Contents
Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
v |
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Elia J. Duh |
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Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
ix |
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PART I CLINICAL ASPECTS OF DIABETIC RETINOPATHY |
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1 |
Nonproliferative Diabetic Retinopathy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
3 |
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Catherine B. Meyerle, Emily Y. Chew, and Frederick L. Ferris III |
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2 |
Proliferative Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
29 |
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Ronald P. Danis and Matthew D. Davis |
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3 |
The Epidemiology of Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . |
67 |
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Ronald Klein |
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4 |
Diagnostic Modalities in Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . |
109 |
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Ron Margolis and Peter K. Kaiser |
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PART II PATHOPHYSIOLOGY / BASIC RESEARCH |
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5 |
In Vivo Models of Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
137 |
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Timothy S. Kern |
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A PATHWAYS OF HYPERGLYCEMIA-INDUCED DAMAGE |
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6 |
The Polyol Pathway and Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . |
159 |
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Mara Lorenzi and Peter J. Oates |
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7 |
The Role of Advanced Glycation in Diabetic Retinopathy . . . . . . . . . . . . . . |
187 |
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Alan W. Stitt |
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8 |
The Role of Protein Kinase C in Diabetic Retinopathy . . . . . . . . . . . . . . . . . |
207 |
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Manvi Prakash, Jennifer K. Sun, and George L. King |
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9 |
Oxidative Stress in Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
217 |
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Ruth B. Caldwell, Azza E.B. El-Remessy, and Robert W. Caldwell |
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B PATHOPHYSIOLOGICAL PROCESS IN DIABETIC RETINOPATHY |
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10 |
Pericyte Loss in the Diabetic Retina. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . |
245 |
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Frederick Pfister, Yuxi Feng, and Hans-Peter Hammes |
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vii
viii |
Contents |
11 Capillary Dropout in Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . 265
Renu A. Kowluru and Pooi-See Chan
12 Neuroglial Dysfunction in Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . 283
Heather D. VanGuilder, Thomas W. Gardner, and Alistair J. Barber
13 The Role of Inflammation in the Pathophysiology
of Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 303
Lauren E. Swenarchuk, Linda E. Whetter, and Anthony P. Adamis
14 Vascular Permeability in Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . 333
David A. Antonetti, Heather D. VanGuilder, and Cheng Mao-Lin
15 Retinal Neovascularization and the Role of VEGF . . . . . . . . . . . . . . . . . . . . 353
Elia J. Duh
16Beyond VEGF – Other Factors Important
in Retinal Neovascularization: Potential Targets
in Proliferative Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 375
Arup Das, Deepti Navaratna, and Paul G. McGuire
PART III EMERGING TREATMENTS AND CONCEPTS IN DIABETIC RETINOPATHY
17 Anti-VEGF Therapy as an Emerging Treatment
for Diabetic Retinopathy. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 401
Diana V. Do, Julia A. Haller, Anthony P. Adamis,
Carla Striata, Quan Dong Nguyen, Syed Mahmood Shah, and Antonia M. Joussen
18 Clinical Trials in Protein Kinase C-β Inhibition in Diabetic Retinopathy . . . 423
Jennifer K. Sun, Rola Hamam, and Lloyd P. Aiello
19 The Role of Intravitreal Steroids in the Management
of Diabetic Retinopathy . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 435
Mark C. Gillies
20 Antagonism of the Growth Hormone
Axis as a Therapeutic Strategy for Diabetic Retinopathy. . . . . . . . . . . . . . . . 449
Alexander V. Ljubimov, Michael Boulton, Sergio Caballero, and Maria B. Grant
21 Diabetic Retinopathy and Systemic Complications . . . . . . . . . . . . . . . . . . . . 466
Ning Cheung and Tien Y. Wong
Name Index. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 483
Subject Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 489