Levator Disinsertion/ Mullerectomy  . . . . . . .  54

3.11.2Graded Full-Thickness

Anterior Blepharotomy  . . .  54

3.12Conclusion  . . . . . . . .   58

Chapter 4

Lower Eyelid Retraction: Current

Concepts in Management

Scott M. Goldstein

4.1Introduction  . . . . . . . .  61

4.2Over-action of the Upper Lid Retractors  . . . . . . . . .  61

4.3Facial Palsy and Lid

Retraction  . . . . . . . . .  62

4.4

Lower Lid Retraction  .

. .

.  63

4.5

Nonsurgical Approaches 

.

.  64

4.6

Surgical Approaches  .

. .

.  66

4.7Recession of Retractors  . . .  66

4.8Spacer Graft  . . . . . . . .  67

4.9

Midface Surgery  . . . . . .  68

4.10Lateral Tarsal Strip  . . . . . . . . . .  70

Chapter 5

Surgical Orbital Anatomy

A. Ducasse

5.1Introduction  . . . . . . . .  73

5.2Bony Orbit  . . . . . . . .   73

5.2.1Embryology  . . . . . . . .  74

5.2.2

Dimensions of the Orbit  . .   74

5.2.3Description  . . . . . . . .   74

5.2.3.1

Upper Orbital Wall   .

. .

. .  74

5.2.3.2

Lateral Orbital Wall  

. . .

.   74

5.2.3.3

Inferior Orbital Wall 

. . .

.   74

5.2.3.4Medial Orbital Wall  . . . . .  75

5.2.4

Orbital Margins or Angles   .   75

5.2.4.1

Superior and Medial Margin 

75

5.2.4.2

Inferior and Medial Margin 

.  75

5.2.4.3

Superior and Lateral Margin 

76

5.2.4.4Inferior and Lateral Margin  . .  76

5.2.5Orbital Rim  . . . . . . . .   76

5.2.6Orbital Apex  . . . . . . . .  76

5.3

Orbital Periosteum  

. .

.

.   77

5.4

Orbital Contents  .

. .

.

. .  77

5.4.1Eyeball  . . . . . . . . . .   78

5.4.2Optic Nerve  . . . . . . . .  78

5.4.3

Orbital Muscles  . . . . . .   78

5.4.3.1Levator Muscle of the Upper Eyelid (Levator Palpebrae

Superioris Muscle)  .

.

.

.

.  78

5.4.3.2 Oculomotor Muscles 

.

.

.

.  79

5.4.3.3Supernumerary Muscles  . .   80

5.4.4

Muscular Fascias   .

. .

.

 

.   80

5.4.5

Main Lacrimal Gland 

.

.

.

.  81

5.4.6

Orbital Arteries  . .

. .

.

 

.   81

5.4.6.1

Ophthalmic Artery  .

.

.

.

.  81

5.4.6.2Infraorbital Artery  . . . . .   88

5.4.6.3Anastomosis Between

the Two Carotid Systems   . .  88

5.4.7Orbital Veins  . . . . . . . .  89

5.4.7.1 Superior Ophthalmic Vein  .   89

5.4.7.2Inferior Ophthalmic Vein  . . . .  89

5.4.7.3 Medial Ophthalmic Vein  . .   89

5.4.7.4Organization of Orbital

Venous Drainage  . . . . .   90

5.4.8Orbital Lymphatics  . . . . .  90

5.4.9Orbital Nerves  . . . . . . .  90

5.4.9.1Intraorbital Oculomotor

Nerves  . . . . . . . . . .   91

5.4.9.2Intraorbital Branches  

of the Trigeminal Nerve  . .   91

5.4.9.3Ciliary Ganglion  . . . . . . . . . . . .  92

5.4.10Orbital Fat  . . . . . . . . .  93

5.5Anatomical Orbital

Topography  . . . . . . . .  93

5.5.1

Intraconal Space   . . . .

.   93

5.5.2

Superior Extraconal Space 

.   94

5.5.3Lateral Extraconal Space  . .   94

5.5.4

Inferior Extraconal Space 

.

