Isolated. Their morphological, tinctorial, cultural and biochemical properties appeared to be

typical for diphtheria causative agents. What study should be conducted in order to drow a

conclusion that this is a pathogenic diphtheria bacillus?

A Estimation of toxigenic properties

B Estimation of proteolytic properties

C Estimation of urease activity

D Estimation of cystinous activity

E Estimation of ability to decompose starch

*03* 75.b-12 A microorganism, isolated from a 5-year-old child's nasopharynx, is identical to Corynebacterium diphtheriae by morphological and biochemical properties, but doesn't form exotoxin. What process can make this microorganism toxigenetic?

Chromosome mutation.

*Phage conversion.

Cultivation on telurite medium.

Passage through the organism of sensitive animals.

Cultivation in the presence of antitoxic serum.

* A child, 5 years old, has admitted to hospital with painful throat and fever. Diagnosis “diphtheria” was made. It is known causative agent of diphtheria secretes toxin which damages translocation. Which way does it make?

*By translocase inhibition

By modification of protein translocation factor

With translation mistakes

By elongation of inhibition

By aminoacyl-m-RNA linkage damage

129. Examining a 6-year-olf child a doctor has noticed on pharyngeal tonsils a grayish "pseudomembrane". Attempt to remove it causes moderate bleeding. Bacterioscopy of tonsils swabs has shown Gram-positive club-shaped bacteria. What symptoms can appear within the next few days without specific treatment?

A. Very strong attack-like cough.

B. Lungs edema

C. *Toxic affection of the cardiac muscle, liver, kidneys.

D.Papular rash on skin.

E.Intermittent fever.

128. Antitoxic sera are used for the prophylaxis and treatment of:

A. Gonorrhea.

B. Whooping cough.

C. Shigellosis.

D. *Diphtheria.

E.Tuberculosis.

157. In the pediatric department of an infectious clinic a boy had diphtheria diagnosed. Which preparation should be injected first of all?

A. *Diphtheritic antitoxin.

B. Diphtheritic anatoxin.

C. APDT.

D.ADT.

E. TABTe

*06*08* In a patient with suspicious diphtheria microscopy of throat sample smear has revealed rod-shaped bacteria with volutin granules. Which etiotropic drug is agent of choice in this case?

Eubiotic

*Antidiphtheric antitoxic serum

Interferone

Diphtheria toxoid

Bacteriophage

168. It is necessary to carry out specific active prophylaxis of diphtheria of children in a kindergarten. What preparation should be used for this purpose?

A. *Toxoid.

B. Antibiotics.

C. Probiotics.

D. Corpuscular vaccine.

E.Immune serum.

Bordetella

b-12 A patient has been suffering from elevated temperature and attacks of typical cough for 10 days. Doctor administered inoculation of mucus from the patient's nasopharynx on the agar. What microorganism is presumed?

A Pertussis bacillus

B Pfeiffer's bacillus

C Listeria

D Klebsiella

E Staphylococcus

*05* 172. In a kindergarten vaccination against pertussis is planned. Which preparation is used for the immunization?

A. Type specific serum.

B.BCG vaccine.

C.*APDT vaccine (DPT).

D.Normal γ-globulin.

E. ADT vaccine.

*01*03*04* b-12 For serological diagnosis of whooping cough test tube reactions with pertussis and parapertussis diagnosticums were made. Granular deposit was formed onto the test tube bottom in which diagnosticum from Bordetella parapertussis had been inoculated. Which type of antibody has this reaction revealed?

Antitoxins

Bacteriolysins

*agglutinins

precipitins

Opsonins

*2013* A patient has severe catarrhal symptoms. Material growth on Bordet-Gengou agar showed mercury-drop-like colonies. Examination of the blood smears revealed some small ovoid gram-positive bacilli sized 1-3 μm. What microorganisms were isolated?

1. Brucella

2. Corynebacteria

3. Meningococcus

4. Mycobacteria

5. *Bordetella