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Pathological Anatomy / ответы для экзамена ЕМ (1).docx
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  1. Heart attack: definition, causes, classification, conditions of development. Macro- and microscopic signs, outcomes, clinical significance.

Infarction is vascular (ischemic) necrosis, a consequence and an extreme manifestation of ischemia. Reasons : 1. prolonged spasm, thrombosis, embolism of the artery 2. functional tension of the organ in conditions of insufficient blood supply 3. insufficiency of anastomoses and collaterals 4. violation of tissue metabolism.

Morphology of types of heart attacks:

a) in shape: wedge-shaped - the main type of branching of the arteries (spleen, kidneys, lungs) and irregular - the loose type of branching of the arteries (heart, brain, intestines)

b) in size: total or subtotal I. and microinfarction (only the bowl is visible)

c) by consistency: I. by type of coagulation necrosis (MI, kidneys, spleen) and I. by type of colliquation necrosis (cerebral infarction, intestines)

d) in appearance (color): 1. white (ischemic) I. - a well-delimited area of white-yellow color (brain, spleen); 2. white with a hemorrhagic corolla - a white area surrounded by a hemorrhage zone (myocardium, kidneys) 3. red (hemorrhagic) - a well-delimited, dark red, blood-soaked necrosis area (more often in the lungs - venous congestion + anastomoses between the bronchial and pulmonary arteries, intestines)

Outcomes: a) autolysis and subsequent complete regeneration of small foci of necrosis b) organization and scar formation c) petrification d) hemosiderosis (hemorrhagic I.) e) cyst at the site of necrosis (in g / m) f) purulent melting.

Meaning: This is a complication of many diseases. Heart attacks are especially dangerous:hearts: heart failure, death.cerebral palsy, disability, death.

  1. Ischemic infarction: definition, causes, localization. Macro- and microscopic changes in organs, outcomes. Clinical significance.

A white (ischemic) infarction occurs as a result of the complete cessation of arterial blood flow in organs, for example, in the heart, kidneys, spleen, brain above the Willis circle. It usually occurs in areas with a single blood flow system (the main type of arterial branching), in which collateral circulation is poorly developed. Due to the undisturbed venous outflow from the ischemic tissue and due to spasm of the distal portion of the arteries after the cessation of blood flow, the pallor of these infarcts is observed. A white (ischemic) infarction is a site clearly delimited from the surrounding tissues, white-yellow in color, structureless.

The essence of the process: a decrease in blood filling of tissue, organ as a result of insufficient arterial blood flow.

Morphological features:

  1. the tissue is pale, flabby;

b) the organ is reduced, its capsule is wrinkled.

Types and causes:

  1. angiospastic (reflex spasm);

b) obstructive (thrombosis, embolism, endarteritis, atherosclerotic plaque);

c) compression (compression of arteries by tumor, effusion, tourniquet), as a result of blood redistribution.

Outcomes:

  1. without consequences for short-term ischemia (reflex vasospasm);

  2. dystrophy, foci of necrosis with prolonged acute ischemia;

c) parenchymal atrophy, stroma sclerosis with prolonged slowly increasing ischemia.