Ординатура / Офтальмология / Английские материалы / Electrodiagnosis of Retinal Disease_Miyake_2005

Yozo Miyake

Electrodiagnosis of Retinal Diseases

Yozo Miyake

Electrodiagnosis of

Retinal Diseases

With 258 Figures, Including 93 in Color

Yozo Miyake

Professor Emeritus, Nagoya University

Head of the National Institute of Sensory Organs National Hospital Organization Tokyo Medical Center 2-5-1 Higashigaoka, Meguro-ku, Tokyo 152-8902, Japan

Library of Congress Control Number: 2005932804

ISBN-10 4-431-25466-8 Springer-Verlag Tokyo Berlin Heidelberg New York ISBN-13 978-4-431-25466-9 Springer-Verlag Tokyo Berlin Heidelberg New York

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Preface

Soon it will be time for me to retire from my position as professor of ophthalmology in the Department of Ophthalmology, Nagoya University School of Medicine. I have therefore decided to summarize my experience of more than 30 years of studies on the clinical electrophysiology of vision. These studies were performed in our department through the hard work and good ideas of many co-workers, and the chapters of this book cover the rationale and results of our studies. Because excellent textbooks on clinical electroretinography already exist, my wish is not to write another textbook; instead, this book is in the form of essays that include my beliefs and philosophy on the clinical electrophysiology of vision. As such, this book does not include every clinical disease but only those that we have identified or studied in detail.

In addition to full-field electroretinography (ERG), we developed the techniques and instrumentation to record focal macular ERG more than two decades ago. Using these techniques, we were able to determine several new physiological properties of the normal macula, many new pathophysiological mechanisms of known diseases, and some new clinical entities with unique functional properties.

Fortunately, the recent advances of macular surgery and imaging are such that the macular configuration can easily be determined. During the process of surgery, we have obtained considerable information on the correlation of macular function and macular morphology using focal macular ERGs and optical coherence tomography (OCT). The development of multifocal ERGs followed our focal macular ERGs, and this technique has allowed the objective examination of macular function throughout the world.

There has been no similar occasion in the past where the advancement of technology has allowed us to discover such correlations and, more importantly, to determine the mechanisms for many retinal diseases. As one who has dedicated his life to this area, I hope that this book will inspire young researchers and clinicians to enjoy the pleasure and fulfillment that can come from studying the retina. Most importantly, there are many more challenges that have to be taken on and conquered.

Yozo Miyake

Nagoya

March 2005

Acknowledgments

There are many people who have helped make this book a reality; however, some merit special attention. Dr. Hiroko Terasaki has contributed very much with her skills in the new surgical procedures and in psychophysical measurements in normal subjects and patients with retinal diseases who underwent retinal surgery. Dr. Mineo Kondo has always been with me to analyze the clinical data and to perform the animal experiments during the past 10 years. Dr. Masayuki Horiguchi worked with me for a long time before he moved to Fujita Health University as chairman and professor of the Department of Ophthalmology. He had many unique ideas and contributed greatly to our studies. Dr. Yoshihiro Hotta opened a new field of molecular genetics in our department and Dr. Makoto Nakamura has provided important molecular genetic data of our patients. It would not have been possible to complete this book without the invaluable contribution of these investigators.

Special thanks go to Dr. Tatsuo Hirose of Boston,who was a great inspiration to me and who also pointed out the importance of focal macular ERGs when I was a young investigator. I learned basic retinal electrophysiology from Dr. Genyo Mitarai in Nagoya, and he has been an important teacher in my life.

Finally, I would like to express my sincere gratitude to Dr. Duco Hamasaki of Miami, my close friend, for his kind revision and many valuable suggestions regarding the English content of this book. During the past 10 years, he has made an enormous contribution to Japanese ophthalmology by revising many manuscripts written by Japanese investigators that eventually were published in English journals. On behalf of the Japanese Society of Ophthalmology, I would like to thank him again.

Yozo Miyake

Contents

Preface V

Acknowledgments VII

1

2

Hereditary Retinal and Allied Diseases 43