*Antimicrobial agents *2*48*4*

#466

*!The mechanism of isoniazid action is

*blocking enzymes - metabolic disorder of mycobacteria

* violation protein synthesis at the level of the ribosome

* violation the permeability of the cytoplasmic membrane

* ++violation synthesis of mycolic acids

* competitive antagonism with PABA

#467

* Amoebocyte that effective at any location of amoebas is

*chiniofon

*tetracycline

*++metronidazole

*emetine hydrochloride

*chingamine

#468

*!Indication for use of nitrofurans is

  *tuberculosis

  *herpes

*malaria

*AIDS

*++salmonellosis

#469

*!Antibiotic for the treatment of plague, tularemia, brucellosis is

*erythromycin

*penicillin

*cefazolin

*polymyxin

*++streptomycin

#470

*!The mechanism of mebendazole anthelminthic action is

*++inhibition glucose utilization of worms and paralyzes them

*inhibition fumarate reductase and disturbs the metabolism of helminths

*inhibition oxidative phosphorylation in helminths and paralyzes them

*inhibition cholinesterase and disrupts neuromuscular transmission

*violation the synthesis of nucleic acids

#471

*!When treating tuberculosis streptomycin sulfate is administered

*inside

*subcutaneously

*++intramuscularly

*rectally

*intraarterialy

#472

*!For the treatment of tuberculosis inside use

  *++isoniazid

  *chloramphenicol

  *streptomycin

  *metronidazole

  *ampicillin

#473

*!For the treatment of giardiasis is used

  * tetracyclines

  *chloramphenicol

  *++furazolidone

  *sodium stibogluconate

  *chloridin

#474

*!When diseases caused by staphylococci produced penicillinase is used

*++oxacillin

*bicillins

*benzylpenicillin sodium

*ampicillin

*carbenicillin

#475

*!Bicillins in contrast to benzylpenicillin sodium salt

*have a broad spectrum of action

*acid resistance

*++are more long lasting

*resistant to penicillinase

*administered intramuscularly

#476

*!Rapid development of resistance of Mycobacterium tuberculosis occurs when using

