5 курс / Инфекционные болезни / Доп. материалы / Лечение_ВИЧ_инфекции,_К_Хоффман,_Дж_К_Роктрох,_Б_С_Кампс
.pdf
556 Лекарственные взаимодействия
Литература
1.Tseng A. www.tthhivclinic.com, General Hospital, Toronto, 2004.
2.Viread™, Gilead.
3.Clinical Pharmacology, Gold Standard Multimedia, 2004. http://www.gsm.com
4.Kearney BP, Damle B, Plummer A, et al.Tenofovir DF (TDF) and didanosine EC (ddl EC): investigation of pharmacokinetic (PK) drug-drug and drug-food interactions. Abstract LBPE9026, XIV Int AIDS Conf 2002, Barcelona. http://www.aegis.com/conferences/14WAC/LbPeB9026.html
5.Kearney BP, Isaacson E, Sayre J, et al. Didanosine and tenofovir DF drug-drug interaction: assessment of didanosine dose reduction. Abstract 533, 10th CROI 2003, Boston. http://www.retroconference.org/2003/abstract/abstract.aspx?abstractID=181
6.Blum MR, Begley J, Zong J, et al. Lack of a pharmacokinetic interaction between emtricitabine and tenofovir DF when coadministered to steady state healthy volunteers. Abstract A-1621, 43rd ICAAC 2003, Chicago. http://www.thebody.com/confs/icaac2003/pdfs/A- 1621_poster.pdf
7.Kaul S, Bassi K, Damle B, et al. Stavudine extendend release formulation and tenofovir disoproxil fumarate: lack of a pharmacokinetic drug interaction. Abstract 602, 11th CROI San Francisco, 2004. http://www.retroconference.org/2004/cd/abstract/602.htm
8.Kearney BP, Isaacson E, Sayre J, et al. The pharmacokinetics of abacavir, a purine nucleotide analog, are not affected by tenofovir DF. AbstractA-1615, 43rd ICAAC 2003, Chicago. http://www.thebody.com/confs/icaac2003/pdfs/A-1615_poster.pdf
9.Kearney B, Flaherty J, Wolf J, et al. Lack of clinically relevant drug-drug interactions between tenofovir DF and efavirenz, indinavir, lamivudine and lopinavir/ritonavir in healthy subjects. Abstract P171, 8th European Conference on Clinical Aspects and Treatment of HIV Infection 2001, Athens. http://www.eacs.ws/conference/index/htm
10.Taburet A, Piketty C, Chazallon C, et al. interactions between atazanavir-ritonavir and tenofovir in heavily pretreated human immunodeficiency virus-infected patients. Antimicrob Agents Chemother 2004; 48:2091-6. http://www.amedeo.com/lit.php?id=15155205
11.Kaul S, Bassi K, Damle B, et al. Pharmacokinetic evaluation of the combination of atazanavir (ATV), enteric coated didanosine (ddl-EC), and tenofovir disoproxil fumarate (TDF) for a once-daily antiretroviral regimen. Abstract A-1616, 43rd ICAAC 2003, Chicago. http://www.natap.org/2003/ICAAC/day6_1.htm
12.Kruse G, Stocker H, Breske A et al. Trough levels of six different atazanavir regimes in HIV-infected patients. Abstract 6.6, 5th Int Worksh Clin Pharmacol HIV Ther 2004, Rome.
13.Truvada, Gilead Sciences, September 2004.
14.Kearney BP, Mittan A, Sayre J, et al. Pharmacokinetic drug interaction and long term safety profile of tenofovir DF and lopinaivr/ritonavir. Abstract A-1617, 43rd ICAAC 2003, Chicago. http://www.thebody.com/confs/icaac2003/pdfs/A.1617_poster.pdf
15.Roszko PJ, Curry K, Brazina B, et al. Standard doses of efavirenz (EFV), zidovudine (ZDV), tenofovir (TDF), and didanosine (ddl) may be given with tipranavir/ritonavir (TPV/r). Abstract 865, 2nd lAS Conference on HIV Pathogenesis and Treatment 2003, Paris. http://www.aegis.com/conferences/2ndIASHIVPT/865.html
16.Ananworanich J, Siangphoe U, Mahanontharit A, et al. Saquinavir Cmin before and after switching NRTI to tenofovir in patients treated with once daily saquinavir-hard gel capsule/ritonavir 1600 mg/ 100 mg. Abstract 4.15, 5th Int Worksh Clin Pharmacol HIV Ther 2004, Rome. http://www.amedeo.com/lit.php?id=15651763
17.Boffito M, D´Avolio A, Di Perri G, et al. Repeated pharmacokinetics of tenofovir disoproxil fumarate (TDF) in HIV-infected-adults receiving Saquinavir hard gel (SQV)/Ritonavir (RTV) 1000/100 mg BID. Abstract 4.19, 5th Int Worksh Clin Pharmacol HIV Ther 2004, Rome.
