Кальциевый канал
Типы кальциевых каналов
Cav1 L (longlasting)type inhibited by dihydropyridine
Cav2 N type not blocked by DHP, blocked by conotoxins
Cav2 P type blocked by agatoxin (low concentration) Cav2 Q type blocked by agatoxin (high concentration) Cav2 R type not blocked by DHP, conotoxins, agatoxin Cav3 T type transient or low–voltageactivated
Cav1.2, Cav 1.3, Cav 1.4 |
L-type |
Cav2.1 |
P/Q-type |
Ca 2.2 |
N-type |
Cav2.3 |
R-type |
Cav3.1, Cav 3.2, Cav 3.3 |
T-type |
Схематическое строение кальциевого канала
•Молекулярные массы (kD)
Субъединицы ионных кналов
Name
Na channel
Human or rat brain
Ca channel
Skeletal muscle
Delayed rectified
K channel
KCNQ
K channel
BK K(Ca) channel
Subunit
Na 1.3
Kv1.1
v
KCNQ1 min K
Slo1
BK
Number |
Residues |
Mass (Da) |
1 |
1 951 |
221 375 |
1 |
218 |
24 707 |
1 |
215 |
24 144 |
1 |
1 883 |
212 018 |
1/1 |
1 106 |
125 018 |
1 |
524 |
57 868 |
1 |
222 |
25 058 |
4 |
495 |
56 541 |
4 |
419 |
46 563 |
4 |
676 |
74 698 |
4 |
129 |
14 675 |
4 |
1 184 |
132 578 |
4 |
191 |
21 957 |
