Ординатура / Офтальмология / Английские материалы / Age Related Macular Degeneration - The Recent Advances in Basic Research and Clinical Care _Ying_2011
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AGE RELATED MACULAR DEGENERATION – THE RECENT ADVANCES IN BASIC RESEARCH AND CLINICAL CARE
Edited by Gui Shuang Ying
Age Related Macular Degeneration –
The Recent Advances in Basic Research and Clinical Care
Edited by Gui-Shuang Ying
Published by InTech
Janeza Trdine 9, 51000 Rijeka, Croatia
Copyright © 2011 InTech
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Notice
Statements and opinions expressed in the chapters are these of the individual contributors and not necessarily those of the editors or publisher. No responsibility is accepted for the accuracy of information contained in the published chapters. The publisher assumes no responsibility for any damage or injury to persons or property arising out of the use of any materials, instructions, methods or ideas contained in the book.
Publishing Process Manager Iva Simcic
Technical Editor Teodora Smiljanic
Cover Designer InTech Design Team
First published January, 2012
Printed in Croatia
A free online edition of this book is available at www.intechopen.com Additional hard copies can be obtained from orders@intechweb.org
Age Related Macular Degeneration –
The Recent Advances in Basic Research and Clinical Care, Edited by Gui-Shuang Ying p. cm.
ISBN 978-953-307-864-9
free online editions of InTech Books and Journals can be found at www.intechopen.com
Contents
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Preface IX |
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Part 1 |
Basic and Translational Research 1 |
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Chapter 1 |
Wet Age Related Macular Degeneration 3 |
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Fardad Afshari, Chris Jacobs, James Fawcett and Keith Martin |
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Chapter 2 |
Pathogenic Roles of Sterile Inflammation in |
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Etiology of Age-Related Macular Degeneration |
25 |
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Suofu Qin |
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Chapter 3 |
Bruch’s Membrane: |
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The Critical Boundary in Macular Degeneration |
49 |
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Robert F. Mullins and Elliott H. Sohn |
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Chapter 4 |
Non-Enzymatic Post-Translational Modifications in |
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the Development of Age-Related Macular Degeneration |
73 |
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Yuichi Kaji, Tetsuro Oshika and Noriko Fujii |
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Chapter 5 |
Experimental Treatments for |
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Neovascular Age-Related Macular Degeneration |
83 |
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C. V. Regatieri, J. L. Dreyfuss and H. B. Nader |
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Chapter 6 |
Basic Research and |
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Clinical Application of Drug Delivery Systems |
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for the Treatment of Age-Related Macular Degeneration |
99 |
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Giuseppe Lo Giudice and Alessandro Galan |
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Part 2 |
Clinical Research 121 |
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Chapter 7 |
Treatment of Neovascular |
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Age Related Macular Degeneration 123 |
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Ratimir Lazić and Nikica Gabrić |
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Chapter 8 |
Re-Treatment Strategies for |
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Neovascular AMD: When to Treat? When to Stop? 143 |
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Sengul Ozdek and Mehmet Cuneyt Ozmen |
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VI Contents
Chapter 9 Combined Therapies to
Treat CNV in AMD: PDT + Anti-VEGF 161
Jorge Mataix, M. Carmen Desco, Elena Palacios and Amparo Navea
Chapter 10 Nutritional Supplement Use and
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Age-Related Macular Degeneration 185 |
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Amy C. Y. Lo and Ian Y. Wong |
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Chapter 11 Two-Photon Excitation |
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Photodynamic Therapy: Working Toward a New |
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Treatment for Wet Age-Related Macular Degeneration 213 |
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Ira Probodh and David Thomas Cramb |
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Chapter 12 |
Clinical Application of |
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Drug Delivery Systems for Treating AMD |
227 |
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Noriyuki Kuno and Shinobu Fujii |
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Chapter 13 |
Use of OCT Imaging in the Diagnosis and |
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Monitoring of Age Related Macular Degeneration 253 |
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Simona-Delia Ţălu and Ştefan Ţălu |
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Chapter 14 |
Treatments of Dry AMD 273 |
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George C. Y. Chiou |
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Chapter 15 |
Promising Treatment Strategies |
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for Neovascular AMD: Anti-VEGF Therapy |
289 |
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Young Gun Park, Hyun Wook Ryu, |
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Seungbum Kang and Young Jung Roh |
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Preface
In the past decade, great progress has been made in understanding the pathobiology and genetics of Age Related Macular Degeneration (AMD), and the effective therapies for this blinding disease have become available. These advancements have lead to the substantial change in the management of AMD patients. The online book Age Related Macular Degeneration – The Recent Advances in Basic Research and Clinical Care presents the most recent advances in basic research and clinical care of AMD. Different from other AMD books, this book aims to cover the new findings from basic and translational research on the biological and genetic mechanism of AMD, and the new interventions to prevent and treat this disease.
The book has a total of 15 chapters, grouped into two sections. Section one includes six chapters covering the basic and translational research of AMD. Section two includes nine chapters describing the clinical research and management of AMD. Each chapter has been contributed to by outstanding researchers or clinicians in the area of AMD. They present a very detailed review of new research and findings in the topic specific AMD area, and also provide direction for future research. The book is targeted at researchers and clinicians who are interested in learning about new advances in the understanding and treatment of AMD, and insights into future research of AMD.
We hope that this AMD book will provide the latest information to its readers. The large amount of information presented in this book will help clinicians to take best care of their AMD patients. Additionally, it will assist researchers in conducting further AMD research and, eventually, achieve the goal of finding effective and safe ways to prevent or treat AMD.
Gui Shuang Ying, PhD
Assistant Professor of Ophthalmology
University of Pennsylvania, Perelman School of Medicine
Philadelphia, PA
USA
