Books / KD TRIPATHI- CLASSIFICATION OF DRUGS

12.Nandrolone decanoate: 25–100 mg i.m. every 3 weeks, DECADURABOLIN 25, 100 mg/ml inj.

13.Oxymetholone: 5–10 mg, children 0.1 mg/kg, OD; ADROYD 5 mg tab.

14.Stanozolol: 2–6 mg/day; MENABOL, NEURABOL, TANZOL 2 mg tab.

Impeded Androgen

15. Danazol: 200–600 mg/day; DANAZOL, LADOGAL, DANOGEN, GONABLOK 50, 100, 200 mg cap.

Antiandrogens

16. Cyproterone acetate: 2 mg OD; GINETTE-35, DINAC-35 (cyproterone acetate 2 mg + ethinylestradiol 35 μg) tab.

17.Flutamide: 250 mg TDS; PROSTAMID, FLUTIDE, CYTOMID 250 mg tab.

18.Bicalutamide: 50 mg OD; BIPROSTA, CALUTIDE, TABI 50 mg tab.

5α-Reductase Inhibitor

19. Finasteride: For benign hypertrophy of prostate (BHP) 5 mg OD, review after 6 months; for male pattern baldness 1 mg/day. FINCAR, FINARA, FINAST 5 mg tab, FINPECIA, ASTIFINE 1 mg tab.

20. Dutasteride: For BHP 0.5 mg/day. DUPROST, DURIZE 0.5 mg tab.

Drugs for Erectile Dysfunction

1. Sildenafil: 50 mg (max. 100 mg) 1 hour before intercourse; elderly 25 mg; PENEGRA, CAVERTA, EDEGRA 25, 50, 100 mg tabs.

2. Tadalafil: 10 mg (max. 20 mg) at least ½ hr before intercourse. MEGALIS, TADARICH, TADALIS 10, 20 mg tab, MANFORCE 10 mg tab.

50 Hormones and Related Drugs

Preparations

Estrogens

1. Estradiol benzoate/cypionate/enanthate/valarate: 2.5–10 mg i.m.; OVOCYCLIN-P 5 mg inj, PROGYNON DEPOT 10 mg/ml inj.

2. Conjugated estrogens: 0.625–1.25 mg/day oral for hormone replacement therapy; PREMARIN 0.625 mg, 1.25 mg tab, 25 mg inj (for dysfunctional uterine bleeding).

3. Ethinylestradiol: for menopausal syndrome 0.02–0.2 mg/day oral; LYNORAL 0.01, 0.05, 1.0 mg tab, PROGYNON-C 0.02 mg tab.

4.Mestranol: 0.1–0.2 mg/day oral; in OVULEN 0.1 mg tab, with ethynodiol diacetate 1 mg.

5.Estriol succinate: 4–8 mg/day initially, maintenance dose in menopause 1–2 mg/day oral;

EVALON 1, 2 mg tab, 1 mg/g cream for vaginal application in atrophic vaginitis 1–3 times daily.

6. Fosfestrol tetrasodium: initially 600–1200 mg slow i.v. inj for 5 days, maintenance dose 120–240 mg/day oral or 300 mg 1–3 times a week i.v.; HONVAN 120 mg tab, 60 mg/ml inj 5 ml amp.

7.Dienestrol: 0.01% topical; DIENESTROL 0.01% vaginal cream.

8.Estradiol transdermal: ESTRADERM-MX: Estradiol 25, 50 or 100 µg per 24 hr transdermal patches; apply

to nonhairy skin below waist, replace every 3–4 days using a different site; add an oral progestin for last 10–12 days every month.

9. Estradiol dermal gel: 1–2.5 mg/day; OESTRAGEL, E2GEL 3 mg/5 g gel in 80 g tube, SANDRENA 1 mg/g gel; apply 1.5–4 g gel over arms & shoulder daily.

10. Tibolone: 2.5 mg/day without interruption in postmenopausal­ women; LIVIAL, TIBOFEM 2.5 mg tab.

52 Hormones and Related Drugs

Antiestrogen

Clomiphene citrate: for infertility in women—50 mg/day for 5 days starting from 5th day of cycle, increase to 100 mg/day after 2–3 unsuccessful cycles (max. 200 mg/day); for oligozoospermia in men—25 mg daily for 24 days

in a month upto 6 months; CLOMID, FERTOMID, CLOFERT, CLOME 25, 50, 100 mg tabs.