.  94

5.5.5

Medial Extraconal Space  

.

.  95

5.6Conclusions  . . . . . . . .  95

Chapter 6

Periocular Capillary Hemangioma: New Concepts in Natural History and Response to Glucocorticoids

David H. Verity, Geoffrey E. Rose

6.1Introduction  . . . . . . .   100

6.1.1Etiology  . . . . . . . . .   100

6.1.2Investigation  . . . . . . .  100

XII Contents

6.1.3Management  . . . . . . .  102

6.2New Insights into the Natural History

of Periorbital Capillary Hemangiomas  . . . . . .   103

6.2.1How Long and How Significant is the Growth Phase of Capillary

Hemangiomas?  . . . . . .  103

6.2.2What is the Nature

of Involution for Capillary Hemangiomas?  . . . . . .  104

6.2.3Do Capillary Hemangiomas

Undergo Complete

Involution?  . . . . . . . .  106

6.3Changes in Capillary Hemangiomas After Local

Steroid Therapy  . . . . . .  107

6.3.1Hemangioma Characteristics Associated with Need for Intervention  . . . . . . .   107

6.3.2Involutional Changes in Volume and Velocity  

After Steroid Therapy  . . .   107

6.4Conclusion  . . . . . . . .  108

Chapter 7

Venous-lymphatic Malformations

(Lymphangioma) of the Orbit:

Diagnostic and Therapeutic

Challenges

William R. Katowitz, Michael Kazim

7.1Introduction  . . . . . . .   113

7.2Classification  . . . . . . .  113

7.3Imaging  . . . . . . . . .   116

7.3.1Magnetic resonance

imaging  . . . . . . . . .   116

7.3.2

Computed Tomography  . .  116

7.4Histology  . . . . . . . . . . . . . . . . .  116

7.5Treatment  . . . . . . . .   117

7.5.1

Treatment Overview 

.

.

.   117

7.5.2

Systemic Steroids  .

. .

.

.  117

7.5.3Surgery  . . . . . . . . .   117

7.5.4

Laser Treatment  . . . . .   117

7.5.5Sclerotherapy   . . . . . .   117

7.5.5.1OK-432  . . . . . . . . . .  118

7.5.5.2Sodium Morrhuate  . . . .   118

7.5.5.3Other Agents  . . . . . . .  119

7.5.5.4Image-guided

Sclerotherapy  . . . . . .   119

7.6Future Treatment

Modalities  . . . . . . . .   119

Chapter 8

Thyroid-related Orbitopathy:

New Immunologic Concepts

and Future Implications

Raymond S. Douglas, Terry J. Smith

8.1Introduction  . . . . . . .   123

8.2Immunologic

Characterization  

of Disease Stages  . . . . .  123

8.2.1Inflammation and Hyaluronan

Accumulation  . . . . . .   123

8.2.2Resolution of Inflammation    124

8.3Autoimmune Target

Epitopes  . . . . . . . . .  124

8.3.1

Thyrotropin Receptor  . . .  124

8.3.2Insulin-like Growth Factor-1 Receptor  . . . . . . . . .  125

8.3.3

Additional Autoantigens  .   125

8.4Central Role

of Orbital Fibroblasts  . . .   126

8.4.1Inflammation   . . . . . .   126

8.4.2Extracellular Matrix

and Volume Expansion  . .   127

8.4.3Surface Molecule

Expression  . . . . . . . .  127

8.4.4Unique Capacity

to Differentiate  . . . . . .  128

8.5Impact of Environmental

and Genetic Factors   . . .   129

8.5.1Genetics   . . . . . . . . .  129

8.5.2Environment  . . . . . . .  129

8.6Therapeutic Implications   .   130

8.6.1Immune Subset Depletion     130

8.6.2Cytokine Therapies  . . . .   131

Chapter 9

Decompression Surgery for ThyroidRelated Orbitopathy: Status of

the Art and Unresolved Issues

Lelio Baldeschi

9.1 Introduction  . . . . . . .   144