Inhabitants of territories with cold climate have high content of an adaptive thermoregulatory hormone. What hormone is it?

A. Somatotropin

*B. Thyroxin

C. Insulin

D. Glucagon

E. Cortisol

A girl has been diagnosed with adrenogenital syndrome (pseudohermaphroditism). This pathology is caused by hypersecretion of the following adrenal hormone:

A. Mineralocorticoids

B. Glucocorticoids

C. Estrogens

D. Catecholamines

*E. Androgens

Which of the following amino acid residues in the structure of thyroglobulin is involved in the synthesis of thyroxine?

A. Threonine

B. Cysteine

C. Methionine

D. Glycine

*E. Tyrosine

Point out the major sex hormone of luteal phase in females:

A. Cortisol

B. 17-ketosteroid

*C. Progesterone

D. Aldosterone

E. Androstenedione

A 2-year-old child experienced convulsions because of calcium ions concentration decrease in the blood plasma. Function of what structure is decreased?

*A. Parathyroid glands

B. Thymus

C. Pineal gland

D. Adrenal cortex

E. Hypophysis

Examination of a patient revealed hyperkalaemia and hyponatraemia. Low secretion of which hormone may cause such changes?

A. Cortisol

B. Atrial natriuretic peptide

*C. Aldosterone

D. Vasopressin

E. Parathyroid hormone

Some diseases reveal symptoms of aldosteronism with hypertension and edema due to sodium retention in the organism. What organ of the internal secretion is affected on aldosteronism?

A. Hypophysis

B. Testicle

C. Ovaries

D. Pancreas

*E. Adrenal glands

Kidneys of a man under examination show increased reabsorption of calcium ions and decreased reabsorption of phosphate ions. What hormone causes this phenomenon?

A. Aldosterone

B. Vasopressin

C. Thyrocalcitonin

D. Calcitriol

*E. Parathormone

A person has reduced diuresis, hypernatremia, hypokalemia. Hypersecretion of what hormone can cause such changes?

A. Auricular sodiumuretic factor

*B. Aldosterone

C. Parathormone

D. Adrenalin

E. Vasopressin

A 44-year-old woman complains of common weakness, heart pain, increase of body weight. Objectively: moon-like face, hirsutism, AP- 165/100 mm Hg, height -164 cm, weight -103 kg; fat is mostly accumulated in the region of neck, upper shoulder girdle, stomach. What is the main pathogenic mechanism of obesity?

A. Decreased production of glucagon

*B. Increased production of glucocorticoids

C. Increased production of insulin

D. Decreased production of thyroid hormones

E. Increased production of mineral corticoids

The intake of oral contraceptives containing sex hormones inhibits secretion of the hypophysial hormones. Secretion of which of the indicated hormones is inhibited while taking oral contraceptives?

A. Thyrotropic

B. Vasopressin

*C. Follicle-stimulating

D. Oxytocin

E. Somatotropic

The precursor of testosterone is:

*A. Pregnenolone

B. Methyl testosterone

C. Estrone

D. Cortisol

E. Aldosterone

Thyrotoxicosis leads to increased production of thyroidal hormones T3 and T4, weight loss, tachycardia, psychic excitement and so on. How do thyroidal hormones influence energy metabolism in the mitochondrion of cells?

*A. Uncouple the oxidative phosphorylation

B. Stop substrate phosphorylation

C. Stop respiratory chain

D. Activate substrate phosphorylation

E. Activate oxidative phosphorylation

A patient is followed up in an endocrinological dispensary on account of hyperthyroidism. Weight loss, tachycardia, finger tremor are accompanied with hypoxia similar symptoms – headache, fatigue, eye flicker. Find out the result for the influence of high level of thyroid hormones on tissue respiration causing the development of hypoxia similar symptoms:

*A. Uncoupling of oxidation and phosphorylation

B. Specific binding of active centers of respiratory enzymes

C. Inhibition of respiratory enzymes synthesis

D. Competitive inhibition of respiratory enzymes

E. Intensification of respiratory enzymes synthesis

Estrogen receptors are seen in:

A. Microsomes

B. Cytoplasmic membrane bound

C. Mitochondria

D. EPR rough part

*E. Nucleus

Parents of a 10 y.o. boy consulted a doctor about extension of hair-covering, growth of beard and moustache, low voice. Intensified secretion of which hormone must be assumed?

A. Of cortisol

B. Of somatotropin

*C. Of testosterone

D. Of progesterone

E. Of oestrogen

A patient has osmotic pressure of blood plasma at the rate of 350 mOsmol/l (norm is 300 mOsmol/l). This will cause hypersecretion of the following hormone:

A. Vasopressin

B. Adrenocorticotropin

C. Aldosterone

*D. Natriuretic

E. Cortisol

Hypocalciemia can be caused by the violation of one hormone secretion. Point out this hormone:

A. Thyroxine

*B. Parathyroid hormone

C. Aldosterone

D. Somatotropic hormone

E. Corticotropic hormone

A 32-year-old female patient was consulted a doctor about the absence of lactation after parturition. Such disorder might be explained by the deficit of the following hormone:

A. Glucagon

*B. Prolactin

C. Calcitonin

D. Vasopressin

E. Somatotropin

People adapted to high external temperatures have such pecularity: profuse sweating isn’t accompanied by loss of large volumes of sodium chloride. This is caused by the effect of the following hormone upon the respiratory glands:

*A. Aldosterone

B. Vasopressin

C. Thyroxin

D. Cortisol

E. Natriuretic

The Simple goiter (enlarged thyroid) may be caused by:

A. Production of thyroid-stimulating IgG

B. Uncontrolled production of T3 and T4

*C. Iodide deficiency

D. Excessive intake of exogenous TSH

E. Decrease of TSH secretion

A patient with the signs of osteoporosis and urobithiasis has been admitted to the endocrinology department. Blood test revealed hypercalcemia and hypophosphatemia. These changes are associated with abnormal synthesis of the following hormone:

A. Calcitriol

B. Calcitonin

C. Cortisol

*D. Parathyroid hormone

E. Aldosterone