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Ординатура / Офтальмология / Английские материалы / Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care _Ying_2011

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AGE RELATED MACULAR DEGENERATION – THE RECENT ADVANCES IN BASIC RESEARCH AND CLINICAL CARE

Edited by Gui Shuang Ying

Age Related Macular Degeneration –

The Recent Advances in Basic Research and Clinical Care

Edited by Gui-Shuang Ying

Published by InTech

Janeza Trdine 9, 51000 Rijeka, Croatia

Copyright © 2011 InTech

All chapters are Open Access distributed under the Creative Commons Attribution 3.0 license, which allows users to download, copy and build upon published articles even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. After this work has been published by InTech, authors have the right to republish it, in whole or part, in any publication of which they are the author, and to make other personal use of the work. Any republication, referencing or personal use of the work must explicitly identify the original source.

As for readers, this license allows users to download, copy and build upon published chapters even for commercial purposes, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications.

Notice

Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book.

Publishing Process Manager Iva Simcic

Technical Editor Teodora Smiljanic

Cover Designer InTech Design Team

First published January, 2012

Printed in Croatia

A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org

Age Related Macular Degeneration –

The Recent Advances in Basic Research and Clinical Care, Edited by Gui-Shuang Ying p. cm.

ISBN 978-953-307-864-9

free online editions of InTech Books and Journals can be found at www.intechopen.com

Contents

 

Preface IX

 

 

Part 1

Basic and Translational Research 1

 

 

Chapter 1

Wet Age Related Macular Degeneration 3

 

 

 

Fardad Afshari, Chris Jacobs, James Fawcett and Keith Martin

 

Chapter 2

Pathogenic Roles of Sterile Inflammation in

 

 

 

Etiology of Age-Related Macular Degeneration

25

 

 

Suofu Qin

 

 

Chapter 3

Bruch’s Membrane:

 

 

 

The Critical Boundary in Macular Degeneration

49

 

 

Robert F. Mullins and Elliott H. Sohn

 

 

Chapter 4

Non-Enzymatic Post-Translational Modifications in

 

 

the Development of Age-Related Macular Degeneration

73

 

Yuichi Kaji, Tetsuro Oshika and Noriko Fujii

 

 

Chapter 5

Experimental Treatments for

 

 

 

Neovascular Age-Related Macular Degeneration

83

 

 

C. V. Regatieri, J. L. Dreyfuss and H. B. Nader

 

 

Chapter 6

Basic Research and

 

 

 

Clinical Application of Drug Delivery Systems

 

 

 

for the Treatment of Age-Related Macular Degeneration

99

 

Giuseppe Lo Giudice and Alessandro Galan

 

 

Part 2

Clinical Research 121

 

 

Chapter 7

Treatment of Neovascular

 

 

 

Age Related Macular Degeneration 123

 

 

 

Ratimir Lazić and Nikica Gabrić

 

 

Chapter 8

Re-Treatment Strategies for

 

 

 

Neovascular AMD: When to Treat? When to Stop? 143

 

 

Sengul Ozdek and Mehmet Cuneyt Ozmen

 

 

VI Contents

Chapter 9 Combined Therapies to

Treat CNV in AMD: PDT + Anti-VEGF 161

Jorge Mataix, M. Carmen Desco, Elena Palacios and Amparo Navea

Chapter 10 Nutritional Supplement Use and

 

Age-Related Macular Degeneration 185

 

 

Amy C. Y. Lo and Ian Y. Wong

 

Chapter 11 Two-Photon Excitation

 

 

Photodynamic Therapy: Working Toward a New

 

Treatment for Wet Age-Related Macular Degeneration 213

 

Ira Probodh and David Thomas Cramb

 

Chapter 12

Clinical Application of

 

 

Drug Delivery Systems for Treating AMD

227

 

Noriyuki Kuno and Shinobu Fujii

 

Chapter 13

Use of OCT Imaging in the Diagnosis and

 

 

Monitoring of Age Related Macular Degeneration 253

 

Simona-Delia Ţălu and Ştefan Ţălu

 

Chapter 14

Treatments of Dry AMD 273

 

 

George C. Y. Chiou

 

Chapter 15

Promising Treatment Strategies

 

 

for Neovascular AMD: Anti-VEGF Therapy

289

 

Young Gun Park, Hyun Wook Ryu,

 

 

Seungbum Kang and Young Jung Roh

 

Preface

In the past decade, great progress has been made in understanding the pathobiology and genetics of Age Related Macular Degeneration (AMD), and the effective therapies for this blinding disease have become available. These advancements have lead to the substantial change in the management of AMD patients. The online book Age Related Macular Degeneration – The Recent Advances in Basic Research and Clinical Care presents the most recent advances in basic research and clinical care of AMD. Different from other AMD books, this book aims to cover the new findings from basic and translational research on the biological and genetic mechanism of AMD, and the new interventions to prevent and treat this disease.

The book has a total of 15 chapters, grouped into two sections. Section one includes six chapters covering the basic and translational research of AMD. Section two includes nine chapters describing the clinical research and management of AMD. Each chapter has been contributed to by outstanding researchers or clinicians in the area of AMD. They present a very detailed review of new research and findings in the topic specific AMD area, and also provide direction for future research. The book is targeted at researchers and clinicians who are interested in learning about new advances in the understanding and treatment of AMD, and insights into future research of AMD.

We hope that this AMD book will provide the latest information to its readers. The large amount of information presented in this book will help clinicians to take best care of their AMD patients. Additionally, it will assist researchers in conducting further AMD research and, eventually, achieve the goal of finding effective and safe ways to prevent or treat AMD.

Gui Shuang Ying, PhD

Assistant Professor of Ophthalmology

University of Pennsylvania, Perelman School of Medicine

Philadelphia, PA

USA