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METHODOLOGY TEXT BOOK 2009 2010.doc
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Diseases of the vascular system and blood diseases

DISEASE

ATHERO-SCLEROSIS

THROMBOPHLEBITIS

DVT

ANEMIA

LEUKEMIA

Definition

Narrowing and hardening of the arteries

Inflammation of the veins with blood clotting

Clot formation commonly in the lower extremities

A deficiency in the red blood cell count

Cancer of the blood and bone marrow

Risk factors and/or causes

Age, diabetes, HBP, HBC, smoking, obesity, a sedentary lifestyle, a family history of stroke and heart attack

Age, history for varicose veins, prior history of the disease, prior IV or blood draw, traumas with bruising,

Chemotherapy mastectomy

risk factors: pregnancy, chronically bedridden or wheelchair bound, immediate postoperative patients, a history of prior DVT, birth control pills

Low iron, blood loss (B12 vitamin and folic acid deficiency, autoimmune d. bone marrow prob. (leukemia), sickle cell d., drug side effects, arsenic poisoning, lead intoxication

Exposure to radiation, chemicals, some drugs, viruses, genetic factors.

Causes are unknown

Symptoms and complications

Often no symptoms (chest pains, leg cramps).

Complications: heart attack, coronary artery disease, stroke, peripheral vascular disease, HBP, kidney disease, abdominal aortic aneurysm, ischemic bowel disease

Pains, tenderness, warmth, slight redness overlying a vein, more common in the lower extremities, also occurs in the arms and hands after an IV line

Unilateral leg swelling and pain, tenderness to the calf extending up the thigh, into the groin

Complications: embolization, pulmonary embolism

Fatigue, faintness or fainting, exertional shortness of breath, palpitations, no red blood vessels in the “whites”, no clearly defined red lines on the palm, black tarry stools, vomiting of coffee ground material

Weakness, fatigue, anemia, pallor, easy bruising, bleeding gums, nosebleeds, weight loss, swollen lymph glands,

Evaluation

Cholesterol tests

Physical examination, CBC

Angiodyno-graphy, venography, CBC,

coagulation profile

CBC, vitamin B12 levels, chemistry, stool tests, chest x-ray, bone marrow biopsy

CBC, microscopic test of white blood cells, bone marrow aspiration and biopsy

Treatment

Avoidance of smoking and stresses, control of diabetes control of HBP, control of weight, control of diet, exercise

Application of warmth, wet compresses, elevation of the site, rest, anti-inflammatory agents, aspirin

Heparin, anti-coagulant medications IV or orally, leg elevation, bed rest, warm compresses, bed rest, anti-inflammatory agents, aspirin

Transfusion of blood products, iron diet, ferrous sulfate, ferrous gluconate, B-complex vitamin

Anti-cancer drugs, chemotherapy, bone marrow transplantation