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Signal to Noise Ratio in a pH amplifier

(a)

Ctox

 

SDGFET

(b)

 

SDGFET

(c)

 

SDGFET

 

 

 

 

 

 

 

 

 

 

Cbox

 

 

 

 

 

 

 

 

 

SISFET

 

 

 

SISFET

 

 

SISFET

 

 

Ctox

 

 

 

 

 

 

 

δVIns

 

Cbox

δVDGFET

 

δVIns

 

 

 

δVISFET

 

 

 

 

 

 

 

 

 

ISFET

DGFET

 

ISFET

DGFET

 

ISFET

DGFET

14

Signal to Noise Ratio in a pH-Amplifier

Alam, Principles of Nanobiosensors,

15

2013

 

Conclusions

Screening of biomolecules is reduced at high frequencies because the screening charges cannot respond fast enough, exposing the entire charge sequence temporarily. Sensors with

Giant Nernst Response amplifies signal electronically to improve sensitivity to pH changes. However, SNR is improved only for special cases.

Amperometric and cantilever sensors do not suffer from screening limits (but diffusion limit still applies).We will discuss them next.

 

Alam, Principles of Nanobiosensors, 2013

16

 

 

 

 

 

 

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