- •The approximate timing of classes
- •Practice work
- •Glossary
- •Office hours (2) Formation of practical skills on the theme «The subject, purposes and methods of pathological physiology”.
- •Case study
- •The approximate timing of classes
- •Practical work of students
- •Questions 1. What factors affect the mouse in this experiment?
- •2. Which of these factors could be considered the leading cause of the pathologic process - hypobaric hypoxia?
- •3. How can you experimentally check your presumptions about the nature of the pathologic process?
- •Pathogenesis of High altitude disease
- •Vicious circle in pathogenesis of High altitute disease
- •Office hours (2) Formation of practical skills on the theme «General etiology and pathogenesis. Effects of low barometric pressure on an organism”
- •Case Study Case 1. A group of tourists came under heavy rain. A day later, one of them developed pneumonia. Questions:
- •The approximate timing of classes
- •Glossary:
- •Office hours (2) Formation of practical skills on the theme «The role of reactivity of an organism in pathology”
- •The approximate timing of classes
- •Practical work of students
- •Explain the pathogenesis of hemolysis in tubes №№ 2-5 and the absence of hemolysis in tube number 1. Glossary
- •Office hours (2) Formation of practical skills on the theme “Cell injury”
- •Case Study
- •The approximate timing of classes
- •Practical work of students
- •I nfection, ischemia, traumas, tumors, burns, immune pathological processes, etc.
- •The significance of acute phase reactions for organism
- •Glossary
- •Types of fever on the basis of the extent of temperature elevation:
- •Types of fever on the basis of temperature fluctuation:
- •- Remittent (fluctuation 1-20c) (viral and bacterial infections, exudative pleuritis)
- •Control -test Office hours (2) Formation of practical skills on the theme “systemic organism’s response to damage. Fever”
- •Case Study
- •Control – conclusions on the cases
- •The approximate timing of class
- •Practical work of students
- •Glossary
- •Office hours (2) Formation of practical skills on the theme “Disorders of water and electrolyte metabolism”
- •The approximate timing of classes
- •Vasoconstriction Vasodilation of brain vessels High irritability of n. Vagus
- •Non respiratory (metabolic) alkalosis
- •Compensatory mechanisms at abb disorders
- •Glossary
- •Nongaseous acidosis (metabolic, exogenous, excretory) develops when there is accumulation of acidic products (metabolic disorders, acid intake from outside, diarrhea)
- •Office hours (2) Formation of practical skills on the theme “Acid-base disorders”
- •The approximate timing of classes
- •Practical work of students
- •Glossary
- •Control -test Office hours (2) Midterm control 1
- •The approximate timing of class
- •Practical work of students
- •Глоссарий
- •Office hours (2) Formation of practical skills on the theme “Disorders of carbohydrate metabolism”
- •The approximate timing of class
- •Case-study case 1
- •Control -test Office hours (2) Formation of practical skills on the theme “Disorders of protein and lipid metabolism”
The approximate timing of classes
№ |
Steps of the class |
Time (min) |
1 |
Organizational part. Roll Call, reading the goals and objectives of the class, distribution of demonstration material |
5 |
2 |
Discussion the questions |
45 |
3 |
Break |
10 |
4 |
Video film and its discussion |
15 |
5 |
Analysis of pathogenetic schemes |
15 |
6 |
Test |
10 |
7 |
Summarizing the classroom work, assessment of competencies |
10 |
Practical work of students
Task №1. To receive the model of Mountain sickness, to study its main symptoms (viewing of video film «Modeling of Mountain sickness»)
Technique. A mouse is placed in a hermetically sealed balloon of Komovsky’s apparatus. Examine an initial condition of an animal: behavior, character of breath, color of skin and mucous, with the help of the pump gradually pump out air, watching for a level of barometric pressure on a manometer. Fix character and sequence of changes at the level of barometric pressure 0.8 atm., 0.6 atm., 0.4 atm., 0.2 atm. In occurrence of convulsions immediately let air under the balloon. The received data bring in the table, conclude.
THE REPORT OF EXPERIMENT.
Level of barometric pressure |
The main symptoms |
Initial condition |
|
0,8 atm. |
|
0,6 atm. |
|
0,4 atm. |
|
0,2 atm. |
|
Questions 1. What factors affect the mouse in this experiment?
2. Which of these factors could be considered the leading cause of the pathologic process - hypobaric hypoxia?
3. How can you experimentally check your presumptions about the nature of the pathologic process?
Manometer reading of Komovsky’s apparatus in comparison with altitude above sea level and saturation of blood by oxygen
Manometer reading (- atm) |
Pressure (mm of Hg) |
Altitude (m) |
Saturation of arterial blood by oxygen (%) |
- 0,1 |
684 |
910 |
94 |
- 0,2 |
608 |
1830 |
91 |
- 0,3 |
532 |
2930 |
88 |
- 0,4 |
486 |
3680 |
84 |
- 0,5 |
380 |
6490 |
70 |
- 0,6 |
304 |
7000 |
51 |
- 0,7 |
228 |
9100 |
21 |
- 0,76 |
198 |
10600 |
10 |
- 0,8 |
152 |
11550 |
0 |
Task №2. To analyze Paul Bert’s experiment.
Two groups of mice are placed into the balloons of Komovsky’s apparatus. The first balloon is filled with air where barometric pressure is gradually reduced up to 210 mm. Hg. Thus animals have symptoms of Mountain sickness, convulsions develop.
The second balloon is filled with oxygen. Barometric pressure in this chamber is reduced up to 200 mm.Hg. Symptoms of Mountain sickness at animals of this group are absent. Which barocamera will have more alive mice? Why? Explain.
The task №3. Study the graphs of logic structure of Mountain sickness (High altitude disease)
№ 1.