Selective Estrogen Receptor Down Regulator/Pure Estrogen Antagonist

Fulvestrant: 250 mg i.m. (in gluteal region) monthly.

Selective Estrogen Receptor Modulators (SERMs)

1. Tamoxifen citrate: 20 mg/day in 1–2 doses (max. 40 mg/day). TAMOXIFEN, MAMOFEN, TAMODEX 10, 20 mg tabs.

2.Toremifene: 60 mg OD.

3.Raloxifene: 60 mg/day; OSRAL, BONMAX, RALOTAB, ESSERM 60 mg tab.

Aromatase Inhibitors

1.Letrozole: 2.5 mg/day oral; FEMARA, ONCOLET, LETOVAL, LETROZ 2.5 mg tab.

2.Anastrozole: 1 mg/day oral; ARMOTRAZ, ALTRAZ, ANABREZ 1 mg tab.

3.Exemestane: 25 mg/day oral.

Progestins 53

54 Hormones and Related Drugs

Preparations

1. Progesterone: 10–100 mg i.m. (as oily solution) OD; PROGEST, PROLUTON, GESTONE 50 mg/ml inj., 1 and 2 ml amp; 100–400 mg OD oral: NATUROGEST, OGEST, DUBAGEST 100, 200, 400 mg caps containing micro-

nized oily suspension.

2. Hydroxyprogesterone caproate: 250–500 mg i.m. at 2–14 days intervals; PROLUTON DEPOT, MAINTANE INJ, PROCAPRIN 250 mg/ml in 1 and 2 ml amp.

3. Medroxyprogesterone acetate: 5–20 mg OD–BD oral, 50–150 mg i.m. at 1–3 month interval; FARLUTAL 2.5, 5, 10 mg tab., PROVERA, MEPRATE, MODUS 10 mg tab, DEPOT-PROVERA 150 mg in 1 ml inj. (as contraceptive).

4.Dydrogesterone: 5–10 mg OD/TDS oral; DUPHASTON­ 5 mg tab.

5.Norethindrone (Norethisterone): 5–10 mg OD–BD oral;

PRIMOLUT-N, STYPTIN, REGESTRONE, NORGEST 5 mg tab; REGESTRONE HRT, NORETA HRT 1 mg tab (for HRT); NORISTERAT 200 mg/ml inj (as enanthate) for contraception 1 ml i.m every 2 months.

6.Lynestrenol (Ethinylestrenol): 5–10 mg OD oral; ORGAMETRIL 5 mg tab.

7.Allylestrenol: 10–40 mg/day; GESTANIN, FETUGARD, MAINTANE 5 mg tab, PROFAR 25 mg tab.

8.Levonorgestrel: 0.1–0.5 mg/day; DUOLUTON-L, OVRAL 0.25 mg + ethinylestradiol 0.05 mg tab.

9.Desogestrel: 150 µg + ethinylestradiol 30 µg (NOVELON)­ tab, 1 tab OD, 3 weeks on and 1 week off cyclic

therapy.

Antiprogestin

Mifepristone: 200–600 mg single oral dose; MIFEGEST, MIFEPRIN 200 mg tab.

Anti implantation SERM

Centchroman (Ormeloxifene): 30 mg twice weekly for 12 weeks and then 30 mg weekly; CENTRON, SAHELI 30 mg tab.

Injectable Contraceptives

1. Depot medroxyprogesterone acetate (DMPA): 150 mg i.m. at 3 month intervals.

DEPOT-PROVERA 150 mg in 1 ml vial for deep i.m. injection during first 5 days of menstrual cycle. Repeat every 3 months.

2. Norethindrone (Norethisterone) enanthate­ (NEE): 200 mg i.m. at 2 month intervals.

NORISTERAT 200 mg in 1 ml vial for deep i.m. injection during first 5 days of menstrual cycle. Repeat every 2 months.

58 Hormones and Related Drugs