  *++rifampicin

  *PAS

  *ethambutol

  *isoniazid

  *pyrazinamide

#477

*!The mechanism of action of potassium permanganate includes

*dehydration of protoplasm proteins of microorganisms

*blockade of SH-groups of enzymes

*++oxidation of the organic components of the protoplasm of microorganisms

*violation of the permeability of the cytoplasmic membrane

*violation of protein synthesis

#478

*!The mechanism of antimicrobial action of heavy metal salts includes

*violation of protein synthesis of the cell wall

*dehydration of protein

*violation of the synthesis of nucleic acids

*violation of the permeability of the cytoplasmic membrane

*++blocking sulfhydryl groups of enzymes

#479

*!Mechanism of action of aminoglycoside antibiotics includes

  *violation of protein synthesis of the cell wall

  *violation of the permeability of the cytoplasmic membrane

 *++violation of protein synthesis at the level of the ribosome

  *violation of the synthesis of nucleic acids

  *blocking of SH-groups of enzymes

#480

*!Ampicillin acts on

*staphylococci, penicillinase-producing

*++staphylococci not producing penicillinase

*mycobacterium tuberculosis

*treponema

*pseudomonas aeruginosa

#481

*!Indication for use of chloramine B is

*++treatment of hand surgery

*reflex stimulation of the respiratory center

*washing the cavities

*sterilization of metal instruments

*compresses and rubdowns

#482

*!Furacilin used for

*disinfection of instruments

*reflex stimulation of the respiratory center

*processing surgeon's hands

*++treatment of wounds

*processing of the patient excretions

#483

*!Indication for use of streptomycin is

  *dysentery

 *++tuberculosis

  *angina

  *pneumonia

  *otitis

#484

*!Mercury monoxide yellow is used for

*disinfection of instruments

*++infectious eye disease

*processing of surgeon's hands

*processing of rooms

*the preservation of drugs

#485

*!The use of erythromycin is limited due to

  *low toxicity

  *well absorbed in the gastrointestinal tract

  *seldom causes side effects

 *++resistance of microorganisms to him quickly developed

  *bacteriostatic effect

#486

*!Gentamycin in contrast to the first generation aminoglycosides active against

*staphylococci

*escherichia coli

*brucella

*shigella

*pseudomonas aeruginosa

#487

*!The mechanism of action of penicillins is

 *++violation of protein synthesis of the cell wall

  *violation of the permeability of the cytoplasmic membrane

  *violation of the synthesis of nucleic acids

  *violation of protein synthesis at the level of the ribosome

  *blocking of SH - groups of proteins – enzymes

#488

*!The mechanism of action of cephalosporins is

  *violation of the permeability of the cytoplasmic membrane

  *++violation of protein synthesis of the cell wall

  *violation of the synthesis of nucleic acids

  *violation of protein synthesis at the level of the ribosome

  *blocking of SH- groups of proteins – enzymes

#489

*!The mechanism of action of macrolides is

  *violation of protein synthesis of the cell wall

  *violation of the permeability of the cytoplasmic membrane

  *violation of the synthesis of nucleic acids

  *++violation of protein synthesis at the level of the ribosome

  *blocking of SH- groups of proteins – enzymes

#490

*!Mechanism of action of chloramphenicol is

*violation of protein synthesis of the cell wall

*++violation of protein synthesis at the level of the ribosome

*violation of the permeability of the cytoplasmic membrane

*violation of the synthesis of nucleic acids

*blocking of SH- groups of proteins – enzymes

#491

*!The mechanism of action of polimixin M is

  *violation of protein synthesis of the cell wall

  *++violation of the permeability of the cytoplasmic membrane

*violation of protein synthesis at the level of the ribosome

*violation of the synthesis of nucleic acids

*blocking of SH- groups of proteins – enzymes

#492

*!The mechanism of action of rifampicin is

  *violation of protein synthesis of the cell wall

  *violation of the permeability of the cytoplasmic membrane

*violation of protein synthesis at the level of the ribosome

*++violation of the synthesis of nucleic acids

*blocking of SH- groups of proteins – enzymes

#493

*!The mechanism of action of tetracyclines is

  *violation of protein synthesis of the cell wall

  *violation of the permeability of the cytoplasmic membrane

*++violation of protein synthesis at the level of the ribosome

*violation of the synthesis of nucleic acids

*blocking of SH- groups of proteins – enzymes

#494

*!Spectrum of oxacillin action is different from the biosynthetic penicillins by action on

*staphylococci not produced penicillinase

*++staphylococci produced penicillinase

*meningococcus

*streptococci

*pneumococci

#495

*!The mechanism of action of isoniazid is

  *blocking enzymes - metabolic disorder of mycobacteria

  *violation of protein synthesis at the level of the ribosome

  *violation of the permeability of the cytoplasmic membrane

 *++violation synthesis of mycolic acids

  *competitive antagonism with PABA

#496

*!Amoebocyte effective at any location of amoebas is

*chiniofon

*tetracycline

* ++metronidazole

*emetine hydrochloride

*chingamine

#497

*!Mean used for relief of attacks of malaria is

*chiniofon

*++chloroquine

*primaquine

*co-trimoxazole

*metronidazole

#498

*!Antibiotic for the treatment of plague, tularemia, brucellosis is

*erythromycin

*penicillin

*cefazolin

*polymyxin

*++streptomycin

#499

*!The mechanism of mebendazole anthelminthic action is

  *++inhibits glucose utilization of worms and paralyzes them

  *inhibits fumarate reductase and disturbs the metabolism of helminths

  *inhibits oxidative phosphorylation in helminths and paralyzes them

  *inhibits cholinesterase and disrupts neuromuscular transmission

  *violates the synthesis of nucleic acids

#500

*!Antibiotic used in the "atypical pneumonia" is

*ampicillin

*amoxicillin

*++azithromycin

*oxacillin

*tetracycline

#501

*!When giardiasis can be used

*tetracycline

*++nitrofuran derivatives

*benzylpenicillin

*chloramphenicol

*nystatine

#502

*!Sulfonamides in the liver undergo the process of

*++acetylation

*oxidation

*deamination

*hydroxylation

*oxidation

#503

*!What sulfanilamide preparation has a bactericidal effect?

*sulfadimezin

*sulfazin

*++co-trimoxazole

*salazosulfapiridazin

*тitroxolinum

#504

*!For washing the cavities can be used

*++furacilinum

*alcoholic solution of iodine

*silver nitrate

*ammonia solution

*brilliant green

#505

*!Antiseptic that can be used in the treatment of fungal infections of the skin is

*formaldehyde

*hydrogen peroxide

*alcohol solution of iodine

*++chloramine B

*yellow mercury oxide

#506

*!Nitrofuran derivative used in diseases of the urinary tract is

*++furagin

*ofloxacin

*nitroxolinum

*cotrimoxazole

*levofloxacin

#507

*!Fluoroquinolone derivative used for tuberculosis is

*furagin

*furazolidone

*nitroxolinum

*levofloxacin

*++ciprofloxacin

#508

*Preparation used in herpes is

*tetracycline

*acyclovir

*amantadine

*fluconazole

*nystatine

#509

*!The azole derivative used in systemic fungal infections is

*nystatine

*furazolidone

*terbinafine

*levofloxacine

*fluconazole

#510

*!Mechanism of antifungal action of ketoconazole is

  *violation of neuromuscular transmission

  *inhibition of fumarate reductase

  *violation the synthesis of nucleic acids

  *inhibition of cholinesterase

  *disruption of ergosterol synthesis

#511

*!Mechanism of antiviral action of acyclovir is

  *inhibition of cholinesterase

  *inhibition of fumarate reductase

  *disruption the synthesis of ergosterol

  *inhibition the synthesis of thymidine kinase

  *violation the synthesis of DNA polymerase

#512

*!Agent used for treatment of trichomoniasis is

*chiniofonum

*chingaminum

*primachinum

*co-trimoxazole

*metronidazole

#513

*!Drug used for the treatment of amoebiasis, giardiasis is

  *erythromycine

  *penicillin

  *cefazoline

  *polymyxin

  *metronidazole