18.Kruse G, EsserS, Stocker H, et al. Tenofovir does not impair the pharmacokinetics of nelfinavir in HIV-infected patients. Abstract A-446, 44th ICAAC 2004, Washington.
19.Kearney BP, Isaacson E, Sayre J, et al. Tenofovir DF and oral contraceptives: Lack of a pharmacokinetic drug interaction. Abstract A-1618, 43rd ICAAC 2003, Chicago. http://www.thebody.com/confs/icaac2003/pdfs/A-1618_poster.pdf
20.Smith P, Kearney B, Cloen D. Tenofovir DF does not affect the pharmacokinetics or pharmacodynamics of methadone. Abstract 869, 2nd IAS Conference on HIV Pathogenesis and Treatment 2003, Paris. http://www.aegis.com/conferences/2ndIASHIVPT/865.html
21.Kearney B, Benhamou Y, Flaherty J, et al. Lack of systemic or renal drug interactions of tenofovir DF with ribavirin or adefovir dipivoxil. Abstract 69, XV Int AIDS Conf 2004, Bangkok.
22.Droste JAH, Kearney BP, v Horssen P, et al. Lack of clinically relevant drug-drug interaction between tenofovir DF and rifampin in healthy volunteers. Abstract 4.11, 5th Int Worksh Clin Pharmacol HIV Ther 2004, Rome.
23.Kearney BP, Mittan A, Sayre J, et al. Pharmacokinetic drug interaction and long term safety profile of tenofovir DF and lopinaivr/ritonavir. Abstract A-1617, 43rd ICAAC 2003, Chicago. http://www.natap.org/2003/ICAAC/day5_2.htm
24.Roszko PJ, Curry K, Brazina B, et al. Standard doses of efavirenz (EFV), zidovudine (ZDV), tenofovir (TDF), and didanosine (ddl) may be given with tipranavir/ritonavir (TPV/r). Abstract 865, 2nd lAS Conference on HIV Pathogenesis and Treatment 2003, Paris.
25.Kurowski M, Walli R, Breske et al. Co-administration of tenofovir 300 mg QD with fosamprenavir / ritonavir 1400/100 mg QD or 1400/200 mg QD does not affect amprenavir pharmacokinetics. Abstract 10, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
26.Peytavin G, Rouault A, Agher R, et al. Plasma concentrations of amprenavir, ritonavir and tenofovir in HIV-infected patients treated with fosamprenavir / ritonavir (700 / 100 mg BID) and tenofovir (300 mg QD) containing regimen. Abstract 32, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
27.Agarwala S, Eley T, Villegas C, et al. Pharmacokinetic interaction between tenofovir and atazanavir co-administered with ritonavir in healthy subjects. Abstract 16, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
28.Breilh D, Rouzes A, Djabarouti S, et al. Pharmacokinetic drug interaction of lopinavir/ritonavir im combination with tenofovir in experienced HIV+ patients. Abstract A-445, 44th ICAAC 2004, Washington.
560 Лекарственные взаимодействия
Литература
1.Tseng A. http://www.tthhivclinic.com/, General Hospital, Toronto, 2004.
2.Agenerase™, GlaxoSmithKline.
3.Telzir™, GlaxoSmithKline.
4.Piscitelli S, Bechtel C, Sadler B, et al. The addition of a second protease inhibitor eliminates amprenavir-efavirenz drug interaction and increases plasma amprenavir concentrations. Abstract 78, 7th CROI 2000, San Francisco. http://www.retroconference.org/2000/abstracts/78.htm
5.Alvarez-Amao D, Pace W, Gold M. Switch from high to low dose amprenavir in combination with efavirenz and ritonavir. Abstract 2.7, 3rd Int Worksh Clin Pharmacol HIV Ther, 2002, Washington.
