Нефротический синдром

“Lipoid nephrosis” is a glomerularmerular disease at last

“lipoid nephrosis” was onlyonly firmlyfirmly established as memberer ofof thethe familyfamily of proteinuric glomerularlar diseasesdiseases by the demonstration inin biopsybiopsy specimens of reversiblele glomerularglomerular podocyte foot processs fusionfusion inin 1957 by Folli &Kark, andnd byby Farquhar, Vernier & Goodood.. “minimal“minimal change(s)” was first usedsed byby Hamburger in 1961. Paediatriciansaediatricians -- who did not adopt biopsypsy untiluntil thethe mid 1960s - continued toto useuse “(lipoid) nephrosis” forr longerlonger..

A return to “nephrosis” ??

•In GN, tubulointerstitial events

-correlate better with GFR than glomeruliglomeruli

-predict outcome better

•are non-specific - same old mix off monocytes, T cells and a few B cells,ells, fibrosis, loss of peri-tubular capillariesllaries etcetc..

•finally, does it matter what the glomeruliomeruli look like if there is some immunopathlogypathlogy??