
- •Lecture 2.2: Classical Sensors I
- •Outline
- •Nanobiosensors are highly sensitive
- •Settling time for biosensors
- •Fractal geometry allows simple solution
- •Response or settling time defined
- •A fundamental relationship of biosensor
- •Operation of a planar sensor
- •Exact solutions for a planar sensor
- •Exact solutions for a planar sensor
- •The concept of the diffusion distance
- •Response time of a planar sensor
- •Response time of cylindrical sensor
- •Geometry of diffusion/sensor response
- •A ‘Mendeleev table’ for biosensors

Exact solutions for a planar sensor
ddtρ = D 2 ρ
ddNt = kF (N0 − N)ρs
kF →∞, ρs = 0 |
ρ(x,t) = ρ0 erf (x 2 |
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Dt |
Alam, Principles of Nanobiosensors, 2013 |
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Exact solutions for a planar sensor
ρ(x,t) = ρ0 erf (x2
Dt )
erf (x)≡ |
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∫0x e−y2 dy |
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Particles captured
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0.8 |
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0.6 |
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erf(x) |
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0.4 |
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erf(x/2) |
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0.2 |
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erf(x/3) |
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erf(x/4) |
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N(t) = ∞∫[ρ0 −ρ(x,t)]dx = ρ0 π4
Dt
0
Alam, Principles of Nanobiosensors, 2013 |
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The concept of the diffusion distance
ddtρ = D 2 ρ
t1 <t2 <t3
x ~ Dt
x ~ Dt
x
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Approximate Solution in 1D:
Diffusion Distance
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Exact |
Approximate |
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Dt |
0.8 |
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0.6 |
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erf(x) |
ρ0 |
0.4 |
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erf(x/2) |
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0.2 |
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erf(x/3) |
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erf(x/4) |
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4 |
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N(t) ~ |
×ρ0 × |
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N(t) = |
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×ρ |
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× |
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Dt |
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Dt |
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π |
0 |
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Alam, Principles of Nanobiosensors, 2013 |
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Approximate Solution in 1D:
Diffusion Distance
Approximate |
Approximate |
Dt |
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Dt |
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ρ |
0 |
ρ0 |
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N(t) ~ ρ0 × |
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N(t) ~ |
×ρ0 × |
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Dt |
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Dt |
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Alam, Principles of Nanobiosensors, 2013 |
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