6.Wire MB, Ballow C, Preston SL, et al. Pharmacokinetics and safety of GW433908 and ritonavir, with and without efavirenz, in healthy volunteers. AIDS 2004, 18: 897-907. http://www.amedeo.com/lit.php?id=15060437
7.Goujard C, Meynard JL, Choudet N, et al. Steady-state pharmacokinetics of amprenavir 600 mg BID and ritonavir 100 mg BID with or without NNRTI in HIV-1 infected patients. Abstract S92, 5th Int Congr Drug Ther HIV Inf 2000, Glasgow. http://www.aegis.com/conferences/hiv5/P268.html
8.DeJesus E, Piliero P, Summers K, et al. Evaluation of the pharmacokinetik drug interaction between fosamprenavir (FPV), FPV plus ritonavir (RTV) and nevirapine (NVP) in HIV-infected patients (APV10014). Abstract A447, 44th ICAAC 2004, Washington.
9.Kashuba ADM, Tierey C, Downey GF, et al. Combining fosamprenavir, 908 with lopinavir/ritonavir in HIV-1 infected adults in substantial reduction in amprenavir and lopinavir concentrations: pharmacokinetic results from Adult ACTG Protocol A5143. Abstract 855, 43rd ICAAC 2003, Chicago.
10.Wire MB, Naderer OJ, Masterman AL, et al. The pharmacokinetic interaction between GW433908 and lopinavir/ritonavir (APV10011 and APV 10012). Abstract 612, 11th CROI 2004, San Francisco. http://www.amedeo.com/lit.php?id=15060437
11.Corbett AH, Davidson L, Park JJ, et al. Dose separation strategies to overcome the pharmacokinetic interaction of a triple protease inhibitor regimen containing fosamprenavir, lopinavir and ritonavir. Abstract 611, 11th CROI 2004, San Francisco.
12.Khanlou H, Graham E, Brill M, et al. Drug interaction between amprenavir and lopinavir/ritonavir in salvage therapy. AIDS 2002; 16: 797-8. http://www.amedeo.com/lit.php?id=11964539
13.Bertz RJ, Foit C, Ashbrenner E, et al. Effect of amprenavir on the steady-state pharmacokinetics of lopinavir/ritonavir in HIV+ and healthy subjects. Abstract A1823, 42nd ICAAC 2002, San Diego.
14.Taburet AM, Raguin G, Le Tiec C, et al. Interaction between Amprenavir and lopinavir -ritonavir combination in heavily pretreated patients infected by HIV. Clin Pharmacol Ther 2004; 75: 310-23. http://www.amedeo.com/lit.php?id=15060509
15.Mauss S, Scholten S, Wolf E, et al. A prospective, controlled study assessing the effect of lopinavir on amprenavir concentrations boosted by ritonavir. HIV Med 2004; 5: 15-7. http://www.amedeo.com/lit.php?id=14731164
16.Wynn Vezina HE, Brundage RC, Bushman L, et al. Pharmacologic management of the drug-drug interaction between lopinavir/ritonavir and amprenavir. Abstract 609, 11th CROI 2004, San Francisco. http://www.retroconference.org/2004/cd/PDFs/609.pdf
17.Zilly M, Nolte C, Weißbrich B, et al. Double PI boosting with atazanavir and fosamprenavir: favourable pharmacokinetics. Abstract 92, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
18.Khamlou H, Bhatti L, Farthing. Interactions between atazanavir and fosamprenavir in the tratment of HIV-infected patients. Abstarct WEPE3.3C11, 3IAS 2005, Rio de Janeiro.
19.Sadler BM, Gillotin C, Lou Y, et al. Pharmacokinetic study of human immunodeficiency virus protease inhibitors used in combination with amprenavir. Antimicrob Agents Chemother 2001, 45: 3663-8. http://www.amedeo.com/lit.php?id=11709366
20.Boffito M, Dickinson L, Hill A, et al. Steady state pharmacokinetics of saquinavir hard gel/fosamprenavir 1000/700 plus 100 und 200 mg of Ritonavir twice daily in HIV+ Patients. Abstract 608, 11th CROI 2004, San Francisco.
21.Wolfe PR, Anderson PG, Gunawan S. Simultaneous administration of amprenavir and saquinavir does not appear to lower plasma levels of either agent when coadministered with low dose ritonavir. Abstract 7.11, 3rd Int Worksh Clin Pharmacol HIV Ther 2002, Washington.
22.Ford SL, Wire MB, Lou Y, et al. The effect of antacids and ranitidine on the pharmacokinetic of GW433908 (APV10007). Abstract A-1606, 43rd ICAAC 2003, Chicago.
23.Wire MB, Baker KL, Moore KHP, et al. The pharmacokinetic interaction of GW 433908 with atorvastatin and 908/ritonavir with atorvastatin (APV 10013). Abstract A1622, 43rd ICAAC 2003, Chicago.
