Ординатура / Офтальмология / Английские материалы / Automated Image Detection of Retinal Pathology_Jelinek, Cree_2009
.pdf
(a) |
|
(b) |
(c) |
|
(d) |
Figure 2.2
Nonproliferative diabetic retinopathy (NPDR). (a) Moderate NPDR and severe diabetic macular edema; hard exudates involve the center of the macula. (b) Moderate NPDR; microaneurysms/dot hemorrhages, hard exudate (ring) and cotton wool spots.
(c) Severe NPDR; > 20 intraretinal hemorrhages in four quadrants (three shown here) and IRMA (possibly NVE). Biomicroscopy showed the latter lesion to be intraretinal, hence it is IRMA. (d) Venous beading.
(a) |
|
(b) |
(c) |
|
(d) |
Figure 2.3
Proliferative diabetic retinopathy (PDR) (a) PDR with moderate diabetic macular edema. There are new vessels disc, new vessels elsewhere, IRMA, blotchy hemorrhages, microaneurysms/dot hemorrhages, and hard exudates. Hard exudate approach the center of the macula. Pan retinal photocoagulation scars are seen in the top left and top and bottom far right. (b) New vessels elsewhere. (c) PDR with preretinal hemorrhage. Hemorrhage is contained within the space between the retina and the posterior vitreous face. The hemorrhage obscures the retinal new vessels. (d) Fibrous proliferation with traction macular detachment. PDR has regressed. Regressed fibro-vascular tissue along the inferior temporal vascular arcade has contracted causing traction macular detachment. Traction lines can be seen extending into the central macula.
Figure 5.1
The outline of the proposed system for automatic identification of retinal exudates and the optic disc in color retinal images.
|
|
(a) Reference image |
(b) Typical retinal image |
(c) Color normalized version |
(d) After contrast enhancement |
Figure 5.3
Color normalization and local contrast enhancement.
(a) Original image |
(b) Ground truth |
(c) T = 0.3 |
(d) Superposition of |
|
|
|
(b) and (c) |
(e) T = 0.5 |
(f) Superposition of |
(g) T = 0.7 |
(h) Superposition of |
|
(b) and (c) |
|
(b) and (g) |
Figure 5.4
Pixel-level exudate recognition application on a retinal image using different ratio of exudate and nonexudate prior probabilities. The identified exudates are shown in blue and TPs are in white.
(a) Original image |
(b) Gray morphology |
(c) L morphology |
(d) HLS (L first) |
(e) L Ch |
(f) Lab |
Figure 5.6
Mathematical morphology closing in different color spaces.
(a) A typical optic disc |
(b) After color mor- |
(c) Lightness image |
(d) Gray-level mor- |
image |
phology |
|
phology closing |
|
|
|
|
(e) Gradient image ob- |
(f) Gradient image ob- |
tained from lightness |
tained from gray-level |
image |
morphology closing. |
Figure 5.7
A comparison between color morphology and gray-level morphology.
(a) A typical retinal |
(b) Vessel elimina- |
(c) Initial snake |
(d) Final snake |
image |
tion in Lab |
|
|
|
|
|
|
(e) Close-up of |
(f) Lab closing of |
(g) Close-up of |
(h) Close-up of |
(i) Overlay of |
optic disc region |
optic disc region |
final snake |
hand-drawn |
(g) and (h) |
|
|
|
ground truth |
|
Figure 5.8
Optic disc localization results.
Figure 6.2
Color normalization of retinal images. Top: color retinal images of a Caucasian and a Polynesian. Bottom: color normalized version of the image directly above.
A
B C
Retinal Vessel Analysis Control
|
Arterioles |
|
Venules |
|
Unknown |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IMAGE: Example Image.tif |
||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Angle |
|
Width |
|
Sigma |
|
|
|
|
ADJUST IMAGE |
|
|
|
|
|
|
|
|
|
|
|
|
APPROVE - NEXT |
|
||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
|
019 |
|
|
|
081.62 |
|
004.80 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
|
|
|
|
|
|
|
|
|
|
< |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
> |
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
APPROVE W/COMMENT - NEXT |
|
||||
|
|
2 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
ZOOM |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|||||||||||||||||||||||||||||||||
|
|
|
096 |
|
|
|
045.89 |
|
|
006.92 |
|
|
|
|
|
|
|
|
|
|
|
|
reset |
|
|
|
|
|
|
|
|
|
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
SKIP - NEXT |
|
||
|
|
3 |
|
103 |
|
|
|
043.84 |
|
|
003.22 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
4 |
|
184 |
|
|
|
083.77 |
|
|
003.03 |
|
Change |
|
|
|
Gray Color |
|
|
|
|
|
|
|
|
|
|
REJECT - NEXT |
|||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CHANGE PARAMS |
|
||||||
|
|
5 |
|
225 |
|
|
|
076.04 |
|
|
005.53 |
|
Change |
|
|
|
|
Contrast |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||||||
|
|
|
273 |
|
|
|
051.26 |
|
|
004.29 |
|
|
|
|
|
Splats |
Fine |
|
|
|
|
|
|
|
|
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
322 |
|
|
|
074.43 |
|
004.04 |
|
|
|
|
|
Full Image |
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
8 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Adjust Overlay |
|
|
|
|
|
|
|
|
|||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vessel Trace |
|
|
|
|
|
|
|
|
||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
10 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Show Zones |
|
|
|
|
|
|
|
|
||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
MANUAL OPERATIONS |
|
|
|
|
|
|
|
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Calculate |
|
|
|||||||||||||||||||
|
|
12 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Move Disk |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Add Vein Seed |
|
|
|
Width |
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
14 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Add Artery Seed |
Width |
|||||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
15 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Draw Vein |
|
|
|
|
|
|
|
|
||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
16 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
Draw Artery |
|
|
|
|
|
|
|
|
|
|
|
|||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Drawing Instructions: |
|
|
|
|
|
|
|
|
|
||||||||||||||||
|
|
17 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
18 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Figure 7.A.2
Secondary monitor — control panel (in arteriole view). The labels are: (A) angle of vessel in degrees, (B) mean width, and (C) standard deviation (sigma).
