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268

Chapter 9

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60. Yoshi M, Murakami A, Akeo K, Nakamura A, Shimoyama M, Ikeda Y, Kikuchi Y, Okisaka S, Yanashima K, Oguchi Y. Visual function and gene analysis in a family with Oguchi’s disease. Ophthalmic Res 1998; 30:394–401.

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10

Macular Disorders

A number of retinal disorders preferentially involve the macula or have distinct macular characteristics. Electrophysiologically, the multifocal ERG provides topographical information and is a useful objective measure of macular function. Although the focal ERG can also assess macular dysfunction, the popularity and availability of focal ERG are diminished with advances in multifocal ERG. An isolated macular lesion is unlikely to reduce the overall ERG response enough to affect the full-field ERG, but in some ‘‘macular’’ conditions such as cone dystrophy and X-linked retinoschisis, the fullfield ERG is still needed diagnostically to determine diffuse retinal abnormalities. The pattern ERG is dominated by macular-related activity but provides no topographical information. Likewise, the VEP is dominated by activity from the central visual field but an impaired VEP may be produced by a deficit anywhere along the visual pathway including the retina, optic nerve, and brain. This chapter discusses the utility of electrophysiologic tests in diseases that may be categorized as ‘‘macular disorders.’’ The conditions covered are:

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