Медицинская вирусология / Букринская А.Г., Жданов В.М. Молекулярные основы патогенности вирусов

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105

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51B,15JeTcH rpoccpopHJIHp0BaJ-JHe.KaK oKa3aJiocb, M1-6e.rIOK B co­ CTaBe BHPH0Ha rp1-mna H B 3apaJKeHH0H KJJeTKe cyJ..UeCTByeT B ABYX cj)opMax, 0TJIH9310ll(IIXC5! no fI0JJ,BHJKH0CTH B flAAr. Ehn (popMbI oKa3aJIHCb cpoccpopHJrnpoBaHbI: B coCTane Bepx• HCH IT0J!0Cbl - 1 10 cep1rny, HH:>KHCH - no cepHHY H Tpeom-my [Gregoriades A. et al., 1984]. <Poc¢op1rnttpoBaHHC M-6eJJKa 6b!JIO IT0IW33H0 11 y JJ.pyrnx BHpyc<JB - napaMHKC0BHpycoB H pa6,ll,OBHpycoB [cM. EyKpHHCKafl A. r., 1985]. <PoccpopHJ!HpO· 13aHHe M0)KCT 6b!Tb TCCH0 CB5133H0 C perymur,uefi ero cpy11Kll_Hl1 npn pa36opKe H c6opr<e n11pyctto11 tJaCTHUbl, K0HTpoJ1»pyj1, ua­ npHMep, B3aHMO)],CHCTBHe C JlHTIH)],aM!I H HYKJ!C0K3ITCl1)],aMH H onpe/.1,eJIRH JI.3JlbHCllllIYIO cyJI.h6y HYKJ!C0K3TICHJJ.3 - J!l160 KaK MaTpHll_LI JJ,Jlfl TpaHCK!)HTIUflll reH0M3, JJII6o K8K c-rpyKTypHoro

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flpH cp3B!ICHHI1 aMHH0KHCJ10THblX IIOCJ!CJ].OBaTCJlbllOCTCH M-6eJma BHpyca naparpnnna 11e.rroseKa nrna 3 c T3K0BbIMH ,npyr11x napaMHKC0BHpycoB 0Ka33J10Cb, lJT0 HaH60J1bl113H CTe­ lICHb fOM0JIOrIIH 6bIJ1a C m1pycoM Cen,naii (61 % ) H HclHMeHI,­ lllaH - c BHpycaMH K0pH H llYMbl co6aK (35%). KoncepBaTHB· lib[ HCK0T0pble aMHH0EHCJ10THble II0CJlC)l0BclTCJlhH0CTH, T3KHe K3K 21/24 f.fJHUHII, 17/19 npoJlHH, 4/5 UHCTCHH, yqaCTBY!OIUHC B KOH<popMa1 1m Mo.rreKyJ1b1 M-6CJ1Ka. Hc:rna111ne.,r1,11aH roMo­ J1or1151 0blJia o6Hapy)KeHa C pcc11npaT0p110-cmrn)ITIIaJll,HJ,IM Bii­ pycoM [,Galinsky M. ct al., 1987]. l1Mc10TcH H rrpOTHBorroJJO)!<­ Hble ; amlble - 06 aHTHreHHoii m1,nns1v yam,II0CTll M-6eJJKoB

107

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109