41 The Morphology of Adenovirus Epithelial Keratitis

Adenovirus Cytopathic E ect in Cell Cultures

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b

Fig. 1.1 (a, b) Cell cultures showing CPE caused by Ad8: (a) cell swelling and rounding (arrowhead) and cell-devoid areas (arrow) caused by cell disappearance, and (b) clumping of rounded/swollen cells (arrowhead). (Ad 589, human lung cell carcinoma)

Comment

Th e adenovirus in vitro CPE does not have any clearly discernible in vivo counterpart; in vivo, a loss of substance does not occur, and the nature of the rounded/abnormal cells (cf. Fig. 1.2, opposite page) is unclear.