- •Foreword
- •Preface
- •Contents
- •Contributors
- •Chapter 1
- •1.1 Introduction
- •1.2 Limitations of Time-Domain OCT
- •1.4 Conclusion
- •References
- •Chapter 2
- •2.1 Background
- •2.3 Clinical Application
- •2.4 Conclusions
- •References
- •Chapter 3
- •Fluorescein Angiography
- •3.1 Principles of Fluorescein Angiography
- •3.2 Procedures for Fluorescein Angiography
- •3.4 Time Course of Fluorescein Angiography
- •3.5 Interpretation of Fluorescein Angiography
- •3.5.1 Hypofluorescent Lesions
- •3.5.2 Hyperfluorescent Lesions
- •3.6 Fluorescein Angiography Today
- •References
- •Chapter 4
- •Wide-Field Imaging and Angiography
- •4.1 Introduction
- •4.2 History of Fundus Imaging
- •4.3.1 Fluorescein Angiography with a Scanning Laser Ophthalmoscope
- •4.3.2 Advantages of Imaging with a Scanning Laser Ophthalmoscope
- •4.4 Clinical Use of Wide-Field Imaging
- •4.4.1 Wide-Field Imaging in Uveitis
- •4.4.4 Wide-Field Imaging of Choroidal Tumors
- •4.5 Future Directions for Fundus Imaging
- •4.6 Conclusion
- •References
- •Chapter 5
- •Autofluorescence Imaging
- •5.1 Introduction
- •5.2 What is Fundus Autofluorescence?
- •5.3 Identification of Early Disease Stages
- •5.4 Phenotyping
- •5.5 Disease Markers
- •5.6 Monitoring of Disease Progression
- •5.7 Disease Mapping
- •5.8 Functional Correlation
- •References
- •Chapter 6
- •Imaging the Macular Pigment
- •6.1 Macular Pigment
- •6.1.1 Characteristics and Potential Functions
- •6.1.3 Spatial Distribution
- •6.1.4 Modifying the Macular Pigment
- •6.1.5 MPOD and Age
- •6.2 Measurement Techniques
- •6.2.1 Heterochromatic Flickerphotometry
- •6.2.2 Fundus reflectance
- •6.2.3 Autofluorescence
- •6.2.4 Raman spectroscopy
- •6.2.5 How do different techniques compare
- •6.3 Imaging
- •6.3.1 Heterochromatic Flickerphotometry
- •6.3.2 Fundus Reflectance
- •6.3.3 Autofluorescence
- •6.3.4 Raman spectroscopy
- •References
- •Chapter 7
- •7.1 Introduction
- •7.2 Origin of Near-Infrared Autofluorescence
- •7.3 RPE Melanin: Role and Aging
- •7.4 Clinical Cases
- •7.4.1 Age-Related Macular Degeneration
- •7.4.2 Retinal Dystrophies
- •7.4.2.1 Stargardt’s Disease
- •7.4.2.2 Best’s Disease
- •7.4.2.3 Retinitis Pigmentosa
- •7.5 Conclusion
- •References
- •Chapter 8
- •8.1 Introduction
- •8.3.1.1 Classic Choroidal Neovascularization
- •8.3.1.2 Occult Choroidal Neovascularization
- •8.3.1.4 Mixed-Type Choroidal Neovascularization
- •8.3.1.5 Retinal Angiomatous Proliferation
- •8.3.3 Fibrovascular Scar
- •8.5 Conclusions
- •References
- •Chapter 9
- •9.1 Fundus Cameras
- •9.1.1 Standard Images
- •9.1.2 Wide-Angle Images
- •9.1.2.1 Pomerantzeff Equator Plus
- •9.1.2.2 RetCam™
- •RetCam™ Camera Description
- •RetCam™ Technique of Image Capture
- •RetCam™ Problems
- •9.1.2.3 Panoret™
- •9.1.2.4 Optos™
- •9.2.1 Retinal Tumors
- •9.2.1.1 Retinoblastoma
- •9.2.1.2 Astrocytic Hamartoma
- •9.2.1.4 Retinal Cavernous Hemangioma
- •9.2.1.5 Retinal Racemose Hemangioma
- •9.2.1.6 Vasoproliferative Tumor
- •9.2.2 Retinal Pigment Epithelium Tumors
- •9.2.3 Choroidal Tumors
- •9.2.3.1 Choroidal Nevus
- •9.2.3.2 Choroidal Melanoma
- •9.2.4 Anterior Segment Lesions
- •9.2.4.1 Iris Lesions
- •References
- •Chapter 10
- •Metabolic Mapping
- •10.1 Aspects of Metabolism
- •10.4.1 Technical Solution
- •10.5 Clinical Results
- •10.5.1 Age-Related Macular Degeneration
- •10.5.1.1 Detection of Alterations in Early AMD
- •10.5.1.2 Lifetime Images in Late AMD
- •Non-Exudative AMD and Geographic Atrophy
- •Exudative AMD
- •10.5.2.1 Arterial Branch Occlusion
- •10.5.3 Metabolic Alteration in Diabetes Mellitus
- •10.5.3.1 Detection of Fields of Reduced Metabolism
- •References
- •Chapter 11
- •11.1 Diabetic Macular Edema
- •11.2 Examinations in Diabetic Macular Edema
- •11.3 Treatment of Diabetic Macular Edema
- •References
- •Chapter 12
- •12.1.1 Incidence and Natural History
- •12.2 Investigation of Diagnostic Accuracy of OCT for Detection of DME
- •12.2.2 Diagnostic Accuracy of OCT for Detection of DME: Are Photography or Biomicroscopy a Valid Gold Standard?
