Lesson 16 Module 1

Point out the drug used for the decrease of cholesterol level in the blood of patients - allosteric inhibitor for key enzyme of cholesterol synthesis:

A. Aspirin

B. Lovastatin*

C. Barbiturate

D. Indomethacin

E. Antimicin A

Point out the atherogenic lipoproteins:

1. Nascent chylomicrones

2. Fatty acid-albumins complex

3. Low density lipoproteins*

4. High density lipoproteins

5. Remnant chylomicrones

The conversion of cholesterol catalyzed by 7α-hydroxylase is inhibited by:

1. Cortisol

2. Bile acids*

3. Testosterone

4. Calcitriol

5. Glycine and taurine

All hereinafter stated compounds are products of cholesterol catabolic conversion except one. Choose it:

1. Glucuronic acid*

2. Cholic acid

3. Chenodeoxycholic acid

4. Glucocorticoids

5. Mineralocorticoids

Find out the coenzyme used in some reactions of cholesterol synthesis:

A. FAD

B. NADH

C. Pyridoxal phosphate

D. NADPH*

E. Biotin

Which statement is not associated with situation of fat deposition?

1. Insulin secretion is increased

2. Blood free fatty acid levels are elevated

3. Hormone sensitive triacylglycerol lipase activity is increased*

4. Blood VLDL and chilomicrone levels are elevated

5. Lipoprotein lipase activity is increased

Which of the following statements explains correctly metabolic alterations that are specific for persons disposed to obesity beside people having standart weight?

1. Coupling of respiration with oxidative phosphorylation is much more

2. There is any genetic defect in leptin*

3. Rate of Krebs cycle reactions is higher

4. Calorie intake is much less

5. Rate of fatty acid β-oxidation is much less

The patient with diabetes mellitus has been delivered in hospital in the state of unconsciousness. Arterial pressure is low. The patient has acidosis. Point substances, which accumulation in the blood results in these manifestations:

1. Ketone bodies*

2. Monosaccharides

3. Cholesterol esters

4. High fatty acids

5. Amines

All of the following statements regarding hypercholesterolemia (type IIa hyperlipidemia) are correct except:

1. There is an increased risk of coronary artery disease

2. The blood serum cholesterol levels are increased

3. The blood serum triacylglycerol levels are elevated*

4. The blood serum low density lipoprotein (LDL) levels are high

5. It is due to a deficiency of LDL receptors

The liver is major site of cholesterol biosynthesis, although other tissues are also active in this regard.

The terminal products of cholesterol catabolism in the liver play the important role during lipids intake in human organism Point out these products:

A. Catecholamines

B. Bile acids*

C. Corticosteroids

D. Acetyl - SCoA

E. Cholanic acid

The synthesis of 1,25-dihydroxycholecalciferol take place:

1. In the skin under action of ultraviolet light from 7-dehydrocholesterol

2. In the intestine from cholecalciferol

3. In the liver from cholecalciferol

4. In the kidney from 25-hydroxycholecalciferol*

5. It is not synthesized in mammals

Find out pathological state associated with hypercholesterolemia in patient:

1. Hypothyroidism

2. Non-insulin dependent diabetes mellitus

3. Cholestasis

4. Nephritic syndrome

5. All the positions are right*

The inhibition of one liver enzyme in cholesterol synthesis was after surplus intake of fat meat. Name this enzyme:

A. Beta-hydroxy-beta-methyl-glutaryl-CoA-reductase*

B. Mevalonate kinase

C. Acetyl - CoA- acetyl transferase

D. Isopentenyl pyrophosphate isomerase

E. Squalene oxygenase

The enzyme system for cholesterol biosynthesis is located in the:

1. Golgi apparatus

2. Cytosol and EPR (smooth part)*

3. Cytosol and mitochodrial membrane

4. Mitochodrial matrix

5. Plasma membrane

Choose the value of Cholesterol _(LDL) + Cholesterol _(VLDL)/ Cholesterol_(HDL) ratio which is peculiar to healthy people:

1. 0.5-1.0

2. More then 3.5

3. Less then 3.5*

4. 4.0-6.0

5. 7.0-8.0