24.Hendrix C, Wakeford J, Wire MB, et al. Pharmacokinetic and pharmacodynamic evaluation of methadone enantiomers following coadministration with amprenavir in opiod-dependent subjects. Abstract 1649, 40th ICAAC 2000, Toronto.
25.Centers for Disease Control and Prevention (CDC). Notice to Readers: Updated guidelines for the use of rifamycins for the treatment of tuberculosis among HIV-infected patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors 2004. MMWR; 53: 37. http://www.amedeo.com/lit.php?id=11795500
26.Nandwani R, Gourlay Y. Possible Interaction between sildenafil and HIV combination therapy. Lancet 1999; 353: 840. http://www.amedeo.com/lit.php?id=10459981
27.Hugen PWH, Burger DM, Brinkman K, et al. Carbamazepine-indinavir interaction causes antiretroviral therapy failure. Ann Pharmacother 2000; 34: 465-70. http://www.amedeo.com/lit.php?id=10772431
28.Pratt CM, Mason J, Russell T. Cardiovascular safety of fexofenadine HCL. Am J Cardiol 1999; 84: 278-9. http://www.amedeo.com/lit.php?id=10335761
29.Abernethy DR, Barbey JT. Loratadine and terfenadine interaction with nefazodone: Both antihistamines are as sociated with QTprolongation. Clin Pharmacol Ther 2001; 69: 96-103. http://www.amedeo.com/lit.php?id=11240972
30.Kurowski M, Walli R, Breske et al. Co-administration of tenofovir 300 mg QD with fosamprenavir/ritonavir 1400/100 mg QD or 1400/200 mg QD does not affect amprenavir pharmacokinetics. Abstract 10, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
31.Peytavin G, Rouault A, Agher R, et al. Plasma concentrations of amprenavir, ritonavir and tenofovir in HIV-infected patients treated with fosamprenavir / ritonavir (700 / 100 mg BID) and tenofovir (300 mg QD) containing regimen. Abstract 32, 6th Int. Worksh Clin Pharmacol HIV Ther 2005, Quebec.
32.Shelton MJ, Wire MB, Lou Y, et al. Co-administration of esomeprazole (ESO) with fosamprenavir (FPV) has no impact on steady-state plasma amprenavir (APV) pharmacokinetics (APV10031). Abstract 24, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
33.Blenke A, van der Lee M, Verweij-van Wissen C, et al. Combined use of paroxetine and fosamprenavir / ritonavir: a pharmacokinetic interaction study in healthy volunteers. Abstract 13, 6th Int Worksh Clin Pharmacol HIV Ther 2005, Quebec.
Лечение ВИЧ-инфекции. 2005 год 561
34.Leith J, Walmsley S, Katlama C, et al. Pharmacokinetics and safety of tipranavir/ritonavir alone or in combination with saquinavir, amprenavir, or lopinavir: interim analysis of BI1182.51. Abstract 34, 5th Int Worksh Clin Pharmacol HIV-Ther 2004, Rome.
35.Justesen US, Klitgaard NA, Brosen K.Pharmacokinetic interaction between amprenavir and delavirdine after multiple-dose administration in healthy volunteers. Br J Clin Pharmacol. 2003;55:100-6. http://www.amedeo.com/lit.php?id=12534646
564 Лекарственные взаимодействия
Препараты |
Взаимодействия |
Рекомендации |
Снотворные |
|
|
Барбексаклон, |
Теоретически: эфавиренз ↓ |
Вместе не назначать или проводить |
фенобарбитал |
|
МСК |
Бензодиазепины (например, |
Теоретически: бензодиазепины ↓ |
Вместе не назначать: мидазолам, |
диазепам, мидазолам, триа- |
|
триазолам (2). Теоретическая альтер- |
золам), золпидем (2,22) |
|
натива: лоразепам, оксазепам, темазе- |
|
|
пам (22) |
Иммунодепрессанты |
|
|
Циклоспорин, сиролимус, |
Описано снижение дозы циклоспорина на фо- |
Коррекция доз иммунодепрессантов по |
такролимус |
не эфавиренза (35) |
данным МСК |
Фитопрепараты |
|
|
Препараты зверобоя (2) |
Теоретически: эфавиренз ↓ |
Вместе не назначать |
Гиполипидемические |
|
|
Аторвастатин, ловастатин, |
Аторвастатин и симвастатин 48% и 58% ↓, со- |
Теоретическая альтернатива: права- |
симвастатин (24-26) |
ответственно |
статин, флувастатин, розувастатин |
|
|
|
Пероральные |
Эстроген ↑, |
Использовать дополнительный метод |
контрацептивы (2) |
этинилэстрадиол ↑ 37% |
контрацепции. Данных недостаточно |
|
|
|
Ингибиторы |
|
|
фосфодиэстеразы |
|
|
Силденафил, тадалафил, |
Теоретически: уровни ингибиторов фосфо- |
Внимание: начинать с низкой дозы |
варденафил |
диэстеразы ↓ ↑ |
|
|
|
|
Наркотики |
|
|
Кокаин (27) |
Теоретически: норкокаин ↑ |
Внимание: гепатотоксичность |
|
|
|
Заместительная терапия |
|
|
Метадон (27) |
Метадон: 60% ↓ |
Абстинентный синдром в течение 2 не- |
|
|
дель. При необходимости повысить до- |
|
|
зу метадона до 100%. Снизить дозу ме- |
|
|
тадона при отмене эфавиренза |
Литература
1.Tseng A. www.tthhivclinic.com, General Hospital, Toronto, 2004.