- •12.2.3 Diagnostic Accuracy of OCT to Detect CSME Using Time-Domain OCTs: How to Use OCT Retinal Thickness Cut-Offs?
- •12.3 Use of OCT When Compared with Photography: Beyond Diagnostic Accuracy
- •12.4 Appendix: Reproducibility of OCT Retinal-Thickness Measurement in Patients with DME
- •12.4.1 How Reproducibility is Reported
- •12.4.3 Spectral-Domain OCTs Reproducibility
- •References
- •Chapter 13
- •13.2 Clinical Features
- •13.3 Examination
- •13.4 Natural History
- •13.5 Ultra-High Resolution OCT and Spectral OCT Findings in Macular Holes
- •13.6 Macular Hole Formation
- •13.7 Postoperative Appearance
- •13.8 Theory of Macular Hole Closure After Vitrectomy
- •13.9 Surgical Considerations
- •13.11 Clinical Features
- •13.12 Treatment
- •References
- •Chapter 14
- •14.1 Introduction
- •14.2 Vitreous Biochemistry
- •14.3 Vitreo-Retinal Interface Anatomy
- •14.4 Anomalous Posterior Vitreous Detachment (PVD)
- •14.5 Spectral-Domain OCT (SD-OCT)
- •14.6 Vitreo-Maculopathies
- •14.6.1 Macular Pucker (MP)
- •14.6.2 Macular Hole (MH)
- •14.6.2.1 Lamellar Hole (LH)
- •14.6.3 Age-Related Macular Degeneration (AMD)
- •14.6.4 Vitreo-Macular Traction Syndrome (VMTS)
- •14.7 Conclusion
- •References
- •Chapter 15
- •15.3 Imaging the Choroid
- •15.4 Age-Related Choroidal Atrophy
- •15.5 Choroid in High Myopia
- •15.8 Volume Rendering
- •15.9 Summary
- •References
- •Chapter 16
- •16.1 Introduction
- •16.2 Optical Coherence Tomography
- •16.3 Role of Optical Coherence Tomography
- •References
- •Chapter 17
- •17.1 Background and Motivation
- •17.2 Three-Dimensional Imaging of the Choroid
- •17.3 In Vivo Cellular Resolution Retinal Imaging
- •17.4 Polarization Sensitive Retinal OCT
- •17.5 Doppler (Blood Flow) Retinal OCT
- •References
- •Chapter 18
- •Toward Molecular Imaging
- •Summaries for the Clinician
- •References
- •Index
Chapter 9 |
|
RetCam™ Imaging of Pediatric |
9 |
Intraocular Tumors1 |
Carol L. Shields, Aparna Ramasubramanian, Sarah Harmon, and Sara Lally
Core Messages
■Photographic imaging of the pediatric fundus can be performed with one of several cameras, including noncontact imaging devices such as standard 30, 45, 50, and 60 cameras or Optos™, or they can be imaged with contact systems using RetCam™ or Panoret™.
■RetCam™ imaging depends on a light source that emanates from the lens handpiece.
■RetCam™ can provide a 30˚, 80˚, 120˚, or 130˚ image of the retina or even a full face portrait depending on the lens employed.
■RetCam™ can provide high-resolution wide-angle fluorescein angiography images using an appropriate filter.
■RetCam™ can provide gonioscopic images using the standard lens, contact gel, and defocusing to the front of the eye.
■RetCam™ can provide anterior segment images of the conjunctiva, cornea, or iris with removal of the lens.
■RetCam™ is usually performed with the child under anesthesia, but can be performed in the office with secure child restraint, topical anesthesia, and eyelid speculum.
■Ideal fundus images with RetCam™ are obtained in young children with wide dilation and without crystalline lens or media opacity.
■Poor fundus images with RetCam™ are the result of inadequate dilation leading to poor transmission of light and a central dark spot on imaging. Media opacity in the cornea, lens, or vitreous precludes sufficient light transmission for fundus illumination and results in poor image. Reflections off intraocular lens cause substantial glare and poor image.
9.1 Fundus Cameras
Imaging of the ocular fundus is important for documentation of numerous retinal and choroidal conditions. Fundus photography is especially important for documentation of intraocular tumors in children and adults. Photograph can be used to judge tumor size and extent, related features, and quantify response following therapy. However, fundus photography can be especially challenging in children because of the lack of cooperation for a
1Support provided by the Retina Research Foundation of the Retina Society in Cape Town, South Africa, a donation from Michael, Bruce, and Ellen Ratner, New York, NY, Mellon Charitable Giving from the Martha W. Rogers Charitable Trust, Philadelphia, PA, the LuEsther Mertz Retina Research Foundation, New York, NY, and the Eye Tumor Research Foundation, Philadelphia, PA.
still photograph of the interior of the eye. Most fundus photography on young children, under the age of 5 years, is performed in the operating suite with the child under general anesthesia.
One important limiting factor of fundus imaging is adequate fundus illumination. The small pupillary aperture, even when fully dilated, can inhibit adequate illumination of the interior of the eye for image capture. In most photographic systems, transpupillary light transmission is employed, where the light is aimed through the pupil, whereas in other systems, transcleral light transmission is used, where a brilliant light source is directed through the sclera. There are currently several fundus imaging systems available for children, most of which use transpupillary illumination techniques, and include standard fundus photography, RetCam™, and Optos™ imaging. Those that use the transcleral technique include Pomerantzeff and Panoret™ systems. Other considerations for fundus imaging
