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Nucleic Acids

The importance of nucleic acids to heredity emerged only gradually. Gregor Mendel's discoveries in 1865, based on his observations on the breeding of peas, were followed 20 years later by August Weismann's hypothesis that the number of chromosomes must be constant. There is not a simple relationship between the number of chromosomes and biological sophistication, however, because the potato possesses more chromosomes than the human being (who has 23 pairs). In 1926, Thomas Morgan suggested that genes are not separated entities, but that they are grouped together in the chromosomes. Sewall Wright had already postulated that genes control the production of enzymes. In 1900, Hugo de Vries had noticed that changes in the colouring of primroses are not gradual, but occur abruptly as spontaneous mutations. Hermann Müller and L. G. Stadlerr discovered that the mutation rate can be greatly increased by exposing the gamete cells (that is to say the fertilized egg cells) to X-rays, and George Beadle and Edward Tatum irradiated specimens of the common bread mould Neurospora crassa and discovered that it was then incapable of producing Vitamin B6. Wright's gene-enzyme link had been proved correct.

Frederick Griffith showed that the pneumonia bacterium, Diplococcus pneumoniae, is virulent when its polysaccharide coat is intact. This is designated the S form, from the smooth appearance of the resulting colonies. Rough-looking colonies are formed by the variety that lacks its coat (the R form), this being a consequence of its not possessing the relevant enzyme. Oswald Avery, Colin MacLeod and Maclin McCarthy repeated the Griffith experiment with various parts of the S form removed. Prior removal of the polysaccharide coat had no effect, nor did removal of an underlying protein capsule. However, if the bacterium's deoxyrobonucleic acid (DNA) is removed or denatured, its lethal potential is destroyed. Avery and his colleagues had established that DNA is the repository of the genetic message.

Observed in an electron microscope, DNA appears as a long, thin thread, its diameter being a mere 2nm. Maurice Wilkins, Rosalind Franklin and Raymond Gosling were surprised to find that X-ray diffraction patterns from such material did not display the expected variation with the species from which it had been extracted, and they were puzzled by the appearance of reflections corresponding to a distance of 3nm, which is considerably larger than the size of a single nucleotide.

Define the words

To breed, an entity, virulent, pneumonia, a repository, to denature.

Complete the sentences

  1. There is not a simple relationship between...

  2. Frederick Griffith showed that...

  3. Rough-looking colonies are formed...

  4. Prior removal of the polysaccharide coat had no effect...

  5. However, if the bacterium's DNA is removed or denatured…

  6. Observed in an electron microscope, DNA...

  7. Maurice Wilkins, Rosalind Franklin and Raymond Gosling were surprised to find that...

Put the following words and word combinations into the gaps

lethal / breeding / entity / specimens / chromosome / intact / diffraction pattern / heredity

Family resemblances are often strong—a visual manifestation of the mechanism of ______________.

For a very long time people believed that it was possible to obtain bizarre composite animals by ______________ widely different species.

The particular location of a gene on a ______________ is referred to as the gene’s locus (plural, loci).

The word “evolution” refers to how an ______________—be it a social system, a gas, or a planet—changes through time.

When examining cell membranes with electron microscopy, ______________ must be prepared for viewing.

The conservative model stated that the parental double helix would remain ______________ and generate DNA copies consisting of entirely new molecules.

Perhaps the most ______________ virus in human history has been the influenza virus.

When individual rays encounter atoms, their path is bent or diffracted, and the ______________ is recorded on photographic film.

Translate the text into Russian orally

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