2.Sustiva™, Bristol-Myers Squibb.
3.Veldkamp AI, Harris M, Montaner JSG, et al. The steady-state pharmacokinetics of efavirenz und nevirapine when used in HIV-1 infected patients. J Infect Dis 2001; 184: 37-42. http://www.amedeo.com/lit.php?id=11398107
4.Degen O, Kurowski M, van Lunzen J, et al. Amprenavir and ritonavir: intraindividual comparison of different doses and influence of concomitant NNRTI on steady-state pharmacokinetics in HIV-infected patients. Abstract 739, 8th CROI 2001, Chicago. http://www.retroconference.org/2001/abstracts/abstracts/abstracts/739.htm
5.Piscitelli S, Bechtel C, Sadler B, et al. The addition of a second protease inhibitor eliminates amprenavir-efavirenz drug interaction and increases plasma amprenavir concentrations. Abstract 78, 7th CROI 2000, San Francisco. http://www.retroconference.org/2000/abstracts/78.htm
6.Alvarez-Amao D, Pace W, Gold M. Switch from high to low dose amprenavir in combination with efavirenz and ritonavir. Abstract 2.7, 3rd Int Worksh Clin Pharmacol HIV Ther 2002, Washington.
7.Preston S, Piliero P, O´Mara E, et al. Evaluation of steady-state interaction between atazanavir and efavirenz. Abstract 433, 9th CROI 2002, Seattle.
8.Reyataz™, Bristol-Myers Squibb.
9.Aarnoutse RE, Grintjes KJT, Telgt DS, et al. The influence of efavirenz on the pharmacokinetics of a twice daily combination of indinavir and low-dose ritonavir in healthy subjects. JAIDS 2003; 34: 134-9. http://www.amedeo.com/lit.php?id=11823758
10.Boyd MA, Aarnoutse RE, Ruxrungtham K, et al. Pharmacokinetics of indinavir/ritonavir (800/100 mg) in combination with efavirenz (600 mg) in HIV-infected subjects. JAIDS 2003; 34: 134-9. http://www.amedeo.com/lit.php?id=14526202
11.Bertz R, Lam W, Hsu A, et al. Assessment of the pharmacokinetic interaction between ABT - 378/r and efavirenz in healthy volunteers and in HIV+subjects. Abstract 424, 40th ICAAC 2000, Toronto.
12.Jorga K, Buss NE. Pharmacokinetic drug interaction with saquinavir sgc. Abstract 339, 39th ICAAC 1999, San Francisco.
13.Hendrix CW, Fiske WD, Fuchs EJ, et al. Pharmacokinetics of the triple combination of saquinavir, ritonavir and efavirenz in HIV+subjects. Abstact 424, 11th CROI 2000, San Francisco.
14.van Heeswijk RP, Cooper C, Gallicano A, et al. The pharmacokinetics of SQV/RTV 400/400 mg BID before, and after shortand long term co-administration of efavirenz 600 mg QD. Abstract 7.4, 3rd Int Worksh Clin Pharmacol HIV-Ther 2002, Washington.
15.Lopez-Cortes LF, Viciana P, Ruiz-Valderas R, et al. Pharmacokinetics, efficacy and safety of once-daily saquinavir-sgc plus low-dose ritonavir (1200/100 mg) in combination with efavirenz in HIV-pretreated patients. Abstract 441, 9th CROI 2002, Seattle.