Retinal Vessel Analysis Image Display
|
|
V9 |
A1 |
|
|
V1 |
|
A9 |
V8 |
|
|
|
A2 |
V2
A8
V7
A7
V3
A6 |
V6 |
V4 |
|
|
A3 |
|
A5 |
A4 |
|
|
V5 |
Figure 7.A.3
Automated display before grader interaction.
Retinal Vessel Analysis Image Display
|
|
V9 |
A1 |
|
|
V1 |
|
A9 |
V8 |
|
|
|
A2 |
V2
A8
V7
A7
V3
A6 |
V6 |
V4 |
|
|
A3 |
|
A5 |
A4 |
|
|
V5 |
Figure 7.A.4
Completed grading with grader interaction.
Retinal Vessel Analysis Control
Arterioles Venules Unknown |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
IMAGE: Example Image.tif |
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
APPROVE - NEXT |
|
|||||||||||||||
|
|
|
|
Angle |
Width |
Sigma |
|
|
ADJUST IMAGE |
|
|
|
|
|
|||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
1 |
019 |
081.62 |
004.80 |
|
Change |
< |
|
|
|
|
|
|
> |
|
|
|
|
APPROVE W/COMMENT - NEXT |
|
|||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
|
2 |
096 |
045.89 |
006.92 |
|
Change |
|
|
|
|
|
ZOOM |
|
reset |
|
|
|
|
SKIP - NEXT |
|
|||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
3 |
103 |
043.84 |
003.22 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
REJECT - NEXT |
|
||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||
|
|
|
|
|
|
|
|
|
|
|
Gray Color |
|
|
|
|
|
|||||||||||||||
|
4 |
184 |
083.77 |
003.03 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CHANGE PARAMS |
|
||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
5 |
225 |
076.04 |
005.53 |
|
Change |
|
|
|
Contrast |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
6 |
273 |
051.26 |
004.29 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
Splats |
|
Fine |
|
|
|
|
|
|
|
|||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
7 |
322 |
074.43 |
004.04 |
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||
|
|
|
Full Image |
|
|
|
|
|
|
|
|||||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||
|
8 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
|
|
|
|
|
Adjust Overlay |
|
|
|
|
|
|
|
||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
9 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vessel Trace |
|
|
|
|
|
|
|
|
|
|
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
10 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||
|
|
|
|
|
|
|
|
Show Zones |
|
|
|
|
|
|
|
||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
11 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
MANUAL OPERATIONS |
|
|
|
|
|
Calculate |
|
||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||||||
|
12 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
|
Move Disk |
|
|
|
|
|
|
|
|
|
|
||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
13 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Paired: |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Add Vein Seed |
|
|
|
Width |
|
|
|
CRAE=141.17 |
|
|||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||
|
14 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CRVE=207.12 |
|
|
|
|
|
|
|
|
|
|
|
Add Artery Seed |
|
Width |
|
|||||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
AVR=0.682 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Parr-Hubbard |
|
|
15 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||
|
|
|
|
|
|
|
|
|
|
Draw Vein |
|
|
|
|
|
||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CRAE=136.14 |
|
|||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CRVE=300.32 |
|
|
16 |
|
|
|
|
|
Change |
|
|
|
|
Draw Artery |
|
|
|
|
|
|
|
|
|
||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
AVR=0.453 |
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Big 6 |
|
|
|
|
|
|
|
|
|
|
|
Drawing Instructions: |
|
|
|
|
|
|
|||||||||||||||
|
17 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
CRAE=122.74 |
|
|||||||||||||||||
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
CRVE=204.75 |
|
|
18 |
|
|
|
|
|
Change |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
AVR=0.599 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
C D
E
A
B
Figure 7.A.5
Control panel view after calculation. The labels are: (A) Calculate button, (B) Results panel, (C) APPROVE, (D) APPROVE W/COMMENT, and (E) REJECT.
(a) |
(b) |
(c) |
(d) |
(e) |
(f ) |
Figure 8.6
Images from the DRIVE and STARE databases and their respective manual segmentations: (a) normal image from the test set of the DRIVE database; (b) manual segmentation from set A; (c) manual segmentation from set B; (d) normal image from the STARE database; (e) manual segmentation by the first observer; and (f) manual segmentation by the second observer.
